Towards an understanding of the structurally based potential for mechanically activated disordering of small molecule organic crystals

Journal of Pharmaceutical Sciences

Volumn 95, Issue 12, 2006, Pages 2645-2656

  Wildfong, Peter L D ^a   Hancock, Bruno C ^b   Moore, Michael D ^c   Morris, Kenneth R ^d  

^a DUQUESNE UNIVERSITY   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^c Formulation Development Services   (India)

^d PURDUE UNIVERSITY   (United States)

Author keywords

Amorphous; Crystal defects; Crystal structure; Dislocations; Disordering; Mechanical activation; Mechanical properties; Milling; Thermal analysis; X ray diffractometry

Indexed keywords

ACETYLSALICYLIC ACID; INDOMETACIN; ORGANIC COMPOUND; PARACETAMOL; PFZ1; PFZ2; SALICYLAMIDE; SUCROSE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; CRYSTAL STRUCTURE; DIFFERENTIAL SCANNING CALORIMETRY; SHEAR STRESS; THERMAL ANALYSIS; X RAY POWDER DIFFRACTION; YOUNG MODULUS;

EID: 33846247122     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.20672     Document Type: Article

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