Botulinum neurotoxin devoid of receptor binding domain translocates active protease

PLoS Pathogens

Volumn 4, Issue 12, 2008, Pages

  Fischer, Audrey ^a   Mushrush, Darren J ^b   Lacy, D Borden ^b   Montal, Mauricio ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BOTULINUM TOXIN; CHAPERONE; PROTEINASE; BOTULINUM TOXIN A; CELL SURFACE RECEPTOR; ION CHANNEL; PEPTIDE HYDROLASE;

ARTICLE; CHANNEL GATING; CYTOSOL; ENZYME SUBSTRATE; LIGHT CHAIN; NERVE CELL; NONHUMAN; OXIDATION REDUCTION REACTION; PATCH CLAMP; PH; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PURIFICATION; RECEPTOR BINDING; WESTERN BLOTTING; CELL CULTURE; CHEMISTRY; DRUG DELIVERY SYSTEM; ENZYME ACTIVATION; GENE DELETION; GENETICS; HUMAN; METABOLISM; METHODOLOGY; PHYSIOLOGY; PROTEIN BINDING; PROTEIN ENGINEERING; PROTEIN TERTIARY STRUCTURE; PROTEIN TRANSPORT; VIRUS ENTRY;

CLOSTRIDIUM BOTULINUM;

BOTULINUM TOXIN TYPE A; CELLS, CULTURED; DRUG DELIVERY SYSTEMS; ENZYME ACTIVATION; GENE DELETION; HUMANS; ION CHANNELS; MOLECULAR CHAPERONES; PEPTIDE HYDROLASES; PROTEIN BINDING; PROTEIN ENGINEERING; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RECEPTORS, CELL SURFACE; VIRUS INTERNALIZATION;

EID: 58149252452     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1000245     Document Type: Article

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