A mild impairment of mitochondrial electron transport has sex-specific effects on lifespan and aging in mice

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Hughes, Bryan G ^a   Hekimi, Siegfried ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; IRON SULFUR PROTEIN; UBIQUINOL CYTOCHROME C REDUCTASE; RIESKE IRON-SULFUR PROTEIN;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION REGULATION; GENE FUNCTION; HETEROZYGOTE; HOMOZYGOTE; LIFESPAN; LIVER MITOCHONDRION; LOSS OF FUNCTION MUTATION; MALE; METABOLIC RATE; MITOCHONDRIAL DNA DISORDER; MITOCHONDRIAL ENERGY TRANSFER; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROTEIN FUNCTION; SEX DIFFERENCE; SURVIVAL RATE; ALLELE; ANIMAL; ELECTRON TRANSPORT; FERTILITY; GENE TARGETING; GENETICS; LONGEVITY; METABOLISM; MITOCHONDRION; PATHOLOGY; PHYSIOLOGY; POINT MUTATION; SEXUAL DEVELOPMENT;

ANIMALIA; CAENORHABDITIS ELEGANS; MAMMALIA; MUS;

ALLELES; ANIMALS; BIOLOGICAL MARKERS; ELECTRON TRANSPORT; ELECTRON TRANSPORT COMPLEX III; FEMALE; FERTILITY; GENE KNOCK-IN TECHNIQUES; HETEROZYGOTE; LONGEVITY; MALE; MICE; MITOCHONDRIA; OXIDATIVE STRESS; POINT MUTATION; SEX CHARACTERISTICS;

EID: 80053921573     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0026116     Document Type: Article

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