메뉴 건너뛰기




Volumn 33, Issue 10-11, 2009, Pages 949-957

Rationale and targets for antifibrotic therapies

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; ANGIOGENESIS INHIBITOR; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANTIFIBROTIC AGENT; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; ANTIVIRUS AGENT; BILE ACID; CANNABINOID 1 RECEPTOR ANTAGONIST; CYTOKINE RECEPTOR ANTAGONIST; DARUSENTAN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; FLAVONOID; GLITAZONE DERIVATIVE; HALOFUGINONE; HISTONE DEACETYLASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMMUNOSUPPRESSIVE AGENT; INTERSTITIAL COLLAGENASE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; NEUTROPHIL COLLAGENASE; PIOGLITAZONE; PLANT MEDICINAL PRODUCT; POLYPHENOL DERIVATIVE; RAPAMYCIN; ROSIGLITAZONE; SILIBININ; TRANSFORMING GROWTH FACTOR BETA; UNINDEXED DRUG;

EID: 70350617790     PISSN: 03998320     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gcb.2009.07.021     Document Type: Short Survey
Times cited : (19)

References (92)
  • 2
    • 15244356690 scopus 로고    scopus 로고
    • Mechanisms of disease: Mechanisms of hepatic fibrosis and therapeutic implications
    • Friedman S.L. Mechanisms of disease: Mechanisms of hepatic fibrosis and therapeutic implications. Nat Clin Pract Gastroenterol Hepatol 1 (2004) 98-105
    • (2004) Nat Clin Pract Gastroenterol Hepatol , vol.1 , pp. 98-105
    • Friedman, S.L.1
  • 4
    • 40049097359 scopus 로고    scopus 로고
    • Liver cirrhosis
    • Schuppan D., and Afdhal N.H. Liver cirrhosis. Lancet 371 (2008) 838-851
    • (2008) Lancet , vol.371 , pp. 838-851
    • Schuppan, D.1    Afdhal, N.H.2
  • 5
    • 36349003677 scopus 로고    scopus 로고
    • Transforming growth factor-beta and substrate stiffness regulate portal fibroblast activation in culture
    • Li Z., Dranoff J.A., Chan E.P., Uemura M., Sévigny J., and Wells R.G. Transforming growth factor-beta and substrate stiffness regulate portal fibroblast activation in culture. Hepatology 46 (2007) 1246-1256
    • (2007) Hepatology , vol.46 , pp. 1246-1256
    • Li, Z.1    Dranoff, J.A.2    Chan, E.P.3    Uemura, M.4    Sévigny, J.5    Wells, R.G.6
  • 6
    • 0034814405 scopus 로고    scopus 로고
    • Extracellular matrix degradation and the role of hepatic stellate cells
    • Benyon R.C., and Arthur M.J. Extracellular matrix degradation and the role of hepatic stellate cells. Semin Liver Dis 21 (2001) 373-384
    • (2001) Semin Liver Dis , vol.21 , pp. 373-384
    • Benyon, R.C.1    Arthur, M.J.2
  • 7
    • 0031018997 scopus 로고    scopus 로고
    • Tissue inhibitors of metalloproteinases in liver fibrosis
    • Iredale J.P. Tissue inhibitors of metalloproteinases in liver fibrosis. Int J Biochem Cell Biol 29 (2001) 43-54
    • (2001) Int J Biochem Cell Biol , vol.29 , pp. 43-54
    • Iredale, J.P.1
  • 8
    • 0032742051 scopus 로고    scopus 로고
    • Rat liver myofibroblasts and hepatic stellate cells: different cell populations of the fibroblast lineage with fibrogenic potential
    • Knittel T., Kobold D., Saile B., Grundmann A., Neubauer K., Piscaglia F., et al. Rat liver myofibroblasts and hepatic stellate cells: different cell populations of the fibroblast lineage with fibrogenic potential. Gastroenterology 117 (1999) 1205-1221
    • (1999) Gastroenterology , vol.117 , pp. 1205-1221
    • Knittel, T.1    Kobold, D.2    Saile, B.3    Grundmann, A.4    Neubauer, K.5    Piscaglia, F.6
  • 10
    • 33846453528 scopus 로고    scopus 로고
    • Bone marrow-derived cells express matrix metalloproteinases and contribute to regression of liver fibrosis in mice
    • Higashiyama R., Inagaki Y., Hong Y.Y., Kushida M., Nakao S., Niioka M., et al. Bone marrow-derived cells express matrix metalloproteinases and contribute to regression of liver fibrosis in mice. Hepatology 45 (2007) 213-222
    • (2007) Hepatology , vol.45 , pp. 213-222
    • Higashiyama, R.1    Inagaki, Y.2    Hong, Y.Y.3    Kushida, M.4    Nakao, S.5    Niioka, M.6
  • 11
    • 34547599359 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 induces an epithelial-to-mesenchymal transition state in mouse hepatocytes in vitro
    • Kaimori A., Potter J., Kaimori J.Y., Wang C., Mezey E., and Koteish A. Transforming growth factor-beta1 induces an epithelial-to-mesenchymal transition state in mouse hepatocytes in vitro. J Biol Chem 282 (2007) 22089-22101
    • (2007) J Biol Chem , vol.282 , pp. 22089-22101
    • Kaimori, A.1    Potter, J.2    Kaimori, J.Y.3    Wang, C.4    Mezey, E.5    Koteish, A.6
  • 12
    • 34548145815 scopus 로고    scopus 로고
    • Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition
    • Zeisberg M., Yang C., Martino M., Duncan M.B., Rieder F., Tanjore H., et al. Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition. J Biol Chem 282 (2007) 23337-23347
    • (2007) J Biol Chem , vol.282 , pp. 23337-23347
    • Zeisberg, M.1    Yang, C.2    Martino, M.3    Duncan, M.B.4    Rieder, F.5    Tanjore, H.6
  • 13
    • 16244416190 scopus 로고    scopus 로고
    • Fibrosis correlates with a ductular reaction in hepatitis C: roles of impaired replication, progenitor cells and steatosis
    • Clouston A.D., Powell E.E., Walsh M.J., Richardson M.M., Demetris A.J., and Jonsson J.R. Fibrosis correlates with a ductular reaction in hepatitis C: roles of impaired replication, progenitor cells and steatosis. Hepatology 41 (2005) 809-818
    • (2005) Hepatology , vol.41 , pp. 809-818
    • Clouston, A.D.1    Powell, E.E.2    Walsh, M.J.3    Richardson, M.M.4    Demetris, A.J.5    Jonsson, J.R.6
  • 14
    • 0032964899 scopus 로고    scopus 로고
    • Oval cell numbers in human chronic liver diseases are directly related to disease severity
    • Lowes K.N., Brennan B.A., Yeoh G.C., and Olynyk J.K. Oval cell numbers in human chronic liver diseases are directly related to disease severity. Am J Pathol 154 (1999) 537-541
    • (1999) Am J Pathol , vol.154 , pp. 537-541
    • Lowes, K.N.1    Brennan, B.A.2    Yeoh, G.C.3    Olynyk, J.K.4
  • 15
    • 0030091214 scopus 로고    scopus 로고
    • Expression of platelet-derived growth factor and its receptors in normal human liver and during active hepatic fibrogenesis
    • Pinzani M., Milani S., Herbst H., DeFranco R., Grappone C., Gentilini A., et al. Expression of platelet-derived growth factor and its receptors in normal human liver and during active hepatic fibrogenesis. Am J Pathol 148 (1996) 785-800
    • (1996) Am J Pathol , vol.148 , pp. 785-800
    • Pinzani, M.1    Milani, S.2    Herbst, H.3    DeFranco, R.4    Grappone, C.5    Gentilini, A.6
  • 16
    • 0026320289 scopus 로고
    • Transforming growth factors beta 1 and beta 2 are differentially expressed in fibrotic liver disease
    • Milani S., Herbst H., Schuppan D., Stein H., and Surrenti C. Transforming growth factors beta 1 and beta 2 are differentially expressed in fibrotic liver disease. Am J Pathol 139 (1991) 1221-1229
    • (1991) Am J Pathol , vol.139 , pp. 1221-1229
    • Milani, S.1    Herbst, H.2    Schuppan, D.3    Stein, H.4    Surrenti, C.5
  • 17
    • 0035066961 scopus 로고    scopus 로고
    • Proliferating bile duct epithelial cells are a major source of connective tissue growth factor in rat biliary fibrosis
    • Sedlaczek N., Jia J.D., Bauer M., Herbst H., Ruehl M., Hahn E.G., et al. Proliferating bile duct epithelial cells are a major source of connective tissue growth factor in rat biliary fibrosis. Am J Pathol 158 (2001) 1239-1244
    • (2001) Am J Pathol , vol.158 , pp. 1239-1244
    • Sedlaczek, N.1    Jia, J.D.2    Bauer, M.3    Herbst, H.4    Ruehl, M.5    Hahn, E.G.6
  • 19
    • 0025058042 scopus 로고
    • Procollagen expression by nonparenchymal rat liver cells in experimental biliary fibrosis
    • Milani S., Herbst H., Schuppan D., Kim K.Y., Riecken E.O., and Stein H. Procollagen expression by nonparenchymal rat liver cells in experimental biliary fibrosis. Gastroenterology 98 (1990) 175-184
    • (1990) Gastroenterology , vol.98 , pp. 175-184
    • Milani, S.1    Herbst, H.2    Schuppan, D.3    Kim, K.Y.4    Riecken, E.O.5    Stein, H.6
  • 20
    • 50249151525 scopus 로고    scopus 로고
    • The hedgehog pathway regulates remodeling responses to biliary obstruction in rats
    • Omenetti A., Popov Y., Jung Y., Choi S.S., Witek R.P., Yang L., et al. The hedgehog pathway regulates remodeling responses to biliary obstruction in rats. Gut 57 (2008) 1275-1282
    • (2008) Gut , vol.57 , pp. 1275-1282
    • Omenetti, A.1    Popov, Y.2    Jung, Y.3    Choi, S.S.4    Witek, R.P.5    Yang, L.6
  • 21
    • 55849135600 scopus 로고    scopus 로고
    • Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans
    • Omenetti A., Porrello A., Jung Y., Yang L., Popov Y., Choi S.S., et al. Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans. J Clin Invest 118 (2008) 3331-3342
    • (2008) J Clin Invest , vol.118 , pp. 3331-3342
    • Omenetti, A.1    Porrello, A.2    Jung, Y.3    Yang, L.4    Popov, Y.5    Choi, S.S.6
  • 22
    • 0034767501 scopus 로고    scopus 로고
    • Transforming growth factor beta and the liver
    • Bissell D.M., Roulot D., and George J. Transforming growth factor beta and the liver. Hepatology 34 (2001) 859-867
    • (2001) Hepatology , vol.34 , pp. 859-867
    • Bissell, D.M.1    Roulot, D.2    George, J.3
  • 24
    • 2942622398 scopus 로고    scopus 로고
    • Spontaneous recovery from micronodular cirrhosis: evidence for incomplete resolution associated with matrix cross-linking
    • Issa R., Zhou X., Constandinou C.M., Fallowfield J., Millward-Sadler H., Gaca M.D., et al. Spontaneous recovery from micronodular cirrhosis: evidence for incomplete resolution associated with matrix cross-linking. Gastroenterology 126 (2004) 1795-1808
    • (2004) Gastroenterology , vol.126 , pp. 1795-1808
    • Issa, R.1    Zhou, X.2    Constandinou, C.M.3    Fallowfield, J.4    Millward-Sadler, H.5    Gaca, M.D.6
  • 25
    • 0035083958 scopus 로고    scopus 로고
    • Apoptosis of hepatic stellate cells: involvement in resolution of biliary fibrosis and regulation by soluble growth factors
    • Issa R., Williams E., Trim N., Kendall T., Arthur M.J., Reichen J., et al. Apoptosis of hepatic stellate cells: involvement in resolution of biliary fibrosis and regulation by soluble growth factors. Gut 48 (2001) 548-557
    • (2001) Gut , vol.48 , pp. 548-557
    • Issa, R.1    Williams, E.2    Trim, N.3    Kendall, T.4    Arthur, M.J.5    Reichen, J.6
  • 26
    • 0017133791 scopus 로고
    • Reversibility of severe hepatic damage caused by jejunoileal bypass after re-establishment of normal intestinal continuity
    • Soyer M.T., Ceballos R., and Aldrete J.S. Reversibility of severe hepatic damage caused by jejunoileal bypass after re-establishment of normal intestinal continuity. Surgery 79 (1976) 601-604
    • (1976) Surgery , vol.79 , pp. 601-604
    • Soyer, M.T.1    Ceballos, R.2    Aldrete, J.S.3
  • 27
    • 0035825721 scopus 로고    scopus 로고
    • Regression of liver fibrosis after biliary drainage in patients with chronic pancreatitis and stenosis of the common bile duct
    • Hammel P., Couvelard A., O'Toole D., Ratouis A., Sauvanet A., Fléjou J.F., et al. Regression of liver fibrosis after biliary drainage in patients with chronic pancreatitis and stenosis of the common bile duct. N Engl J Med 344 (2001) 418-423
    • (2001) N Engl J Med , vol.344 , pp. 418-423
    • Hammel, P.1    Couvelard, A.2    O'Toole, D.3    Ratouis, A.4    Sauvanet, A.5    Fléjou, J.F.6
  • 28
    • 0030692704 scopus 로고    scopus 로고
    • Reversibility of hepatic fibrosis in autoimmune hepatitis
    • Dufour J.F., DeLellis R., and Kaplan M.M. Reversibility of hepatic fibrosis in autoimmune hepatitis. Ann Intern Med 127 (1997) 981-985
    • (1997) Ann Intern Med , vol.127 , pp. 981-985
    • Dufour, J.F.1    DeLellis, R.2    Kaplan, M.M.3
  • 30
    • 19544391413 scopus 로고    scopus 로고
    • Lamivudine for patients with chronic hepatitis B and advanced liver disease
    • Liaw Y.F., Sung J.J., Chow W.C., Farrell G., Lee C.Z., Yuen H., et al. Lamivudine for patients with chronic hepatitis B and advanced liver disease. N Engl J Med 351 (2004) 1521-1531
    • (2004) N Engl J Med , vol.351 , pp. 1521-1531
    • Liaw, Y.F.1    Sung, J.J.2    Chow, W.C.3    Farrell, G.4    Lee, C.Z.5    Yuen, H.6
  • 31
    • 0036242165 scopus 로고    scopus 로고
    • Impact of pegylated interferon alfa-2b and ribavirin on liver fibrosis in patients with chronic hepatitis C
    • Poynard T., McHutchison J., Manns M., Farrell G., Lee C.Z., Yuen H., et al. Impact of pegylated interferon alfa-2b and ribavirin on liver fibrosis in patients with chronic hepatitis C. Gastroenterology 122 (2002) 1303-1313
    • (2002) Gastroenterology , vol.122 , pp. 1303-1313
    • Poynard, T.1    McHutchison, J.2    Manns, M.3    Farrell, G.4    Lee, C.Z.5    Yuen, H.6
  • 32
    • 33644499498 scopus 로고    scopus 로고
    • Reversal of hepatic fibrosis - fact or fantasy?
    • Friedman S.L., and Bansal M.B. Reversal of hepatic fibrosis - fact or fantasy?. Hepatology 43 2 Suppl. 1 (2006) S82-S88
    • (2006) Hepatology , vol.43 , Issue.2 SUPPL. 1
    • Friedman, S.L.1    Bansal, M.B.2
  • 33
    • 0029585289 scopus 로고
    • Collagen and collagenase gene expression in three-dimensional collagen lattices are differentially regulated by alpha 1 beta 1 and alpha 2 beta 1 integrins
    • Langholz O., Röckel D., Mauch C., Kozlowska E., Bank I., Krieg T., et al. Collagen and collagenase gene expression in three-dimensional collagen lattices are differentially regulated by alpha 1 beta 1 and alpha 2 beta 1 integrins. J Cell Biol 131 (1995) 1903-1915
    • (1995) J Cell Biol , vol.131 , pp. 1903-1915
    • Langholz, O.1    Röckel, D.2    Mauch, C.3    Kozlowska, E.4    Bank, I.5    Krieg, T.6
  • 34
    • 13744255589 scopus 로고    scopus 로고
    • Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair
    • Duffield J.S., Forbes S.J., Constandinou C.M., Clay S., Partolina M., Vuthoori S., et al. Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair. J Clin Invest 115 (2005) 56-65
    • (2005) J Clin Invest , vol.115 , pp. 56-65
    • Duffield, J.S.1    Forbes, S.J.2    Constandinou, C.M.3    Clay, S.4    Partolina, M.5    Vuthoori, S.6
  • 35
    • 0031947715 scopus 로고    scopus 로고
    • Steatohepatitis: a tale of two "hits"?
    • Day C.P., and James O.F. Steatohepatitis: a tale of two "hits"?. Gastroenterology 114 (1998) 842-845
    • (1998) Gastroenterology , vol.114 , pp. 842-845
    • Day, C.P.1    James, O.F.2
  • 36
    • 17144459376 scopus 로고    scopus 로고
    • A novel MCP-1 gene polymorphism is associated with hepatic MCP-1 expression and severity of HCV-related liver disease
    • Muhlbauer M., Bosserhoff A.K., Hartmann A., Thasler W.E., Weiss T.S., Herfarth H., et al. A novel MCP-1 gene polymorphism is associated with hepatic MCP-1 expression and severity of HCV-related liver disease. Gastroenterology 125 (2003) 1085-1093
    • (2003) Gastroenterology , vol.125 , pp. 1085-1093
    • Muhlbauer, M.1    Bosserhoff, A.K.2    Hartmann, A.3    Thasler, W.E.4    Weiss, T.S.5    Herfarth, H.6
  • 37
    • 0344796403 scopus 로고    scopus 로고
    • Association of genetic variants of the chemokine receptor CCR5 and its ligands, RANTES and MCP-2, with outcome of HCV infection
    • Hellier S., Frodsham A.J., Hennig B.J., Klenerman P., Knapp S., Ramaley P., et al. Association of genetic variants of the chemokine receptor CCR5 and its ligands, RANTES and MCP-2, with outcome of HCV infection. Hepatology 38 (2003) 1468-1476
    • (2003) Hepatology , vol.38 , pp. 1468-1476
    • Hellier, S.1    Frodsham, A.J.2    Hennig, B.J.3    Klenerman, P.4    Knapp, S.5    Ramaley, P.6
  • 38
    • 0034950485 scopus 로고    scopus 로고
    • A functional polymorphism of the stromelysin gene (MMP-3) influences susceptibility to primary sclerosing cholangitis
    • Satsangi J., Chapman R.W., Haldar N., Donaldson P., Mitchell S., Simmons J., et al. A functional polymorphism of the stromelysin gene (MMP-3) influences susceptibility to primary sclerosing cholangitis. Gastroenterology 121 (2001) 124-130
    • (2001) Gastroenterology , vol.121 , pp. 124-130
    • Satsangi, J.1    Chapman, R.W.2    Haldar, N.3    Donaldson, P.4    Mitchell, S.5    Simmons, J.6
  • 39
    • 0038637369 scopus 로고    scopus 로고
    • Factor V Leiden polymorphism and the rate of fibrosis development in chronic hepatitis C virus infection
    • Wright M., Goldin R., Hellier S., Knapp S., Frodsham A., Hennig B., et al. Factor V Leiden polymorphism and the rate of fibrosis development in chronic hepatitis C virus infection. Gut 52 (2003) 1206-1210
    • (2003) Gut , vol.52 , pp. 1206-1210
    • Wright, M.1    Goldin, R.2    Hellier, S.3    Knapp, S.4    Frodsham, A.5    Hennig, B.6
  • 40
    • 12444253524 scopus 로고    scopus 로고
    • Long-term follow-up of hepatitis C virus infection: HLA class II loci influences the natural history of the disease
    • Yoshizawa K., Ota M., Saito S., Maruyama A., Yamaura T., Rokuhara A., et al. Long-term follow-up of hepatitis C virus infection: HLA class II loci influences the natural history of the disease. Tissue Antigens 61 (2003) 159-165
    • (2003) Tissue Antigens , vol.61 , pp. 159-165
    • Yoshizawa, K.1    Ota, M.2    Saito, S.3    Maruyama, A.4    Yamaura, T.5    Rokuhara, A.6
  • 41
    • 0037336495 scopus 로고    scopus 로고
    • HFE mutations and chronic hepatitis C: H63D and C282Y heterozygosity are independent risk factors for liver fibrosis and cirrhosis
    • Erhardt A., Maschner-Olberg A., Mellenthin C., Kappert G., Adams O., Donner A., et al. HFE mutations and chronic hepatitis C: H63D and C282Y heterozygosity are independent risk factors for liver fibrosis and cirrhosis. J Hepatol 38 (2003) 335-342
    • (2003) J Hepatol , vol.38 , pp. 335-342
    • Erhardt, A.1    Maschner-Olberg, A.2    Mellenthin, C.3    Kappert, G.4    Adams, O.5    Donner, A.6
  • 42
    • 0037431433 scopus 로고    scopus 로고
    • CYP enzyme polymorphisms and susceptibility to HCV-related chronic liver disease and liver cancer
    • Silvestri L., Sonzogni L., De Silvestri A., Gritti C., Foti L., Zavaglia C., et al. CYP enzyme polymorphisms and susceptibility to HCV-related chronic liver disease and liver cancer. Int J Cancer 104 (2003) 310-317
    • (2003) Int J Cancer , vol.104 , pp. 310-317
    • Silvestri, L.1    Sonzogni, L.2    De Silvestri, A.3    Gritti, C.4    Foti, L.5    Zavaglia, C.6
  • 43
    • 25144486612 scopus 로고    scopus 로고
    • Prediction of progression to cirrhosis by a glutathione S-transferase P1 polymorphism in subjects with hereditary hemochromatosis
    • Stickel F., Osterreicher C.H., Datz C., Ferenci P., Wölfel M., Norgauer W., et al. Prediction of progression to cirrhosis by a glutathione S-transferase P1 polymorphism in subjects with hereditary hemochromatosis. Arch Intern Med 165 (2005) 1835-1840
    • (2005) Arch Intern Med , vol.165 , pp. 1835-1840
    • Stickel, F.1    Osterreicher, C.H.2    Datz, C.3    Ferenci, P.4    Wölfel, M.5    Norgauer, W.6
  • 44
    • 56749096610 scopus 로고    scopus 로고
    • Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
    • Romeo S., Kozlitina J., Xing C., Pertsemlidis A., Cox D., Pennacchio L.A., et al. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet 40 (2008) 1461-1465
    • (2008) Nat Genet , vol.40 , pp. 1461-1465
    • Romeo, S.1    Kozlitina, J.2    Xing, C.3    Pertsemlidis, A.4    Cox, D.5    Pennacchio, L.A.6
  • 45
    • 34548301514 scopus 로고    scopus 로고
    • A 7 gene signature identifies the risk of developing cirrhosis in patients with chronic hepatitis C
    • Huang H., Shiffman M.L., Friedman S., Venkatesh R., Bzowej N., Abar O.T., et al. A 7 gene signature identifies the risk of developing cirrhosis in patients with chronic hepatitis C. Hepatology 46 (2007) 297-306
    • (2007) Hepatology , vol.46 , pp. 297-306
    • Huang, H.1    Shiffman, M.L.2    Friedman, S.3    Venkatesh, R.4    Bzowej, N.5    Abar, O.T.6
  • 47
    • 0036792679 scopus 로고    scopus 로고
    • Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection
    • Regev A., Berho M., Jeffers L.J., Milikowski C., Molina E.G., Pyrsopoulos N.T., et al. Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection. Am J Gastroenterol 97 (2002) 2614-2618
    • (2002) Am J Gastroenterol , vol.97 , pp. 2614-2618
    • Regev, A.1    Berho, M.2    Jeffers, L.J.3    Milikowski, C.4    Molina, E.G.5    Pyrsopoulos, N.T.6
  • 48
    • 0345017740 scopus 로고    scopus 로고
    • Sampling variability of liver fibrosis in chronic hepatitis C
    • Bedossa P., Dargere D., and Paradis V. Sampling variability of liver fibrosis in chronic hepatitis C. Hepatology 38 (2003) 1449-1457
    • (2003) Hepatology , vol.38 , pp. 1449-1457
    • Bedossa, P.1    Dargere, D.2    Paradis, V.3
  • 50
    • 48549103201 scopus 로고    scopus 로고
    • Inhibition of Integrin alphavbeta6 on cholangiocytes blocks transforming growth factor-beta activation and retards biliary fibrosis Progression
    • Patsenker E., Popov Y., Stickel F., Jonczyk A., Goodman S.L., and Schuppan D. Inhibition of Integrin alphavbeta6 on cholangiocytes blocks transforming growth factor-beta activation and retards biliary fibrosis Progression. Gastroenterology 135 (2008) 660-670
    • (2008) Gastroenterology , vol.135 , pp. 660-670
    • Patsenker, E.1    Popov, Y.2    Stickel, F.3    Jonczyk, A.4    Goodman, S.L.5    Schuppan, D.6
  • 51
    • 27744512904 scopus 로고    scopus 로고
    • Mdr2 (Abcb4)-/- mice spontaneously develop severe biliary fibrosis via massive dysregulation of pro- and antifibrogenic genes
    • Popov Y., Patsenker E., Fickert P., Trauner M., and Schuppan D. Mdr2 (Abcb4)-/- mice spontaneously develop severe biliary fibrosis via massive dysregulation of pro- and antifibrogenic genes. J Hepatol 43 (2005) 1045-1054
    • (2005) J Hepatol , vol.43 , pp. 1045-1054
    • Popov, Y.1    Patsenker, E.2    Fickert, P.3    Trauner, M.4    Schuppan, D.5
  • 52
    • 33744956853 scopus 로고    scopus 로고
    • Halofuginone induces matrix metalloproteinases in rat hepatic stellate cells via activation of p38 and NFkappaB
    • Popov Y., Patsenker E., Bauer M., Niedobitek E., Schulze-Krebs A., and Schuppan D. Halofuginone induces matrix metalloproteinases in rat hepatic stellate cells via activation of p38 and NFkappaB. J Biol Chem 281 (2006) 15090-15098
    • (2006) J Biol Chem , vol.281 , pp. 15090-15098
    • Popov, Y.1    Patsenker, E.2    Bauer, M.3    Niedobitek, E.4    Schulze-Krebs, A.5    Schuppan, D.6
  • 53
    • 33846253661 scopus 로고    scopus 로고
    • Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis
    • Ota T., Takamura T., Kurita S., Matsuzawa N., Kita Y., Uno M., et al. Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis. Gastroenterology 132 (2007) 282-293
    • (2007) Gastroenterology , vol.132 , pp. 282-293
    • Ota, T.1    Takamura, T.2    Kurita, S.3    Matsuzawa, N.4    Kita, Y.5    Uno, M.6
  • 54
    • 14944343292 scopus 로고    scopus 로고
    • Fibrosis in chronic liver diseases: diagnosis and management
    • Pinzani M., Rombouts K., and Colagrande S. Fibrosis in chronic liver diseases: diagnosis and management. J Hepatol 42 Suppl. 1 (2005) S22-36
    • (2005) J Hepatol , vol.42 , Issue.SUPPL. 1
    • Pinzani, M.1    Rombouts, K.2    Colagrande, S.3
  • 55
    • 54549119172 scopus 로고    scopus 로고
    • Current and future antifibrotic therapies for chronic liver disease
    • Rockey D.C. Current and future antifibrotic therapies for chronic liver disease. Clin Liver Dis 12 (2008) 939-962
    • (2008) Clin Liver Dis , vol.12 , pp. 939-962
    • Rockey, D.C.1
  • 56
    • 42949163491 scopus 로고    scopus 로고
    • Mechanisms of hepatic fibrogenesis
    • Friedman S.L. Mechanisms of hepatic fibrogenesis. Gastroenterology 134 (2008) 1655-1669
    • (2008) Gastroenterology , vol.134 , pp. 1655-1669
    • Friedman, S.L.1
  • 57
    • 0033515099 scopus 로고    scopus 로고
    • Blockade of type beta transforming growth factor signaling prevents liver fibrosis and dysfunction in the rat
    • Qi Z., Atsuchi N., Ooshima A., Takeshita A., and Ueno H. Blockade of type beta transforming growth factor signaling prevents liver fibrosis and dysfunction in the rat. Proc Natl Acad Sci U S A 96 (1999) 2345-2349
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 2345-2349
    • Qi, Z.1    Atsuchi, N.2    Ooshima, A.3    Takeshita, A.4    Ueno, H.5
  • 58
    • 0033607304 scopus 로고    scopus 로고
    • In vivo inhibition of rat stellate cell activation by soluble transforming growth factor beta type II receptor: a potential new therapy for hepatic fibrosis
    • George J., Roulot D., Koteliansky V.E., and Bissell D.M. In vivo inhibition of rat stellate cell activation by soluble transforming growth factor beta type II receptor: a potential new therapy for hepatic fibrosis. Proc Natl Acad Sci U S A 96 (1999) 12719-12724
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 12719-12724
    • George, J.1    Roulot, D.2    Koteliansky, V.E.3    Bissell, D.M.4
  • 59
    • 0036242557 scopus 로고    scopus 로고
    • Dose-dependent inhibition of hepatic fibrosis in mice by a TGF-beta soluble receptor: implications for antifibrotic therapy
    • Yata Y., Gotwals P., Koteliansky V., and Rockey D.C. Dose-dependent inhibition of hepatic fibrosis in mice by a TGF-beta soluble receptor: implications for antifibrotic therapy. Hepatology 35 (2002) 1022-1030
    • (2002) Hepatology , vol.35 , pp. 1022-1030
    • Yata, Y.1    Gotwals, P.2    Koteliansky, V.3    Rockey, D.C.4
  • 60
    • 0026320289 scopus 로고
    • Transforming growth factors β1 and β2 are differentially expressed in fibrotic liver disease
    • Milani S., Herbst H., Schuppan D., Stein H., and Surrenti C. Transforming growth factors β1 and β2 are differentially expressed in fibrotic liver disease. Am J Pathol 139 (1991) 1221-1229
    • (1991) Am J Pathol , vol.139 , pp. 1221-1229
    • Milani, S.1    Herbst, H.2    Schuppan, D.3    Stein, H.4    Surrenti, C.5
  • 61
    • 39149111929 scopus 로고    scopus 로고
    • Integrin alphavbeta6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies
    • Popov Y., Patsenker E., Stickel F., Zaks J., Bhaskar K.R., Niedobitek G., et al. Integrin alphavbeta6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies. J Hepatol 48 (2008) 453-464
    • (2008) J Hepatol , vol.48 , pp. 453-464
    • Popov, Y.1    Patsenker, E.2    Stickel, F.3    Zaks, J.4    Bhaskar, K.R.5    Niedobitek, G.6
  • 63
    • 0035142629 scopus 로고    scopus 로고
    • Halofuginone to prevent and treat thioacetamide-induced liver fibrosis in rats
    • Bruck R., Genina O., Aeed H., Alexiev R., Nagler A., Avni Y., et al. Halofuginone to prevent and treat thioacetamide-induced liver fibrosis in rats. Hepatology 33 (2001) 379-386
    • (2001) Hepatology , vol.33 , pp. 379-386
    • Bruck, R.1    Genina, O.2    Aeed, H.3    Alexiev, R.4    Nagler, A.5    Avni, Y.6
  • 64
    • 0037308337 scopus 로고    scopus 로고
    • Delivery of matrix metalloproteinase-1 attenuates established liver fibrosis in the rat
    • Iimuro Y., Nishio T., Morimoto T., Nitta T., Stefanovic B., Choi S.K., et al. Delivery of matrix metalloproteinase-1 attenuates established liver fibrosis in the rat. Gastroenterology 124 (2003) 445-458
    • (2003) Gastroenterology , vol.124 , pp. 445-458
    • Iimuro, Y.1    Nishio, T.2    Morimoto, T.3    Nitta, T.4    Stefanovic, B.5    Choi, S.K.6
  • 65
    • 11144357753 scopus 로고    scopus 로고
    • Treatment with human metalloproteinase-8 gene delivery ameliorates experimental rat liver cirrhosis
    • Siller-Lopez F., Sandoval A., Salgado S., Salazar A., Bueno M., Garcia J., et al. Treatment with human metalloproteinase-8 gene delivery ameliorates experimental rat liver cirrhosis. Gastroenterology 126 (2004) 1122-1133
    • (2004) Gastroenterology , vol.126 , pp. 1122-1133
    • Siller-Lopez, F.1    Sandoval, A.2    Salgado, S.3    Salazar, A.4    Bueno, M.5    Garcia, J.6
  • 66
    • 0033607653 scopus 로고    scopus 로고
    • Glutathione levels discriminate between oxidative stress and transforming growth factor-beta signaling in activated rat hepatic stellate cells
    • De Bleser P.J., Xu G., Rombouts K., Rogiers V., and Geerts A. Glutathione levels discriminate between oxidative stress and transforming growth factor-beta signaling in activated rat hepatic stellate cells. J Biol Chem 274 (1999) 33881-33887
    • (1999) J Biol Chem , vol.274 , pp. 33881-33887
    • De Bleser, P.J.1    Xu, G.2    Rombouts, K.3    Rogiers, V.4    Geerts, A.5
  • 67
    • 0033053458 scopus 로고    scopus 로고
    • Transforming growth factor beta1 induces the expression of alpha1(I) procollagen mRNA by a hydrogen peroxide-C/EBPbeta-dependent mechanism in rat hepatic stellate cells
    • Garcia-Trevijano E.R., Iraburu M.J., Fontana L., Domínguez-Rosales J.A., Auster A., Covarrubias-Pinedo A., et al. Transforming growth factor beta1 induces the expression of alpha1(I) procollagen mRNA by a hydrogen peroxide-C/EBPbeta-dependent mechanism in rat hepatic stellate cells. Hepatology 29 (1999) 960-970
    • (1999) Hepatology , vol.29 , pp. 960-970
    • Garcia-Trevijano, E.R.1    Iraburu, M.J.2    Fontana, L.3    Domínguez-Rosales, J.A.4    Auster, A.5    Covarrubias-Pinedo, A.6
  • 68
    • 0034843656 scopus 로고    scopus 로고
    • Antifibrotic effect of silymarin in rat secondary biliary fibrosis is mediated by downregulation of procollagen I TIMP-1 and TGF-β1 RNA
    • Jia J.D., Bauer M., Cho J.J., Ruehl M., Milani S., Boigk G., et al. Antifibrotic effect of silymarin in rat secondary biliary fibrosis is mediated by downregulation of procollagen I TIMP-1 and TGF-β1 RNA. J Hepatol 35 (2001) 392-398
    • (2001) J Hepatol , vol.35 , pp. 392-398
    • Jia, J.D.1    Bauer, M.2    Cho, J.J.3    Ruehl, M.4    Milani, S.5    Boigk, G.6
  • 69
    • 0032923588 scopus 로고    scopus 로고
    • Effects of Sho-saiko-to, a Japanese herbal medicine, on hepatic fibrosis in rats
    • Shimizu I., Ma Y.R., Mizobuchi Y., Liu F., Miura T., Nakai Y., et al. Effects of Sho-saiko-to, a Japanese herbal medicine, on hepatic fibrosis in rats. Hepatology 29 (1999) 282-284
    • (1999) Hepatology , vol.29 , pp. 282-284
    • Shimizu, I.1    Ma, Y.R.2    Mizobuchi, Y.3    Liu, F.4    Miura, T.5    Nakai, Y.6
  • 70
    • 0036082703 scopus 로고    scopus 로고
    • Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro
    • Galli A., Crabb D.W., Ceni E., Salzano R., Mello T., Svegliati-Baroni G., et al. Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro. Gastroenterology 122 (2002) 1924-1940
    • (2002) Gastroenterology , vol.122 , pp. 1924-1940
    • Galli, A.1    Crabb, D.W.2    Ceni, E.3    Salzano, R.4    Mello, T.5    Svegliati-Baroni, G.6
  • 71
    • 7644244675 scopus 로고    scopus 로고
    • The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis
    • Fiorucci S., Antonelli E., Rizzo G., Renga B., Mencarelli A., Riccardi L., et al. The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis. Gastroenterology 127 (2004) 1497-1512
    • (2004) Gastroenterology , vol.127 , pp. 1497-1512
    • Fiorucci, S.1    Antonelli, E.2    Rizzo, G.3    Renga, B.4    Mencarelli, A.5    Riccardi, L.6
  • 72
    • 66149144715 scopus 로고    scopus 로고
    • Pioglitazone: more than just an insulin sensitizer
    • Czaja M.J. Pioglitazone: more than just an insulin sensitizer. Hepatology 49 (2009) 1427-1430
    • (2009) Hepatology , vol.49 , pp. 1427-1430
    • Czaja, M.J.1
  • 73
    • 0034120477 scopus 로고    scopus 로고
    • An oral endothelin A receptor antagonist blocks collagen synthesis and deposition in advanced rat secondary fibrosis
    • Cho J.J., Hocher B., Herbst H., Jia J.D., Ruehl M., Hahn E.G., et al. An oral endothelin A receptor antagonist blocks collagen synthesis and deposition in advanced rat secondary fibrosis. Gastroenterology 118 (2000) 1169-1178
    • (2000) Gastroenterology , vol.118 , pp. 1169-1178
    • Cho, J.J.1    Hocher, B.2    Herbst, H.3    Jia, J.D.4    Ruehl, M.5    Hahn, E.G.6
  • 74
    • 0034849945 scopus 로고    scopus 로고
    • Effect of angiotensin II type 1 receptor blockade on experimental hepatic fibrogenesis
    • Paizis G., Gilbert R.E., Cooper M.E., Murthi P., Schembri J.M., Wu L.L., et al. Effect of angiotensin II type 1 receptor blockade on experimental hepatic fibrogenesis. J Hepatol 35 (2001) 376-385
    • (2001) J Hepatol , vol.35 , pp. 376-385
    • Paizis, G.1    Gilbert, R.E.2    Cooper, M.E.3    Murthi, P.4    Schembri, J.M.5    Wu, L.L.6
  • 75
    • 0036893741 scopus 로고    scopus 로고
    • Hemodynamic and antifibrotic effects of losartan in rats with liver fibrosis and/or portal hypertension
    • Croquet V., Moal F., Veal N., Wang J., Oberti F., Roux J., et al. Hemodynamic and antifibrotic effects of losartan in rats with liver fibrosis and/or portal hypertension. J Hepatol 37 (2002) 773-780
    • (2002) J Hepatol , vol.37 , pp. 773-780
    • Croquet, V.1    Moal, F.2    Veal, N.3    Wang, J.4    Oberti, F.5    Roux, J.6
  • 76
    • 54549098072 scopus 로고    scopus 로고
    • Cytokines and renin-angiotensin system signaling in hepatic fibrosis
    • Moreno M., and Bataller R. Cytokines and renin-angiotensin system signaling in hepatic fibrosis. Clin Liver Dis 12 (2008) 825-852
    • (2008) Clin Liver Dis , vol.12 , pp. 825-852
    • Moreno, M.1    Bataller, R.2
  • 77
    • 0141892569 scopus 로고    scopus 로고
    • Review of the antiproliferative properties of mycophenolate mofetil in non-immune cells
    • Morath C., and Zeier M. Review of the antiproliferative properties of mycophenolate mofetil in non-immune cells. Int J Clin Pharmacol Ther 41 (2003) 465-469
    • (2003) Int J Clin Pharmacol Ther , vol.41 , pp. 465-469
    • Morath, C.1    Zeier, M.2
  • 78
    • 0032738763 scopus 로고    scopus 로고
    • Rapamycin inhibits hepatic stellate cell proliferation in vitro and limits fibrogenesis in an in vivo model of liver fibrosis
    • Zhu J., Wu J., Frizell E., Liu S.L., Bashey R., Rubin R., et al. Rapamycin inhibits hepatic stellate cell proliferation in vitro and limits fibrogenesis in an in vivo model of liver fibrosis. Gastroenterology 117 (1999) 1198-1204
    • (1999) Gastroenterology , vol.117 , pp. 1198-1204
    • Zhu, J.1    Wu, J.2    Frizell, E.3    Liu, S.L.4    Bashey, R.5    Rubin, R.6
  • 79
    • 0038555527 scopus 로고    scopus 로고
    • Effect of HMG-CoA reductase inhibitors on proliferation and protein synthesis by rat hepatic stellate cells
    • Rombouts K., Kisanga E., Hellemans K., Wielant A., Schuppan D., and Geerts A. Effect of HMG-CoA reductase inhibitors on proliferation and protein synthesis by rat hepatic stellate cells. J Hepatol 38 (2003) 564-572
    • (2003) J Hepatol , vol.38 , pp. 564-572
    • Rombouts, K.1    Kisanga, E.2    Hellemans, K.3    Wielant, A.4    Schuppan, D.5    Geerts, A.6
  • 80
    • 37749049919 scopus 로고    scopus 로고
    • Antiangiogenic treatment with sunitinib ameliorates inflammatory infiltrate, fibrosis, and portal pressure in cirrhotic rats
    • Tugues S., Fernandez-Varo G., Munoz-Luque J., Ros J., Arroyo V., Rodes J., et al. Antiangiogenic treatment with sunitinib ameliorates inflammatory infiltrate, fibrosis, and portal pressure in cirrhotic rats. Hepatology 46 (2007) 1919-1926
    • (2007) Hepatology , vol.46 , pp. 1919-1926
    • Tugues, S.1    Fernandez-Varo, G.2    Munoz-Luque, J.3    Ros, J.4    Arroyo, V.5    Rodes, J.6
  • 81
    • 0141740706 scopus 로고    scopus 로고
    • The preferential homing of a platelet derived growth factor receptor-recognizing macromolecule to fibroblast-like cells in fibrotic tissue
    • Beljaars L., Weert B., Geerts A., Meijer D.K., and Poelstra K. The preferential homing of a platelet derived growth factor receptor-recognizing macromolecule to fibroblast-like cells in fibrotic tissue. Biochem Pharmacol 66 (2003) 1307-1317
    • (2003) Biochem Pharmacol , vol.66 , pp. 1307-1317
    • Beljaars, L.1    Weert, B.2    Geerts, A.3    Meijer, D.K.4    Poelstra, K.5
  • 82
    • 0034724911 scopus 로고    scopus 로고
    • Successful targeting to rat hepatic stellate cells using albumin modified with cyclic peptides that recognize the collagen type VI receptor
    • Beljaars L, Molema G, Schuppan D, Geerts A, De Bleser PJ, Weert B, et al. Successful targeting to rat hepatic stellate cells using albumin modified with cyclic peptides that recognize the collagen type VI receptor. J Biol Chem 2000;275:12743-51.
    • (2000) J Biol Chem , vol.275 , pp. 12743-12751
    • Beljaars, L.1    Molema, G.2    Schuppan, D.3    Geerts, A.4    De Bleser, P.J.5    Weert, B.6
  • 83
    • 26244454363 scopus 로고    scopus 로고
    • Studies on the targeted delivery of the antifibrogenic compound mycophenolic acid to the hepatic stellate cell
    • Greupink R., Bakker H.I., Reker-Smit C., van Loenen-Weemaes A.M., Kok R.J., Meijer D.K., et al. Studies on the targeted delivery of the antifibrogenic compound mycophenolic acid to the hepatic stellate cell. J Hepatol 43 (2005) 884-892
    • (2005) J Hepatol , vol.43 , pp. 884-892
    • Greupink, R.1    Bakker, H.I.2    Reker-Smit, C.3    van Loenen-Weemaes, A.M.4    Kok, R.J.5    Meijer, D.K.6
  • 85
    • 41649096578 scopus 로고    scopus 로고
    • Antibody-targeted myofibroblast apoptosis reduces fibrosis during sustained liver injury
    • Douglass A., Wallace K., Parr R., Park J., Durward E., Broadbent I., et al. Antibody-targeted myofibroblast apoptosis reduces fibrosis during sustained liver injury. J Hepatol 49 (2008) 88-98
    • (2008) J Hepatol , vol.49 , pp. 88-98
    • Douglass, A.1    Wallace, K.2    Parr, R.3    Park, J.4    Durward, E.5    Broadbent, I.6
  • 86
    • 41849117310 scopus 로고    scopus 로고
    • Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone
    • Sato Y., Murase K., Kato J., Kobune M., Sato T., Kawano Y., et al. Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone. Nat Biotechnol 26 (2008) 431-442
    • (2008) Nat Biotechnol , vol.26 , pp. 431-442
    • Sato, Y.1    Murase, K.2    Kato, J.3    Kobune, M.4    Sato, T.5    Kawano, Y.6
  • 87
    • 0034067582 scopus 로고    scopus 로고
    • Hepatocyte transplantation in rats with decompensated cirrhosis
    • Kobayashi N., Ito M., Nakamura J., Cai J., Gao C., Hammel J.M., et al. Hepatocyte transplantation in rats with decompensated cirrhosis. Hepatology 31 (2000) 851-857
    • (2000) Hepatology , vol.31 , pp. 851-857
    • Kobayashi, N.1    Ito, M.2    Nakamura, J.3    Cai, J.4    Gao, C.5    Hammel, J.M.6
  • 88
    • 0036629340 scopus 로고    scopus 로고
    • Isolation of human progenitor liver epithelial cells with extensive replication capacity and differentiation into mature hepatocytes
    • Malhi H., Irani A.N., Gagandeep S., and Gupta S. Isolation of human progenitor liver epithelial cells with extensive replication capacity and differentiation into mature hepatocytes. J Cell Sci 115 (2002) 2679-2688
    • (2002) J Cell Sci , vol.115 , pp. 2679-2688
    • Malhi, H.1    Irani, A.N.2    Gagandeep, S.3    Gupta, S.4
  • 89
    • 0037464545 scopus 로고    scopus 로고
    • Transplanted bone marrow regenerates liver by cell fusion
    • Vassilopoulos G., Wang P.R., and Russell D.W. Transplanted bone marrow regenerates liver by cell fusion. Nature 422 (2003) 901-904
    • (2003) Nature , vol.422 , pp. 901-904
    • Vassilopoulos, G.1    Wang, P.R.2    Russell, D.W.3
  • 90
    • 2542601615 scopus 로고    scopus 로고
    • Liver regeneration and repair: hepatocytes, progenitor cells, and stem cells
    • Fausto N. Liver regeneration and repair: hepatocytes, progenitor cells, and stem cells. Hepatology 39 (2004) 1477-1487
    • (2004) Hepatology , vol.39 , pp. 1477-1487
    • Fausto, N.1
  • 91
    • 21044434329 scopus 로고    scopus 로고
    • Identification of expandable human hepatic progenitors which differentiate into mature hepatic cells in vivo
    • Nowak G., Ericzon B.G., Nava S., Jaksch M., Westgren M., and Sumitran-Holgersson S. Identification of expandable human hepatic progenitors which differentiate into mature hepatic cells in vivo. Gut 54 (2005) 972-979
    • (2005) Gut , vol.54 , pp. 972-979
    • Nowak, G.1    Ericzon, B.G.2    Nava, S.3    Jaksch, M.4    Westgren, M.5    Sumitran-Holgersson, S.6
  • 92
    • 33644509480 scopus 로고    scopus 로고
    • Hematopoietic cells as hepatocyte stem cells: a critical review of the evidence
    • Thorgeirsson S.S., and Grisham J.W. Hematopoietic cells as hepatocyte stem cells: a critical review of the evidence. Hepatology 43 (2006) 2-8
    • (2006) Hepatology , vol.43 , pp. 2-8
    • Thorgeirsson, S.S.1    Grisham, J.W.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.