Small rat islets are superior to large islets in in vitro function and in transplantation outcomes

American Journal of Physiology - Endocrinology and Metabolism

Volumn 290, Issue 5, 2006, Pages

  MacGregor, R R ^b   Williams, S J ^b   Tong, P Y ^c   Kover, K ^c   Moore, W V ^c   Stehno Bittel, L ^a  

^a UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^c CHILDREN S MERCY HOSPITAL   (United States)

Author keywords

Insulin secretion; Islet transplant; Viability

Indexed keywords

GLUCOSE; INSULIN; POTASSIUM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INCUBATION TIME; INSULIN RELEASE; MALE; NONHUMAN; OXYGEN CONSUMPTION; PANCREAS ISLET; PANCREAS TRANSPLANTATION; POTASSIUM BLOOD LEVEL; PRIORITY JOURNAL; PROGNOSIS; RAT;

ANIMALS; APOPTOSIS; BLOOD GLUCOSE; CELL SURVIVAL; DIABETES MELLITUS, EXPERIMENTAL; GLUCAGON-SECRETING CELLS; GLUCOSE; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; MALE; NECROSIS; OXYGEN CONSUMPTION; POTASSIUM; RATS; TREATMENT OUTCOME;

EID: 33646425820     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00097.2005     Document Type: Article

References (24)

1. Chan CB, Saleh MC, Purje A, and MacPhail RM. Glucose-inducible hypertrophy and suppression of anion efflux in rat beta cells. J Endocrinol 173: 45-52, 2002.
2. Chan CB and Surette JJ. Glucose refractoriness of beta-cells from fed fa/fa rats is ameliorated by nonesterified fatty acids. Can J Physiol Pharmacol 77: 934-942, 1999.
3. Cui YF, Ma M, Wang GY, Han DE, Vollmar B, and Menger MD. Prevention of core cell damage in isolated islets of Langerhans by low temperature preconditioning. World J Gastroenterol 11: 545-550, 2005.
4. Dufrane D, Goebbels RM, Fdilat I, Guiot Y, and Gianello P. Impact of porcine islet size on cellular structure and engraftment after transplantation: adult versus young pigs. Pancreas 30: 138-147, 2005.
5. Giordano E, Cirulli V, Bosco D, Rouiller D, Halban P, and Meda P. β-Cell size influences glucose-stimulated insulin secretion. Am J Physiol Cell Physiol 265: C358-C364, 1993.
6. Giuliana M, Moritz W, Bodmer E, Dindo D, Kugelmeier P, Lehmann R, Gassmann M, Groscurth P, and Weber M. Central necrosis in isolated hypoxic human pancreatic islets: evidence for postisolation ischemia. Cell Transplant 14: 67-76, 2005.
7. Hu YF, Cheng RL, Shao AH, Ye RS, Gu ZF, Zhang HD, Zhang ZG, Hen LR, Bi HF, and Shi GF. The influences of islet transplantation on metabolic abnormalities and diabetic complications. Horm Metab Res 21: 198-202, 1989.
8. Hu YF, Zhang H, Zhang HD, Shao AH, Li LX, and Zhao BH. Clinical researches on islet transplantation in 20 patients with insulin-dependent diabetes mellitus. Acta Acad Med Wuhan 4: 145-151, 1984.
9. Hutton JC and Malaisse WJ. Dynamics of O2 consumption in rat pancreatic islets. Diabetologia 18: 395-405, 1980.
10. Kaihow T, Masuda T, Sasano N, and Takahashi T. The size and number of Langerhans islets correlated with their endocrine function: a morphometry on immunostained serial sectioned adult human pancreases. Tohoku J Exp Med 149: 1-10, 1986.
11. Krichhahn M, Buhler C, Meyer T, Thiede A, and Ulrichs K. The morphology of islets within the porcine donor pancrease determines the isolation result: successful isolation of pancreatic islets can now be achieved from young market pigs. Cell Transplant 11: 827-838, 2002.
12. Krickhahn M, Buhler C, Meyer T, Thiede A, and Ulrichs K. The morphology of islets within the porcine donor pancreas determines the isolation result: successful isolation of pancreatic islets can now be achieved from young market pigs. Cell Transplant 11: 827-838, 2002.
13. Latif ZA, Noel J, and Alejandro R. A simple method of staining fresh and cultured islets. Transplantation 45: 827-830, 1988.
14. Mattson G, Jansson L, and Carlsson PO. Decreased vascular density in mouse pancreatic islets after tranplantation. Diabetes 51: 1362-1366, 2002.
15. Menger MD, Jaeger S, Walter P, Feifel G, Hammersen F, and Messmer K. Angiogenesis and hemodynamics of microvasculature of transplanted islets of Langerhans. Diabetes 38, Suppl: 199-201, 1989.
16. Ritz-Laser B, Oberholzer J, Toso C, Brulhart MC, Zakrzewska K, Ris F, Bucher P, Morel P, and Philippe J. Molecular detection of circulating beta-cells after islet transplantation. Diabetes 51: 557-561, 2002.
17. Scharp DW, Lacy PE, Santiago J, McCullough C, Weide LG, Falqui L, Marchetti P, Gingerich R, Jaffe A, Cryer P, Anderson C, and Flye W. Insulin independence following islet transplantation into patient with Type I, insulin dependent diabetes mellitus. Diabetes 39: 515-518, 1990.
18. Shapiro AM, Lakey JR, Ryan EA, Korbutt GS, Toth E, Warnock GL, Knetman NM, and Rajotte RV. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regime. N Engl J Med 343: 230-238, 2000.
19. Sutherland DE, Gores PF, Farney AC, Wahoff DC, Matas AJ, Dunn DL, Gruessner RW, and Najarian JS. Evolution of kidney, pancreas, and islet transplantation for patients with diabetes at the University of Minnesota. Am J Surg 166: 456-491, 1993.
20. Sweet IR, Khalil G, Wallen AR, Steedman M, Schenkman KA, Reems JA, Kahn SE, and Callis JB. Continuous measurement of oxygen consumption by pancreatic islets. Diabetes Technol Ther 4: 661-672, 2002.
21. Tatarkiewicz K, Garcia M, Lopez-Avalos M, Bonner-Weir S, and Weir GC. Porcine neonatal pancreatic cell clusters in tissue culture: benefits of serum and immobilization in alginate hydrogel. Transplanation 71: 1518-1526, 2001.
22. von Mach MA, Schlosser J, Weiland M, Feilen PJ, Ringel M, Hengstler JG, Weilemann LS, Beyer J, Kann P, and Schneider S. Size of pancreatic islets of Langerhans: a key parameter for viability after cryopreservation. Acta Diabetol 40: 123-129, 2003.
23. Warnock GL, Ellis DK, Cattral M, Untch D, Kneteman NM, and Rajotte RV. Viable purified islets of Langerhans from collagenase-perfused human pancreas. Diabetes 38: 136-139, 1989.
24. Xu W, McDough RC, Langsdorf B, Demas JN, and DeGraff BA. Oxygen sensors based on luminescence quenching: interaction metal complexes with the polymer supports. Anal Chem 66: 4133-4141, 1994.