Rational design of selective ligands for trypanothione reductase from Trypanosoma cruzi. Structural effects on the inhibition by dibenzazepines based on imipramine

Journal of Enzyme Inhibition

Volumn 12, Issue 3, 1997, Pages 161-173

  Garforth, Jacqueline ^a   Yin, Hong ^a   Mckie, James H ^a   Douglas, Kenneth T ^a   Fairlamb, Alan H ^b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Antiparasitic drugs; Leishmaniasis; Rational drug design; Tricyclics; Trypanosomiasis

Indexed keywords

ANTIPARASITIC AGENT; DIBENZAZEPINE DERIVATIVE; ENZYME INHIBITOR; IMIPRAMINE; OXIDOREDUCTASE;

ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG STRUCTURE; ENZYME ASSAY; ENZYME INHIBITION; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA CRUZI;

TRYPANOSOMA; TRYPANOSOMA CRUZI;

EID: 0030773120     PISSN: 87555093     EISSN: None     Source Type: Journal    
DOI: 10.3109/14756369709029312     Document Type: Article

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