메뉴 건너뛰기




Volumn 25, Issue 3, 2011, Pages 360-365

S-Nitroso-N-acetylcysteine induces de-differentiation of activated hepatic stellate cells and promotes antifibrotic effects in vitro

Author keywords

Fibrogenesis; Hepatic stellate cells; S Nitroso N acetylcysteine

Indexed keywords

ACETYLCYSTEINE; COLLAGENASE 3; GELATINASE A; N ACETYL S NITROSOCYSTEINE; NITRIC OXIDE DONOR; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

EID: 80053924454     PISSN: 10898603     EISSN: 10898611     Source Type: Journal    
DOI: 10.1016/j.niox.2011.07.001     Document Type: Article
Times cited : (10)

References (67)
  • 2
    • 35948954244 scopus 로고    scopus 로고
    • Hepatic stellate cells: Protean, multifunctional, and enigmatic cells of the liver
    • S.L. Friedman Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver Physiol. Rev. 88 2008 125 172
    • (2008) Physiol. Rev. , vol.88 , pp. 125-172
    • Friedman, S.L.1
  • 3
    • 34247149014 scopus 로고    scopus 로고
    • Scar-associated macrophages are a major source of hepatic matrix metalloproteinase-13 and facilitate the resolution of murine hepatic fibrosis
    • J.A. Fallowfield, M. Mizuno, T.J. Kendall, C.M. Constandinou, R.C. Benyon, J.S. Duffield, and J.P. Iredale Scar-associated macrophages are a major source of hepatic matrix metalloproteinase-13 and facilitate the resolution of murine hepatic fibrosis J. Immunol. 178 2007 5288 5295 (Pubitemid 46595314)
    • (2007) Journal of Immunology , vol.178 , Issue.8 , pp. 5288-5295
    • Fallowfield, J.A.1    Mizuno, M.2    Kendall, T.J.3    Constandinou, C.M.4    Benyon, R.C.5    Duffield, J.S.6    Iredale, J.P.7
  • 5
    • 35948978184 scopus 로고    scopus 로고
    • Hepatic fibrogenesis
    • DOI 10.1055/s-2007-991517
    • J. Guo, and S.L. Friedman Hepatic fibrogenesis Semin. Liver Dis. 27 2007 413 426 (Pubitemid 350071841)
    • (2007) Seminars in Liver Disease , vol.27 , Issue.4 , pp. 413-426
    • Guo, J.1    Friedman, S.L.2
  • 6
    • 40049097359 scopus 로고    scopus 로고
    • Liver cirrhosis
    • DOI 10.1016/S0140-6736(08)60383-9, PII S0140673608603839
    • D. Schuppan, and N.H. Afdhal Liver cirrhosis Lancet 371 2008 838 851 (Pubitemid 351323895)
    • (2008) The Lancet , vol.371 , Issue.9615 , pp. 838-851
    • Schuppan, D.1    Afdhal, N.H.2
  • 7
    • 73349136974 scopus 로고    scopus 로고
    • Role of free radicals in liver diseases
    • P. Muriel Role of free radicals in liver diseases Hepatol. Int. 3 2009 526 536
    • (2009) Hepatol. Int. , vol.3 , pp. 526-536
    • Muriel, P.1
  • 8
    • 70350617790 scopus 로고    scopus 로고
    • Rationale and targets for antifibrotic therapies
    • D. Schuppan, and Y. Popov Rationale and targets for antifibrotic therapies Gastroenterol. Clin. Biol. 33 2009 949 957
    • (2009) Gastroenterol. Clin. Biol. , vol.33 , pp. 949-957
    • Schuppan, D.1    Popov, Y.2
  • 10
    • 0035871817 scopus 로고    scopus 로고
    • 2(I) collagen gene activity by JNK in hepatic stellate cells
    • DOI 10.1016/S0891-5849(01)00470-1, PII S0891584901004701
    • F.A. Anania, L. Womack, M. Jiang, and N.K. Saxena Aldehydes potentiate alpha(2)(I) collagen gene activity by JNK in hepatic stellate cells Free Radic. Biol. Med. 30 2001 846 857 (Pubitemid 32289262)
    • (2001) Free Radical Biology and Medicine , vol.30 , Issue.8 , pp. 846-857
    • Anania, F.A.1    Womack, L.2    Jiang, M.3    Saxena, N.K.4
  • 12
    • 78649884101 scopus 로고    scopus 로고
    • Molecular mechanisms os stellate cell activation and extracellular remodeling
    • I. Okazaki, Y. Ninomiya, S.L. Friedman, K. Tanikawa, Academic Press Flórida
    • D. Li, and S.L. Friedman Molecular mechanisms os stellate cell activation and extracellular remodeling I. Okazaki, Y. Ninomiya, S.L. Friedman, K. Tanikawa, Extracellular Matrix and the Liver: Approach to Gene Therapy 2003 Academic Press Flórida 155 178
    • (2003) Extracellular Matrix and the Liver: Approach to Gene Therapy , pp. 155-178
    • Li, D.1    Friedman, S.L.2
  • 13
    • 33644613954 scopus 로고    scopus 로고
    • Cells responsible for extracellular matrix production in the liver
    • I. Okazaki, Y. Ninomiya, S.L. Friedman, K. Tanikawa, Academic Press Flórida
    • T. Ueno, M. Sata, and K. Tanikawa Cells responsible for extracellular matrix production in the liver I. Okazaki, Y. Ninomiya, S.L. Friedman, K. Tanikawa, Extracellular Matrix and the Liver: Approach to Gene Therapy 2003 Academic Press Flórida 89 103
    • (2003) Extracellular Matrix and the Liver: Approach to Gene Therapy , pp. 89-103
    • Ueno, T.1    Sata, M.2    Tanikawa, K.3
  • 14
    • 34548385362 scopus 로고    scopus 로고
    • Hepatic stellate cells and oxidative stress
    • R. Urtasun, and N. Nieto Hepatic stellate cells and oxidative stress Rev. Esp. Enferm. Dig. 99 2007 223 230
    • (2007) Rev. Esp. Enferm. Dig. , vol.99 , pp. 223-230
    • Urtasun, R.1    Nieto, N.2
  • 16
    • 0036855335 scopus 로고    scopus 로고
    • Elevated nitric oxide levels in patients with chronic liver disease and cirrhosis correlate with disease stage and parameters of hyperdynamic circulation
    • H.T. Arkenau, D.O. Stichtenoth, J.C. Frölich, M.P. Manns, and K.H. Böker Elevated nitric oxide levels in patients with chronic liver disease and cirrhosis correlate with disease stage and parameters of hyperdynamic circulation Z. Gastroenterol. 40 2002 907 913
    • (2002) Z. Gastroenterol. , vol.40 , pp. 907-913
    • Arkenau, H.T.1    Stichtenoth, D.O.2    Frölich, J.C.3    Manns, M.P.4    Böker, K.H.5
  • 17
    • 51049097668 scopus 로고    scopus 로고
    • Nitric oxide levels in chronic liver disease patients with and without oesophageal varices
    • A.M. El-Sherif, M.A. Abou-Shady, A.M. Al-Bahrawy, R.M. Bakr, and A.M. Hosny Nitric oxide levels in chronic liver disease patients with and without oesophageal varices Hepatol. Int. 2 2008 341 345
    • (2008) Hepatol. Int. , vol.2 , pp. 341-345
    • El-Sherif, A.M.1    Abou-Shady, M.A.2    Al-Bahrawy, A.M.3    Bakr, R.M.4    Hosny, A.M.5
  • 24
    • 0035710746 scopus 로고    scopus 로고
    • -ΔΔCT method
    • DOI 10.1006/meth.2001.1262
    • K.J. Livak, and T.D. Schmittgen Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method Methods 25 2001 402 408 (Pubitemid 34164012)
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 25
    • 0031040684 scopus 로고    scopus 로고
    • Lipid metabolism during in vitro induction of the lipocyte phenotype in hepatic stellate cells
    • DOI 10.1023/A:1006845808305
    • C.P. Vicente, R.M. Guaragna, and R. Borojevic Lipid metabolism during in vitro induction of the lipocyte phenotype in hepatic stellate cells Mol. Cell. Biochem. 168 1997 31 39 (Pubitemid 27091053)
    • (1997) Molecular and Cellular Biochemistry , vol.168 , Issue.1-2 , pp. 31-39
    • Vicente, C.P.1    Guaragna, R.M.2    Borojevic, R.3
  • 26
    • 42949163491 scopus 로고    scopus 로고
    • Mechanisms of Hepatic Fibrogenesis
    • DOI 10.1053/j.gastro.2008.03.003, PII S0016508508004290
    • S.L. Friedman Mechanisms of hepatic fibrogenesis Gastroenterology 134 2008 1655 1669 (Pubitemid 351615417)
    • (2008) Gastroenterology , vol.134 , Issue.6 , pp. 1655-1669
    • Friedman, S.L.1
  • 27
    • 0033965330 scopus 로고    scopus 로고
    • Hydrogen peroxide: A link between acetaldehyde-elicited α1(I) collagen gene up-regulation and oxidative stress in mouse hepatic stellate cells
    • P. Greenwel, J.A. Domínguez-Rosales, G. Mavi, A.M. Rivas-Estilla, and M. Rojkind Hydrogen peroxide: a link between acetaldehyde-elicited alpha1(I) collagen gene up-regulation and oxidative stress in mouse hepatic stellate cells Hepatology 31 2000 109 116 (Pubitemid 30033696)
    • (2000) Hepatology , vol.31 , Issue.1 , pp. 109-116
    • Greenwel, P.1    Dominguez-Rosales, J.-A.2    Mavi, G.3    Maria Rivas-Estilla, A.4    Rojkind, M.5
  • 28
    • 0033607304 scopus 로고    scopus 로고
    • In vivo inhibition of rat stellate cell activation by soluble transforming growth factor β type II receptor: A potential new therapy for hepatic fibrosis
    • DOI 10.1073/pnas.96.22.12719
    • J. George, D. Roulot, V.E. Koteliansky, and D.M. Bissell In vivo inhibition of rat stellate cell activation by soluble transforming growth factor beta type II receptor: a potential new therapy for hepatic fibrosis Proc. Natl. Acad. Sci. USA 96 1999 12719 12724 (Pubitemid 29513569)
    • (1999) Proceedings of the National Academy of Sciences of the United States of America , vol.96 , Issue.22 , pp. 12719-12724
    • George, J.1    Roulot, D.2    Koteliansky, V.E.3    Bissell, D.M.4
  • 29
    • 0034785348 scopus 로고    scopus 로고
    • TGF-β signaling in tumor suppression and cancer progression
    • DOI 10.1038/ng1001-117
    • R. Derynck, R.J. Akhurst, and A. Balmain TGF-beta signaling in tumor suppression and cancer progression Nat. Genet. 29 2001 117 129 (Pubitemid 32952643)
    • (2001) Nature Genetics , vol.29 , Issue.2 , pp. 117-129
    • Derynck, R.1    Akhurst, R.J.2    Balmain, A.3
  • 32
    • 0037220482 scopus 로고    scopus 로고
    • Liver fibrosis - From bench to bedside
    • S.L. Friedman Liver fibrosis - from bench to bedside J. Hepatol. 38 Suppl. 1 2003 S38 S53
    • (2003) J. Hepatol. , vol.38 , Issue.SUPPL. 1
    • Friedman, S.L.1
  • 33
    • 8844266275 scopus 로고    scopus 로고
    • Glucocorticoids decrease the bioavailability of TGF-β which leads to a reduced TGF-β signaling in hepatic stellate cells
    • DOI 10.1016/j.bbrc.2004.10.164, PII S0006291X0402340X
    • U. Bolkenius, D. Hahn, A.M. Gressner, K. Breitkopf, S. Dooley, and L. Wickert Glucocorticoids decrease the bioavailability of TGF-beta which leads to a reduced TGF-beta signaling in hepatic stellate cells Biochem. Biophys. Res. Commun. 325 2004 1264 1270 (Pubitemid 39535899)
    • (2004) Biochemical and Biophysical Research Communications , vol.325 , Issue.4 , pp. 1264-1270
    • Bolkenius, U.1    Hahn, D.2    Gressner, A.M.3    Breitkopf, K.4    Dooley, S.5    Wickert, L.6
  • 34
  • 35
    • 0034830886 scopus 로고    scopus 로고
    • Gliotoxin stimulates the apoptosis of human and rat hepatic stellate cells and enhances the resolution of liver fibrosis in rats
    • M.C. Wright, R. Issa, D.E. Smart, N. Trim, G.I. Murray, J.N. Primrose, M.J. Arthur, J.P. Iredale, and D.A. Mann Gliotoxin stimulates the apoptosis of human and rat hepatic stellate cells and enhances the resolution of liver fibrosis in rats Gastroenterology 121 2001 685 698 (Pubitemid 32822584)
    • (2001) Gastroenterology , vol.121 , Issue.3 , pp. 685-698
    • Wright, M.C.1    Issa, R.2    Smart, D.E.3    Trim, N.4    Murray, G.I.5    Primrose, J.N.6    Arthur, M.J.P.7    Iredale, J.P.8    Mann, D.A.9
  • 38
    • 0031969571 scopus 로고    scopus 로고
    • Effect of antioxidants, resveratrol, quercetin, and N-acetylcysteine, on the functions of cultured rat hepatic stellate cells and kupffer cells
    • DOI 10.1002/hep.510270512
    • N. Kawada, S. Seki, M. Inoue, and T. Kuroki Effect of antioxidants, resveratrol, quercetin, and N-acetylcysteine, on the functions of cultured rat hepatic stellate cells and Kupffer cells Hepatology 27 1998 1265 1274 (Pubitemid 28227853)
    • (1998) Hepatology , vol.27 , Issue.5 , pp. 1265-1274
    • Kawada, N.1    Seki, S.2    Inoue, M.3    Kuroki, T.4
  • 40
    • 0035798603 scopus 로고    scopus 로고
    • N-Acetylcysteine induces cell cycle arrest in hepatic stellate cells through its reducing activity
    • K.Y. Kim, T. Rhim, I. Choi, and S.S. Kim N-Acetylcysteine induces cell cycle arrest in hepatic stellate cells through its reducing activity J. Biol. Chem. 276 2001 40591 40598
    • (2001) J. Biol. Chem. , vol.276 , pp. 40591-40598
    • Kim, K.Y.1    Rhim, T.2    Choi, I.3    Kim, S.S.4
  • 41
    • 0344742265 scopus 로고    scopus 로고
    • Vitamin E and Vitamin C Treatment Improves Fibrosis in Patients with Nonalcoholic Steatohepatitis
    • DOI 10.1111/j.1572-0241.2003.08699.x
    • S.A. Harrison, S. Torgerson, P. Hayashi, J. Ward, and S. Schenker Vitamin E and vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis Am. J. Gastroenterol. 98 2003 2485 2490 (Pubitemid 37448761)
    • (2003) American Journal of Gastroenterology , vol.98 , Issue.11 , pp. 2485-2490
    • Harrison, S.A.1    Torgerson, S.2    Hayashi, P.3    Ward, J.4    Schenker, S.5
  • 42
    • 0030569525 scopus 로고    scopus 로고
    • Smooth muscle α-actin expression in rat hepatic stellate cell is regulated by nitric oxide and cGMP production
    • DOI 10.1006/bbrc.1996.1786
    • N. Kawada, T. Kuroki, M. Uoya, M. Inoue, and K. Kobayashi Smooth muscle alpha-actin expression in rat hepatic stellate cell is regulated by nitric oxide and cGMP production Biochem. Biophys. Res. Commun. 229 1996 238 242 (Pubitemid 27013737)
    • (1996) Biochemical and Biophysical Research Communications , vol.229 , Issue.1 , pp. 238-242
    • Kawada, N.1    Kuroki, T.2    Uoya, M.3    Inoue, M.4    Kobayashi, K.5
  • 45
    • 0032526251 scopus 로고    scopus 로고
    • Nitric oxide inhibition induces early activation of type I collagen gene in renal resistance vessels and glomeruli in transgenic mice: Role of endothelin
    • C. Chatziantoniou, J.J. Boffa, R. Ardaillou, and J.C. Dussaule Nitric oxide inhibition induces early activation of type I collagen gene in renal resistance vessels and glomeruli in transgenic mice. Role of endothelin J. Clin. Invest. 101 1998 2780 2789 (Pubitemid 28294587)
    • (1998) Journal of Clinical Investigation , vol.101 , Issue.12 , pp. 2780-2789
    • Chatziantoniou, C.1    Boffa, J.-J.2    Ardaillou, R.3    Dussaule, J.-C.4
  • 46
    • 46249116797 scopus 로고    scopus 로고
    • Nitric oxide promotes caspase-independent hepatic stellate cell apoptosis through the generation of reactive oxygen species
    • DOI 10.1002/hep.22285
    • D.A. Langer, A. Das, D. Semela, N. Kang-Decker, H. Hendrickson, S.F. Bronk, Z.S. Katusic, G.J. Gores, and V.H. Shah Nitric oxide promotes caspase-independent hepatic stellate cell apoptosis through the generation of reactive oxygen species Hepatology 47 2008 1983 1993 (Pubitemid 351945565)
    • (2008) Hepatology , vol.47 , Issue.6 , pp. 1983-1993
    • Langer, D.A.1    Das, A.2    Semela, D.3    Kang-Decker, N.4    Hendrickson, H.5    Bronk, S.F.6    Katusic, Z.S.7    Gores, G.J.8    Shah, V.H.9
  • 48
    • 0028821706 scopus 로고
    • Angiotensin II-induced cardiac fibrosis in the rat is increased by chronic inhibition of nitric oxide synthase
    • J. Hou, H. Kato, R.A. Cohen, A.V. Chobanian, and P. Brecher Angiotensin II-induced cardiac fibrosis in the rat is increased by chronic inhibition of nitric oxide synthase J. Clin. Invest. 96 1995 2469 2477
    • (1995) J. Clin. Invest. , vol.96 , pp. 2469-2477
    • Hou, J.1    Kato, H.2    Cohen, R.A.3    Chobanian, A.V.4    Brecher, P.5
  • 50
    • 0035110585 scopus 로고    scopus 로고
    • Aging-related expression of inducible nitric oxide synthase and markers of tissue damage in the rat penis
    • M. Ferrini, T.R. Magee, D. Vernet, J. Rajfer, and N.F. González-Cadavid Aging-related expression of inducible nitric oxide synthase and markers of tissue damage in the rat penis Biol. Reprod. 64 2001 974 982 (Pubitemid 32174071)
    • (2001) Biology of Reproduction , vol.64 , Issue.3 , pp. 974-982
    • Ferrini, M.1    Magee, T.R.2    Vernet, D.3    Rajfer, J.4    Gonzalez-Cadavid, N.F.5
  • 51
    • 0034940139 scopus 로고    scopus 로고
    • Aging-related increased expression of inducible nitric oxide synthase and cytotoxicity markers in rat hypothalamic regions associated with male reproductive function
    • DOI 10.1159/000054665
    • M. Ferrini, C. Wang, R.S. Swerdloff, A.P. Sinha Hikim, J. Rajfer, and N.F. Gonzalez-Cadavid Aging-related increased expression of inducible nitric oxide synthase and cytotoxicity markers in rat hypothalamic regions associated with male reproductive function Neuroendocrinology 74 2001 1 11 (Pubitemid 32642074)
    • (2001) Neuroendocrinology , vol.74 , Issue.1 , pp. 1-11
    • Ferrini, M.1    Wang, C.2    Swerdloff, R.S.3    Sinha Hikim, A.P.4    Rajfer, J.5    Gonzalez-Cadavid, N.F.6
  • 52
    • 0031193675 scopus 로고    scopus 로고
    • Nitric oxide modulates basal and endothelin-induced coronary artery vascular smooth muscle cell proliferation and collagen levels
    • DOI 10.1006/jmcc.1996.0480
    • M.A. Rizvi, and P.R. Myers Nitric oxide modulates basal and endothelin-induced coronary artery vascular smooth muscle cell proliferation and collagen levels J. Mol. Cell. Cardiol. 29 1997 1779 1789 (Pubitemid 27303084)
    • (1997) Journal of Molecular and Cellular Cardiology , vol.29 , Issue.7 , pp. 1779-1789
    • Rizvi, M.A.D.1    Myers, P.R.2
  • 53
    • 0035890074 scopus 로고    scopus 로고
    • Nitric oxide is an essential negative regulator of cell proliferation in Xenopus brain
    • N. Peunova, V. Scheinker, H. Cline, and G. Enikolopov Nitric oxide is an essential negative regulator of cell proliferation in Xenopus brain J. Neurosci. 21 2001 8809 8818 (Pubitemid 33054845)
    • (2001) Journal of Neuroscience , vol.21 , Issue.22 , pp. 8809-8818
    • Peunova, N.1    Scheinker, V.2    Cline, H.3    Enikolopov, G.4
  • 54
    • 0031879095 scopus 로고    scopus 로고
    • Biphasic effect of exogenous nitric oxide on proliferation and differentiation in skin derived keratinocytes but not fibroblasts
    • DOI 10.1046/j.1523-1747.1998.00268.x
    • V. Krischel, D. Bruch-Gerharz, C. Suschek, K.D. Kröncke, T. Ruzicka, and V. Kolb-Bachofen Biphasic effect of exogenous nitric oxide on proliferation and differentiation in skin derived keratinocytes but not fibroblasts J. Invest. Dermatol. 111 1998 286 291 (Pubitemid 28354717)
    • (1998) Journal of Investigative Dermatology , vol.111 , Issue.2 , pp. 286-291
    • Krischel, V.1    Bruch-Gerharz, D.2    Suschek, C.3    Kroncke, K.-D.4    Ruzicka, T.5    Kolb-Bachofen, V.6
  • 56
    • 0342646900 scopus 로고    scopus 로고
    • Nitric oxide induces differentiation in the NB69 human catecholamine- rich cell line
    • DOI 10.1016/S0028-3908(00)00049-6, PII S0028390800000496
    • E. Rodríguez-Martín, M.J. Casarejos, E. Bazán, S. Canals, A.S. Herranz, and M.A. Mena Nitric oxide induces differentiation in the NB69 human catecholamine-rich cell line Neuropharmacology 39 2000 2090 2100 (Pubitemid 30645632)
    • (2000) Neuropharmacology , vol.39 , Issue.11 , pp. 2090-2100
    • Rodriguez-Martin, E.1    Casarejos, M.J.2    Bazan, E.3    Canals, S.4    Herranz, A.S.5    Mena, M.A.6
  • 58
    • 41749099262 scopus 로고    scopus 로고
    • Inhibition of inducible nitric oxide synthase activity prevents liver recovery in rat thioacetamide-induced fibrosis reversal
    • DOI 10.1111/j.1365-2362.2008.01941.x
    • O. Lukivskaya, E. Patsenker, R. Lis, and V.U. Buko Inhibition of inducible nitric oxide synthase activity prevents liver recovery in rat thioacetamide-induced fibrosis reversal Eur. J. Clin. Invest. 38 2008 317 325 (Pubitemid 351489908)
    • (2008) European Journal of Clinical Investigation , vol.38 , Issue.5 , pp. 317-325
    • Lukivskaya, O.1    Patsenker, E.2    Lis, R.3    Buko, V.U.4
  • 60
    • 0033858063 scopus 로고    scopus 로고
    • Fibrogenesis II. Metalloproteinases and their inhibitors in liver fibrosis
    • M.J. Arthur Fibrogenesis II. Metalloproteinases and their inhibitors in liver fibrosis Am. J. Physiol. Gastrointest. Liver Physiol. 279 2000 G245 G249
    • (2000) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.279
    • Arthur, M.J.1
  • 61
    • 0032952079 scopus 로고    scopus 로고
    • Expression patterns of matrix metalloproteinases and their inhibitors in parenchymal and non-parenchymal cells of rat liver: Regulation by TNF-α and TGF-β1
    • DOI 10.1016/S0168-8278(99)80007-5
    • T. Knittel, M. Mehde, D. Kobold, B. Saile, C. Dinter, and G. Ramadori Expression patterns of matrix metalloproteinases and their inhibitors in parenchymal and non-parenchymal cells of rat liver: regulation by TNF-alpha and TGF-beta1 J. Hepatol. 30 1999 48 60 (Pubitemid 29023652)
    • (1999) Journal of Hepatology , vol.30 , Issue.1 , pp. 48-60
    • Knittel, T.1    Mehde, M.2    Kobold, D.3    Saile, B.4    Dinter, C.5    Ramadori, G.6
  • 63
    • 2942682928 scopus 로고    scopus 로고
    • Regulation of PDGF and its receptors in fibrotic diseases
    • DOI 10.1016/j.cytogfr.2004.03.006, PII S1359610104000164
    • J.C. Bonner Regulation of PDGF and its receptors in fibrotic diseases Cytokine Growth Factor Rev. 15 2004 255 273 (Pubitemid 38781050)
    • (2004) Cytokine and Growth Factor Reviews , vol.15 , Issue.4 , pp. 255-273
    • Bonner, J.C.1
  • 65
    • 0035989936 scopus 로고    scopus 로고
    • Adenoviral delivery of an antisense RNA complementary to the 3′ coding sequence of transforming growth factor-β1 inhibits fibrogenic activities of hepatic stellate cells
    • M. Arias Adenoviral delivery of an antisense RNA complementary to the 3' coding sequence of transforming growth factor-beta1 inhibits fibrogenic activities of hepatic stellate cells Cell Growth Differ. 13 6 2002 265 273 (Pubitemid 34755379)
    • (2002) Cell Growth and Differentiation , vol.13 , Issue.6 , pp. 265-273
    • Arias, M.1    Lahme, B.2    Van De Leur, E.3    Gressner, A.M.4    Weiskirchen, R.5
  • 66
    • 0031018997 scopus 로고    scopus 로고
    • Tissue inhibitors of metalloproteinases in liver fibrosis
    • DOI 10.1016/S1357-2725(96)00118-5, PII S1357272596001185
    • J.P. Iredale Tissue inhibitors of metalloproteinases in liver fibrosis Int. J. Biochem. Cell Biol. 29 1997 43 54 (Pubitemid 27096418)
    • (1997) International Journal of Biochemistry and Cell Biology , vol.29 , Issue.1 , pp. 43-54
    • Iredale, J.P.1
  • 67
    • 0038244001 scopus 로고    scopus 로고
    • Reciprocal modulation of matrix metalloproteinase-13 and type I collagen genes in rat hepatic stellate cells
    • B. Schaefer Reciprocal modulation of matrix metalloproteinase-13 and type I collagen genes in rat hepatic stellate cells Am. J. Pathol. 162 6 2003 1771 1780 (Pubitemid 36613036)
    • (2003) American Journal of Pathology , vol.162 , Issue.6 , pp. 1771-1780
    • Schaefer, B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.