Synthesis of 2- and 2,3-substituted Pyrazolo[1,5- a ]pyridines: Scope and mechanistic considerations of a domino direct alkynylation and cyclization of n -iminopyridinium ylides using alkenyl bromides, alkenyl iodides, and alkynes

Journal of Organic Chemistry

Volumn 76, Issue 20, 2011, Pages 8243-8261

  Mousseau, James J ^a   Bull, James A ^a   Ladd, Carolyn L ^a   Fortier, Angélique ^a   Sustac Roman, Daniela ^a   Charette, André B ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALKENYL; ALKYL SUBSTITUTION; ALKYNYLATIONS; FUNCTIONALIZATIONS; MECHANISTIC STUDIES; REACTIVE SITE; TANDEM PROCESS; TERMINAL ALKYNE; TIME EFFICIENCIES;

ACETYLENE; ALKYLATION; BROMINE COMPOUNDS; PYRIDINE; SYNTHESIS (CHEMICAL);

CYCLIZATION;

2 SUBSTITUTED PYRAZOLO(1,5 ALPHA)PYRIDINE; ALKENYL BROMIDE; ALKENYL IODIDE; ALKYNE DERIVATIVE; PALLADIUM; PYRIDINE DERIVATIVE; SILVER; UNCLASSIFIED DRUG;

ALKYNYLATION; ARTICLE; CONTROLLED STUDY; CYCLIZATION; DRUG MECHANISM; DRUG SCREENING; DRUG SYNTHESIS; STOICHIOMETRY; TEMPERATURE SENSITIVITY;

ALKENES; ALKYNES; BROMIDES; CATALYSIS; CHEMISTRY, PHARMACEUTICAL; CYCLIZATION; DOPAMINE AGONISTS; DOPAMINE ANTAGONISTS; HUMANS; IODIDES; MAGNETIC RESONANCE SPECTROSCOPY; NEURODEGENERATIVE DISEASES; PALLADIUM; PYRAZOLES; PYRIDINES; RECEPTORS, DOPAMINE; SILVER;

EID: 80054106457     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo201303x     Document Type: Article

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