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Volumn 17, Issue 23, 2011, Pages 2421-2427

Bioenergetics Pathways and Therapeutic Resistance in Gliomas: Emerging Role of Mitochondria

Author keywords

Chemoresistance; Electron transport chain; Glucose metabolism; Glycolysis; Mdr; Mitochondria; Oxidative phosphorylation; Temozolomide

Indexed keywords

ABC TRANSPORTER; ADENOSINE TRIPHOSPHATE; BLEOMYCIN; BREAST CANCER RESISTANCE PROTEIN; CISPLATIN; CYCLOPHOSPHAMIDE; CYTOCHROME C OXIDASE; DOXORUBICIN; FLUOROURACIL; GLYCOPROTEIN P; INTERFERON; LUNG RESISTANCE PROTEIN; MITOCHONDRIAL DNA; MULTIDRUG RESISTANCE PROTEIN; NITROSOUREA DERIVATIVE; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; TAMOXIFEN; TEMOZOLOMIDE; TOPOTECAN; VINCRISTINE;

EID: 80053487181     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/138161211797249251     Document Type: Review
Times cited : (54)

References (75)
  • 1
    • 2542590281 scopus 로고    scopus 로고
    • Plasma and cerebrospinal fluid population pharmacokinetics of temozolomide in malignant glioma patients
    • Ostermann S, Csajka C, Buclin T, et al. Plasma and cerebrospinal fluid population pharmacokinetics of temozolomide in malignant glioma patients. Clin Cancer Res 2004; 10(11): 3728-36.
    • (2004) Clin Cancer Res , vol.10 , Issue.11 , pp. 3728-3736
    • Ostermann, S.1    Csajka, C.2    Buclin, T.3
  • 2
    • 20044366163 scopus 로고    scopus 로고
    • Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
    • Stupp R, Mason WP, van den Bent MJ, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005; 352(10): 987-96.
    • (2005) N Engl J Med , vol.352 , Issue.10 , pp. 987-996
    • Stupp, R.1    Mason, W.P.2    van den Bent, M.J.3
  • 3
    • 77956294442 scopus 로고    scopus 로고
    • Gamma-secretase inhibitors enhance temozolomide treatment of human gliomas by inhibiting neurosphere repopulation and xenograft recurrence
    • [Gilbert CA, Daou MC, Moser RP, Ross AH. Gamma-secretase inhibitors enhance temozolomide treatment of human gliomas by inhibiting neurosphere repopulation and xenograft recurrence. Cancer Res; 70(17): 6870-9.
    • Cancer Res , vol.70 , Issue.17 , pp. 6870-6879
    • Gilbert, C.A.1    Daou, M.C.2    Moser, R.P.3    Ross, A.H.4
  • 5
    • 34548848002 scopus 로고    scopus 로고
    • Bioluminescence monitoring of intracranial glioblastoma xenograft: Response to primary and salvage temozolomide therapy
    • Dinca EB, Sarkaria JN, Schroeder MA, et al. Bioluminescence monitoring of intracranial glioblastoma xenograft: response to primary and salvage temozolomide therapy. J Neurosurg 2007; 107(3): 610-6.
    • (2007) J Neurosurg , vol.107 , Issue.3 , pp. 610-616
    • Dinca, E.B.1    Sarkaria, J.N.2    Schroeder, M.A.3
  • 6
    • 59349101857 scopus 로고    scopus 로고
    • Evaluation of MGMT promoter methylation status and correlation with temozolomide response in orthotopic glioblastoma xenograft model
    • Kitange GJ, Carlson BL, Mladek AC, et al. Evaluation of MGMT promoter methylation status and correlation with temozolomide response in orthotopic glioblastoma xenograft model. J Neurooncol 2009; 92(1): 23-31.
    • (2009) J Neurooncol , vol.92 , Issue.1 , pp. 23-31
    • Kitange, G.J.1    Carlson, B.L.2    Mladek, A.C.3
  • 7
    • 67649610349 scopus 로고    scopus 로고
    • Induction of MGMT expression is associated with temozolomide resistance in glioblastoma xenografts
    • Kitange GJ, Carlson BL, Schroeder MA, et al. Induction of MGMT expression is associated with temozolomide resistance in glioblastoma xenografts. Neuro Oncol 2009; 11(3): 281-91.
    • (2009) Neuro Oncol , vol.11 , Issue.3 , pp. 281-291
    • Kitange, G.J.1    Carlson, B.L.2    Schroeder, M.A.3
  • 8
    • 4143084896 scopus 로고    scopus 로고
    • CpG island hypermethylation of the DNA repair enzyme methyltransferase predicts response to temozolomide in primary gliomas
    • Paz MF, Yaya-Tur R, Rojas-Marcos I, et al. CpG island hypermethylation of the DNA repair enzyme methyltransferase predicts response to temozolomide in primary gliomas. Clin Cancer Res 2004; 10(15): 4933-8.
    • (2004) Clin Cancer Res , vol.10 , Issue.15 , pp. 4933-4938
    • Paz, M.F.1    Yaya-Tur, R.2    Rojas-Marcos, I.3
  • 9
    • 0001221508 scopus 로고
    • On respiratory impairment in cancer cells
    • Warburg O. On respiratory impairment in cancer cells. Science 1956; 124(3215): 269-70.
    • (1956) Science , vol.124 , Issue.3215 , pp. 269-270
    • Warburg, O.1
  • 10
    • 0036651818 scopus 로고    scopus 로고
    • A mitochondrial Achilles' heel in cancer?
    • Hockenbery DM. A mitochondrial Achilles' heel in cancer? Cancer Cell 2002; 2(1): 1-2.
    • (2002) Cancer Cell , vol.2 , Issue.1 , pp. 1-2
    • Hockenbery, D.M.1
  • 11
    • 0017841405 scopus 로고
    • Tumor mitochondria and the bioenergetics of cancer cells
    • Pedersen PL. Tumor mitochondria and the bioenergetics of cancer cells. Prog Exp Tumor Res 1978; 22: 190-274.
    • (1978) Prog Exp Tumor Res , vol.22 , pp. 190-274
    • Pedersen, P.L.1
  • 12
    • 0029891049 scopus 로고    scopus 로고
    • Glucose catabolism in cancer cells: Amplification of the gene encoding type II hexokinase
    • Rempel A, Mathupala SP, Griffin CA, Hawkins AL, Pedersen PL. Glucose catabolism in cancer cells: amplification of the gene encoding type II hexokinase. Cancer Res 1996; 56(11): 2468-71.
    • (1996) Cancer Res , vol.56 , Issue.11 , pp. 2468-2471
    • Rempel, A.1    Mathupala, S.P.2    Griffin, C.A.3    Hawkins, A.L.4    Pedersen, P.L.5
  • 13
    • 27944501189 scopus 로고    scopus 로고
    • Glycolytic glioma cells with active glycogen synthase are sensitive to PTEN and inhibitors of PI3K and gluconeogenesis
    • Beckner ME, Gobbel GT, Abounader R, et al. Glycolytic glioma cells with active glycogen synthase are sensitive to PTEN and inhibitors of PI3K and gluconeogenesis. Lab Invest 2005; 85(12): 1457-70.
    • (2005) Lab Invest , vol.85 , Issue.12 , pp. 1457-1470
    • Beckner, M.E.1    Gobbel, G.T.2    Abounader, R.3
  • 14
    • 2542561169 scopus 로고    scopus 로고
    • Akt stimulates aerobic glycolysis in cancer cells
    • Elstrom RL, Bauer DE, Buzzai M, et al. Akt stimulates aerobic glycolysis in cancer cells. Cancer Res 2004; 64(11): 3892-9.
    • (2004) Cancer Res , vol.64 , Issue.11 , pp. 3892-3899
    • Elstrom, R.L.1    Bauer, D.E.2    Buzzai, M.3
  • 15
    • 26944452745 scopus 로고    scopus 로고
    • Glucose metabolism heterogeneity in human and mouse malignant glioma cell lines
    • Griguer CE, Oliva CR, Gillespie GY. Glucose metabolism heterogeneity in human and mouse malignant glioma cell lines. J Neurooncol 2005; 74(2): 123-33.
    • (2005) J Neurooncol , vol.74 , Issue.2 , pp. 123-133
    • Griguer, C.E.1    Oliva, C.R.2    Gillespie, G.Y.3
  • 16
    • 0016300146 scopus 로고
    • History of the Pasteur effect and its pathobiology
    • Racker E. History of the Pasteur effect and its pathobiology. Mol Cell Biochem 1974; 5(1-2): 17-23.
    • (1974) Mol Cell Biochem , vol.5 , Issue.1-2 , pp. 17-23
    • Racker, E.1
  • 17
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg O. On the origin of cancer cells. Science 1956; 123(3191): 309-14.
    • (1956) Science , vol.123 , Issue.3191 , pp. 309-314
    • Warburg, O.1
  • 18
    • 85006768050 scopus 로고
    • The Metabolism of Tumors in the Body
    • Warburg O, Wind F, Negelein E. The Metabolism of Tumors in the Body. J Gen Physiol 1927; 8(6): 519-30.
    • (1927) J Gen Physiol , vol.8 , Issue.6 , pp. 519-530
    • Warburg, O.1    Wind, F.2    Negelein, E.3
  • 19
    • 0022870258 scopus 로고
    • Quantification of ATP-producing and consuming processes of Ehrlich ascites tumour cells
    • Muller M, Siems W, Buttgereit F, Dumdey R, Rapoport SM. Quantification of ATP-producing and consuming processes of Ehrlich ascites tumour cells. Eur J Biochem 1986; 161(3): 701-5.
    • (1986) Eur J Biochem , vol.161 , Issue.3 , pp. 701-705
    • Muller, M.1    Siems, W.2    Buttgereit, F.3    Dumdey, R.4    Rapoport, S.M.5
  • 20
    • 33845713975 scopus 로고    scopus 로고
    • Pharmacologic manipulations of mitochondrial membrane potential (DeltaPsim) selectively in glioma cells
    • Griguer CE, Oliva CR, Gillespie GY, Gobin E, Marcorelles P, Yancey Gillespie G. Pharmacologic manipulations of mitochondrial membrane potential (DeltaPsim) selectively in glioma cells. J Neurooncol 2007; 81(1): 9-20.
    • (2007) J Neurooncol , vol.81 , Issue.1 , pp. 9-20
    • Griguer, C.E.1    Oliva, C.R.2    Gillespie, G.Y.3    Gobin, E.4    Marcorelles, P.5    Yancey, G.G.6
  • 21
    • 0037065972 scopus 로고    scopus 로고
    • Variation in mitochondrial function in hypoxia-sensitive and hypoxiatolerant human glioma cells
    • Turcotte ML, Parliament M, Franko A, Allalunis-Turner J. Variation in mitochondrial function in hypoxia-sensitive and hypoxiatolerant human glioma cells. Br J Cancer 2002; 86(4): 619-24.
    • (2002) Br J Cancer , vol.86 , Issue.4 , pp. 619-624
    • Turcotte, M.L.1    Parliament, M.2    Franko, A.3    Allalunis-Turner, J.4
  • 22
    • 0032538422 scopus 로고    scopus 로고
    • Compartmentation of lactate and glucose metabolism in C6 glioma cells. A 13c and 1H NMR study
    • Bouzier AK, Goodwin R, de Gannes FM, et al. Compartmentation of lactate and glucose metabolism in C6 glioma cells. A 13c and 1H NMR study. J Biol Chem 1998; 273(42): 27162-9.
    • (1998) J Biol Chem , vol.273 , Issue.42 , pp. 27162-27169
    • Bouzier, A.K.1    Goodwin, R.2    de Gannes, F.M.3
  • 23
    • 0031731913 scopus 로고    scopus 로고
    • Glucose and lactate metabolism in C6 glioma cells: Evidence for the preferential utilization of lactate for cell oxidative metabolism
    • Bouzier AK, Voisin P, Goodwin R, Canioni P, Merle M. Glucose and lactate metabolism in C6 glioma cells: evidence for the preferential utilization of lactate for cell oxidative metabolism. Dev Neurosci 1998; 20(4-5): 331-8.
    • (1998) Dev Neurosci , vol.20 , Issue.4-5 , pp. 331-338
    • Bouzier, A.K.1    Voisin, P.2    Goodwin, R.3    Canioni, P.4    Merle, M.5
  • 25
    • 33745274726 scopus 로고    scopus 로고
    • Mitochondria: Dynamic organelles in disease, aging, and development
    • Chan DC. Mitochondria: dynamic organelles in disease, aging, and development. Cell 2006; 125(7): 1241-52.
    • (2006) Cell , vol.125 , Issue.7 , pp. 1241-1252
    • Chan, D.C.1
  • 26
    • 0026554863 scopus 로고
    • Counting target molecules by exponential polymerase chain reaction: Copy number of mitochondrial DNA in rat tissues
    • Wiesner RJ, Ruegg JC, Morano I. Counting target molecules by exponential polymerase chain reaction: copy number of mitochondrial DNA in rat tissues. Biochem Biophys Res Commun 1992; 183(2): 553-9.
    • (1992) Biochem Biophys Res Commun , vol.183 , Issue.2 , pp. 553-559
    • Wiesner, R.J.1    Ruegg, J.C.2    Morano, I.3
  • 27
    • 0035882532 scopus 로고    scopus 로고
    • High frequency of mitochondrial DNA mutations in glioblastoma multiforme identified by direct sequence comparison to blood samples
    • Kirches E, Krause G, Warich-Kirches M, et al. High frequency of mitochondrial DNA mutations in glioblastoma multiforme identified by direct sequence comparison to blood samples. Int J Cancer 2001; 93(4): 534-8.
    • (2001) Int J Cancer , vol.93 , Issue.4 , pp. 534-538
    • Kirches, E.1    Krause, G.2    Warich-Kirches, M.3
  • 28
    • 2942531063 scopus 로고    scopus 로고
    • Mitochondrial defects in cancer
    • Carew JS, Huang P. Mitochondrial defects in cancer. Mol Cancer 2002; 1: 9.
    • (2002) Mol Cancer , vol.1 , pp. 9
    • Carew, J.S.1    Huang, P.2
  • 29
    • 0034643388 scopus 로고    scopus 로고
    • Somatic mitochondrial DNA (mtDNA) mutations in papillary thyroid carcinomas and differential mtDNA sequence variants in cases with thyroid tumours
    • Yeh JJ, Lunetta KL, van Orsouw NJ, et al. Somatic mitochondrial DNA (mtDNA) mutations in papillary thyroid carcinomas and differential mtDNA sequence variants in cases with thyroid tumours. Oncogene 2000; 19(16): 2060-6.
    • (2000) Oncogene , vol.19 , Issue.16 , pp. 2060-2066
    • Yeh, J.J.1    Lunetta, K.L.2    van Orsouw, N.J.3
  • 30
    • 0039250954 scopus 로고    scopus 로고
    • Facile detection of mitochondrial DNA mutations in tumors and bodily fluids
    • Fliss MS, Usadel H, Caballero OL, et al. Facile detection of mitochondrial DNA mutations in tumors and bodily fluids. Science 2000; 287(5460): 2017-9.
    • (2000) Science , vol.287 , Issue.5460 , pp. 2017-2019
    • Fliss, M.S.1    Usadel, H.2    Caballero, O.L.3
  • 31
    • 0031736203 scopus 로고    scopus 로고
    • Somatic mutations of the mitochondrial genome in human colorectal tumours
    • Polyak K, Li Y, Zhu H, et al. Somatic mutations of the mitochondrial genome in human colorectal tumours. Nat Genet 1998; 20(3): 291-3.
    • (1998) Nat Genet , vol.20 , Issue.3 , pp. 291-293
    • Polyak, K.1    Li, Y.2    Zhu, H.3
  • 33
    • 13644267272 scopus 로고    scopus 로고
    • Mutation in mitochondrial complex I ND6 subunit is associated with defective response to hypoxia in human glioma cells
    • DeHaan C, Habibi-Nazhad B, Yan E, Salloum N, Parliament M, Allalunis-Turner J. Mutation in mitochondrial complex I ND6 subunit is associated with defective response to hypoxia in human glioma cells. Mol Cancer 2004; 3: 19.
    • (2004) Mol Cancer , vol.3 , pp. 19
    • Dehaan, C.1    Habibi-Nazhad, B.2    Yan, E.3    Salloum, N.4    Parliament, M.5    Allalunis-Turner, J.6
  • 34
    • 0033941733 scopus 로고    scopus 로고
    • Temozolomide and treatment of malignant glioma
    • Friedman HS, Kerby T, Calvert H. Temozolomide and treatment of malignant glioma. Clin Cancer Res 2000; 6(7): 2585-97.
    • (2000) Clin Cancer Res , vol.6 , Issue.7 , pp. 2585-2597
    • Friedman, H.S.1    Kerby, T.2    Calvert, H.3
  • 35
    • 0036570062 scopus 로고    scopus 로고
    • Clinical relevance of MGMT in the treatment of cancer
    • Gerson SL. Clinical relevance of MGMT in the treatment of cancer. J Clin Oncol 2002; 20(9): 2388-99.
    • (2002) J Clin Oncol , vol.20 , Issue.9 , pp. 2388-2399
    • Gerson, S.L.1
  • 36
    • 0026468376 scopus 로고
    • Identification of the crosslink between human O6-methylguanine-DNA methyltransferase and chloroethylnitrosourea-treated DNA
    • Gonzaga PE, Potter PM, Niu TQ, et al. Identification of the crosslink between human O6-methylguanine-DNA methyltransferase and chloroethylnitrosourea-treated DNA. Cancer Res 1992; 52(21): 6052-8.
    • (1992) Cancer Res , vol.52 , Issue.21 , pp. 6052-6058
    • Gonzaga, P.E.1    Potter, P.M.2    Niu, T.Q.3
  • 37
    • 56349113871 scopus 로고    scopus 로고
    • CD133 is a marker of bioenergetic stress in human glioma
    • [Griguer CE, Oliva CR, Gobin E, et al. CD133 is a marker of bioenergetic stress in human glioma. PLoS ONE 2008; 3(11): e3655.
    • (2008) PLoS ONE , vol.3 , Issue.11
    • Griguer, C.E.1    Oliva, C.R.2    Gobin, E.3
  • 38
    • 0024448458 scopus 로고
    • Human cells lacking mtDNA: Repopulation with exogenous mitochondria by complementation
    • King MP, Attardi G. Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation. Science 1989; 246(4929): 500-3.
    • (1989) Science , vol.246 , Issue.4929 , pp. 500-503
    • King, M.P.1    Attardi, G.2
  • 39
    • 1542350182 scopus 로고    scopus 로고
    • Resistance of mitochondrial DNA-depleted cells against cell death: Role of mitochondrial superoxide dismutase
    • Park SY, Chang I, Kim JY, et al. Resistance of mitochondrial DNA-depleted cells against cell death: role of mitochondrial superoxide dismutase. J Biol Chem 2004; 279(9): 7512-20.
    • (2004) J Biol Chem , vol.279 , Issue.9 , pp. 7512-7520
    • Park, S.Y.1    Chang, I.2    Kim, J.Y.3
  • 40
    • 0033581893 scopus 로고    scopus 로고
    • Mitochondrial DNA determines the cellular response to cancer therapeutic agents
    • Singh KK, Russell J, Sigala B, Zhang Y, Williams J, Keshav KF. Mitochondrial DNA determines the cellular response to cancer therapeutic agents. Oncogene 1999; 18(48): 6641-6.
    • (1999) Oncogene , vol.18 , Issue.48 , pp. 6641-6646
    • Singh, K.K.1    Russell, J.2    Sigala, B.3    Zhang, Y.4    Williams, J.5    Keshav, K.F.6
  • 41
    • 79956209042 scopus 로고    scopus 로고
    • Mitochondria determine the efficacy of anti-cancer agents that interact with DNA but not the cytoskeleton
    • In Press
    • [Hara K, Kasahara E, Takahashi N, et al. Mitochondria determine the efficacy of anti-cancer agents that interact with DNA but not the cytoskeleton. J Pharmacol Exp Ther 2011: In Press.
    • (2011) J Pharmacol Exp Ther
    • Hara, K.1    Kasahara, E.2    Takahashi, N.3
  • 42
    • 14944369831 scopus 로고    scopus 로고
    • Mechanism of mitochondrial stress-induced resistance to apoptosis in mitochondrial DNA-depleted C2C12 myocytes
    • Biswas G, Anandatheerthavarada HK, Avadhani NG. Mechanism of mitochondrial stress-induced resistance to apoptosis in mitochondrial DNA-depleted C2C12 myocytes. Cell Death Differ 2005; 12(3): 266-78.
    • (2005) Cell Death Differ , vol.12 , Issue.3 , pp. 266-278
    • Biswas, G.1    Anandatheerthavarada, H.K.2    Avadhani, N.G.3
  • 43
    • 33750375542 scopus 로고    scopus 로고
    • Cisplatin preferentially binds mitochondrial DNA and voltagedependent anion channel protein in the mitochondrial membrane of head and neck squamous cell carcinoma: Possible role in apoptosis
    • Yang Z, Schumaker LM, Egorin MJ, Zuhowski EG, Guo Z, Cullen KJ. Cisplatin preferentially binds mitochondrial DNA and voltagedependent anion channel protein in the mitochondrial membrane of head and neck squamous cell carcinoma: possible role in apoptosis. Clin Cancer Res 2006; 12(19): 5817-25.
    • (2006) Clin Cancer Res , vol.12 , Issue.19 , pp. 5817-5825
    • Yang, Z.1    Schumaker, L.M.2    Egorin, M.J.3    Zuhowski, E.G.4    Guo, Z.5    Cullen, K.J.6
  • 44
    • 40449119533 scopus 로고    scopus 로고
    • Depletion of mitochondrial DNA up-regulates the expression of MDR1 gene via an increase in mRNA stability
    • Lee W, Choi HI, Kim MJ, Park SY. Depletion of mitochondrial DNA up-regulates the expression of MDR1 gene via an increase in mRNA stability. Exp Mol Med 2008; 40(1): 109-17.
    • (2008) Exp Mol Med , vol.40 , Issue.1 , pp. 109-117
    • Lee, W.1    Choi, H.I.2    Kim, M.J.3    Park, S.Y.4
  • 45
    • 77953384917 scopus 로고    scopus 로고
    • Redox regulation in cancer: A double-edged sword with therapeutic potential
    • [Acharya A, Das I, Chandhok D, Saha T. Redox regulation in cancer: a double-edged sword with therapeutic potential. Oxid Med Cell Longev; 3(1): 23-34.
    • Oxid Med Cell Longev , vol.3 , Issue.1 , pp. 23-34
    • Acharya, A.1    Das, I.2    Chandhok, D.3    Saha, T.4
  • 46
    • 9244261938 scopus 로고    scopus 로고
    • Chemotherapy-associated oxidative stress: Impact on chemotherapeutic effectiveness
    • Conklin KA. Chemotherapy-associated oxidative stress: impact on chemotherapeutic effectiveness. Integr Cancer Ther 2004; 3(4): 294-300.
    • (2004) Integr Cancer Ther , vol.3 , Issue.4 , pp. 294-300
    • Conklin, K.A.1
  • 47
    • 0032697363 scopus 로고    scopus 로고
    • Antioxidants in cancer therapy; their actions and interactions with oncologic therapies
    • Lamson DW, Brignall MS. Antioxidants in cancer therapy; their actions and interactions with oncologic therapies. Altern Med Rev 1999; 4(5): 304-29.
    • (1999) Altern Med Rev , vol.4 , Issue.5 , pp. 304-329
    • Lamson, D.W.1    Brignall, M.S.2
  • 48
    • 34748858784 scopus 로고    scopus 로고
    • Oxidative stress and apoptosis: Impact on cancer therapy
    • Ozben T. Oxidative stress and apoptosis: impact on cancer therapy. J Pharm Sci 2007; 96(9): 2181-96.
    • (2007) J Pharm Sci , vol.96 , Issue.9 , pp. 2181-2196
    • Ozben, T.1
  • 49
    • 0034991034 scopus 로고    scopus 로고
    • Signalling apoptosis: A radical approach
    • Carmody RJ, Cotter TG. Signalling apoptosis: a radical approach. Redox Rep 2001; 6(2): 77-90.
    • (2001) Redox Rep , vol.6 , Issue.2 , pp. 77-90
    • Carmody, R.J.1    Cotter, T.G.2
  • 50
    • 0033862305 scopus 로고    scopus 로고
    • A threshold concept for cancer therapy
    • Kong Q, Beel JA, Lillehei KO. A threshold concept for cancer therapy. Med Hypotheses 2000; 55(1): 29-35.
    • (2000) Med Hypotheses , vol.55 , Issue.1 , pp. 29-35
    • Kong, Q.1    Beel, J.A.2    Lillehei, K.O.3
  • 51
    • 0034629336 scopus 로고    scopus 로고
    • Lack of oxidative phosphorylation and low mitochondrial membrane potential decrease susceptibility to apoptosis and do not modulate the protective effect of Bcl-x(L) in osteosarcoma cells
    • Dey R, Moraes CT. Lack of oxidative phosphorylation and low mitochondrial membrane potential decrease susceptibility to apoptosis and do not modulate the protective effect of Bcl-x(L) in osteosarcoma cells. J Biol Chem 2000; 275(10): 7087-94.
    • (2000) J Biol Chem , vol.275 , Issue.10 , pp. 7087-7094
    • Dey, R.1    Moraes, C.T.2
  • 52
    • 85047695600 scopus 로고    scopus 로고
    • Resistance of mitochondrial DNA-deficient cells to TRAIL: Role of Bax in TRAIL-induced apoptosis
    • Kim JY, Kim YH, Chang I, et al. Resistance of mitochondrial DNA-deficient cells to TRAIL: role of Bax in TRAIL-induced apoptosis. Oncogene 2002; 21(20): 3139-48.
    • (2002) Oncogene , vol.21 , Issue.20 , pp. 3139-3148
    • Kim, J.Y.1    Kim, Y.H.2    Chang, I.3
  • 53
    • 33646165559 scopus 로고    scopus 로고
    • Efficient execution of cell death in non-glycolytic cells requires the generation of ROS controlled by the activity of mitochondrial H+-ATP synthase
    • Santamaria G, Martinez-Diez M, Fabregat I, Cuezva JM. Efficient execution of cell death in non-glycolytic cells requires the generation of ROS controlled by the activity of mitochondrial H+-ATP synthase. Carcinogenesis 2006; 27(5): 925-35.
    • (2006) Carcinogenesis , vol.27 , Issue.5 , pp. 925-935
    • Santamaria, G.1    Martinez-Diez, M.2    Fabregat, I.3    Cuezva, J.M.4
  • 54
    • 0036496854 scopus 로고    scopus 로고
    • Alterations in the expression of cytochrome c oxidase subunits in doxorubicinresistant leukemia K562 cells
    • Grandjean F, Bremaud L, Robert J, Ratinaud MH. Alterations in the expression of cytochrome c oxidase subunits in doxorubicinresistant leukemia K562 cells. Biochem Pharmacol 2002; 63(5): 823-31.
    • (2002) Biochem Pharmacol , vol.63 , Issue.5 , pp. 823-831
    • Grandjean, F.1    Bremaud, L.2    Robert, J.3    Ratinaud, M.H.4
  • 55
    • 0031722711 scopus 로고    scopus 로고
    • Modifications of oxido-reductase activities in adriamycin-resistant leukaemia K562 cells
    • Denis-Gay M, Petit JM, Mazat JP, Ratinaud MH. Modifications of oxido-reductase activities in adriamycin-resistant leukaemia K562 cells. Biochem Pharmacol 1998; 56(4): 451-7.
    • (1998) Biochem Pharmacol , vol.56 , Issue.4 , pp. 451-457
    • Denis-Gay, M.1    Petit, J.M.2    Mazat, J.P.3    Ratinaud, M.H.4
  • 56
    • 17144430514 scopus 로고    scopus 로고
    • Down-regulation of mitochondrial F1F0-ATP synthase in human colon cancer cells with induced 5-fluorouracil resistance
    • Shin YK, Yoo BC, Chang HJ, et al. Down-regulation of mitochondrial F1F0-ATP synthase in human colon cancer cells with induced 5-fluorouracil resistance. Cancer Res 2005; 65(8): 3162-70.
    • (2005) Cancer Res , vol.65 , Issue.8 , pp. 3162-3170
    • Shin, Y.K.1    Yoo, B.C.2    Chang, H.J.3
  • 57
    • 78650069506 scopus 로고    scopus 로고
    • Acquisition of temozolomide chemoresistance in gliomas leads to remodeling of mitochondrial electron transport chain
    • [Oliva CR, Nozell SE, Diers A, et al. Acquisition of temozolomide chemoresistance in gliomas leads to remodeling of mitochondrial electron transport chain. J Biol Chem; 285(51): 39759-67.
    • J Biol Chem , vol.285 , Issue.51 , pp. 39759-39767
    • Oliva, C.R.1    Nozell, S.E.2    Diers, A.3
  • 58
    • 0035016885 scopus 로고    scopus 로고
    • Anticancer drug resistance in primary human brain tumors
    • Bredel M. Anticancer drug resistance in primary human brain tumors. Brain Res Brain Res Rev 2001; 35(2): 161-204.
    • (2001) Brain Res Brain Res Rev , vol.35 , Issue.2 , pp. 161-204
    • Bredel, M.1
  • 59
    • 16844368698 scopus 로고    scopus 로고
    • Tumour stem cells and drug resistance
    • Dean M, Fojo T, Bates S. Tumour stem cells and drug resistance. Nat Rev Cancer 2005; 5(4): 275-84.
    • (2005) Nat Rev Cancer , vol.5 , Issue.4 , pp. 275-284
    • Dean, M.1    Fojo, T.2    Bates, S.3
  • 60
    • 80053556348 scopus 로고    scopus 로고
    • Effect of Hypoxia-inducible Factor-1alpha Silencing on the Sensitivity of Human Brain Glioma Cells to Doxorubicin and Etoposide
    • [Chen L, Feng P, Li S, Long D, Cheng J, Lu Y, Zhou D. Effect of Hypoxia-inducible Factor-1alpha Silencing on the Sensitivity of Human Brain Glioma Cells to Doxorubicin and Etoposide. Neurochem Res 2008.
    • (2008) Neurochem Res
    • Chen, L.1    Feng, P.2    Li, S.3    Long, D.4    Cheng, J.5    Lu, Y.6    Zhou, D.7
  • 61
    • 0027960078 scopus 로고
    • Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells
    • Cole SP, Sparks KE, Fraser K, et al. Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells. Cancer Res 1994; 54(22): 5902-10.
    • (1994) Cancer Res , vol.54 , Issue.22 , pp. 5902-5910
    • Cole, S.P.1    Sparks, K.E.2    Fraser, K.3
  • 62
    • 0037051092 scopus 로고    scopus 로고
    • Molecular and functional MDR1-Pgp and MRPs expression in human glioblastoma multiforme cell lines
    • Decleves X, Fajac A, Lehmann-Che J, et al. Molecular and functional MDR1-Pgp and MRPs expression in human glioblastoma multiforme cell lines. Int J Cancer 2002; 98(2): 173-80.
    • (2002) Int J Cancer , vol.98 , Issue.2 , pp. 173-180
    • Decleves, X.1    Fajac, A.2    Lehmann-Che, J.3
  • 63
    • 0034527893 scopus 로고    scopus 로고
    • Expression of multidrug resistance- associated protein (MRP) in human gliomas
    • Mohri M, Nitta H, Yamashita J. Expression of multidrug resistance- associated protein (MRP) in human gliomas. J Neurooncol 2000; 49(2): 105-15.
    • (2000) J Neurooncol , vol.49 , Issue.2 , pp. 105-115
    • Mohri, M.1    Nitta, H.2    Yamashita, J.3
  • 64
    • 20544436363 scopus 로고    scopus 로고
    • Localization of breast cancer resistance protein (BCRP) in microvessel endothelium of human control and epileptic brain
    • Aronica E, Gorter JA, Redeker S, et al. Localization of breast cancer resistance protein (BCRP) in microvessel endothelium of human control and epileptic brain. Epilepsia 2005; 46(6): 849-57.
    • (2005) Epilepsia , vol.46 , Issue.6 , pp. 849-857
    • Aronica, E.1    Gorter, J.A.2    Redeker, S.3
  • 65
    • 0035501672 scopus 로고    scopus 로고
    • Overexpression of the human major vault protein in astrocytic brain tumor cells
    • Berger W, Spiegl-Kreinecker S, Buchroithner J, et al. Overexpression of the human major vault protein in astrocytic brain tumor cells. Int J Cancer 2001; 94(3): 377-82.
    • (2001) Int J Cancer , vol.94 , Issue.3 , pp. 377-382
    • Berger, W.1    Spiegl-Kreinecker, S.2    Buchroithner, J.3
  • 66
    • 0032031480 scopus 로고    scopus 로고
    • Expression of the lung resistance protein predicts poor outcome in de novo acute myeloid leukemia
    • Filipits M, Pohl G, Stranzl T, et al. Expression of the lung resistance protein predicts poor outcome in de novo acute myeloid leukemia. Blood 1998; 91(5): 1508-13.
    • (1998) Blood , vol.91 , Issue.5 , pp. 1508-1513
    • Filipits, M.1    Pohl, G.2    Stranzl, T.3
  • 67
    • 0034478036 scopus 로고    scopus 로고
    • Drug resistanceassociated factors in primary and secondary glioblastomas and their precursor tumors
    • Tews DS, Nissen A, Kulgen C, Gaumann AK. Drug resistanceassociated factors in primary and secondary glioblastomas and their precursor tumors. J Neurooncol 2000; 50(3): 227-37.
    • (2000) J Neurooncol , vol.50 , Issue.3 , pp. 227-237
    • Tews, D.S.1    Nissen, A.2    Kulgen, C.3    Gaumann, A.K.4
  • 68
    • 0031259697 scopus 로고    scopus 로고
    • Characterization of the sea urchin major vault protein: A possible role for vault ribonucleoprotein particles in nucleocytoplasmic transport
    • Hamill DR, Suprenant KA. Characterization of the sea urchin major vault protein: a possible role for vault ribonucleoprotein particles in nucleocytoplasmic transport. Dev Biol 1997; 190(1): 117-28.
    • (1997) Dev Biol , vol.190 , Issue.1 , pp. 117-128
    • Hamill, D.R.1    Suprenant, K.A.2
  • 69
    • 0000029964 scopus 로고    scopus 로고
    • Structure of the vault, a ubiquitous celular component
    • Kong LB, Siva AC, Rome LH, Stewart PL. Structure of the vault, a ubiquitous celular component. Structure 1999; 7(4): 371-9.
    • (1999) Structure , vol.7 , Issue.4 , pp. 371-379
    • Kong, L.B.1    Siva, A.C.2    Rome, L.H.3    Stewart, P.L.4
  • 70
    • 0027491276 scopus 로고
    • Evidence that vault ribonucleoprotein particles localize to the nuclear pore complex
    • Chugani DC, Rome LH, Kedersha NL. Evidence that vault ribonucleoprotein particles localize to the nuclear pore complex. J Cell Sci 1993; 106 (Pt 1): 23-9.
    • (1993) J Cell Sci , vol.106 , Issue.PART 1 , pp. 23-29
    • Chugani, D.C.1    Rome, L.H.2    Kedersha, N.L.3
  • 71
    • 22144451399 scopus 로고    scopus 로고
    • Nuclear localization of the major vault protein in U373 cells
    • Slesina M, Inman EM, Rome LH, Volknandt W. Nuclear localization of the major vault protein in U373 cells. Cell Tissue Res 2005; 321(1): 97-104.
    • (2005) Cell Tissue Res , vol.321 , Issue.1 , pp. 97-104
    • Slesina, M.1    Inman, E.M.2    Rome, L.H.3    Volknandt, W.4
  • 72
    • 0027466646 scopus 로고
    • Overexpression of a M(r) 110,000 vesicular protein in non-P-glycoprotein-mediated multidrug resistance
    • Scheper RJ, Broxterman HJ, Scheffer GL, et al. Overexpression of a M(r) 110,000 vesicular protein in non-P-glycoprotein-mediated multidrug resistance. Cancer Res 1993; 53(7): 1475-9.
    • (1993) Cancer Res , vol.53 , Issue.7 , pp. 1475-1479
    • Scheper, R.J.1    Broxterman, H.J.2    Scheffer, G.L.3
  • 73
    • 16644394187 scopus 로고    scopus 로고
    • Clinical study on treatment of advanced stage non-small cell lung cancer by guben xiaoliu capsule
    • Wang XM, Xin H, Yang Z, et al. [Clinical study on treatment of advanced stage non-small cell lung cancer by guben xiaoliu capsule]. Zhongguo Zhong Xi Yi Jie He Za Zhi 2004; 24(11): 986-8.
    • (2004) Zhongguo Zhong Xi Yi Jie He Za Zhi , vol.24 , Issue.11 , pp. 986-988
    • Wang, X.M.1    Xin, H.2    Yang, Z.3
  • 74
    • 27744557065 scopus 로고    scopus 로고
    • Oxidative stress and apoptosis: A new treatment paradigm in cancer
    • Engel RH, Evens AM. Oxidative stress and apoptosis: a new treatment paradigm in cancer. Front Biosci 2006; 11: 300-12.
    • (2006) Front Biosci , vol.11 , pp. 300-312
    • Engel, R.H.1    Evens, A.M.2


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