Two carbohydrate binding sites in the HCC-domain of tetanus neurotoxin are required for toxicity

Journal of Molecular Biology

Volumn 326, Issue 3, 2003, Pages 835-847

  Rummel, Andreas ^a   Bade, Steffen ^a   Alves, Jürgen ^a   Bigalke, Hans ^a   Binz, Thomas ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Ganglioside binding site; HC fragment; MALDI TOF mass spectroscopy; Phrenic nerve toxicity assay; Recombinant tetanus neurotoxin

Indexed keywords

AMINO ACID DERIVATIVE; ASPARAGINE; ASPARTIC ACID; CARBOHYDRATE; CHOLERA TOXIN; GANGLIOSIDE GT 1B; GLYCOPROTEIN; LACTOSE; LYSINE; NEUROTOXIN; RECEPTOR; SERINE; SIALIC ACID; TETANUS TOXIN; TRYPTOPHAN; TYROSINE;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; BRAIN SYNAPTOSOME; CARBOXY TERMINAL SEQUENCE; CIRCULAR DICHROISM; CONTROLLED STUDY; EXOCYTOSIS; FLUORESCENCE SPECTROSCOPY; GEL PERMEATION CHROMATOGRAPHY; INHIBITION KINETICS; MASS SPECTROMETRY; MOUSE; NEUROTOXICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PERIPHERAL NERVE; PHRENIC NERVE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; SITE DIRECTED MUTAGENESIS; TOXIN STRUCTURE;

EID: 0037459107     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2836(02)01403-1     Document Type: Article

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