Survey of GMP bulk reactions run in a research facility between 1985 and 2002

Organic Process Research and Development

Volumn 9, Issue 3, 2005, Pages 253-258

  Dugger, Robert W ^a   Ragan, John A ^a   Brown Ripin, David H ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RESERPINE; TSUKUBAENOLIDE;

ADDITION REACTION; ALDOL REACTION; CHEMICAL BOND; DEPROTECTION REACTION; FRIEDEL CRAFTS REACTION; GRIGNARD REACTION; MICHAEL ADDITION; ORGANIC CHEMISTRY; OXIDATION REDUCTION REACTION; REVIEW;

EID: 20444492038     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op050021j     Document Type: Review

References (15)

1. A common misperception of Process Chemistry is that many modern synthetic methods or reagents cannot be run on scale under any circumstances; in reality, there are few reagents or methods that cannot be scaled. The more relevant questions include: can it be done safely and cost-effectively? Are there patent issues with the technology? Is the method sufficiently robust to operate reliably in a variety of facilities? Not surprisingly, there are few methods or reagents for which the answer to all of these questions is either "definitely yes" or "absolutely not." There are gray areas, and the issue is rarely "we cannot do this on any scale, an alternative must be identified", but rather "we can probably do this with the appropriate support and background work to render the process safe and robust, but there might be alternatives which will be faster and more cost-effective than optimizing the current process".
2. Our data set was limited to Pfizer drug candidates, but given the wide variety of therapeutic areas and molecular targets pursued by Pfizer Discovery, we feel it is likely that conclusions drawn from this data set will have some relevance to pharmaceutical products as a whole.
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