Combination effects of poly(ADP-ribose) polymerase inhibitors and DNA-damaging agents in ovarian tumor cell lines - With special reference to cisplatin

Journal of Cancer Research and Clinical Oncology

Volumn 122, Issue 11, 1996, Pages 665-670

  Bernges, Frithjof ^a   Zeller, W Jens ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Alkylating agents; Cisplatin; Combination chemotherapy; Poly(ADP ribose) polymerase

Indexed keywords

CAFFEINE; CARMUSTINE; CISPLATIN; ENZYME INHIBITOR; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; THEOPHYLLINE; TREOSULFAN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA REPAIR; DRUG POTENTIATION; DRUG RESISTANCE; HUMAN; HUMAN CELL; NONHUMAN; OVARY CANCER; PRIORITY JOURNAL; RAT; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARMUSTINE; CELL SURVIVAL; CISPLATIN; DNA DAMAGE; DNA REPAIR; ENZYME INHIBITORS; FEMALE; HUMANS; METHYLNITRONITROSOGUANIDINE; OVARIAN NEOPLASMS; POLY ADENOSINE DIPHOSPHATE RIBOSE; RATS; TUMOR CELLS, CULTURED;

EID: 0029862017     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01209029     Document Type: Article

References (63)

1. Alaoui-Jamali M, Loubaba B-B, Robyn S, Tapiero H, Batist G (1994) Effect of DNA-repair-enzyme modulators on cytotoxicity of L-phenylalanine mustard and cis-diamminedichloroplatinum(II) in mammary carcinoma cells resistant to alkylating drugs. Cancer Chemother Pharmacol 34:153-158
2. Althaus FR, Richter C (1987) ADP-ribosylation of proteins. Enzymology and biological significance. Mol Biol Biochem Biophys 37:1-237
3. August EM, Cooper DL, Prusoff WH (1991) Inhibition of poly(adenosine diphosphate-ribose) polymerase by thymidine and thymidine analogues in L 1210 cells and its relationship to the potentiation of the antitumor activity of l,3-bis(2-chloroethyl)-1-nitrosourea but not of 3′-[3-(2-chloroethyl)-3-nitrosoureido]-3′-deoxythymidine. Cancer Res 51:1586-1590
4. Banasik M, Komura H, Shimoyama M, Ueda K (1992) Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl) transferase. J Biol Chem 267:1569-1575
5. Berger NA, Catino DM, Vietti TJ (1982) Synergistic antileukemic effect of 6-aminonicotinamide and 1,3-bis(2-chloroethyl)-1-nitrosourea on L 1210 cells in vitro and in vivo. Cancer Res 42:4382-4386
6. Boike GM, Petru E, Sevin BU, Averette HE, Chou TC, Penalver M, Donato D, Schiano M, Hilsenbeck SG, Perras J (1990) Chemical enhancement of cisplatin cytotoxicity in a human ovarian and cervical cancer cell line. Gynecol Oncol 38:315-322
7. Boorstein RJ, Pardee AB (1984) Factors modifying 3-aminobenzamide cytotoxicity in normal and repair-deficient human fibroblasts. J Cell Physiol 120:335-344
8. Borek C, Morgan WF, Ong A, Cleaver JE (1984) Inhibition of malignant transformation in vitro by inhibitors of poly(ADP-ribose) synthesis. Proc Natl Acad Sci USA 81:243-247
9. Boulikas T (1991) Relation between carcinogenesis, chromatin structure and poly(ADP-ribosylation) (review). Anticancer Res 11:489-528
10. Bürkle A, Chen G, Küpper JH, Grube KH, Zeller WJ (1993) Increased poly(ADP-ribosyl)ation in intact cells by cisplatin treatment. Carcinogenesis 14:559-561
11. Calsou P, Salles B (1993) Role of DNA repair in the mechanisms of cell resistance to alkylating agents and cisplatin. Cancer Chemother Pharmacol 32:85-89
12. Chen G, Pan QC (1988) Potentiation of the antitumor activity of cisplatin in mice by 3-aminobenzamide and nicotinamide. Cancer Chemother Pharmacol 22:303-307
13. Chen G, Zeller WJ (1990) Enhancement of cisplatin (DDP) antitumor activity by 3-aminobenzamide in rat ovarian tumors sensitive and resistant to DDP in vivo. Cancer Chemother Pharmacol 26:37-41
14. Chen G, Zeller WJ (1991) Untersuchungen zum Synergismus von Buthionin-Sulfoximin und 3-Aminobenzamid bei der Überwindung einer Cisplatin-Resistenz. Tumor Diagn Ther 12:226-229
15. Chen G, Zeller WJ (1992) Multiple effects of 3-aminobenzamide on DNA damage induced by cisplatin (DDP) in DDP-sensitive and resistant rat ovarian tumor cell lines. Cancer Lett 67:27-33
16. Chen G, Zeller WJ (1993) Reversal of acquired cisplatin resistance by nicotinamide in vitro and in vivo. Cancer Chemother Pharmacol 33:157-162
17. Cleaver JE, Morgan WF (1991) Poly(ADP-ribose) polymerase: a perplexing participiant in cellular responses to DNA breakage. Mutat Res 257:1-18
18. Cleaver JE, Milam KM, Morgan WF (1985) Do inhibitor studies demonstrate a role for poly(ADP-ribose) in DNA repair? Radiat Res 101:16-28
19. 2-induced apoptosis. Exp Cell Res 221:462-469
20. Dijt FJ, Fichtinger-Schepman AMJ, Berends F, Reedijk J (1988) Formation and repair of cisplatin induced adducts to DNA in cultured normal and repair-deficient human fibroblasts. Cancer Res 48:6058-6062
21. Durkacz BW, Omidiji O, Gray DA, Shall S (1980) (ADP-Ribose)n participates in DNA excision repair. Nature 283:593-596
22. Erlichman C, Hanada P, Wu A (1984) Enhanced cytotoxicity of cisplatin by 3-aminobenzamide. Proc Am Assoc Cancer Res 25:368
23. Fogh J (ed) (1975) Human tumor cells in vitro, Plenum, New York, p 122
24. Fox M (1984) Drug resistance and DNA repair. In: Fox BW, Fox M (eds) Antitumor drug resistance. Springer, New York Berlin Heidelberg, pp 335-369
25. Fraval HNA, Rawlings CJ, Roberts JJ (1978) Increased sensitivity of UV-repair deficient human cells to DNA-bound platinum products which unlike thymidine dimers are not recognized by an endonuclease extracted from Micrococcus luteus. Mutat Res 51:121-132
26. Hansson J, Wood RD (1989) Repair synthesis by human cell extracts in DNA by cis- and trans-diamminedichloroplatinum(II). Nucleic Acids Res 17:8073-8091
27. Heim ME (1993) Platinum and non-platinum complexes in clinical trials. Current status and new developments. In: Keppler BK (ed) Metal complexes in cancer chemotherapy, VCH, Weinheim, pp 11-24
28. Horsman MR, Brown DM, Hirst DG, Brown JM (1986) Changes in the response of the RIF-1 tumor to melphalan in vivo induced by inhibitors of nuclear ADP-ribosyl transferase. Br J Cancer 53:247-254
29. Kato T, Suzumura Y, Fukoshima M (1988) Enhancement of bleomycin activity by 3-aminobenzamide, a poly(ADP-ribose) synthesis inhibitor, in vitro and in vivo. Anticancer Res 8:239-243
30. Kaufmann SH (1989) Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note. Cancer Res 49:5870-5878
31. Kubo S, Matsutani M, Nakagawa K, Ogura T, Esumi H, Saijo N (1992) Participation of poly(ADP-ribose) polymerase in the drug sensitivity in human lung cancer cell lines. J Cancer Res Clin Oncol 118:244-248
32. Küpper JH, Müller M, Jacobson MK, Tatsumi-Miyajima J, Coyle DL, Jacobson EL, Bürkle A (1995) trans-dominant inhibition of poly(ADP-ribosyl)ation sensitizes cells against gamma-irradiation and N-methyl-N′-nitro-N-nitrosoguanidine but does not limit DNA replication of a polyomavirus replicon. Mol Cell Biol 15:3154-3163
33. Lau CC, Pardee AB (1982) Mechanism by which caffeine potentiates lethality of nitrogen mustard. Proc Natl Acad Sci USA 79:2942-2946
34. Lindahl T, Satoh MS, Poirier GG, Klungland A (1995) Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks. Trends Biochem Sci 20:405-411
35. Loehrer PJ, Einhorn LH (1984) Drugs five years later: cisplatin. Ann Intern Med 100:704-713
36. Los G, Muggia FM (1994) Platinum resistance: experimental and clinical status. Hematol Oncol Clin North Am 8:411-429
37. Milam KM, Cleaver JE (1984) Inhibitors of poly(adenosine diphosphate-ribose) synthesis: effect on other metabolic processes. Science 223:589-591
38. Molinete M, Vermeulen W, Bürkle A, Menissier-de Murcia J, Küpper JH, Hoeijmakers JHJ, Murcia G de (1993) Overproduction of the poly(ADP-ribose) polymerase DNA-binding domain blocks alkylation-induced DNA repair synthesis in mammalian cells. EMBO J 12:2109-2117
39. Moosman T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods, 65:55-63
40. de Murcia G, Menissier de Murcia J (1994) Poly(ADP-ribose) polymerase: a molecular nick-sensor. Trends Biochem Sci 19:172-176
41. Moses K, Willimore E, Harris AL, Durkacz BW (1990) Correlation of enhanced 6-mercaptopurine cytotoxicity with increased phosphoribosylpyrophosphate levels in Chinese hamster ovary cells treated with 3-aminobenzamide. Cancer Res 50:1992-1996
42. Nicholson DW, Ali A, Thornberry NA, Vaillancourt JP, Ding CK, Gallant M, Goreau Y, Griffin PR, Labelle M, Lazebnik YA, et al (1995) Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376:37-43
43. Ozols RF, Young RC (1984) Chemotherapy of ovarian cancer. Semin Oncol 11:251-263
44. Plooy ACM, Dijl M van, Berends F, Lohman PHM (1985) Formation and repair of DNA interstrand crosslinks in relation to cytotoxicity and unscheduled DNA synthesis induced in control and mutant human cells treated with cis-diamminedichloroplatinum(II). Cancer Res 45:4178-4184
45. Poll EHA, Abrahams PJ, Anwert F, Ericksson AW (1984) Host cell reactivation of cis-diamminedichloroplatinum(II) treated SV 40 DNA in normal human Fanconi anaemia and Xeroderma pigmentosum fibroblasts. Mutat Res 132:181-187
46. Purnell MR, Kidwell WR, Minshall L, Whish WJD (1985) Specificity of poly(ADP-ribose) synthetase inhibitors. In: Althaus FR, Hilz H, Shall S (eds) ADP-ribosylation of proteins. Springer, Berlin Heidelberg New York, pp 98-107
47. Rosenberg B (1985) Fundamental studies with cisplatin. Cancer 55:2303-2316
48. +-dependent repair of damaged DNA by human cell extracts. J Biol Chem 268:5480-5487
49. Schreiber V, Hunting D, Trucco C, Gowans B, Grunwald D, DeMurcia G, De-Murcia JM (1995) A dominant-negative mutant of human poly(ADP-ribose) polymerase affects cell recovery, apoptosis, and sister chromatid exchange following DNA damage. Proc Natl Acad Sci USA 92:4753-4757
50. Sebold-Leopold JS, Scavone SV (1992) Enhancement of alkylating agent activity in vitro by PD 128763, a potent Poly(ADP-ribose)synthesis inhibitor. Int J Radiat Oncol Biol Phys 22:619-621
51. Shall S (1984) ADP-ribose in DNA repair: a new component of DNA excision repair. Adv Radiat Biol 11:1-69
52. Shinomiya N, Shinomiya M, Wakiyama H, Katsura Y, Rokutanda M (1994) Enhancement of CDDP cytotoxicity by caffeine is characterized by apoptotic cell death. Exp Cell Res 210:236-242
53. Sibghat-Ullah, Hussain I, Carlton W, Sancar A (1989) Human nucleotide excision repair in vitro: repair of pyrimidine dimers, psoralen and cisplatin adducts by HeLa cell-free extract. Nucleic Acids Res 17:4471-4484
54. Swinnen LJ, Ellis N, Erickson LC (1991) Sensitization of resistant human tumor cells to cisplatin or carboplatin by inhibitors of DNA excision repair. In: Howell SB (ed) Platinum and other metal coordination compounds in cancer chemotherapy. Plenum, New York, pp 253-268
55. Swinnen LJ, Fisher SG, Eickson LC (1989) Ultraviolet irradiation produces cytotoxic synergy and increased DNA interstrand crosslinking with cis- and trans-diamminedichloroplatin. Carcinogenesis 10:1465-1470
56. Tewari M, Quan LT, O'Rourke K, Desnoyers S, Zeng Z, Beidler DR, Poirier GG, Salvesen GS, Dixit VM (1995) Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell 81:801-809
57. Umbach G, Poethen J, Umbach U (1985a) Effect of 3-aminobenzamide on the cytotoxicity of cisplatin in a human ovarian cancer cell line. Proc Am Assoc Cancer Res 26:26
58. Umbach GE, Poethen J, Matthiesen H von, Koldovsky U (1985b) Effect of aminobenzamide on the cytotoxic efficacy of cisplatin in two human ovarian cancer cell lines. IRCS Med Sci 13:578
59. Vaux DL, Strasser A (1996) The molecular biology of apoptosis. Proc Natl Acad Sci USA 93:2239-2244
60. Vilpo JA, Vilpo LM, Szymkowsky DE, O'Donovan A, Wood RD (1995) An XPG DNA repair defect causing mutagen hypersensitivity in mouse leukemia L1210 cells. Mol Cell Biol 15:290-297
61. Wang Z, Wu X, Friedberg EC (1993) Nucleotide excision repair of DNA in cell-free extracts of the yeast Saccaromyces cerevisiae. Proc Natl Acad Sci USA 90:4907-4911
62. Wang Z, Auer B, Stingl L, Berghammer H, Haidacher D, Schweiger M, Wagner EF (1995) Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease. Genes Dev 9:509-520
63. Wilson AP (1984) Characterization of a cell line derived from the ascites of a patient with papillary serous cystadenocarcinoma of the ovary. J Natl Cancer Inst 72:513-521