NV-128, a novel isoflavone derivative, induces caspase-independent cell death through the Akt/mammalian target of rapamycin pathway

Cancer

Volumn 115, Issue 14, 2009, Pages 3204-3216

  Alvero, Ayesha B ^a   Montagna, Michele K ^a   Chen, Rui ^a,b   Ki, Hyung Kim ^a   Kyungjin, Kim ^a   Visintin, Irene ^a   Fu, Han Hsuan ^a   Brown, David ^c   Mor, Gil ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY   (United States)

^c Novogen Ltd   (Australia)

Author keywords

Caspase independent apoptosis; Chemoresistance; Mammalian target of rapamycin; Ovarian cancer

Indexed keywords

APOPTOSIS REGULATORY PROTEIN; BECLIN 1; CARBOPLATIN; CASPASE; ENDONUCLEASE G; ISOFLAVONE DERIVATIVE; MAMMALIAN TARGET OF RAPAMYCIN; NV 128; PACLITAXEL; PROTEIN KINASE B; S6 KINASE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL CULTURE; CELL DEATH; CHEMOSENSITIVITY; CHROMATIN CONDENSATION; CONTROLLED STUDY; ENZYME ACTIVITY; FLOW CYTOMETRY; GENE TRANSLOCATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; IN VIVO STUDY; MITOCHONDRION; MOUSE; NONHUMAN; OVARY CANCER; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; AUTOPHAGY; CASPASES; CELL DEATH; CELL LINE, TUMOR; CELL SURVIVAL; CHROMATIN; DOWN-REGULATION; FEMALE; HUMANS; ISOFLAVONES; MICE; MITOCHONDRIA; ONCOGENE PROTEIN V-AKT; OVARIAN NEOPLASMS; PHOSPHORYLATION; PROTEIN KINASES; SIGNAL TRANSDUCTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 68549087108     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.24397     Document Type: Article

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