Mechanism and structure-activity relationships of norspermidine-based peptidic inhibitors of trypanothione reductase

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 14, 2005, Pages 4513-4526

  Dixon, Mark J ^a,c   Maurer, Richard I ^a   Biggi, Cristina ^a   Oyarzabal, Julen ^a,d   Essex, Jonathan W ^a   Bradley, Mark ^a,b  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c UNIVERSITY OF DUNDEE   (United Kingdom)

^d Johnson and Johnson Pharmaceutical R and D   (Spain)

Author keywords

Mechanism of action; Parallel synthesis; Structure activity relationships; Trypanothione reductase

Indexed keywords

ANTIPARASITIC AGENT; N 1 ARGINYL N 9 ACETYLNORSPERMIDINE; N 1 ARGINYL N 9 HEXANOYLNORSPERMIDINE; N 1 ARGINYL(2,2,5,7,8 PENTAMETHYLCHROMAN 6 SULFONAMIDE) N 9 ACETYLNORSPERMIDINE; N 1 ARGINYL(2,2,5,7,8 PENTAMETHYLCHROMAN 6 SULFONAMIDE) N 9 ARGINYLNORSPERMIDINE; N 1 ARGINYL(2,2,5,7,8 PENTAMETHYLCHROMAN 6 SULFONAMIDE) N 9 HEXANOYLNORSPERMIDINE; N 1 ARGINYL(2,2,5,7,8 PENTAMETHYLCHROMAN 6 SULFONAMIDE)NORSPERMIDINE; N 1 ARGINYLNORSPERMIDINE; N 1 TRYPTOPHYL N 9 ACETYLNORSPERMIDINE; N 1 TRYPTOPHYL N 9 HEXANOYLNORSPERMIDINE; N 1 TRYPTOPHYLARGINYL N 9 ACETYLNORSPERMIDINE; N 1 TRYPTOPHYLARGINYL N 9 HEXANOYLNORSPERMIDINE; N 1 TRYPTOPHYLARGINYL N 9 TRYPTOPHYLARGINYL(2,2,5,7,8 PENTAMETHYLCHROMAN 6 SULFONAMIDE)NORSPERMIDINE; N 1 TRYPTOPHYLARGINYL(2,2,5,7,8 PENTAMETHYLCHROMAN 6 SULFONAMIDE) N 9 ACETYLNORSPERMIDINE; N 1 TRYPTOPHYLARGINYL(2,2,5,7,8 PENTAMETHYLCHROMAN 6 SULFONAMIDE) N 9 HEXANOYLNORSPERMIDINE; N 1 TRYPTOPHYLARGINYL(2,2,5,7,8 PENTAMETHYLCHROMAN 6 SULFONAMIDE) NORSPERMIDINE; N 1 TRYPTOPHYLARGINYLNORSPERMIDINE; N 1 TRYPTOPHYLNORSPERMIDINE; N 1,N 9 BIS(TRYPTOPHYL)NORSPERMIDINE; N 1,N 9 BIS(TRYPTOPHYLARGINYL)NORSPERMIDINE; N 1,N 9 BIS[ARGINYL(2,2,5,7,8 PENTAMETHYLCHROMAN 6 SULFONAMIDE)] NORSPERMIDINE; N 1,N 9 BIS[TRYPTOPHYLARGINYL(2,2,5,7,8 PENTAMETHYLCHROMAN 6 SULFONAMIDE)]NORSPERMIDINE; OXIDOREDUCTASE INHIBITOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SPERMIDINE DERIVATIVE; TRYPANOTHIONE REDUCTASE INHIBITOR; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; CHEMISTRY; ENZYME INHIBITION; GEL FILTRATION CHROMATOGRAPHY; KINETICS; SCREENING; SOLID PHASE SYNTHESIS; STRUCTURE ACTIVITY RELATION; SYNTHESIS; ULTRACENTRIFUGATION;

CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME INHIBITORS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; NADH, NADPH OXIDOREDUCTASES; PEPTIDES; SPERMIDINE; STRUCTURE-ACTIVITY RELATIONSHIP; ULTRACENTRIFUGATION;

EID: 20444436765     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.04.039     Document Type: Article

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