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Volumn 607, Issue 1-3, 2009, Pages 114-120

The mGlu5 receptor antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP) supports intravenous self-administration and induces conditioned place preference in the rat

Author keywords

Drug abuse; Heroin; Ketamine; Metabotropic glutamate receptor; Reinforcement; Reward

Indexed keywords

2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; DIAMORPHINE; KETAMINE; SODIUM CHLORIDE;

EID: 62549140970     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.01.049     Document Type: Article
Times cited : (34)

References (43)
  • 2
    • 4644335722 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor 5 localized in the limbic forebrain is critical for the devlopment of morphine-induced rewarding effect in mice
    • Aoki T., Narita M., Shibasaki M., and Suzuki T. Metabotropic glutamate receptor 5 localized in the limbic forebrain is critical for the devlopment of morphine-induced rewarding effect in mice. Eur. J. Neurosci. 20 (2004) 1633-1638
    • (2004) Eur. J. Neurosci. , vol.20 , pp. 1633-1638
    • Aoki, T.1    Narita, M.2    Shibasaki, M.3    Suzuki, T.4
  • 3
    • 33645025726 scopus 로고    scopus 로고
    • Ionotropic and metabotropic glutamate receptor antagonism attenuates cue-induced cocaine-seeking
    • Backstrom P., and Hyytia P. Ionotropic and metabotropic glutamate receptor antagonism attenuates cue-induced cocaine-seeking. NeuroPsychopharmacology 31 (2006) 778-786
    • (2006) NeuroPsychopharmacology , vol.31 , pp. 778-786
    • Backstrom, P.1    Hyytia, P.2
  • 4
    • 33750448347 scopus 로고    scopus 로고
    • mGlu5 receptors are involved in the discriminative stimulus effects of self-administered ethanol in rats
    • Besheer J., Stevenson R.A., and Hodge C.W. mGlu5 receptors are involved in the discriminative stimulus effects of self-administered ethanol in rats. Eur. J. Pharmacol. 551 (2006) 71-75
    • (2006) Eur. J. Pharmacol. , vol.551 , pp. 71-75
    • Besheer, J.1    Stevenson, R.A.2    Hodge, C.W.3
  • 5
    • 23644451337 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor (mGlu5 receptor) antagonist MPEP attenuated cue- and schedule-induced reinstatement of nicotine self-administration behavior in rats
    • Bespalov A.Y., Dravolina O.A., Sukhanov I., Zakharova E., Blokhina E., Zvartau E., Danysz W., van Heeke G., and Markou A. Metabotropic glutamate receptor (mGlu5 receptor) antagonist MPEP attenuated cue- and schedule-induced reinstatement of nicotine self-administration behavior in rats. Neuropharmacology 49 (2005) 167-178
    • (2005) Neuropharmacology , vol.49 , pp. 167-178
    • Bespalov, A.Y.1    Dravolina, O.A.2    Sukhanov, I.3    Zakharova, E.4    Blokhina, E.5    Zvartau, E.6    Danysz, W.7    van Heeke, G.8    Markou, A.9
  • 6
    • 0027499418 scopus 로고
    • Species difference in sensitivity to ethanol's hedonic effects
    • Cunningham C.L., Niehus J.S., and Noble D. Species difference in sensitivity to ethanol's hedonic effects. Alcohol. 10 (1993) 97-102
    • (1993) Alcohol. , vol.10 , pp. 97-102
    • Cunningham, C.L.1    Niehus, J.S.2    Noble, D.3
  • 7
    • 0036011307 scopus 로고    scopus 로고
    • Injection timing determines whether intragastric ethanol produces conditioned place preference or aversion in mice
    • Cunningham C.L., Clemans J.M., and Fidler T.L. Injection timing determines whether intragastric ethanol produces conditioned place preference or aversion in mice. Pharmacol. Biochem. Behav. 72 (2002) 659-668
    • (2002) Pharmacol. Biochem. Behav. , vol.72 , pp. 659-668
    • Cunningham, C.L.1    Clemans, J.M.2    Fidler, T.L.3
  • 8
    • 33750037317 scopus 로고    scopus 로고
    • Spatial location is critical for conditioning place preference with visual but not tactile stimuli
    • Cunningham C.L., Patel P., and Milner L. Spatial location is critical for conditioning place preference with visual but not tactile stimuli. Behav. Neurosci. 120 (2006) 1115-1132
    • (2006) Behav. Neurosci. , vol.120 , pp. 1115-1132
    • Cunningham, C.L.1    Patel, P.2    Milner, L.3
  • 10
    • 0042698316 scopus 로고    scopus 로고
    • Neuroprotective action of MPEP, a selective mGlu5 receptor antagonist, in methamphetamine-induced dopaminergic neurotoxicity is associated with a decrease in dopamine outflow and inhibition of hyperthermia in rats
    • Golembiowska K., Konieczny J., Wolfarth S., and Ossowska K. Neuroprotective action of MPEP, a selective mGlu5 receptor antagonist, in methamphetamine-induced dopaminergic neurotoxicity is associated with a decrease in dopamine outflow and inhibition of hyperthermia in rats. Neuropharmacology 45 (2003) 484-492
    • (2003) Neuropharmacology , vol.45 , pp. 484-492
    • Golembiowska, K.1    Konieczny, J.2    Wolfarth, S.3    Ossowska, K.4
  • 11
    • 24944590000 scopus 로고    scopus 로고
    • Effects of MPEP on expression of food-, MDMA- or amphetamine-conditioned place preference in rats
    • Herzig V., Capuani E.M.I., Kovar K.A., and Schmidt W.J. Effects of MPEP on expression of food-, MDMA- or amphetamine-conditioned place preference in rats. Addict. Biol. 10 (2005) 243-249
    • (2005) Addict. Biol. , vol.10 , pp. 243-249
    • Herzig, V.1    Capuani, E.M.I.2    Kovar, K.A.3    Schmidt, W.J.4
  • 12
    • 8844238423 scopus 로고    scopus 로고
    • Effects of MPEP on locomotion, sensitzation and conditioned rewards induced by cocaine or morphine
    • Herzig V., and Schmidt W.J. Effects of MPEP on locomotion, sensitzation and conditioned rewards induced by cocaine or morphine. Neuropharmacology 47 (2004) 973-984
    • (2004) Neuropharmacology , vol.47 , pp. 973-984
    • Herzig, V.1    Schmidt, W.J.2
  • 13
    • 2942650911 scopus 로고    scopus 로고
    • Functional interaction between NMDA and mGlu5 receptors: effects on working memory, instrumental learning, motor behaviors, and dopamine release
    • Homayoun H., Stefani M.R., Adams B.W., Tamagan G.D., and Moghaddam B. Functional interaction between NMDA and mGlu5 receptors: effects on working memory, instrumental learning, motor behaviors, and dopamine release. Neuropsychopharmacology 29 (2004) 1259-1269
    • (2004) Neuropsychopharmacology , vol.29 , pp. 1259-1269
    • Homayoun, H.1    Stefani, M.R.2    Adams, B.W.3    Tamagan, G.D.4    Moghaddam, B.5
  • 14
    • 17744400697 scopus 로고    scopus 로고
    • Metabotropic glutamate 5 receptor blockade may attenuate cocaine self-administration by decreasing barain reward function in rats
    • Kenny P.J., Boutrel B., Gasparini F., Koob G.F., and Markou A. Metabotropic glutamate 5 receptor blockade may attenuate cocaine self-administration by decreasing barain reward function in rats. Psychopharmacology (Berl) 179 (2005) 247-254
    • (2005) Psychopharmacology (Berl) , vol.179 , pp. 247-254
    • Kenny, P.J.1    Boutrel, B.2    Gasparini, F.3    Koob, G.F.4    Markou, A.5
  • 15
    • 2142757234 scopus 로고    scopus 로고
    • The ups and downs of addiction: role of metabotropic glutamate receptors
    • Kenny P.J., and Markou A. The ups and downs of addiction: role of metabotropic glutamate receptors. Trends Pharmacol. Sci. 25 (2004) 265-272
    • (2004) Trends Pharmacol. Sci. , vol.25 , pp. 265-272
    • Kenny, P.J.1    Markou, A.2
  • 17
    • 16844379120 scopus 로고    scopus 로고
    • Nicotine induced conditioned place preference over a large range of doses in rats
    • Le Foll B., and Goldberg S.R. Nicotine induced conditioned place preference over a large range of doses in rats. Psychopharmacology (Berl) 178 (2005) 481-491
    • (2005) Psychopharmacology (Berl) , vol.178 , pp. 481-491
    • Le Foll, B.1    Goldberg, S.R.2
  • 18
    • 33748062344 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP
    • Lea I.V.P.M., and Faden A.I. Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP. CNS Drug Rev. 12 (2006) 149-166
    • (2006) CNS Drug Rev. , vol.12 , pp. 149-166
    • Lea, I.V.P.M.1    Faden, A.I.2
  • 19
    • 14344261021 scopus 로고    scopus 로고
    • Attenuation of behavioural effects of cocaine by the metabotrobic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)-pyridine in squirrel monkeys: comparison wirh dizocilpine
    • Lee B., Platt D.M., Rowlett J.K., Adewale A.S., and Spealman R.D. Attenuation of behavioural effects of cocaine by the metabotrobic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)-pyridine in squirrel monkeys: comparison wirh dizocilpine. J. Pharmacol. Exp. Ther. 312 (2005) 1232-1240
    • (2005) J. Pharmacol. Exp. Ther. , vol.312 , pp. 1232-1240
    • Lee, B.1    Platt, D.M.2    Rowlett, J.K.3    Adewale, A.S.4    Spealman, R.D.5
  • 21
    • 33845283874 scopus 로고    scopus 로고
    • Interactive effects of the mGlu5 receptor antagonist MPEP and the mGlu2/3 receptor antagonist LY341495 on nicotine self-administration and reward deficits associated with nicotine withdrawal in rats
    • Liechti M.E., and Markou A. Interactive effects of the mGlu5 receptor antagonist MPEP and the mGlu2/3 receptor antagonist LY341495 on nicotine self-administration and reward deficits associated with nicotine withdrawal in rats. Eur. J. Pharmacol. 554 (2007) 164-174
    • (2007) Eur. J. Pharmacol. , vol.554 , pp. 164-174
    • Liechti, M.E.1    Markou, A.2
  • 22
    • 28844464785 scopus 로고    scopus 로고
    • The serotonin/noradrenaline reuptake inhibitor venlafaxine attenuates acquisition, but not maintenance, of intravenous self-administration of heroin in rats
    • Magalas Z., De Vry J., and Tzschentke T.M. The serotonin/noradrenaline reuptake inhibitor venlafaxine attenuates acquisition, but not maintenance, of intravenous self-administration of heroin in rats. Eur. J. Pharmacol. 528 (2005) 103-109
    • (2005) Eur. J. Pharmacol. , vol.528 , pp. 103-109
    • Magalas, Z.1    De Vry, J.2    Tzschentke, T.M.3
  • 23
    • 0030900732 scopus 로고    scopus 로고
    • Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex
    • Moghaddam B., Adams B., Verma A., and Daly D. Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex. J. Neurosci. 17 (1997) 2921-2927
    • (1997) J. Neurosci. , vol.17 , pp. 2921-2927
    • Moghaddam, B.1    Adams, B.2    Verma, A.3    Daly, D.4
  • 24
    • 0033638723 scopus 로고    scopus 로고
    • Selective mGlu5 receptor antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonism
    • O'Leary D.M., Movsesyan V., Vicini S., and Faden A.I. Selective mGlu5 receptor antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonism. Br. J. Pharmacol. 131 (2000) 1429-1437
    • (2000) Br. J. Pharmacol. , vol.131 , pp. 1429-1437
    • O'Leary, D.M.1    Movsesyan, V.2    Vicini, S.3    Faden, A.I.4
  • 25
    • 13444291828 scopus 로고    scopus 로고
    • The mGlu5 receptor antagonist 6-methyl-2-(phenylethynyl)pyridine decreases ethanol consumption via a protein kinase C epsilon-dependent mechanism
    • Olive M.F., McGeehan A.J., Kinder J.R., McMahon T., Hodge C.W., Janak P.H., and Messing R.O. The mGlu5 receptor antagonist 6-methyl-2-(phenylethynyl)pyridine decreases ethanol consumption via a protein kinase C epsilon-dependent mechanism. Mol. Pharmacol. 67 (2005) 349-355
    • (2005) Mol. Pharmacol. , vol.67 , pp. 349-355
    • Olive, M.F.1    McGeehan, A.J.2    Kinder, J.R.3    McMahon, T.4    Hodge, C.W.5    Janak, P.H.6    Messing, R.O.7
  • 26
    • 17744383991 scopus 로고    scopus 로고
    • The metabotropic glutamate receptor 5 antagonist MPEP decreased break points for nicotine, cocaine and food in rats
    • Paterson N.E., and Markou A. The metabotropic glutamate receptor 5 antagonist MPEP decreased break points for nicotine, cocaine and food in rats. Psychopharmacology (Berl) 179 (2005) 255-261
    • (2005) Psychopharmacology (Berl) , vol.179 , pp. 255-261
    • Paterson, N.E.1    Markou, A.2
  • 27
    • 0038240644 scopus 로고    scopus 로고
    • The mGlu5 receptor antagonist MPEP decreased nicotine self-administration in rats and mice
    • Paterson N.E., Semenova S., Gasparini F., and Markou A. The mGlu5 receptor antagonist MPEP decreased nicotine self-administration in rats and mice. Psychopharmacology (Berl) 167 (2003) 257-264
    • (2003) Psychopharmacology (Berl) , vol.167 , pp. 257-264
    • Paterson, N.E.1    Semenova, S.2    Gasparini, F.3    Markou, A.4
  • 28
    • 0036951025 scopus 로고    scopus 로고
    • Morphine conditioned reward is inhibited by MPEP, the mGlu5 receptor antagonist
    • Popik P., and Wrobel M. Morphine conditioned reward is inhibited by MPEP, the mGlu5 receptor antagonist. Neuropharmacology 43 (2002) 1210-1217
    • (2002) Neuropharmacology , vol.43 , pp. 1210-1217
    • Popik, P.1    Wrobel, M.2
  • 29
    • 0033872089 scopus 로고    scopus 로고
    • Sensitization to cocaine's reinforcing effects produced by various cocaine pretreatment regimens in rats
    • Schenk S., and Partridge B. Sensitization to cocaine's reinforcing effects produced by various cocaine pretreatment regimens in rats. Pharmacol. Biochem. Behav. 66 (2000) 765-770
    • (2000) Pharmacol. Biochem. Behav. , vol.66 , pp. 765-770
    • Schenk, S.1    Partridge, B.2
  • 30
    • 17744365745 scopus 로고    scopus 로고
    • The mGlu5 receptor antagonist MPEP decreases operant ethanol self-administration during maintenance and after repeated alcohol deprivations in alcohol-preferring (P) rats
    • Schroeder J.P., Overstreet D.H., and Hodge C.W. The mGlu5 receptor antagonist MPEP decreases operant ethanol self-administration during maintenance and after repeated alcohol deprivations in alcohol-preferring (P) rats. Psychopharmacology (Berl) 179 (2005) 262-270
    • (2005) Psychopharmacology (Berl) , vol.179 , pp. 262-270
    • Schroeder, J.P.1    Overstreet, D.H.2    Hodge, C.W.3
  • 31
    • 24144442457 scopus 로고    scopus 로고
    • Adolescent abuse of dextromethorphan
    • Schwartz R.H. Adolescent abuse of dextromethorphan. Clin. Pediatr. (Phila) 44 (2005) 565-568
    • (2005) Clin. Pediatr. (Phila) , vol.44 , pp. 565-568
    • Schwartz, R.H.1
  • 32
    • 0034945780 scopus 로고    scopus 로고
    • Time-dependent changes in extinction behavior and stress-induced reinstatement of drug seeking following withdrawal from heroin in rats
    • Shalev U., Morales M., Hope B., Yap J., and Shaham Y. Time-dependent changes in extinction behavior and stress-induced reinstatement of drug seeking following withdrawal from heroin in rats. Psychopharmacology (Berl) 156 (2001) 98-107
    • (2001) Psychopharmacology (Berl) , vol.156 , pp. 98-107
    • Shalev, U.1    Morales, M.2    Hope, B.3    Yap, J.4    Shaham, Y.5
  • 33
    • 0036194738 scopus 로고    scopus 로고
    • Neurobiology of relapse to heroin and cocaine seeking: a review
    • Shalev U., Grimm J.W., and Shaham Y. Neurobiology of relapse to heroin and cocaine seeking: a review. Pharmacol. Rev. 54 (2002) 1-42
    • (2002) Pharmacol. Rev. , vol.54 , pp. 1-42
    • Shalev, U.1    Grimm, J.W.2    Shaham, Y.3
  • 34
    • 0030032399 scopus 로고    scopus 로고
    • Adaptation of the N-methyl-d-aspartate (NMDA) receptors following antidepressant treatment: implications for the pharmacotherapy of depression
    • Skolnick P., Layer R.T., Popik P., Nowak G., and Paul I.A. Adaptation of the N-methyl-d-aspartate (NMDA) receptors following antidepressant treatment: implications for the pharmacotherapy of depression. Pharmacopsychiatry 29 (1996) 23-26
    • (1996) Pharmacopsychiatry , vol.29 , pp. 23-26
    • Skolnick, P.1    Layer, R.T.2    Popik, P.3    Nowak, G.4    Paul, I.A.5
  • 35
    • 0035069188 scopus 로고    scopus 로고
    • Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist
    • Tatarczynska E., Klodzinska A., Chojnacka-Wojcik E., Palucha A., Gasparini F., Kuhn R., and Pilc A. Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist. Br. J. Pharmacol. 132 (2001) 1423-1430
    • (2001) Br. J. Pharmacol. , vol.132 , pp. 1423-1430
    • Tatarczynska, E.1    Klodzinska, A.2    Chojnacka-Wojcik, E.3    Palucha, A.4    Gasparini, F.5    Kuhn, R.6    Pilc, A.7
  • 36
    • 1542284242 scopus 로고    scopus 로고
    • Reassessment of buprenorphine in conditioned place preference: temporal and pharmacological considerations
    • Tzschentke T.M. Reassessment of buprenorphine in conditioned place preference: temporal and pharmacological considerations. Psychopharmacology (Berl) 172 (2004) 58-67
    • (2004) Psychopharmacology (Berl) , vol.172 , pp. 58-67
    • Tzschentke, T.M.1
  • 37
    • 0037162627 scopus 로고    scopus 로고
    • Lack of sensitization during place conditioning in rats is consistent with the low abuse potential of tramadol
    • Tzschentke T.M., Bruckmann W., and Friderichs E. Lack of sensitization during place conditioning in rats is consistent with the low abuse potential of tramadol. Neurosci. Lett. 329 (2002) 25-28
    • (2002) Neurosci. Lett. , vol.329 , pp. 25-28
    • Tzschentke, T.M.1    Bruckmann, W.2    Friderichs, E.3
  • 38
    • 35948936012 scopus 로고    scopus 로고
    • Effect of 2-methyl-6-(phenylethynyl)pyridine on intravenous self-administration of ketamine and heroin in the rat
    • Van der Kam E.L., De Vry J., and Tzschentke T.M. Effect of 2-methyl-6-(phenylethynyl)pyridine on intravenous self-administration of ketamine and heroin in the rat. Beh. Pharmacology 18 8 (2007) 717-724
    • (2007) Beh. Pharmacology , vol.18 , Issue.8 , pp. 717-724
    • Van der Kam, E.L.1    De Vry, J.2    Tzschentke, T.M.3
  • 41
    • 0030034191 scopus 로고    scopus 로고
    • NMDA receptor antagonists impair prefrontal cortex function as assessed via spatial delayed alternation performance in rats: modulation by dopamine
    • Verma A., and Moghaddam B. NMDA receptor antagonists impair prefrontal cortex function as assessed via spatial delayed alternation performance in rats: modulation by dopamine. J. Neurosci. 16 (1996) 373-379
    • (1996) J. Neurosci. , vol.16 , pp. 373-379
    • Verma, A.1    Moghaddam, B.2
  • 42
    • 1042266416 scopus 로고    scopus 로고
    • Sensitization of midbrain dopaminergic neuron reactivity and the self-administration of psychomotor stimulant drugs
    • Vezina P. Sensitization of midbrain dopaminergic neuron reactivity and the self-administration of psychomotor stimulant drugs. Neurosci. Biobehav. Rev. 27 (2004) 827-839
    • (2004) Neurosci. Biobehav. Rev. , vol.27 , pp. 827-839
    • Vezina, P.1
  • 43
    • 33644897612 scopus 로고    scopus 로고
    • Ketamine: from medicine to misuse
    • Wolff K., and Winstock A.R. Ketamine: from medicine to misuse. CNS Drugs 20 (2006) 199-218
    • (2006) CNS Drugs , vol.20 , pp. 199-218
    • Wolff, K.1    Winstock, A.R.2


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