Characterization of two novel proteins, NgRH1 and NgRH2, structurally and biochemically homologous to the Nogo-66 receptor

Journal of Neurochemistry

Volumn 85, Issue 3, 2003, Pages 717-728

  Pignot, V ^a,b   Hein, A E ^a   Barske, C ^a   Wiessner, C ^a   Walmsley, A R ^a   Kaupmann, K ^a   Mayeur, H ^a,b   Sommer, B ^c   Mir, A K ^a   Frentzel, Stefan ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b PSL RESEARCH UNIVERSITY   (France)

^c BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

GPI anchor; MAG; Nogo 66 receptor; Nogo A; OMgp; Reticulon

Indexed keywords

GENE PRODUCT; GLYCOSYLPHOSPHATIDYLINOSITOL; LEUCINE; LIPID; MESSENGER RNA; NOGO 66 RECEPTOR; PROTEIN NGRH1; PROTEIN NGRH2; RECEPTOR PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CELL SURFACE; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; NERVE CELL; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY;

ANIMALIA;

EID: 0038708340     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2003.01710.x     Document Type: Article

References (39)

1. Bickel P. E., Scherer P. E., Schnitzer J. E., Oh P., Lisanti M. P. and Lodish H. F. (1997) Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins. J. Biol. Chem. 272, 13793-13802.
2. Bilderback T. R., Grigsby R. J. and Dobrowsky R. T. (1997) Association of p75 (NTR) with caveolin and localization of neurotrophin-induced sphingomyelin hydrolysis to caveolae. J. Biol. Chem. 272, 10922-10927.
3. Bilderback T. R., Gazula V. R., Lisanti M. P. and Dobrowsky R. T. (1999) Caveolin interacts with TrkA and p75 (NTR) and regulates neurotrophin signaling pathways. J. Biol. Chem. 274, 257-263.
4. Bregman B. S., Kunkel-Bagden E., Schnell L., Dai H. N., Gao D. and Schwab M. E. (1995) Recovery from spinal cord injury mediated by antibodies to neurite growth inhibitors. Nature 378, 498-501.
5. Brown D. A. and Rose J. K. (1992) Sorting of GP-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface. Cell 68, 533-544.
6. Brown H. C., Kristenssen T., Rothaul A. and Perry V. H. (1998) The influence of plasma proteins on the distribution of leucocytes within the brain parenchyma in a murine model of stroke. Neuropathol. Appl. Neurobiol. 24, 177-186.
7. Brown M. C., Perry V. H., Lunn E. R., Gordon S. and Heumann R. (1991) Macrophage dependence of peripheral sensory nerve regeneration: possible involvement of nerve growth factor. Neuron 6, 359-370.
8. Cardoso de Almeida M. L. and Turner M. J. (1983) The membrane form of variant surface glycoproteins of Trypanosoma brucei. Nature 302, 349-352.
9. Caroni P. (2001) New EMBO members' review: actin cytoskeleton regulation through modulation of PI(4,5) P(2) rafts. EMBO J. 20, 4332-4336.
10. Chen M. S., Huber A. B., van der Haar M. E., Frank M., Schnell L., Spillmann A. A., Christ F. and Schwab M. E. (2000) Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1. Nature 403, 434-439.
11. DeBellard M. E., Tang S., Mukhopadhyay G., Shen Y. J. and Filbin M. T. (1996) Myelin-associated glycoprotein inhibits axonal regeneration from a variety of neurons via interaction with a sialoglycoprotein. Mol. Cell Neurosci. 7, 89-101.
12. Domeniconi M., Cao Z., Spencer T., Sivasankaran R., Wang K. C., Nikulina E., Kimura N., Cai H., Deng K., Gao Y., He Z. and Filbin M. T. (2002) Myelin-associated glycoprotein interacts with the Nogo66 receptor to inhibit neurite outgrowth. Neuron 35, 283-290.
13. Fawcett J. W. and Keynes R. J. (1990) Peripheral nerve regeneration. Annu. Rev. Neurosci. 13, 43-60.
14. Fournier A. E., GrandPre T. and Strittmatter S. M. (2001) Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration. Nature 409, 341-346.
15. Fournier A. E., Gould G. C., Liu B. P. and Strittmatter S. M. (2002) Truncated soluble Nogo receptor binds Nogo-66 and blocks inhibition of axon growth by myelin. J. Neurosci. 22, 8876-8883.
16. GrandPre T., Nakamura F., Vartanian T. and Strittmatter S. M. (2000) Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein. Nature 403, 439-444.
17. GrandPre T., Li S. and Strittmatter S. M. (2002) Nogo-66 receptor antagonist peptide promotes axonal regeneration. Nature 417, 547-551.
18. Huber A. B. and Schwab M. E. (2000) Nogo-A, a potent inhibitor of neurite outgrowth and regeneration. Biol. Chem. 381, 407-419.
19. Hunt D., Mason M. R., Campbell G., Coffin R. and Anderson P. N. (2002) Nogo receptor mRNA expression in intact and regenerating CNS neurons. Mol. Cell Neurosci. 20, 537-552.
20. Josephson A., Trifunovski A., Widmer H. R., Widenfalk J., Olson L. and Spenger C. (2002) Nogo-receptor gene activity: cellular localization and developmental regulation of mRNA in mice and humans. J. Comp. Neurol. 453, 292-304.
21. Kobe B, and Deisenhofer J. (1994) The leucine-rich repeat: a versatile binding motif. TIBS 19, 415-421.
22. Kobe B. and Deisenhofer J. (1995) A structural basis of the interactions between leucine-rich repeats and protein ligands. Nature 374, 183-186.
23. Kobe B. and Kajava A. V. (2001) The leucine-rich repeat as a protein recognition motif. Curr. Opin. Struct. Biol. 11, 725-732.
24. Lai C., Brow M. A., Nave K. A., Noronha A. B., Quarles R. H., Bloom F. E., Milner R. J. and Sutcliffe J. G. (1987) Two forms of 1B236/myelin-associated glycoprotein, a cell adhesion molecule for postnatal neural development, are produced by alternative splicing. Proc. Natl. Acad. Sci. USA 84, 4337-4341.
25. Littlewood G. M., Hooper N. M. and Turner A. J. (1989) Ectoenzymes of the kidney microvillar membrane. Affinity purification, characterization and localization of the phospholipase C-solubilized form of renal dipeptidase. Biochem. J. 257, 361-367.
26. Liu B. P., Fournier A., GrandPre T. and Strittmatter S. M. (2002) Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor. Science 16, 1190-1193.
27. Martini R. and Schachner M. (1988) Immunoelectron microscopic localization of neural cell adhesion molecules (LI, N-CAM, and myelin-associated glycoprotein) in regenerating adult mouse sciatic nerve. J. Cell Biol. 106, 1735-1746.
28. Mukhopadhyay G., Doherty R, Walsh F. S., Crocker P. R. and Filbin M. T. (1994) A novel role for myelin-associated glycoprotein as an inhibitor of axonal regeneration. Neuron 13, 757-767.
29. Prinjha R., Moore S. E., Vinson M., Blake S., Morrow R., Christie G., Michalovich D., Simmons D. L. and Walsh F. S. (2000) Inhibitor of neurite outgrowth in humans. Nature 403, 383-384.
30. Rupalla K., Allegrini P., Sauer D. and Wiessner C. (1998) Time course of microglia activation and apoptosis in various brain regions after permanent focal cerebral ischemia in mice. Acta Neuropathol. 96, 172-178.
31. Salzer J. L., Holmes W. P. and Colman D. R. (1987) The amino acid sequences of the myelin-associated glycoproteins: homology to the immunoglobulin gene superfamily. J. Cell. Biol. 104, 957-965.
32. Schnell L. and Schwab M. E. (1990) Axonal regeneration in the rat spinal cord produced by an antibody against myelin-associated neurite growth inhibitors. Nature 343, 269-272.
33. Simons K. and Toomre D. (2000) Lipid rafts and signal transduction. Nature Rev. 1, 31-41.
34. Stahl N., Borchelt D. R., Hsiao K. and Prusiner S. B. (1987) Scrapie prion protein contains a phosphatidylinositol glycolipid. Cell 51, 229-240.
35. Towbin H., Staehelin T. and Gordon J. (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA 76, 4350-4354.
36. Wang K. C., Koprivica V., Kim J. A., Sivasankaran R., Guo Y., Neve R. L. and He Z. (2002a) Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth. Nature 417, 941-914.
37. Wang X., Chun S. J., Treloar H., Vartanian T., Greer C. A. and Strittmatter S. M. (2002b) Localization of Nogo-A and Nogo-66 receptor proteins at sites of axon-myelin and synaptic contact. J. Neurosci. 22, 5505-5515.
38. Wiessner C., Gehrmann J., Lindholm D., Topper R., Kreutzberg G. W. and Hossmann K. A. (1993) Expression of transforming growth factor-beta 1 and interleukin-1 beta mRNA in rat brain following transient forebrain ischemia. Acta Neuropathol. 86, 439-446.
39. Yamashita T., Higuchi H. and Tohyama M. (2002) The p75 receptor transduces the signal from myelin-associated glycoprotein to Rho. J. Cell. Biol. 157, 565-570.