Development of diabetes in lean Ncb5or-null mice is associated with manifestations of endoplasmic reticulum and oxidative stress in beta cells

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1812, Issue 11, 2011, Pages 1532-1541

  Wang, WenFang ^a,b   Guo, Ying ^a,f   Xu, Ming ^a   Huang, Han Hung ^a   Novikova, Lesya ^a   Larade, Kevin ^c   Jiang, Zhi Gang ^c   Thayer, Terri C ^d   Frontera, Jennifer R ^b   Aires, Daniel ^b   Ding, Helin ^f   Turk, John ^e   Mathews, Clayton E ^d   Bunn, H Franklin ^c   Stehno Bittel, Lisa ^a   Zhu, Hao ^a,b  

^a UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^e WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f SUN YAT SEN MEMORIAL HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

Author keywords

Beta cell; Diabetes; ER stress; Free fatty acid; Oxidative stress

Indexed keywords

CYTOCHROME B5 REDUCTASE; FATTY ACID; GLUCAGON; GLUCOSE REGULATED PROTEIN 78; INITIATION FACTOR 2ALPHA; INSULIN; MONOUNSATURATED FATTY ACID; PALMITIC ACID; REACTIVE OXYGEN METABOLITE; SATURATED FATTY ACID; SOMATOSTATIN; TRIACYLGLYCEROL;

ALLOXAN DIABETES MELLITUS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DAMAGE; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE COURSE; ENDOPLASMIC RETICULUM STRESS; FATTY ACID METABOLISM; GENETIC ASSOCIATION; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; HISTOPATHOLOGY; HORMONE RELEASE; HYPERGLYCEMIA; IMMUNOFLUORESCENCE; INSULIN SENSITIVITY; ISOLATED PANCREAS ISLET; LEAN BODY WEIGHT; LIPOATROPHY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PANCREAS ISLET DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; UNFOLDED PROTEIN RESPONSE;

ALLOXAN; ANIMALS; BLOTTING, WESTERN; CYTOCHROME-B(5) REDUCTASE; DIABETES MELLITUS, EXPERIMENTAL; ENDOPLASMIC RETICULUM; FATTY ACIDS, UNSATURATED; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HEAT-SHOCK PROTEINS; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIA; OXIDATION-REDUCTION; OXIDATIVE STRESS; PALMITATES; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; UNFOLDED PROTEIN RESPONSE;

MUS;

EID: 80053453887     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2011.07.016     Document Type: Article

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