Downregulation of differentiation specific gene expression by oxidative stress in ARPE-19 cells

Investigative Ophthalmology and Visual Science

Volumn 42, Issue 11, 2001, Pages 2706-2713

  Alizadeh, M ^a   Wada, M ^a   Gelfman, C M ^a   Handa, J T ^a   Hjelmeland, L M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CELL DIFFERENTIATION; CELL VIABILITY; DOWN REGULATION; GENE EXPRESSION; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PIGMENT EPITHELIUM; PRIORITY JOURNAL;

BLOTTING, NORTHERN; CARRIER PROTEINS; CELL DIFFERENTIATION; CELL LINE; DOWN-REGULATION; EYE PROTEINS; GENE EXPRESSION; HEME OXYGENASE (DECYCLIZING); HEME OXYGENASE-1; HUMANS; HYDROGEN PEROXIDE; MEMBRANE PROTEINS; OXIDATIVE STRESS; PROTEINS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 1; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 2; RECEPTORS, FIBROBLAST GROWTH FACTOR; RETINAL GANGLION CELLS; RNA, MESSENGER; TERT-BUTYLHYDROPEROXIDE; TIME FACTORS;

EID: 0034787989     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Systemic hyperoxia decreases vascular endothelial growth factor gene expression in ischemic primate retina
2. Oxidative damage and age-related macular degeneration
3. Oxygen modulates the response of the retinal pigment epithelium to basic fibroblast growth factor and epidermal growth factor by receptor regulation
4. Neurotrophic factors, cytokines and stress increase expression of basic fibroblast growth factor in retinal pigmented epithelial cells
5. 2 induce catalase and metallothionein gene expression in human retinal pigment epithelial cells
6. Induction of stress proteins in cultured human RPE-derived cells
7. Oxidant-induced apoptosis in cultured human retinal pigment epithelial cells
8. ARPE-19, a human retinal pigment epithelial cell line with differentiated properties
9. Use of the ARPE-19 cell line as a model of RPE polarity: Basolateral secretion of FGF5
10. Cloning of the cDNAs encoding the cellular retinaldehyde-binding protein from bovine and human retina and comparison of the protein structures
11. Molecular characterization of the human gene encoding an abundant 61 kDa protein specific to the retinal pigment epithelium
12. Molecular cloning and expression of RPE65, a novel retinal pigment epithelium-specific microsomal protein that is post-transcriptionally regulated in vitro
13. Differentiation of retinal pigment epithelial cells in vitro uncovers silencer activity in the FGF-5 gene promoter
14. Expression and splicing of FGF receptor mRNAs during APRE-19 cell differentiation in vitro
15. Oxidative damage and protection of the RPE
16. Induction of the mammalian stress response gene GADD153 by oxidative stress: Role of AP-1 element
17. Cell density, regulates differential production of bFGF transcripts
18. Cloning and expression of cDNA for rat heme oxygenase
19. A microplate assay for the detection of oxidative products using 2′,7′-dichlorofluorescein-diacetate
20. Heme oxygenase: Recent advances in understanding its regulation and role
21. Induction of heme oxygenase: A general response to oxidant stress in cultured mammalian cells
22. Antioxidant enzymes in the aging human retinal pigment epithelium
23. Evaluation of oxidative processes in human pigment epithelial cells associated with retinal outer segment phagocytosis
24. Characterization of t-butyl hydroperoxide toxicity, in cultured rat cortical neurones and astrocytes
25. Regulation of antioxidant enzyme gene expression in response to oxidative stress and during differentiation of mouse skeletal muscle
26. Oxidative stress and gene regulation
27. Low glutathione reductase and peroxidase activity in age-related macular degeneration
28. Antioxidant enzymes in the macular retinal pigment epithelium of eyes with neovascular age-related macular degeneration
29. Receptor specificity of the fibroblast growth factor family
30. Identification of fibroblast growth factor 9 (FGF9) as a high affinity, heparin dependent ligand for FGF receptors 3 and 2 but not for FGF receptors 1 and 4
31. Splice variants of FGFR2 and FGFR3 form a potential autocrine/paracrine loop with FGF9 in human RPE