Expression of multidrug resistance-associated protein (MRP) in human gliomas

Journal of Neuro-Oncology

Volumn 49, Issue 2, 2000, Pages 105-115

  Mohri, M ^a   Nitta, H ^a   Yamashita, J ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

Antisense oligonucleotide; Chemotherapy; Glioma; Immunohistochemistry; MRP; RT PCR

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CISPLATIN; DOXORUBICIN; ETOPOSIDE; MULTIDRUG RESISTANCE PROTEIN; NIMUSTINE;

ADOLESCENT; ADULT; AGED; ARTICLE; ASTROCYTOMA; CELL LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION FUNCTION; DRUG SENSITIVITY; FEMALE; GLIOBLASTOMA; GLIOMA; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MALE; MULTIDRUG RESISTANCE; PROTEIN EXPRESSION; TUMOR CELL LINE;

ADOLESCENT; ADULT; AGED; ANTINEOPLASTIC AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; BLOTTING, WESTERN; BRAIN NEOPLASMS; CELL SURVIVAL; DNA PRIMERS; DRUG RESISTANCE, MULTIPLE; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; GENE EXPRESSION; GLIOMA; HUMANS; IMMUNOENZYME TECHNIQUES; MALE; MIDDLE AGED; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; OLIGONUCLEOTIDES, ANTISENSE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 0034527893     PISSN: 0167594X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1026528926482     Document Type: Article

References (51)

1. BCNU-5-fluorouracil combination therapy for recurrent malignant brain tumors
2. A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants
3. Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells
4. Expression of P-glycoprotein in human glioma cell lines and surgical glioma cells specimens
5. Mdr1 P-glycoprotein is expressed by endothelial cells of newly formed capillaries in human gliomas but is not expressed in the neovasculature of other primary tumors
6. Metallothionein in glioma
7. Immunohistochemical demonstration of the placental form of glutathione S-transferase, a detoxifying enzyme in human gliomas
8. A study of the expression of four chemoresistance-related genes in human primary and metastatic brain tumors
9. 6-methylguanine-DNA methyl-transferase and chloroethylnitrosourea resistance of human brain tumors
10. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line
11. Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs
12. Tissue distribution of the multidrug resistance protein
13. Expression of the multidrug resistance-associated protein (MRP) gene in human cancers
14. The prognostic significance of expression of the multidrug resistance-associated protein (MRP) in primary breast cancer
15. Membrane transport proteins associated with drug resistance expressed in human melanoma
16. Extension of life-span of human endothelial cells by an interleukin-1α antisense oligomer
17. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
18. Immunochemical detection of the multidrug resistance-associated protein MRP in human multidrug-resistant tumor cells by monoclonal antibodies
19. Quantitative analysis of MDR1 (multidrug resistance) gene expression in human tumors by polymerase chain reaction
20. Quantification of mRNA by non-radioactive RT-PCR and CCD imaging system
21. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
22. Reduction of expression of the multidrug resistance protein (MRP) in human tumor cells by antisense phosphorothioate oligonucleotides
23. Overcoming multidrug resistance in human tumor cells using free and liposomally encapsulated antisense oligodeoxynucleotides
24. Increased phosphorylation of DNA topoisomerase II in etoposide-resistant mutants of human cancer KB cells
25. Overexpression of metallothionein confers resistance to anticancer drugs
26. Expression of human glutathione S-transferases in Saccharomyces cerevisiae confers resistance to the anticancer drugs adriamycin and chlorambucil
27. Evaluation of the importance of hydrophobic interactions in drug binding to dihydrofolate reductase
28. 6-alkylguanine-DNA alkyltransferase: Regulation and importance in response to alkylating carcinogenic and therapeutic agents
29. The human multidrug resistance (mdrl) gene. cDNA cloning and transcription initiation
30. Multidrug resistance (mdr) genes in human cancer
31. Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites
32. Expression of multidrug resistance protein in patients with glioma after chemotherapy
33. The MRP gene associated with a non-P-glycoprotein multidrug resistance encodes a 190-kDa membrane bound glycoprotein
34. The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump
35. Expression of the multidrug resistance-associated protein (MRP) gene in colorectal carcinomas
36. Expression of the MRP and MDR1 multidrug resistance genes in small cell lung cancer
37. MRP and MDR1 gene expression in primary breast carcinomas
38. Multidrug resistance protein (MRP) expression in retinoblastoma correlates with the rare failure of chemotherapy despite cyclosporine for reversal of p-glycoprotein
39. Deletion of gene for multidrug resistance in acute myeloid leukaemia with inversion in chromosome 16: Prognostic implications
40. Analysis of the expression of MRP, the gene for a new putative transmembrane drug transporter, in human multidrug resistant lung cancer cell lines
41. Possible involvement of multidrug-resistance-associated protein (MRP) gene expression in spontaneous drug resistance to vincristine, etoposide and adriamycin in human glioma cells
42. Expression complementary DNA library transfer establishes mrp as a multidrug resistance gene
43. The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates
44. Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport
45. Doxrubicin- and daunorubicin-glutathione conjugates, but not unconjugated drugs, competitively inhibit leukotriene C4 transport mediated by MRP/GS-X pump
46. Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump
47. Coordinated induction of MRP/GSX pump and gamma-glutamylcysteine synthetase by heavy metals in human leukemia cells
48. Phosphorothioate analogs of oligodeoxynucleotides: Inhibitors of replication and cytopathic effects of human immunodeficiency virus
49. Co-transfection of MDR1 and MRP antisense RNAs abolishes the drug resistance in multidrug-resistant human lung cancer cells
50. Characterization of the Mr 190,000 multidrug resistance protein (MRP) in drug-selected and transfected human tumor cell