Hypoxia-selective macroautophagy and cell survival signaled by autocrine PDGFR activity

Genes and Development

Volumn 23, Issue 11, 2009, Pages 1283-1288

  Wilkinson, Simon ^a   O'Prey, Jim ^a   Fricker, Michael ^a   Ryan, Kevin M ^a  

^a BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

Author keywords

Autophagy; Cancer; Cell death; Hypoxia

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; OXYGEN; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; HYPOXIA INDUCIBLE FACTOR 1BETA; PLATELET DERIVED GROWTH FACTOR RECEPTOR;

ANIMAL CELL; ARTICLE; AUTOCRINE EFFECT; AUTOPHAGY; CELL LEVEL; CELL SURVIVAL; CONTROLLED STUDY; DROSOPHILA; HUMAN; HUMAN CELL; HYPOXIA; NONHUMAN; OXYGEN TENSION; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TUMOR CELL; ANIMAL; ANOXIA; CELL LINE; CELL STRAIN HCT116; CYTOSOL; DROSOPHILA MELANOGASTER; METABOLISM; PHYSIOLOGY; TUMOR CELL LINE;

ANIMALS; ANOXIA; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR; AUTOCRINE COMMUNICATION; AUTOPHAGY; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; CYTOSOL; DROSOPHILA MELANOGASTER; HCT116 CELLS; HUMANS; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR; SIGNAL TRANSDUCTION;

EID: 66149179367     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.521709     Document Type: Article

References (22)

1. Boya P, Gonzalez-Polo RA, Casares N, Perfettini JL, Dessen P, Larochette N, Metivier D, Meley D, Souquere S, Yoshimori T, et al. 2005. Inhibition of macroautophagy triggers apoptosis. Mol Cell Biol 25: 1025-1040. (Pubitemid 40165810)
2. Colell A, Ricci JE, Tait S, Milasta S, Maurer U, Bouchier-Hayes L, Fitzgerald P, Guio-Carrion A, Waterhouse NJ, Li CW, et al. 2007. GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation. Cell 129: 983-997. (Pubitemid 46813151)
3. Crighton D, Wilkinson S, O'Prey J, Syed N, Smith P, Harrison PR, Gasco M, Garrone O, Crook T, Ryan KM. 2006. DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell 126: 121-134. (Pubitemid 44040988)
4. Degenhardt K, Mathew R, Beaudoin B, Bray K, Anderson D, Chen G, Mukherjee C, Shi Y, Gelinas C, Fan Y, et al. 2006. Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell 10: 51-64.
5. Feng Z, Zhang H, Levine AJ, Jin S. 2005. The coordinate regulation of the p53 and mTOR pathways in cells. Proc Natl Acad Sci 102: 8204-8209. (Pubitemid 40800067)
6. Hara T, Nakamura K, Matsui M, Yamamoto A, Nakahara Y, Suzuki-Migishima R, Yokoyama M, Mishima K, Saito I, Okano H, et al. 2006. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 441: 885-889. (Pubitemid 43910423)
7. Jin S, Dipaola RS, Mathew R, White E. 2007. Metabolic catastrophe as a means to cancer cell death. J Cell Sci 120: 379-383. (Pubitemid 46332501)
8. Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, Kominami E, Ohsumi Y, Yoshimori T. 2000. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 19: 5720-5728.
9. Komatsu M, Waguri S, Chiba T, Murata S, Iwata JI, Tanida I, Ueno T, Koike M, Uchiyama Y, Kominami E, et al. 2006. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 441: 880-884. (Pubitemid 43910422)
10. Kuma A, Hatano M, Matsui M, Yamamoto A, Nakaya H, Yoshimori T, Ohsumi Y, Tokuhisa T, Mizushima N. 2004. The role of autophagy during the early neonatal starvation period. Nature 432: 1032-1036. (Pubitemid 40052234)
11. Lum JJ, Bauer DE, Kong M, Harris MH, Li C, Lindsten T, Thompson CB. 2005. Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 120: 237-248. (Pubitemid 40174766)
12. Mizushima N, Yamamoto A, Matsui M, Yoshimori T, Ohsumi Y. 2004. In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell 15: 1101-1111.
13. Papandreou I, Lim AL, Laderoute K, Denko NC. 2008. Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L. Cell Death Differ 15: 1572-1581.
14. Pouyssegur J, Dayan F, Mazure NM. 2006. Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature 441: 437-443. (Pubitemid 44050138)
15. Sandoval H, Thiagarajan P, Dasgupta SK, Schumacher A, Prchal JT, Chen M, Wang J. 2008. Essential role for Nix in autophagic maturation of erythroid cells. Nature 454: 232-235.
16. Scott RC, Schuldiner O, Neufeld TP. 2004. Role and regulation of starvation-induced autophagy in the Drosophila fat body. Dev Cell 7: 167-178. (Pubitemid 39145023)
17. Shimizu S, Kanaseki T, Mizushima N, Mizuta T, Arakawa-Kobayashi S, Thompson CB, Tsujimoto Y. 2004. Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat Cell Biol 6: 1221-1228. (Pubitemid 39625121)
18. Tracy K, Dibling BC, Spike BT, Knabb JR, Schumacker P, Macleod KF. 2007. BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy. Mol Cell Biol 27: 6229-6242. (Pubitemid 47326709)
19. Xie Z, Klionsky DJ. 2007. Autophagosome formation: Core machinery and adaptations. Nat Cell Biol 9: 1102-1109. (Pubitemid 47500484)
20. Xue L, Fletcher GC, Tolkovsky AM. 2001. Mitochondria are selectively eliminated from eukaryotic cells after blockade of caspases during apoptosis. Curr Biol 11: 361-365. (Pubitemid 32200740)
21. Yu L, Alva A, Su H, Dutt P, Freundt E, Welsh S, Baehrecke EH, Lenardo MJ. 2004. Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science 304: 1500-1502. (Pubitemid 38720930)
22. Zhang H, Bosch-Marce M, Shimoda LA, Tan YS, Baek JH, Wesley JB, Gonzalez FJ, Semenza GL. 2008. Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J Biol Chem 283: 10892-10903.