Autophagy is induced by 3β-O-succinyl-lupeol (LD9-4) in A549 cells via up-regulation of Beclin 1 and down-regulation mTOR pathway

European Journal of Pharmacology

Volumn 670, Issue 1, 2011, Pages 29-38

  Hao, Jing ^a,b   Pei, Ying ^c   Ji, Guiyuan ^d   Li, Weijie ^e   Feng, Shixiu ^a,b   Qiu, Shengxiang ^a  

^a SOUTH CHINA INSTITUTE OF BOTANY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c JINAN UNIVERSITY   (China)

^d SUN YAT SEN UNIVERSITY   (China)

^e HANSHAN NORMAL UNIVERSITY   (China)

Author keywords

A549; Apoptosis; Autophagy; Beclin 1; LD9 4; mTOR

Indexed keywords

3BETA O SUCCINYL LUPEOL; 4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; ANTINEOPLASTIC AGENT; BECLIN 1; DOXORUBICIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; LUPEOL; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; PHOSPHATIDYLSERINE; REACTIVE OXYGEN METABOLITE; S6 KINASE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CELL CULTURE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL CYCLE ARREST; CELL DEATH; CELL STRAIN A549; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IC 50; INCUBATION TIME; LUNG NON SMALL CELL CANCER; MITOSIS INHIBITION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTON NUCLEAR MAGNETIC RESONANCE; SIGNAL TRANSDUCTION; TRANSMISSION ELECTRON MICROSCOPY; UPREGULATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; CELL LINE, TUMOR; HUMANS; INTRACELLULAR SPACE; MATRIX METALLOPROTEINASES; MEMBRANE PROTEINS; NECROSIS; PENTACYCLIC TRITERPENES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SUCCINATES; TOR SERINE-THREONINE KINASES; UP-REGULATION;

EID: 80054721860     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.08.045     Document Type: Article

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