Pentagalloylglucose induces autophagy and caspase-independent programmed deaths in human PC-3 and mouse TRAMP-C2 prostate cancer cells

Molecular Cancer Therapeutics

Volumn 8, Issue 10, 2009, Pages 2833-2843

  Hu, Hongbo ^a,c   Chai, Yubo ^a   Wang, Lei ^a   Zhang, Jinhui ^a   Lee, Hyo Jeong ^a,b   Kim, Sung Hoon ^a,b   Lü, Junxuan ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b Kyung Hee University   (South Korea)

^c CHINA AGRICULTURAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BECLIN 1; CASPASE; DEATH RECEPTOR; GLUCOSE PENTAGALLATE; LIPID; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SYNAPSIN I;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; BIOCHEMISTRY; CANCER CELL CULTURE; CANCER INHIBITION; CELL DEATH; CELL STRAIN DU 145; CELL STRAIN LNCAP; CELL STRAIN PC 3; CELL STRAIN TRAMP C2; CONTROLLED STUDY; HUMAN; HUMAN CELL; MALE; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN PHOSPHORYLATION; TUMOR XENOGRAFT;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADENINE; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; CASPASES; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME ACTIVATION; GENE KNOCKDOWN TECHNIQUES; GTPASE-ACTIVATING PROTEINS; HUMANS; HYDROLYZABLE TANNINS; MALE; MEMBRANE PROTEINS; MICE; PROSTATIC NEOPLASMS; PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; SIROLIMUS; TUMOR STEM CELL ASSAY;

EID: 70350218946     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-09-0288     Document Type: Article

References (42)

1. Kroemer G,Ga lluzzi L, Vandenabeele P,et al. Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009. Cell Death Differ 2009;16:3-11.
2. Festjens N,V anden Berghe T,Cornelis S,V andenabeele P. RIP1,a kinase on the crossroads of a cell's decision to live or die. Cell Death Differ 2007;14:400-410
3. Vandenabeele P,V anden Berghe T,Festjens N. Caspase inhibitors promote alternative cell death pathways. Sci STKE 2006;2006:e44.
4. Kroemer G,Jaattela M. Lysosomes and autophagy in cell death control. Nat Rev Cancer 2005;5:886-897 (Pubitemid 41746033)
5. Hu H, Lee HJ, Jiang C, et al. Penta-1,2,3,4,6-O-galloyl-β-D-glucose induces p53 and inhibits STAT3 in prostate cancer cells in vitro and suppresses prostate xenograft tumor growth in vivo. Mol Cancer Ther 2008;7:2681-2691
6. Kuo PT,Lin TP,Liu LC, et al. Penta-O-galloyl-β-D-glucose suppresses prostate cancer bone metastasis by transcriptionally repressing EGF-induced MMP-9 expression. J Agric Food Chem 2009;57:3331-3339
7. van Bokhoven A,V arella-Garcia M, Korch C,et al. Molecular characterization of human prostate carcinoma cell lines. Prostate 2003;57:205-225
8. Shin DS,Kim HN,Shin KD, et al. Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells. Cancer Res 2009;69:193-202.
9. Levine B,Sinha S,Kroemer G. Bcl-2 family members: dual regulators of apoptosis and autophagy. Autophagy 2008;4:600-606
10. Guertin DA,Sa batini DM. An expanding role for mTOR in cancer. Trends Mol Med 2005;11:353-361
11. Huh JE, Lee EO,Kim MS,e t al. Penta-O-galloyl-β-D-glucose suppresses tumor growth via inhibition of angiogenesis and stimulation of apoptosis: roles of cyclooxygenase-2 and mitogen-activated protein kinase pathways. Carcinogenesis 2005;26:1436-1445
12. Foster BA,Gingrich JR,Kwon ED,Madias C, Greenberg NM. Characterization of prostatic epithelial cell lines derived from transgenic adenocarcinoma of the mouse prostate (TRAMP) model. Cancer Res 1997;57:3325-3330
13. Jiang C,W ang Z, Ganther H,L u J. Caspases as key executors of methyl selenium-induced apoptosis (anoikis) of DU-145 prostate cancer cells. Cancer Res 2001;61:3062-3070
14. Hu H,Jiang C,Ip C,Rustum YM,Lu J. Methylseleninic acid potentiates apoptosis induced by chemotherapeutic drugs in androgen-independent prostate cancer cells. Clin Cancer Res 2005;11:2379-2388 (Pubitemid 40490199)
15. Hu H,Zhang J,Lee HJ, Kim SH,Lu J. Penta-O-galloyl-β-D-glucose induces S- and G(1)-cell cycle arrests in prostate cancer cells targeting DNA replication and cyclin D1. Carcinogenesis 2009;30:818-823
16. Budihardjo I,Oli ver H,Lut ter M,Lu o X, Wang X. Biochemical pathways of caspase activation during apoptosis. Annu Rev Cell Dev Biol 1999;15:269-290
17. Jiang X,W ang X. Cytochrome c-mediated apoptosis. Annu Rev Biochem 2004;73:87-106.
18. Ruchaud S,Se ite P,Fou lkes NS,S assone-Corsi P,L anotte M. The transcriptional repressor ICER and cAMP-induced programmed cell death. Oncogene 1997;15:827-836
19. Vento R,Giuliano M,Lauricella M,Carabillo M,Di Liberto D, Tesoriere G. Induction of programmed cell death in human retinoblastoma Y79 cells by C2-ceramide. Mol Cell Biochem 1998;185:7-15. (Pubitemid 28408491)
20. Herman-Antosiewicz A,Johnson DE, Singh SV. Sulforaphane causes autophagy to inhibit release of cytochrome c and apoptosis in human prostate cancer cells. Cancer Res 2006;66:5828-5835
21. del Peso L,Gonzalez-Garcia M,Page C,Herrera R, Nunez G. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science 1997;278:687-689 (Pubitemid 27464966)
22. Cardone MH,Roy N, Stennicke HR,et al. Regulation of cell death protease caspase-9 by phosphorylation. Science 1998;282:1318-1321
23. Degterev A,Hitomi J,Germscheid M,et al. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol 2008;4:313-321
24. Hu H,Jiang C,Li G,Lu J. PKB/AKT and ERK regulation of caspase-mediated apoptosis by methylseleninic acid in LNCaP prostate cancer cells. Carcinogenesis 2005;26:1374-1381 (Pubitemid 41417880)
25. Nesterov A, Lu X,Jo hnson M,Mi ller GJ, Ivashchenko Y,Kra ft AS. Elevated AKT activity protects the prostate cancer cell line LNCaP from TRAIL-induced apoptosis. J Biol Chem 2001;276:10767-10774
26. Rokhlin OW,Gus eva N,T agiyev A, Knudson CM,Co hen MB. Bcl-2 oncoprotein protects the human prostatic carcinoma cell line PC3 from TRAIL-mediated apoptosis. Oncogene 2001;20:2836-2843
27. Hu H,Jiang C,Schuster T,Li GX,Daniel PT, Lu J. Inorganic selenium sensitizes prostate cancer cells to TRAIL-induced apoptosis through superoxide/ p53/Bax-mediated activation of mitochondrial pathway. Mol Cancer Ther 2006;5:1873-1882 (Pubitemid 44323256)
28. Miyashita T,Reed JC. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 1995;80:293-299
29. Nakano K,V ousden KH. PUMA,a novel proapoptotic gene, is induced by p53. Mol Cell 2001;7:683-694
30. Yu J, Zhang L, Hwang PM,Ki nzler KW,V ogelstein B. PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell 2001;7:673-682
31. Liu X,Y ue P,Khuri FR, Sun SY. p53 Upregulates death receptor 4 expression through an intronic p53 binding site. Cancer Res 2004;64:5078-5083
32. Sheikh MS,Burns TF, Huang Y,et al. p53-Dependent and -independent regulation of the death receptor KILLER/DR5 gene expression in response to genotoxic stress and tumor necrosis factor α. Cancer Res 1998;58:1593-1598
33. Chipuk JE,Kuwana T, Bouchier-Hayes L,et al. Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 2004;303:1010-1014
34. Chipuk JE,Bouchier-Hayes L,Kuwana T,Newmeyer DD,Green DR. PUMA couples the nuclear and cytoplasmic proapoptotic function of p53. Science 2005;309:1732-1735
35. Sayan BS,Sayan AE,Knight RA, Melino G,Cohen GM. p53 Is cleaved by caspases generating fragments localizing to mitochondria. J Biol Chem 2006;281:13566-13573
36. Liu B,Chen Y, St Clair DK. ROS and p53: a versatile partnership. Free Radic Biol Med 2008;44:1529-1535
37. Wan X,Harkavy B,Shen N,Grohar P, Helman LJ. Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism. Oncogene 2007;26:1932-1940
38. O'Reilly KE,Rojo F,She QB,et al. mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res 2006;66:1500-1508
39. Sun SY,Rosenberg LM,W ang X,et al. Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition. Cancer Res 2005;65:7052-7058
40. Tasdemir E,Maiuri MC, Galluzzi L, et al. Regulation of autophagy by cytoplasmic p53. Nat Cell Biol 2008;10:676-687
41. Tasdemir E,Maiuri MC, Orhon I,et al. p53 Represses autophagy in a cell cycle-dependent fashion. Cell Cycle 2008;7:3006-3011
42. Morselli E,T asdemir E, Maiuri MC,et al. Mutant p53 protein localized in the cytoplasm inhibits autophagy. Cell Cycle 2008;7:3056-3061