-
1
-
-
66249108601
-
Understanding the warburg effect: The metabolic requirements of cell proliferation
-
Vander Heiden M G, Cantley L C, Thompson C B. Understanding the Warburg effect: the metabolic requirements of cell proliferation, Science, 2009, 324(5930): 1029-1033
-
(2009)
Science
, vol.324
, Issue.5930
, pp. 1029-1033
-
-
Vander Heiden, M.G.1
Cantley, L.C.2
Thompson, C.B.3
-
2
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D, Weinberg R A. The hallmarks of cancer. Cell, 2000, 100(1): 57-70 (Pubitemid 30046295)
-
(2000)
Cell
, vol.100
, Issue.1
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
3
-
-
57449087215
-
Is cancer a disease of abnormal cellular metabolism?. New angles on an old idea
-
DeBerardinis R J. Is cancer a disease of abnormal cellular metabolism?. New angles on an old idea. Genet Med, 2008, 10(11): 767-777
-
(2008)
Genet Med
, vol.10
, Issue.11
, pp. 767-777
-
-
DeBerardinis, R.J.1
-
4
-
-
0001221508
-
On respiratory impairment in cancer cells
-
Warburg O. On respiratory impairment in cancer cells. Science, 1956, 124(3215): 269-270
-
(1956)
Science
, vol.124
, Issue.3215
, pp. 269-270
-
-
Warburg, O.1
-
5
-
-
64549106080
-
Mitochondrial function and energy metabolism in cancer cells: Past overview and future perspectives
-
Mayevsky A. Mitochondrial function and energy metabolism in cancer cells: past overview and future perspectives, Mitochondrion, 2009, 9(3): 165-179
-
(2009)
Mitochondrion
, vol.9
, Issue.3
, pp. 165-179
-
-
Mayevsky, A.1
-
6
-
-
44449147036
-
Tumor cell metabolism: Cancer's achilles' heel
-
DOI 10.1016/j.ccr.2008.05.005, PII S1535610808001608
-
Kroemer G, Pouyssegur J. Tumor cell metabolism: cancer's Achilles' heel. Cancer Cell, 2008, 13(6): 472-482 (Pubitemid 351766797)
-
(2008)
Cancer Cell
, vol.13
, Issue.6
, pp. 472-482
-
-
Kroemer, G.1
Pouyssegur, J.2
-
7
-
-
52649107626
-
Cancer cell metabolism: Warburg and beyond
-
Hsu P P, Sabatini D M. Cancer cell metabolism: Warburg and beyond. Cell, 2008,134(5): 703-707
-
(2008)
Cell
, vol.134
, Issue.5
, pp. 703-707
-
-
Hsu, P.P.1
Sabatini, D.M.2
-
8
-
-
35448982216
-
Hypoxia, glucose metabolism and the Warburg's effect
-
DOI 10.1007/s10863-007-9080-3, Special Topic: The Warburg Effect: Its Continued Impact on Cancer Research into the 21st Century
-
Bartrons R, Caro J. Hypoxia, glucose metabolism and the Warburg's effect. J Bioenerg Biomembr, 2007, 39(3): 223-229 (Pubitemid 47619374)
-
(2007)
Journal of Bioenergetics and Biomembranes
, vol.39
, Issue.3
, pp. 223-229
-
-
Bartrons, R.1
Caro, J.2
-
9
-
-
43649093915
-
Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway
-
DOI 10.1016/j.molcel.2008.04.009, PII S109727650800292X
-
Kaelin W G, Ratcliffe Jr P J. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol Cell, 2008, 30(4): 393-402 (Pubitemid 351681994)
-
(2008)
Molecular Cell
, vol.30
, Issue.4
, pp. 393-402
-
-
Kaelin Jr., W.G.1
Ratcliffe, P.J.2
-
10
-
-
76049100577
-
HIF-1: Upstream and downstream of cancer metabolism
-
Semenza G L. HIF-1: upstream and downstream of cancer metabolism. Curr Opin Genet Dev, 2010, 20(1): 51-56
-
(2010)
Curr Opin Genet Dev
, vol.20
, Issue.1
, pp. 51-56
-
-
Semenza, G.L.1
-
11
-
-
35348904953
-
Rsume, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1α during hypoxia
-
DOI 10.1016/j.cell.2007.07.044, PII S0092867407010240
-
Carbia-Nagashima A, Gerez J, Perez-Castro C, et al. RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1 alpha during hypoxia. Cell, 2007, 131(2): 309-323 (Pubitemid 47592916)
-
(2007)
Cell
, vol.131
, Issue.2
, pp. 309-323
-
-
Carbia-Nagashima, A.1
Gerez, J.2
Perez-Castro, C.3
Paez-Pereda, M.4
Silberstein, S.5
Stalla, G.K.6
Holsboer, F.7
Arzt, E.8
-
12
-
-
35548935098
-
SUMO-specific protease 1 is essential for stabilization of HIF1α during hypoxia
-
DOI 10.1016/j.cell.2007.08.045, PII S0092867407011439
-
Cheng J, Kang X, Zhang S, et al. SUMO-specific protease 1 is essential for stabilization of HIF1 alpha during hypoxia. Cell, 2007, 131(3): 584-595 (Pubitemid 350007694)
-
(2007)
Cell
, vol.131
, Issue.3
, pp. 584-595
-
-
Cheng, J.1
Kang, X.2
Zhang, S.3
Yeh, E.T.H.4
-
14
-
-
12944262229
-
Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer
-
DOI 10.1002/jcp.20166
-
Macheda M L, Rogers S, Best J D, Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer. J Cell Physiol, 2005, 202(3): 654-662 (Pubitemid 40175840)
-
(2005)
Journal of Cellular Physiology
, vol.202
, Issue.3
, pp. 654-662
-
-
Macheda, M.L.1
Rogers, S.2
Best, J.D.3
-
15
-
-
33644614520
-
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
-
Kim J W, Tchemyshyov I, Semenza G L, et al. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab, 2006, 3(3): 177-185
-
(2006)
Cell Metab
, vol.3
, Issue.3
, pp. 177-185
-
-
Kim, J.W.1
Tchemyshyov, I.2
Semenza, G.L.3
-
16
-
-
35649014840
-
Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1
-
DOI 10.1128/MCB.00440-07
-
Kim J W, Gao P, Liu Y C, et al. Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1. Mol Cell Biol, 2007, 27(21): 7381-7393 (Pubitemid 350033646)
-
(2007)
Molecular and Cellular Biology
, vol.27
, Issue.21
, pp. 7381-7393
-
-
Kim, J.-W.1
Gao, P.2
Liu, Y.-C.3
Semenza, G.L.4
Dang, C.V.5
-
17
-
-
43649104579
-
Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia
-
Zhang H, Bosch-Marce M, Shimoda L A, et al. Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J Biol Chem, 2008, 283(16): 10892-10903
-
(2008)
J Biol Chem
, vol.283
, Issue.16
, pp. 10892-10903
-
-
Zhang, H.1
Bosch-Marce, M.2
Shimoda, L.A.3
-
18
-
-
34250788809
-
AKT/PKB signaling: Navigating downstream
-
DOI 10.1016/j.cell.2007.06.009, PII S0092867407007751
-
Manning B D, Cantley L C. AKT/PKB signaling: navigating downstream. Cell, 2007, 129(7): 1261-1274 (Pubitemid 46962095)
-
(2007)
Cell
, vol.129
, Issue.7
, pp. 1261-1274
-
-
Manning, B.D.1
Cantley, L.C.2
-
19
-
-
60549111398
-
Is akt the "warburg kinase"?-Akt-energy metabolism interactions and oncogenesis
-
Robey R B, Hay N. Is Akt the "Warburg kinase"?-Akt-energy metabolism interactions and oncogenesis. Semin Cancer Biol, 2009, 19(1): 25-31
-
(2009)
Semin Cancer Biol
, vol.19
, Issue.1
, pp. 25-31
-
-
Robey, R.B.1
Hay, N.2
-
20
-
-
70349331678
-
Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells
-
Yun J, Rago C, Cheong I, et al. Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells. Science, 2009, 325(5947): 1555-1559
-
(2009)
Science
, vol.325
, Issue.5947
, pp. 1555-1559
-
-
Yun, J.1
Rago, C.2
Cheong, I.3
-
21
-
-
67650480092
-
MTOR and HIF-1 alpha-mediated tumor metabolism in an LKBl mouse model of Peutz-Jeghers syndrome
-
Shackelford D B, Vasquez D S, Corbeil J, et al. mTOR and HIF-1 alpha-mediated tumor metabolism in an LKBl mouse model of Peutz-Jeghers syndrome. Proc Natl Acad Sci USA, 2009, 106(27): 11137-11142
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, Issue.27
, pp. 11137-11142
-
-
Shackelford, D.B.1
Vasquez, D.S.2
Corbeil, J.3
-
22
-
-
35448940790
-
A pivotal role for p53: Balancing aerobic respiration and glycolysis
-
DOI 10.1007/s10863-007-9083-0, Special Topic: The Warburg Effect: Its Continued Impact on Cancer Research into the 21st Century
-
Ma W, Sung H J, Park J Y, et al. A pivotal role for p53: balancing aerobic respiration and glycolysis. J Bioenerg Biomembr, 2007, 39(3): 243-246 (Pubitemid 47619376)
-
(2007)
Journal of Bioenergetics and Biomembranes
, vol.39
, Issue.3
, pp. 243-246
-
-
Ma, W.1
Sung, H.J.2
Park, J.Y.3
Matoba, S.4
Hwang, P.M.5
-
23
-
-
33745149291
-
P53 regulates mitochondrial respiration
-
DOI 10.1126/science.1126863
-
Matoba S, Kang J G, Patino W D, et al. p53 regulates mitochondrial respiration. Science, 2006, 312(5780): 1650-1653 (Pubitemid 43902663)
-
(2006)
Science
, vol.312
, Issue.5780
, pp. 1650-1653
-
-
Matoba, S.1
Kang, J.-G.2
Patino, W.D.3
Wragg, A.4
Boehm, M.5
Gavrilova, O.6
Hurley, P.J.7
Bunz, F.8
Hwang, P.M.9
-
24
-
-
33745727109
-
Differential utilization of two ATPgenerating pathways is regulated by p53
-
Assaily W, Benchimol S. Differential utilization of two ATPgenerating pathways is regulated by p53. Cancer Cell, 2006, 10(1): 4-6
-
(2006)
Cancer Cell
, vol.10
, Issue.1
, pp. 4-6
-
-
Assaily, W.1
Benchimol, S.2
-
25
-
-
20844449238
-
AMP-activated protein kinase induces a p53-dependent metabolic checkpoint
-
DOI 10.1016/j.molcel.2005.03.027, PII S1097276505012207
-
Jones R G, Plas D R, Kubek S, et al. AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Mol Cell, 2005, 18(3): 283-293 (Pubitemid 41350534)
-
(2005)
Molecular Cell
, vol.18
, Issue.3
, pp. 283-293
-
-
Jones, R.G.1
Plas, D.R.2
Kubek, S.3
Buzzai, M.4
Mu, J.5
Xu, Y.6
Birnbaum, M.J.7
Thompson, C.B.8
-
26
-
-
33745918951
-
TIGAR, a p53-inducible regulator of glycolysis and apoptosis
-
DOI 10.1016/j.cell.2006.05.036, PII S0092867406007628
-
Bensaad K, Tsuruta A, Selak M A, et al. TIGAR, a p.m. regulator of glycolysis and apoptosis. Cell, 2006, 126(1): 107-120 (Pubitemid 44040989)
-
(2006)
Cell
, vol.126
, Issue.1
, pp. 107-120
-
-
Bensaad, K.1
Tsuruta, A.2
Selak, M.A.3
Vidal, M.N.C.4
Nakano, K.5
Bartrons, R.6
Gottlieb, E.7
Vousden, K.H.8
-
27
-
-
43049139541
-
P53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation
-
DOI 10.1038/ncb1724, PII NCB1724
-
Kawauchi K, Araki K, Tobiume K, et al. p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation. Nat Cell Biol, 2008, 10(5): 611-618 (Pubitemid 351627381)
-
(2008)
Nature Cell Biology
, vol.10
, Issue.5
, pp. 611-618
-
-
Kawauchi, K.1
Araki, K.2
Tobiume, K.3
Tanaka, N.4
-
28
-
-
34047255064
-
Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates
-
DOI 10.1074/jbc.M608337200
-
Hewitson K S, Lienard B M, McDonough M A, et al. Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates. J Biol Chem, 2007, 282(5): 3293-3301 (Pubitemid 47084322)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.5
, pp. 3293-3301
-
-
Hewitson, K.S.1
Lienard, B.M.R.2
McDonough, M.A.3
Clifton, I.J.4
Butler, D.5
Soares, A.S.6
Oldham, N.J.7
McNeill, L.A.8
Schofield, C.J.9
-
29
-
-
64849098267
-
Glioma-derived mutations in IDHl dominantly inhibit IDHl catalytic activity and induce HIF-1 alpha
-
Zhao S, Lin Y, Xu W, et al. Glioma-derived mutations in IDHl dominantly inhibit IDHl catalytic activity and induce HIF-1 alpha. Science, 2009, 324(5924): 261-265
-
(2009)
Science
, vol.324
, Issue.5924
, pp. 261-265
-
-
Zhao, S.1
Lin, Y.2
Xu, W.3
-
30
-
-
57449097020
-
Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
-
Sonveaux P, Vegran F, Schroeder T, et al. Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. J Clin Invest, 2008, 118(12): 3930-3942
-
(2008)
J Clin Invest
, vol.118
, Issue.12
, pp. 3930-3942
-
-
Sonveaux, P.1
Vegran, F.2
Schroeder, T.3
-
31
-
-
0035881307
-
Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo
-
Fukumura D, Xu L, Chen Y, et al. Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo. Cancer Res, 2001, 61(16): 6020-6024 (Pubitemid 32762531)
-
(2001)
Cancer Research
, vol.61
, Issue.16
, pp. 6020-6024
-
-
Fukumura, D.1
Xu, L.2
Chen, Y.3
Gohongi, T.4
Seed, B.5
Jain, R.K.6
-
32
-
-
66149179367
-
Hypoxia-selective macroautophagy and cell survival signaled by autocrine PDGFR activity
-
Wilkinson S, O'Prey J, Flicker M, et al. Hypoxia-selective macroautophagy and cell survival signaled by autocrine PDGFR activity. Genes Dev, 2009, 23(11): 1283-1288
-
(2009)
Genes Dev
, vol.23
, Issue.11
, pp. 1283-1288
-
-
Wilkinson, S.1
O'Prey, J.2
Flicker, M.3
-
33
-
-
23044500915
-
Pyruvate kinase type M2 and its role in tumor growth and spreading
-
DOI 10.1016/j.semcancer.2005.04.009, PII S1044579X0500026X, Tumor Metabolome
-
Mazurek S, Boschek C B, Hugo F, et al. Pyruvate kinase type M2 and its role in tumor growth and spreading. Semin Cancer Biol, 2005, 15(4): 300-308 (Pubitemid 41058775)
-
(2005)
Seminars in Cancer Biology
, vol.15
, Issue.4
, pp. 300-308
-
-
Mazurek, S.1
Boschek, C.B.2
Hugo, F.3
Eigenbrodt, E.4
-
34
-
-
40749099894
-
Pyruvate kinase M2 is a phosphotyrosine-binding protein
-
DOI 10.1038/nature06667, PII NATURE06667
-
Christofk H R, Vender Heiden M G, Wu N, et al. Pyruvate kinase M2 is a phosphotyrosine-binding protein. Nature, 2008, 452(7184): 181-186 (Pubitemid 351380242)
-
(2008)
Nature
, vol.452
, Issue.7184
, pp. 181-186
-
-
Christofk, H.R.1
Vander, H.M.G.2
Wu, N.3
Asara, J.M.4
Cantley, L.C.5
-
35
-
-
37449034854
-
Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
-
DeBerardinis R J, Mancuso A, Daikhin E, et al. Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc Natl Acad Sci USA, 2007, 104(49): 19345-19350
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, Issue.49
, pp. 19345-19350
-
-
DeBerardinis, R.J.1
Mancuso, A.2
Daikhin, E.3
-
36
-
-
77951213471
-
-
Zhao G J, Lu Z Q, Yao Y M. Prog Biochem Biophys, 2010, 37(3): 252-260
-
(2010)
Prog Biochem Biophys
, vol.37
, Issue.3
, pp. 252-260
-
-
Zhao, G.J.1
Lu, Z.Q.2
Yao, Y.M.3
-
37
-
-
70349207206
-
-
Xiang B, Wang L, Yi M, et al. Prog Biochem Biophys, 2009, 36(6): 709-714
-
(2009)
Prog Biochem Biophys
, vol.36
, Issue.6
, pp. 709-714
-
-
Xiang, B.1
Wang, L.2
Yi, M.3
-
38
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza G L. Targeting HIF-1 for cancer therapy. Nat Rev Cancer, 2003, 3(10): 721-732 (Pubitemid 37328811)
-
(2003)
Nature Reviews Cancer
, vol.3
, Issue.10
, pp. 721-732
-
-
Semenza, G.L.1
-
39
-
-
33846002728
-
+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth
-
+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell, 2007, 11(1): 37-51
-
(2007)
Cancer Cell
, vol.11
, Issue.1
, pp. 37-51
-
-
Bonnet, S.1
Archer, S.L.2
Allalunis-Turner, J.3
-
40
-
-
0343717915
-
Frataxin activates mitochondrial energy conversion and oxidative phosphorylation
-
Ristow M, Pfister M F, Yee A J, et al. Frataxin activates mitochondrial energy conversion and oxidative phosphorylation. Proc Natl Acad Sci USA, 2000, 97(22): 12239-12243
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, Issue.22
, pp. 12239-12243
-
-
Ristow, M.1
Pfister, M.F.2
Yee, A.J.3
-
41
-
-
33947109972
-
Avicins, a novel plant-derived metabolite lowers energy metabolism in tumor cells by targeting the outer mitochondrial membrane
-
DOI 10.1016/j.mito.2006.12.005, PII S1567724907000025
-
Haridas V, Li X, Mizumachi T, et al. Avicins, a novel plant-derived metabolite lowers energy metabolism in tumor cells by targeting the outer mitochondrial membrane. Mitochondrion, 2007, 7 (3): 234-240 (Pubitemid 46395201)
-
(2007)
Mitochondrion
, vol.7
, Issue.3
, pp. 234-240
-
-
Haridas, V.1
Li, X.2
Mizumachi, T.3
Higuchi, M.4
Lemeshko, V.V.5
Colombini, M.6
Gutterman, J.U.7
-
42
-
-
33746930794
-
Succinate dehydrogenase and fumarate hydratase: Linking mitochondrial dysfunction and cancer
-
DOI 10.1038/sj.onc.1209594, PII 1209594
-
King A, Selak M A, Gottlieb E. Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer. Oncogene, 2006, 25(34): 4675-4682 (Pubitemid 44187617)
-
(2006)
Oncogene
, vol.25
, Issue.34
, pp. 4675-4682
-
-
King, A.1
Selak, M.A.2
Gottlieb, E.3
-
43
-
-
35449007618
-
Vitamin E analogues as a novel group of mitocans: Anti-cancer agents that act by targeting mitochondria
-
DOI 10.1016/j.mam.2007.02.003, PII S0098299707000271, Vitamin E: An Overview of Major Research Directions
-
Neuzil J, Dong L F, Ramanathapuram L, et al. Vitamin E analogues as a novel group of mitocans: anti-cancer agents that act by targeting mitochondria. Mol Aspects Med, 2007, 28(5-6): 607-645 (Pubitemid 47625532)
-
(2007)
Molecular Aspects of Medicine
, vol.28
, Issue.5-6
, pp. 607-645
-
-
Neuzil, J.1
Dong, L.-F.2
Ramanathapuram, L.3
Hahn, T.4
Chladova, M.5
Wang, X.-F.6
Zobalova, R.7
Prochazka, L.8
Gold, M.9
Freeman, R.10
Turanek, J.11
Akporiaye, E.T.12
Dyason, J.C.13
Ralph, S.J.14
-
44
-
-
8144228566
-
Why do cancers have high aerobic glycolysis?
-
DOI 10.1038/nrc1478
-
Gatenby R A, Gillies R J. Why do cancers have high aerobic glycolysis?. Nat Rev Cancer, 2004, 4(11): 891-899 (Pubitemid 39472955)
-
(2004)
Nature Reviews Cancer
, vol.4
, Issue.11
, pp. 891-899
-
-
Gatenby, R.A.1
Gillies, R.J.2
-
45
-
-
77953937409
-
-
Wang J, Liu Q, Jiang L H, et al. Chin J Magnetic Resonance, 2010, 27(3): 341-354
-
(2010)
Chin J Magnetic Resonance
, vol.27
, Issue.3
, pp. 341-354
-
-
Wang, J.1
Liu, Q.2
Jiang, L.H.3
|