Combination strategies for repair, plasticity, and regeneration using regulation of gene expression during the chronic phase after spinal cord injury

Synapse

Volumn 65, Issue 12, 2011, Pages 1255-1281

  Gerin, Christine G ^a   Madueke, Ikenna C ^a,b   Perkins, Tina ^b   Hill, Seritta ^b   Smith, Kristin ^b   Haley, Benjamin ^c   Allen, Shannon A ^b   Garcia, Richard P ^b   Paunesku, Tanjana ^c   Woloschak, Gayle ^c  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b CHICAGO STATE UNIVERSITY   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Central nervous system regeneration; Combination therapy; Gene regulation; Sensorimotor function

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; MESSENGER RNA; NEUROMODULIN; PROTEIN; PROTEIN LINGO 1; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

CHRONICITY; GENE CONTROL; GENE EXPRESSION REGULATION; HUMAN; NERVE CELL PLASTICITY; NERVE DEGENERATION; NERVE REGENERATION; NEUROPATHOLOGY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; SPINAL CORD INJURY;

ANIMALS; CHRONIC DISEASE; COMBINED MODALITY THERAPY; GENE EXPRESSION REGULATION; GENE THERAPY; HUMANS; NERVE REGENERATION; NEURONAL PLASTICITY; SPINAL CORD INJURIES;

EID: 80053920820     PISSN: 08874476     EISSN: 10982396     Source Type: Journal    
DOI: 10.1002/syn.20903     Document Type: Review

References (123)

1. Allen S, Garcia R, Hill S, Simpson J, Madueke I, Hendricks R, Hollins C, Erhart M, Gerin C. 2006. Regulation of early gene expression in response to acute spinal cord injury. ABRCMS conference November 8-11
2. Amano M, Fukata Y, Kaibuchi K. 2000. Regulation and functions of rho-associated kinase. Exp Cell Res 261: 44-51.
3. Balkowiec A, Katz DM. 2000. Activity-dependent release of endogenous brain-derived neurotrophic factor from primary sensory neurons detected by ELISA in situ. J Neurosci 20: 7417-7423.
4. Bareyre F, Haudenschild B, Schwab M. 2002. Long-lasting sprouting and gene expression changes induced by the monoclonal antibody IN-1 in the adult spinal cord. J Neurosci 22: 7097-7110.
5. Barton W, Liu B, Tzvetkova D, Jeffrey P, Fournier A, Sah D, Cate R, Strittmatter S, Nikolov D. 2003. Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins. EMBO J 22: 3291-3302.
6. Beattie M, Hermann G, Rogers R, Bresnahan J. 2002. Cell death in models of spinal cord injury. Prog Brain Res 137: 37-47.
7. Blight A, Curt A, Ditunno J, Dobkin B, Ellaway P, Fawcett J, Fehlings M, Grossman R, Lammertse D, Privat A, Steeves J, Tuszynski M, Kalichman M, Guest J. 2009. Position statement on the sale of unproven cellular therapies for spinal cord injury: the international campaign for cures of spinal cord injury paralysis. Spinal Cord 47: 713-714.
8. Blight AR. 1983. Cellular morphology of chronic spinal cord injury in the cat: the relation of injury intensity to survival of myelinated axons. Neurosci 19: 321-341.
9. Bronfman F, Fainzilber M. 2004. Multi-tasking by the p75 neurotrophin receptor: sortilin things out? EMBO Rep 5: 867-871.
10. Carmel J, Galante A, Soteropoulos P, Tolias P, Recce M, Young W, Hart R. 2001. Gene expression profiling of acute spinal cord injury reveals spreading inflammatory signals and neuron loss. Physiol Genomics 7: 201-213.
11. Cheng H, Wu J, Tzeng S. 2002. Neuroprotection of glial cell line-derived neurotrophic factor in damaged spinal cords following contusive injury. J Neurosci Res 69: 397-405.
12. Chong M, Woolf C, Andrews P, Turmaine M, Schreyer D, Anderson P. 1994. The downregulation of GAP-43 is not responsible for the failure of regeneration in freezekilled nerve grafts in the rat. Exp Neurol 129: 311-320.
13. Chung K, Kang HS. 1987. Dorsal root ganglion neurons with central processes in both dorsal and ventral roots in rats. Neurosci Letters 80: 202-206.
14. Condorelli D, Dell'Albani P, Mudò G, Timmusk T, Belluardo N. 1994. Expression of neurotrophins and their receptors in primary astroglial cultures: induction by cyclic AMP-elevating agents. J Neurochem 63: 509-516.
15. De Biase A, Knoblach S, Di Giovanni S, Fan C, Molon A, Hoffman E, Faden A. 2005. Gene expression profiling of experimental traumatic spinal cord injury as a function of distance from impact site and injury severity. Physiol Genomics 22: 368-381.
16. Deloulme J, Laeng P, Janet T, Sensenbrenner M, Baudier J. 1993. Expression of neuromodulin (GAP-43) and its regulation by basic fibroblast growth factor during the differentiation of O-2A progenitor cells. J Neurosci Res 36: 147-162.
17. Dergham P, Ellezam B, Essagian C, Avedissian H, Lubell W, McKerracher L. 2002. Rho signaling pathway targeted to promote spinal cord repair. J Neurosci 22: 6570-6577.
18. Di Giovanni S, Faden A, Yakovlev A, Jonathan S. Duke-Cohan J, Finn T, Thouin M, Knoblach S, de Biase A, Bregman B, Hoffman E. 2005. Neuronal plasticity after spinal cord injury: identification of a gene cluster driving neurite outgrowth. FASEB Journal 19: 153-154.
19. Di Giovanni S, Knoblach SM, Brandoli C, Aden S, Hoffman E, Faden A. 2003. Gene profiling in spinal cord injury shows role of cell cycle genes in neuronal death. Ann Neurol 53: 454-468.
20. Domeniconi M, Cao Z, Spencer T, Sivasankaran R, Wang K, Nikulina E, Kimura N, Cai H, Deng K, Gao Y, He Z, Filbin M. 2002. Myelin-associated glycoprotein interacts with the Nogo66 receptor to inhibit neurite outgrowth. Neuron 35: 283-290.
21. Dong H, Fazzaro A, Xiang C, Korsmeyer S, Jacquin M, McDonald J. 2003. Enhanced oligodendrocyte survival after spinal cord injury in Bax-deficient mice and mice with delayed Wallerian degeneration. J Neurosci 23: 8682-8691.
22. Donovan M, Yamaguchi M, Eisch A. 2008. Dynamic expression of TrkB receptor protein on proliferating and maturing cells in the adult mouse dentate gyrus. Hippocampus 18: 435-439.
23. Dou F, Huang L, Yu P, Zhu H, Wang X, Zou J, Lu P, Xu X. 2009. Temporospatial expression and cellular localization of oligodendrocyte myelin glycoprotein (OMgp) after traumatic spinal cord injury in adult rats. J Neurotrauma 26: 2299-2311.
24. Dougherty K, Milner T. 1999. p75NTR immunoreactivity in the rat dentate gyrus is mostly within presynaptic profiles but is also found in some astrocytic and postsynaptic profiles. J Comp Neurol 407: 77-91.
25. Erschbamer M, Hofstetter C, Olson L. 2005. RhoA, RhoB, RhoC, Rac1, Cdc42, and Tc10 mRNA levels in spinal cord, sensory ganglia, and corticospinal tract neurons and long-lasting specific changes following spinal cord injury. J Comp Neurol 484: 224-233.
26. Fehlings M, Perrin R. 2005. The role and timing of early decompression for cervical spinal cord injury: update with a review of recent clinical evidence. Injury 36: B13-B26.
27. Fournier AE, Gould GC, Liu BP, Strittmatter SM. 2002. Truncated soluble Nogo receptor binds Nogo-66 and blocks inhibition of axon growth by myelin. J Neurosci 22: 8876-8883.
28. Fournier AE, GrandPre T, Strittmatter SM. 2001. Identification of a receptor mediating nogo-66 inhibition of axonal regeneration. Nature 409: 341-346.
29. Fournier AE, Takizawa BT, Strittmatter SM. 2003. Rho kinase inhibition enhances axonal regeneration in the injured CNS. J Neurosci 23: 1416-1423.
30. Fulton D, Paez PM, Campagnoni AT. 2010. The multiple roles of myelin protein genes during the development of the oligodendrocyte. ASN Neuro 2: 25-37.
31. Gerin CG, Hill A, Hill S, Smith K, Privat A. 2010. Serotonin release variations during recovery of motor function after a spinal cord injury in rats. Synapse 64: 855-861.
32. Gimenez y Ribotta M, Rajaofetra N, Morin-Richaud C, Alonso G, Bochelen D, Sandillon F, Legrand A, Mersel M, A P. 1995. Oxysterol (7 beta-hydroxycholesteryl-3-oleate) promotes serotonergic reinnervation in the lesioned rat spinal cord by reducing glial reaction. J Neurosci Res 41: 79-95.
33. Goslin K, Schreyer D, Skene J, Banker G. 1988. Development of neuronal polarity: GAP-43 distinguishes axonal from dendritic growth cones. Nature 336: 672-674.
34. GrandPre T, Nakamura F, Vartanian T, Strittmatter SM. 2000. Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein. Nature 403: 439-444.
35. Gulino R, Lombardo SA, Casabona A, Leanza G, Perciavalle V. 2004. Levels of brain-derived neurotrophic factor and neurotrophin-4 in lumbar motoneurons after low-thoracic spinal cord hemisection. Brain Research 1013: 174-181.
36. Harauz G, Libich D. 2009. The classic basic protein of myelin--conserved structural motifs and the dynamic molecular barcode involved in membrane adhesion and protein-protein interactions. Curr Protein Pept Sci 10: 196-215.
37. Hasegawa Y, Fujitani M, Hata K, Tohyama M, Yamagishi S, Yamashita T. 2004. Promotion of axon regeneration by myelin-associated glycoprotein and Nogo through divergent signals downstream of Gi/G. J Neurosci 24: 6826-6832.
38. Hashimoto M, Nitta A, Fukumitsu H, Nomoto H, Shen L, Furukawa S. 2005. Inflammation-induced GDNF improves locomotor function after spinal cord injury. Neuroreport 16: 99-102.
39. Hiebert G, Khodarahmi K, McGraw J, Steeves J, Tetzlaff W. 2002. Brain-derived neurotrophic factor applied to the motor cortex promotes sprouting of corticospinal fibers but not regeneration into a peripheral nerve transplant. Journal of Neuroscience Research 69: 160-168.
40. Hill S, Smith K, Gerin C. 2008. Metal Repartition and Expressed Genes in Spinal Cord of Rats. US Department of Energy Journal of Undergraduate Research p. 154.
41. Hoffman P. 2010. A conditioning lesion induces changes in gene expression and axonal transport that enhance regeneration by increasing the intrinsic growth state of axons. Exp Neurol 223: 11-18.
42. Houle JD, Tessler A. 2003. Repair of chronic spinal cord injury. Exp Neurol 182: 247-260.
43. Huang E, Reichardt LF. 2003. Trk receptors: roles in neuronal signal transduction. Annu Rev Biochem 72: 609-642.
44. Huang J, Phillips G, Roth A, Pedraza L, Shan W, Belkaid W, Mi S, Fex-Svenningsen A, Florens L, Yates J, Colman D. 2005. Glial membranes at the node of Ranvier prevent neurite outgrowth. Science 310: 1813-1817.
45. Hughes JT. 1966. Pathology of the Spinal Cord. Philadelphia: Lippincott.
46. Hunt D, Coffin R, Prinjha R, Campbell G, Anderson P. 2003. Nogo-A expression in the intact and injured nervous system. Mol Cell Neurosci 4: 1083-1102.
47. Hunt D, Coffin RS, Anderson PN. 2002. The Nogo receptor, its ligands and axonal regeneration in the spinal cord; A review. J Neurocytol 31: 93-120.
48. Iannotti C, Ping Zhang Y, Shields C, Han Y, Burke D, Xu X. 2004. A neuroprotective role of glial cell line-derived neurotrophic factor following moderate spinal cord contusion injury. Exp Neurol 189: 317-332.
49. Ibanez C. 1998. Emerging themes in structural biology of neurotrophic factors. Trends Neurosci 21: 438-444.
50. Ikeda O, Murakami M, Ino H, Yamazaki M, Koda M, Nakayama C, Moriya H. 2002. Effects of brain-derived neurotrophic factor (BDNF) on compression-induced spinal cord injury: BDNF attenuates down-regulation of superoxide dismutase expression and promotes up-regulation of myelin basic protein expression. J Neuropathol Exp Neurol 61: 142-153.
51. Ikeda O, Murakami M, Ino H, Yamazaki M, Nemoto T, Koda M, Nakayama C, Moriya H. 2001. Acute up-regulation of brain-derived neurotrophic factor expression resulting from experimentally induced injury in the rat spinal cord. Acta Neuropathol (Berl) 102: 239-245.
52. Ikeda T, Xia X, Xia Y, Ikenoue T, Choi B. 1999. Expression of glial cell line-derived neurotrophic factor in the brain and cerebrospinal fluid of the developing rat. Int J Dev Neurosci 17: 681-691.
53. Inoue S, Susukida M, Ikeda K, Murase K, Hayashi K. 1997. Dopaminergic transmitter up-regulation of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) synthesis in mouse astrocytes in culture. Biochem Biophys Res Commun 238: 468-472.
54. Irving E, Vinson M, Rosin C, Roberts J, Chapman D, Facci L, Virley D, Skaper S, Burbidge S, Walsh F, Hunter A, Parsons A. 2005. Identification of neuroprotective properties of anti-MAG antibody: a novel approach for the treatment of stroke? J Cereb Blood Flow Metab 25: 98-107.
55. Jareb M, Banker G. 1998. The polarized sorting of membrane proteins expressed in cultured hippocampal neurons using viral vectors. Neuron 20: 855-867.
56. Ji B, Li M, Wu W, Yick L, Lee X, Shao Z, Wang J, So K, McCoy J, Pepinsky R, Mi S, Relton J. 2006. LINGO-1 antagonist promotes functional recovery and axonal sprouting after spinal cord injury. Mol Cell Neurosci 33: 311-320.
57. Jones L, Margolis R, Tuszynski M. 2003. The chondroitin sulfate proteoglycans neurocan, brevican, phosphacan, and versican are differentially regulated following spinal cord injury. Exp Neurol 182: 399-411.
58. Josephson A, Widenfalk J, Widmer HW, Olson L, Spenger C. 2001. NOGO mRNA expression in adult and fetal human and rat nervous tissue and in weight drop injury. Exp Neurol 169: 319-328.
59. Kasahara K, Nakagawa T, Kubota T. 2006. Neuronal loss and expression of neurotrophic factors in a model of rat chronic compressive spinal cord injury. Spine 31: 2059-2066.
60. Keita M, Magy L, Heape A, Richard L, Piaser M, Vallat J. 2002. Immunocytological studies of L-MAG expression regulation during myelination of embryonic brain cell cocultures. Dev Neurosci 24: 495-503.
61. Kim M-W, Bang M-S, Han T-R, Ko Y-J, Yoon B-W, Kim J-H, Kang L-M, Lee K-M, Kim M-H. 2005. Exercise increased BDNF and trkB in the contralateral hemisphere of the ischemic rat brain. Brain Res 1052: 16-21.
62. King V, Bradbury E, McMahon S, Priestley J. 2000. Changes in truncated trkB and p75 receptor expression in the rat spinal cord following spinal cord hemisection and spinal cord hemisection plus neurotrophin treatment. Exp Neurol 165: 327-341.
63. Koda M, Hashimoto M, Murakami M, Yoshinaga K, Ikeda O, Yamazaki M, Koshizuka S, Kamada T, Moriya H, Shirasawa H, Sakao S, Ino H. 2004. Adenovirus vector-mediated in vivo gene transfer of brain-derived neurotrophic factor (BDNF) promotes rubrospinal axonal regeneration and functional recovery after complete transection of the adult rat spinal cord. J Neurotrauma 21: 329-337.
64. Ledda F, Paratcha G, Sandoval-Guzmán T, Ibáñez C. 2007. GDNF and GFRalpha1 promote formation of neuronal synapses by ligand-induced cell adhesion. Nat Neurosci 10: 293-300.
65. Lee J, Geoffroy C, Chan A, Tolentino K, Crawford M, Leal M, Kang B, Zheng B. 2010. Assessing spinal axon regeneration and sprouting in Nogo-, MAG-, and OMgp-deficient mice. Neuron 66: 663-670.
66. Lee X, Yang Y, Shao Z, Rosenberg S, Levesque M, Pepinsky R, Qiu M, Miller R, Chan J, Mi S. 2007. NGF regulates the expression of axonal LINGO-1 to inhibit oligodendrocyte differentiation and myelination. J Neurosci 27: 220-225.
67. Lever IJ, Bradbury E, Cunningham J, Adelson D, Jones M, McMahon S, Marvizón J, Malcangio M. 2001. Brain-derived neurotrophic factor is released in the dorsal horn by distinctive patterns of afferent fiber stimulation. J Neurosci 21: 4469-4477.
68. Liebl DJ, Huang W, Young W, Parada LF. 2001. Regulation of trk receptors following contusion of the rat spinal cord. Exp Neurol 167: 15-26.
69. Liu BP, Fournier A, GrandPre T, Strittmatter SM. 2002. Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor. Science 297: 1190-1193.
70. Marklund N, Fulp CT, Shimizu S, Puri R, McMillan A, Strittmatter SM, McIntosh TK. 2006. Selective temporal and regional alterations of Nogo-A and small proline-rich repeat protein 1A (SPRR1A) but not Nogo-66 receptor (NgR) occur following traumatic brain injury in the rat. Exp Neurol 197: 70-83.
71. McDonald N, Hendrickson W. 1993. A structural superfamily of growth factors containing a cystine knot motif. Cell 73: 421-424.
72. McKerracher L, David S, Jackson D, Kottis V, Dunn R, Braun P. 1994. Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite growth. Neuron 13: 805-811.
73. Mele T, Carman-Krzan M, Juric DM. 2010. Regulatory role of monoamine neurotransmitters in astrocytic NT-3 synthesis. Int J Dev Neurosci 28: 13-19.
74. Mendell LM, Munson JB, Arvanian VL. 2001. Neurotrophins and synaptic plasticity in the mammalian spinal cord. J Physiol 533(Pt 1): 91-97.
75. Mi S, Lee X, Shao Z, Thill G, Ji B, Relton J, Levesque M, Allaire N, Perrin S, Sands B, Crowel lT, Cate RL, McCoy JM, Pepinsky RB. 2004. LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex. Nat Neurosci 7: 221-228.
76. Miklic S, Juric DM, Carman-Krzan M. 2004. Differences in the regulation of BDNF and NGF synthesis in cultured neonatal rat astrocytes. Int J Dev Neurosci 22: 119-130.
77. Mueller B, Mack H, Teusch N. 2005. Rho kinase, a promising drug target for neurological disorders. Nat Rev Drug Discov 4: 387-398.
78. Mukhopadhyay G, Doherty P, Walsh FS, Crocker PR, Filbin MT. 1994. A novel role for myelin-associated glycoprotein as an inhibitor of axonal regeneration. Neuron 13: 757-767.
79. Nakamura M, Bregman B. 2001. Differences in neurotrophic factor gene expression profiles between neonate and adult rat spinal cord after injury. Experimental neurology 169: 407-415.
80. Nakashima S, Matsuyama Y, Yu Y, Kiuchi K, Ishiguro N. 2004. Suppression of GDNF production by MPSS treatment following spinal cord injury in the rat. Neuroreport 15: 2337-2340.
81. Newman S, Saito M, Yu R. 1995. Myelin. In: Kettenmann H RB, editor. Neuroglia: Oxford University Press. p. 535-554.
82. Nishio Y, Koda M, Kitajo K, Seto M, Hata K, Taniguchi J, Moriya H, Fujitani M, Kubo T, Yamashita T. 2006. Delayed treatment with rho-kinase inhibitor does not enhance axonal regeneration or functional recovery after spinal cord injury in rats. Exp Neurol 200: 392-397.
83. Pan W, Csernus B, Kastin AJ. 2003. Upregulation of p55 and p75 receptors mediating TNF-alpha transport across the injured blood-spinal cord barrier. J Mol Neurosci 21: 173-184.
84. Paxinos G, Watson C, editors. 1982. The rat brain in stereotaxic coordinates. Sydney: Academic Press.
85. Pehar M, Cassina P, Vargas MR, Xie Y, Beckman JS, Massa SM, Longo FM, Barbeito L. 2006. Modulation of p75-dependent motor neuron death by a small non-peptidyl mimetic of the neurotrophin loop 1 domain. Eur J Neurosci 24: 1575-1580.
86. Pignot V, Hein A, Barske C, Wiessner C, Walmsley A, Kaupmann K, Mayeur H, Sommer B, Mir A, Frentzel S. 2003. Characterization of two novel proteins, NgRH1 and NgRH2, structurally and biochemically homologous to the Nogo-66 receptor. J Neurochem 85: 717-728.
87. Pochon N, Menoud A, Tseng J, Zurn A, Aebischer P. 1997. Neuronal GDNF expression in the adult rat nervous system identified by in situ hybridization. Eur J Neurosci 9: 463-471.
88. Prinjha R, Moore S, Vinson M, Blake S, Morrow R, Christie G, Michalovich D, Simmons D, Walsh F. 2000. Inhibitor of neurite outgrowth in humans. Nature 403: 383-384.
89. Qian MD, Zhang J, Tan X-Y, Wood A, Gill D, Cho S. 2006. Novel Agonist Monoclonal Antibodies Activate TrkB Receptors and Demonstrate Potent Neurotrophic Activities. J Neurosci 26: 9394-9403.
90. Resnick D, Schmitt C, Miranpuri G, Dhodda V, Isaacson J, Vemuganti R. 2004. Molecular evidence of repair and plasticity following spinal cord injury. Neuroreport 15: 837-839.
91. Satake K, Matsuyama Y, Kamiya M, Kawakami H, Iwata H, Adachi K, Kiuchi K. 2000. Up-regulation of glial cell line-derived neurotrophic factor (GDNF) following traumatic spinal cord injury. Neuroreport 11: 3877-3881.
92. Schaar D, Sieber B, Dreyfus C, Black I. 1993. Regional and cell-specific expression of GDNF in rat brain. Exp Neurol 124: 368-371.
93. Schmitt C, Miranpuri G, Dhodda V, Isaacson J, Vemuganti R, Resnick D. 2006. Changes in spinal cord injury-induced gene expression in rat are strain-dependent. The Spine Journal 6: 113-119.
94. Schmoll H, Ramboiu S, Platt D, Herndon J, Kessler C, Popa-Wagner A. 2005. Age influences the expression of GAP-43 in the rat hippocampus following seizure. Gerontology 51: 215-224.
95. Schwartz J, Nishiyama N. 1994. Neurotrophic factor gene expression in astrocytes during development and following injury. Brain Res Bull 35: 403-407.
96. Sekhon LHS, Fehlings MG. 2001. Epidemiology, Demographics, and Pathophysiology of Acute Spinal Cord Injury. Spine 26: S2-S12.
97. Shao Z, Browning J, Lee X, Scott M, Shulga-Morskaya S, Allaire N, Thill G, Levesque M, Sah D, McCoy J, Murray B, Jung V, Pepinsky R, Mi S. 2005. TAJ/TROY, an orphan TNF receptor family member, binds Nogo-66 receptor 1 and regulates axonal regeneration. Neuron 45: 353-359.
98. Sharma H. 2006. Post-traumatic application of brain-derived neurotrophic factor and glia-derived neurotrophic factor on the rat spinal cord enhances neuroprotection and improves motor function. Acta Neurochir Suppl 96: 329-334.
99. Song G, Cechvala C, Resnick D, Dempsey R, Rao V. 2001. GeneChip analysis after acute spinal cord injury in rat. J Neurochem 79: 804-815.
100. Starkey G, Petratos S, Shipham K, Butzkueven H, Bucci T, Lowry K, Cheema S, Kilpatrick T. 2001. Neurotrophin receptor expression and responsiveness by postnatal cerebral oligodendroglia. Neuroreport 12: 4081-4086.
101. Strelau J, Unsicker K. 1999. GDNF family members and their receptors: expression and functions in two oligodendroglial cell lines representing distinct stages of oligodendroglial development. Glia 26: 291-301.
102. Strittmatter S, Cannon S, Ross E, Higashijima T, Fishman M. 1993. GAP-43 augments G protein-coupled receptor transduction in Xenopus laevis oocytes. Proc Natl Acad Sci U S A 90: 5327-5331.
103. Tachibana T, Noguchi K, Ruda M. 2002. Analysis of gene expression following spinal cord injury in rat using complementary DNA microarray. Neurosci Lett 327: 133-137.
104. Tai M-H, Cheng H, Wu J-P, Liu Y-L, Lin P-R, Kuo J-S, Tseng C-J, Tzeng S-F. 2003. Gene transfer of glial cell line-derived neurotrophic factor promotes functional recovery following spinal cord contusion. Exp Neurol 183: 508-515.
105. Tartaglia G, Pechmann S, Dobson C, M V. 2009. A relationship between mRNA expression levels and protein solubility in E. coli. J Mol Biol 388: 381-389.
106. Teng F, Tang B. 2005. Why do Nogo/Nogo-66 receptor gene knockouts result in inferior regeneration compared to treatment with neutralizing agents? J Neurochem 94: 865-874.
107. Thompson HJ, Marklund N, LeBold DG, Morales DM, Keck CA, Vinson M, Royo NC, Grundy R, McIntosh TK. 2006. Tissue sparing and functional recovery following experimental traumatic brain injury is provided by treatment with an anti-myelin-associated glycoprotein antibody. Eur J Neurosci 24: 3063-3072.
108. Tian DS, Yu ZY, Xie MJ, Bu BT, Witte OW, Wang W. 2006. Suppression of astroglial scar formation and enhanced axonal regeneration associated with functional recovery in a spinal cord injury rat model by the cell cycle inhibitor olomoucine. J Neurosci Res 84: 1053-1063.
109. Venkatesh K, Chivatakarn O, Lee H, Joshi P, Kantor D, Newman B, Mage R, Rader C, Giger R. 2005. The Nogo-66 receptor homolog NgR2 is a sialic acid-dependent receptor selective for myelin-associated glycoprotein. J Neurosci 25: 808-822.
110. Vourch P, Andres C. 2004. Oligodendrocyte myelin glycoprotein (OMgp): evolution, structure and function. Brain Res Brain Res Rev 45: 115-124.
111. Wang X, Chun SJ, Treloar H, Vartanian T, Greer CA, Strittmatter SM. 2002. Localization of nogo-A and nogo-66 receptor proteins at sites of axon-myelin and synaptic contact. J Neurosci 22: 5505-5515.
112. Widenfalk J, Lundströmer K, Jubran M, Brene S, Olson L. 2001. Neurotrophic factors and receptors in the immature and adult spinal cord after mechanical injury or kainic acid. J Neurosci 21: 3457-3475.
113. Wilkins A, Majed H, Layfield R, Compston A, Chandran S. 2003. Oligodendrocytes promote neuronal survival and axonal length by distinct intracellular mechanisms: a novel role for oligodendrocyte-derived glial cell line-derived neurotrophic factor. J Neurosci 23: 4967-4974.
114. Wong ST, Henley JR, Kanning KC, Huang KH, Bothwell M, Poo M. 2002. A p75 (NTR) and nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein. Nature Neurosci 5: 1302-1308.
115. Wrathall JR, Li W, Hudson LD. 1998. Myelin gene expression after experimental contusive spinal cord injury. J Neurosci 18: 8780-8793.
116. Wu X, Yoo S, Wrathall J. 2005. Real-time quantitative PCR analysis of temporal-spatial alterations in gene expression after spinal cord contusion. J Neurochem 93: 943-952.
117. Xie F, Zheng B. 2008. White matter inhibitors in CNS axon regeneration failure. Exp Neurol 209: 302-312.
118. Yamashita T, Higuchi H, Tohyama M. 2002. The p75 receptor transduces the signal from myelin-associated glycoprotein to rho. J Cell Biol 157: 565-570.
119. Yamashita T, Tucker KL, Barde YA. 1999. Neurotrophin binding to the p75 receptor modulates rho activity and axonal outgrowth. Neuron 24: 585-593.
120. Young W. 2002a. Spinal cord contusion models. Prog Brain Res 137: 231-255.
121. Young W. 2002b. Methylprednisolone and spinal cord injury. J Neurosurg 96: 141-142.
122. Zhang K, Xiao H, Lu P, Shi J, Li G, Wang Y, Han S, Zhang F, Lu Y, Zhang X, Xu X. 2004. Differential gene expression after complete spinal cord transection in adult rats: An analysis focused on a subchronic post-injury stage. Neuroscience 128: 375-388.
123. Zhou L, Baumgartner BJ, Hill-Felberg SJ, McGowen LR, Shine HD. 2003. Neurotrophin-3 expressed in situ induces axonal plasticity in the adult injured spinal cord. J Neurosci 23: 1424-1431.