Serotonin release variations during recovery of motor function after a spinal cord injury in rats

Synapse

Volumn 64, Issue 11, 2010, Pages 855-861

  Gerin, Christine G ^a,b   Hill, Angela ^c   Hill, Seritta ^c   Smith, Kristin ^c   Privat, Alain ^b  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b Montpellier University Medical Center   (France)

^c CSU   (United States)

Author keywords

5 HT; Motor function; Spinal cord injury; Treadmill exercise; Ventral horn

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DAMAGE; CELL REGENERATION; CONTROLLED STUDY; EXERCISE TEST; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMPLANT; LOCOMOTION; MALE; MICRODIALYSIS; MOTOR PERFORMANCE; NONHUMAN; PRIORITY JOURNAL; RAT; REST; SEROTONIN RELEASE; SEROTONINERGIC NERVE CELL; SEROTONINERGIC SYSTEM; SPINAL CORD INJURY; SPINAL CORD VENTRAL HORN; TREADMILL EXERCISE;

ANIMALS; BIOGENIC MONOAMINES; DISEASE MODELS, ANIMAL; FUNCTIONAL LATERALITY; GLIAL FIBRILLARY ACIDIC PROTEIN; LOCOMOTION; MALE; MICRODIALYSIS; MOVEMENT DISORDERS; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; SEROTONIN; SPINAL CORD INJURIES; TIME FACTORS;

EID: 78149491473     PISSN: 08874476     EISSN: 10982396     Source Type: Journal    
DOI: 10.1002/syn.20802     Document Type: Article

References (19)

1. Barbeau H, Rossignol S. 1991. Initiation and modulation of locomotor pattern in the adult chronic spinal cat by noradrenergic, serotonergic and dopaminergic drugs. Brain Res 546: 250-260.
2. Basbaum AI, Zahs K, Lord B. 1988. The fiber caliber of 5-HT immunoreactive axons in the dorsolateral funiculus of the spinal cord of the rat and cat. Somatosens Res 5: 177-185.
3. Bedford TG, Tipton CM, Wison NC, Oppliger RA, Gisolfi CV. 1979. Maximum oxygen consumption of rats and its changes with various experimental procedures. J Appl Physiol 47: 1278-1283.
4. Dietz V, Harkema SJ. 2004. Locomotor activity in spinal cord-injured persons. J Appl Physiol 5: 1954-1960.
5. Gerin C. 2003. Possible role of 5-HT release in spinal cord regenerative processes. Molecular aspects of neuro-degenerative diseases conference, Sweden.
6. Gerin C, Becquet D, Privat A. 1995. Direct evidence for the link in-between monoaminergic descending pathways and motor activity. I. A study with microdialysis probes implanted in the ventral funiculus of the spinal cord. Brain Res 704: 191-201.
7. Gerin C, Legrand A, Privat A. 1994. Study of 5-HT release with a chronically implanted microdialysis probe in the ventral horn of the spinal cord of unrestrained rats during exercise on a treadmill. J Neurosci Meth 52: 129-141.
8. Gerin C, Teilhac J-R, Smith K, Privat A. 2008. Motor activity induces release of serotonin in the dorsal horn of the rat lumbar spinal cord. Neurosci Lett 436: 91-95.
9. Goldshmit Y, Lythgo N, Galea MP, Turnley AM. 2008. Treadmill training after spinal cord hemisection in mice promotes axonal sprouting and synapse formation and improves motor recovery. J Neurotrauma 25: 449-465.
10. Harkema SJ. 2001. Neural plasticity after human spinal cord injury: Application of the locomotor training to the rehabilitation of walking. Neuroscientist 7: 455-468.
11. Holstege JC, Kuypers HGJM. 1987. Brainstem projections to spinal motoneurons: An update. Neuroscience 23: 809-821.
12. Kim D, Adipudi V, Shibayama M, Giszter S, Tessler A, Murray M, Simansky KJ. 1999. Direct agonists for serotonin receptors enhance locomotor function in rats that received neural transplants after neonatal spinal transection. J Neurosci 19: 6213-6224.
13. Miller JF, Paul KD, Lee RH, Rymer WZ, Heckman CJ. 1996. Restoration of extensor excitability in the acute spinal cat by the 5-HT2 agonist DOI. J Neurophysiol 75: 620-628.
14. Molander c, Xu Q, Grant G. 1984. The cytoarchitectonic organization of the spinal cord in the rat. I. The lower thoracic and lumbosacral cord. J Comp Neurol 230: 133-141.
15. Paxinos G, Watson C, editors. 1997. The rat brain in stereotaxic coordinates.Compact third edition ed. San Diego, CA: Academic Press.
16. Schwartz EJ, Gerachshenko T, Alford S. 2005. 5-HT prolongs ventral root bursting via presynaptic inhibition of synaptic activity during fictive locomotion in lamprey. J Neurophysiol 93: 980-988.
17. Sharma A, Punhani T, Fone K. 1997. Distribution of 5-hydroxytryptamine2C receptor protein in adult rat brain and spinal cord determined using a receptor-directed antibody: Effect of 5, 7-dihydroxy-tryptamine. Synapse 27: 45-56.
18. Skagerberg G, Bjorklund A. 1985. Topographic principles in the spinal projections of serotonergic and non-serotonergic brainstem neurons in the rat. Neuroscience 15: 445-480.
19. Westerink BH, Tuinte MH. 1986. Chronic use of intracerebral dialysis for the in vivo measurement of 3, 4-dihydroxyphenylethylamine and its metabolite 3, 4-dihydroxyphenylacetic acid. J Neurochem 46: 181-185.