Structure-guided design of cell wall biosynthesis inhibitors that overcome β-lactam resistance in staphylococcus aureus (MRSA)

ACS Chemical Biology

Volumn 6, Issue 9, 2011, Pages 943-951

  Contreras Martel, Carlos ^a,b,c   Amoroso, Ana ^d   Woon, Esther C Y ^e   Zervosen, Astrid ^d   Inglis, Steven ^e   Martins, Alexandre ^a,b,c   Verlaine, Olivier ^d   Rydzik, Anna M ^e   Job, Viviana ^a,b,c   Luxen, André ^d   Joris, Bernard ^d   Schofield, Christopher J ^e   Dessen, Andréa ^a,b,c  

^a INSTITUT DE BIOLOGIE STRUCTURALE   (France)

^b CEA GRENOBLE   (France)

^c CNRS   (France)

^d UNIVERSITY OF LIÈGE   (Belgium)

^e UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE DERIVATIVE; ANTIBIOTIC AGENT; BETA LACTAM ANTIBIOTIC; BETA LACTAMASE; BETA LACTAMASE SHV; BETA LACTAMASE TEM 1; BORONIC ACID DERIVATIVE; GLYCINE DERIVATIVE; LINEZOLID; PENICILLIN BINDING PROTEIN; PENICILLIN BINDING PROTEIN 1; PENICILLIN BINDING PROTEIN 1B; PENICILLIN BINDING PROTEIN 2A; PENICILLIN BINDING PROTEIN INHIBITOR; PEPTIDOGLYCAN; UNCLASSIFIED DRUG; VANCOMYCIN;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL CELL WALL; BACTERIAL MEMBRANE; BACTERICIDAL ACTIVITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG MECHANISM; DRUG PROTEIN BINDING; ENZYME ACTIVE SITE; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE;

ANTI-BACTERIAL AGENTS; BETA-LACTAM RESISTANCE; BETA-LACTAMS; BORONIC ACIDS; CELL WALL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PENICILLIN-BINDING PROTEINS; STAPHYLOCOCCUS AUREUS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS); POSIBACTERIA; STAPHYLOCOCCUS AUREUS;

EID: 80053618769     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb2001846     Document Type: Article

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