Crystal structure of PBP2x from a highly penicillin-resistant Streptococcus pneumoniae clinical isolate: A mosaic framework containing 83 mutations

Journal of Biological Chemistry

Volumn 276, Issue 48, 2001, Pages 45106-45112

  Dessen, Andréa ^a   Mouz, Nicolas ^a   Gordon, Elspeth ^a   Hopkins, Julie ^a   Dideberg, Otto ^a  

^a CEA GRENOBLE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; BACTERIA; CRYSTAL STRUCTURE; HYDROGEN BONDS; PHYSIOLOGY;

RESISTANCE MECHANISM;

PROTEINS;

BETA LACTAM ANTIBIOTIC; BETA LACTAMASE; CEPHALOSPORIN DERIVATIVE; PENICILLIN BINDING PROTEIN; PENICILLIN DERIVATIVE; PEPTIDOGLYCAN; PROTEIN PBP2X; UNCLASSIFIED DRUG; ALANINE; ANTIBIOTIC AGENT; ASPARAGINE; CARRIER PROTEIN; LEUCINE; PBP 2X PROTEIN; THREONINE;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL STRAIN; BACTERIUM ISOLATE; CRYSTAL STRUCTURE; GENE MUTATION; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL; PROTEIN ISOLATION; PROTEIN STRUCTURE; STREPTOCOCCUS PNEUMONIAE; X RAY CRYSTALLOGRAPHY; AMINO ACID SEQUENCE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG RESISTANCE; GENETICS; MOLECULAR GENETICS; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; SITE DIRECTED MUTAGENESIS;

BACTERIA (MICROORGANISMS); POSIBACTERIA; STREPTOCOCCUS; STREPTOCOCCUS PNEUMONIAE;

ALANINE; AMINO ACID SEQUENCE; ANTIBIOTICS; ASPARAGINE; BINDING SITES; CARRIER PROTEINS; CRYSTALLOGRAPHY, X-RAY; DRUG RESISTANCE; LEUCINE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; PENICILLINS; PROTEIN BINDING; PROTEIN CONFORMATION; STREPTOCOCCUS PNEUMONIAE; SUPPORT, NON-U.S. GOV'T; THREONINE;

EID: 0035977042     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M107608200     Document Type: Article

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