Two interacting binding sites for quinacrine derivatives in the active site of trypanothione reductase: A template for drug design

Journal of Biological Chemistry

Volumn 279, Issue 28, 2004, Pages 29493-29500

  Saravanamuthu, Ahilan ^a   Vickers, Tim J ^a   Bond, Charles S ^a   Peterson, Mark R ^a   Hunter, William N ^a   Fairlamb, Alan H ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DERIVATIVES; MOLECULAR STRUCTURE; MONOMERS; PATHOLOGY; VITAMINS;

GLUTATHIONE; SELECTIVE INHIBITION;

ENZYMES;

ANTIPROTOZOAL AGENT; CLOMIPRAMINE; FLAVOPROTEIN; GLUTATHIONE; GLUTATHIONE REDUCTASE; MEPACRINE; MEPACRINE MUSTARD; QUINACRINE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TRYPANOTHIONE REDUCTASE; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; DRUG BINDING SITE; DRUG DESIGN; DRUG POTENTIATION; DRUG SELECTIVITY; ENZYME ACTIVE SITE; ENZYME INHIBITOR INTERACTION; INHIBITION KINETICS; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA CRUZI;

ANIMALS; BINDING SITES; CLOMIPRAMINE; DRUG DESIGN; ENZYME INHIBITORS; GLUTATHIONE REDUCTASE; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NADH, NADPH OXIDOREDUCTASES; OXIDATION-REDUCTION; QUINACRINE; QUINACRINE MUSTARD; TRYPANOSOMA CRUZI;

TRYPANOSOMA; TRYPANOSOMA CRUZI;

EID: 3142719178     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M403187200     Document Type: Article

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