Discovery of 6-oxo-3 (2-phenylpyrazolo[1,5-α]pyridin-3-yl) 1(6H)- pyridazinebutanoic acid (FK 838): A novel non-xanthine adenosine A1 receptor antagonist with potent diuretic activity [1]

Journal of Medicinal Chemistry

Volumn 42, Issue 5, 1999, Pages 779-783

  Akahane, Atsushi ^a   Katayama, Hirohito ^a   Mitsunaga, Takafumi ^a   Kato, Takeshi ^a   Kinoshita, Takayoshi ^a   Kita, Yasuhiro ^a   Kusunoki, Takahiro ^a   Terai, Takao ^a   Yoshida, Keizo ^a   Shiokawa, Youichi ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

6 OXO 3 (2 PHENYLPYRAZOLO[1,5 A]PYRIDIN 3 YL) 1(6H) PYRIDAZINEBUTYRIC ACID; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ACRYLIC ACID METHYL ESTER; ADENOSINE; ADENOSINE A1 RECEPTOR ANTAGONIST; PURINE NUCLEOSIDE; PYRIDAZINONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANTIDIURESIS; BINDING AFFINITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG BINDING; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROPHOBICITY; LETTER; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; DIURETICS; DRUG DESIGN; PYRAZOLES; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033545638     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980671w     Document Type: Letter

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