Metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl) pyridine (MPEP) microinfusions into the nucleus accumbens shell or ventral tegmental area attenuate the reinforcing effects of nicotine in rats

Neuropharmacology

Volumn 61, Issue 8, 2011, Pages 1399-1405

  D'Souza, Manoranjan S ^a   Markou, Athina ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Food self administration; Microinjections; Motivation; Nicotine; Self administration

Indexed keywords

2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; METABOTROPIC RECEPTOR 5; METABOTROPIC RECEPTOR 5 ANTAGONIST; METABOTROPIC RECEPTOR ANTAGONIST; NICOTINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG MEGADOSE; DRUG POTENTIATION; DRUG SELF ADMINISTRATION; MALE; NEUROTRANSMISSION; NONHUMAN; NUCLEUS ACCUMBENS; PRESYNAPTIC POTENTIAL; PRIORITY JOURNAL; RAT; VENTRAL TEGMENTUM;

ANALYSIS OF VARIANCE; ANIMALS; CONDITIONING, OPERANT; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID ANTAGONISTS; FOOD PREFERENCES; MALE; NICOTINE; NICOTINIC AGONISTS; NUCLEUS ACCUMBENS; PYRIDINES; RATS; RATS, WISTAR; REINFORCEMENT (PSYCHOLOGY); REINFORCEMENT SCHEDULE; SELF ADMINISTRATION; VENTRAL TEGMENTAL AREA;

EID: 80053614459     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2011.08.028     Document Type: Article

References (55)

1. T. Aoki, M. Narita, M. Shibasaki, and T. Suzuki Metabotropic glutamate receptor 5 localized in the limbic forebrain is critical for the development of morphine-induced rewarding effect in mice Eur. J. Neurosci. 20 2004 1633 1638 (Pubitemid 39274046)
2. J. Besheer, J.J. Grondin, R. Cannady, A.C. Sharko, S. Faccidomo, and C.W. Hodge Metabotropic glutamate receptor 5 activity in the nucleus accumbens Is required for the maintenance of ethanol self-administration in a rat genetic model of high alcohol intake Biol. Psychiatry 67 2009 812 822
3. A.W. Bruijnzeel, and A. Markou Decreased sensitivity to the effects of dopamine D1-like, but not D2-like, receptor antagonism in the posterior hypothalamic region/anterior ventral tegmental area on brain reward function during chronic exposure to nicotine in rats Brain Res. 1058 2005 91 100 (Pubitemid 41416803)
4. N.D. Cosford, L. Tehrani, J. Roppe, E. Schweiger, N.D. Smith, J. Anderson, L. Bristow, J. Brodkin, X. Jiang, I. McDonald, S. Rao, M. Washburn, and M.A. Varney 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity J. Med. Chem. 46 2003 204 206 (Pubitemid 36078139)
5. W.A. Corrigall, K.M. Coen, and K.L. Adamson Self-administered nicotine activates the mesolimbic dopamine system through the ventral tegmental area Brain Res. 653 1994 278 284 (Pubitemid 24252850)
6. W.A. Corrigall, K.B. Franklin, K.M. Coen, and P.B.S. Clarke The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine Psychopharmacology (Berl.) 107 1992 285 289
7. F. Gasparini, K. Lingenhohl, N. Stoehr, P.J. Flor, M. Heinrich, I. Vranesic, M. Biollaz, H. Allgeier, R. Heckendorn, S. Urwyler, M.A. Varney, E.C. Johnson, S.D. Hess, S.P. Rao, A.I. Sacaan, E.M. Santori, G. Velicelebi, and R. Kuhn 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist Neuropharmacology 38 1999 1493 1503 (Pubitemid 29457731)
8. J.T. Gass, and M.F. Olive Role of protein kinase C epsilon (PKCvarepsilon) in the reduction of ethanol reinforcement due to mGluR5 antagonism in the nucleus accumbens shell Psychopharmacology (Berl.) 204 2009 587 597
9. S. Geisler, and R.A. Wise Functional implications of glutamatergic projections to the ventral tegmental area Rev. Neurosci. 19 2008 227 244
10. M.B. Ghasemzadeh, L.C. Nelson, X.Y. Lu, and P.W. Kalivas Neuroadaptations in ionotropic and metabotropic glutamate receptor mRNA produced by cocaine treatment J. Neurochem. 72 1999 157 165 (Pubitemid 29013889)
11. S.R. Goldberg, and J.E. Henningfield Reinforcing effects of nicotine in humans and experimental animals responding under intermittent schedules of i.v. drug injection Pharmacol. Biochem. Behav. 30 1988 227 234 (Pubitemid 19268815)
12. A.A. Harrison, F. Gasparini, and A. Markou Nicotine potentiation of brain stimulation reward reversed by DHβE and SCH 23390, but not by eticlopride, LY 314582 or MPEP in rats Psychopharmacology (Berl.) 160 2002 56 66 (Pubitemid 34169826)
13. C.A. Heidbreder, M. Bianchi, L.P. Lacroix, S. Faedo, E. Perdona, R. Remelli, P. Cavanni, and F. Crespi Evidence that the metabotropic glutamate receptor 5 antagonist MPEP may act as an inhibitor of the norepinephrine transporter in vitro and in vivo Synapse 50 2003 269 276 (Pubitemid 37420581)
14. V. Herzig, E.M. Capuani, K.A. Kovar, and W.J. Schmidt Effects of MPEP on expression of food-, MDMA- or amphetamine-conditioned place preference in rats Addict. Biol. 10 2005 243 249 (Pubitemid 41306327)
15. V. Herzig, and W.J. Schmidt Effects of MPEP on locomotion, sensitization and conditioned reward induced by cocaine or morphine Neuropharmacology 47 2004 973 984 (Pubitemid 39535838)
16. S. Ikemoto Dopamine reward circuitry: two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complex Brain Res. Rev. 56 2007 27 78 (Pubitemid 350110353)
17. S. Ikemoto, M. Qin, and Z.H. Liu Primary reinforcing effects of nicotine are triggered from multiple regions both inside and outside the ventral tegmental area J. Neurosci. 26 2006 723 730 (Pubitemid 43237066)
18. A. Imperato, T. Honore, and L.H. Jensen Dopamine release in the nucleus caudatus and in the nucleus accumbens is under glutamatergic control through non-NMDA receptors: a study in freely-moving rats Brain Res. 530 1990 223 228 (Pubitemid 20340698)
19. P.J. Kenny, E. Chartoff, M. Roberto, W.A. Carlezon Jr., and A. Markou NMDA receptors regulate nicotine-enhanced brain reward function and intravenous nicotine self-administration: role of the ventral tegmental area and central nucleus of the amygdala Neuropsychopharmacology 34 2009 266 281
20. P.J. Kenny, F. Gasparini, and A. Markou Group II metabotropic and α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)/kainate glutamate receptors regulate the deficit in brain reward function associated with nicotine withdrawal in rats J. Pharmacol. Exp. Ther. 306 2003 1068 1076 (Pubitemid 37025315)
21. P.J. Kenny, and A. Markou The ups and downs of addiction: role of metabotropic glutamate receptors Trends Pharmacol. Sci. 25 2004 265 272 (Pubitemid 38553829)
22. G.F. Koob, and N.D. Volkow Neurocircuitry of addiction Neuropsychopharmacology 35 2010 217 238 (erratum: 35, 1051)
23. C. Kornetsky, and R.U. Esposito Euphorigenic drugs: effects on the reward pathways of the brain Fed. Proc. 38 1979 2473 2476 (Pubitemid 10249276)
24. R. Kuhn, A. Pagano, N. Stoehr, I. Vranesic, P.J. Flor, K. Lingenhohl, W. Spooren, C. Gentsch, A. Vassout, A. Pilc, and F. Gasparini In vitro and in vivo characterization of MPEP, an allosteric modulator of the metabotropic glutamate receptor subtype 5: review article Amino Acids 23 2002 207 211
25. M.E. Liechti, L. Lhuillier, K. Kaupmann, and A. Markou Metabotropic glutamate 2/3 receptors in the ventral tegmental area and the nucleus accumbens shell are involved in behaviors relating to nicotine dependence J. Neurosci. 27 2007 9077 9085 (Pubitemid 47312061)
26. M.E. Liechti, and A. Markou Interactive effects of the mGlu5 receptor antagonist MPEP and the mGlu2/3 receptor antagonist LY341495 on nicotine self-administration and reward deficits associated with nicotine withdrawal in rats Eur. J. Pharmacol. 554 2007 164 174 (Pubitemid 44879414)
27. M.E. Liechti, and A. Markou Role of the glutamatergic system in nicotine dependence: implications for the discovery and development of new pharmacological smoking cessation therapies CNS Drugs 22 2008 705 724
28. H.D. Mansvelder, and D.S. McGehee Cellular and synaptic mechanisms of nicotine addiction J. Neurobiol. 53 2002 606 617 (Pubitemid 35375590)
29. A. Markou Neurobiology of nicotine dependence Philos. Trans. R. Soc. Lond. B Biol. Sci. 363 2008 3159 3168
30. G. Martin, Z. Nie, and G.R. Siggins Metabotropic glutamate receptors regulate N-methyl-d-aspartate-mediated synaptic transmission in nucleus accumbens J. Neurophysiol. 78 1997 3028 3038 (Pubitemid 28098811)
31. J.M. Mathiesen, N. Svendsen, H. Brauner-Osborne, C. Thomsen, and M.T. Ramirez Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP Br. J. Pharmacol. 138 2003 1026 1030 (Pubitemid 36459824)
32. D.A. Mitrano, J.F. Pare, and Y. Smith Ultrastructural relationships between cortical, thalamic, and amygdala glutamatergic inputs and group I metabotropic glutamate receptors in the rat accumbens J. Comp. Neurol. 518 2010 1315 1329
33. D.A. Mitrano, and Y. Smith Comparative analysis of the subcellular and subsynaptic localization of mGluR1a and mGluR5 metabotropic glutamate receptors in the shell and core of the nucleus accumbens in rat and monkey J. Comp. Neurol. 500 2007 788 806 (Pubitemid 46075023)
34. C.J. Murray, and A.D. Lopez Alternative projections of mortality and disability by cause 1990-2020: global burden of disease study Lancet 349 1997 1498 1504 (Pubitemid 27216360)
35. D.M. O'Leary, V. Movsesyan, S. Vicini, and A.I. Faden Selective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonism Br. J. Pharmacol. 131 2000 1429 1437
36. P.G. Overton, and D. Clark Burst firing in midbrain dopaminergic neurons Brain Res. Rev. 25 1997 312 334 (Pubitemid 28070309)
37. M.I. Palmatier, X. Liu, E.C. Donny, A.R. Caggiula, and A.F. Sved Metabotropic glutamate 5 receptor (mGluR5) antagonists decrease nicotine seeking, but do not affect the reinforcement enhancing effects of nicotine Neuropsychopharmacology 33 2008 2139 2147 (Pubitemid 351992092)
38. N.E. Paterson, and A. Markou The metabotropic glutamate receptor 5 antagonist MPEP decreased break points for nicotine, cocaine and food in rats Psychopharmacology (Berl.) 179 2005 255 261 (Pubitemid 40576713)
39. N.E. Paterson, S. Semenova, F. Gasparini, and A. Markou The mGluR5 antagonist MPEP decreased nicotine self-administration in rats and mice Psychopharmacology (Berl.) 167 2003 257 264 (Pubitemid 36712972)
40. G. Paxinos, and C. Watson The Rat Brain in Stereotaxic Coordinates fourth ed. 1998 Academic Press San Diego
41. P. Popik, and M. Wrobel Morphine conditioned reward is inhibited by MPEP, the mGluR5 antagonist Neuropharmacology 43 2002 1210 1217 (Pubitemid 36084432)
42. S. Prisco, S. Natoli, G. Bernardi, and N.B. Mercuri Group I metabotropic glutamate receptors activate burst firing in rat midbrain dopaminergic neurons Neuropharmacology 42 2002 289 296 (Pubitemid 34230481)
43. G. Renoldi, E. Calcagno, F. Borsini, and R.W. Invernizzi Stimulation of group I mGlu receptors in the ventrotegmental area enhances extracellular dopamine in the rat medial prefrontal cortex J. Neurochem. 100 2007 1658 1666 (Pubitemid 46376204)
44. D. Robbe, M. Kopf, A. Remaury, J. Bockaert, and O.J. Manzoni Endogenous cannabinoids mediate long-term synaptic depression in the nucleus accumbens Proc. Natl. Acad. Sci. U.S.A. 99 2002 8384 8388 (Pubitemid 34651061)
45. C. Romano, M.A. Sesma, C.T. McDonald, K. O'Malley, A.N. Van den Pol, and J.W. Olney Distribution of metabotropic glutamate receptor mGluR5 immunoreactivity in rat brain J. Comp. Neurol. 355 1995 455 469
46. B. Schilstrom, M.V. Fagerquist, X. Zhang, P. Hertel, G. Panagis, G.G. Nomikos, and T.H. Svensson Putative role of presynaptic α7 (*) nicotinic receptors in nicotine stimulated increases of extracellular levels of glutamate and aspartate in the ventral tegmental area Synapse 38 2000 375 383
47. S.M. Schotanus, and K. Chergui Dopamine D1 receptors and group I metabotropic glutamate receptors contribute to the induction of long-term potentiation in the nucleus accumbens Neuropharmacology 54 2008 837 844
48. I.P. Stolerman, and M.J. Jarvis The scientific case that nicotine is addictive Psychopharmacology (Berl.) 117 1995 2 10 (discussion 14-20)
49. M.T. Taber, and H.C. Fibiger Electrical stimulation of the prefrontal cortex increases dopamine release in the nucleus accumbens of the rat: modulation by metabotropic glutamate receptors J. Neurosci. 15 1995 3896 3904
50. M. Tessari, M. Pilla, M. Andreoli, D.M. Hutcheson, and C.A. Heidbreder Antagonism at metabotropic glutamate 5 receptors inhibits nicotine- and cocaine-taking behaviours and prevents nicotine-triggered relapse to nicotine-seeking Eur. J. Pharmacol. 499 2004 121 133 (Pubitemid 39201219)
51. V. Tronci, S. Vronskaya, N. Montgomery, D. Mura, and D.J. Balfour The effects of the mGluR5 receptor antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) on behavioural responses to nicotine Psychopharmacology 211 2010 33 42
52. E.L. van der Kam, J. De Vry, and T.M. Tzschentke 2-Methyl-6- (phenylethynyl)-pyridine (MPEP) potentiates ketamine and heroin reward as assessed by acquisition, extinction, and reinstatement of conditioned place preference in the rat Eur. J. Pharmacol. 606 2009 94 101
53. E.L. van der Kam, J. De Vry, and T.M. Tzschentke The mGlu5 receptor antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP) supports intravenous self-administration and induces conditioned place preference in the rat Eur. J. Pharmacol. 607 2009 114 120
54. F. Wang, H. Chen, and B.M. Sharp Neuroadaptive changes in the mesocortical glutamatergic system during chronic nicotine self-administration and after extinction in rats J. Neurochem. 106 2008 943 956
55. F. Wang, H. Chen, J.D. Steketee, and B.M. Sharp Upregulation of ionotropic glutamate receptor subunits within specific mesocorticolimbic regions during chronic nicotine self-administration Neuropsychopharmacology 32 2007 103 109 (Pubitemid 44967788)