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Volumn 290, Issue 1, 2011, Pages 60-72

Data-driven modeling of Alzheimer Disease pathogenesis

Author keywords

Biological regulation; Complex systems; Model checking; Neurological disease; Term rewriting

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; CASPASE 3; HYPOXIA INDUCIBLE FACTOR;

EID: 80053362041     PISSN: 00225193     EISSN: 10958541     Source Type: Journal    
DOI: 10.1016/j.jtbi.2011.08.038     Document Type: Article
Times cited : (32)

References (75)
  • 3
    • 10044235332 scopus 로고    scopus 로고
    • Secreted beta-amyloid precursor protein activates microglia via JNK and p38-MAPK
    • Bodles A.M., Barger S.W. Secreted beta-amyloid precursor protein activates microglia via JNK and p38-MAPK. Neurobiology of Aging 2005, 26:9-16.
    • (2005) Neurobiology of Aging , vol.26 , pp. 9-16
    • Bodles, A.M.1    Barger, S.W.2
  • 4
    • 70449460896 scopus 로고    scopus 로고
    • Desacyl-ghrelin and synthetic GH-secretagogus modulate the production of inflammatory cyotkines in mouse microglia cells stimulated by beta-amyloid fibrils
    • Bulgarelli I., Tamiazzo L., Bresciani E., Rapetti D., Caporali S., Lattuada D., Locatelli V., Torsello A. Desacyl-ghrelin and synthetic GH-secretagogus modulate the production of inflammatory cyotkines in mouse microglia cells stimulated by beta-amyloid fibrils. Journal of Neuroscience Research 2009, 87:2718-2727.
    • (2009) Journal of Neuroscience Research , vol.87 , pp. 2718-2727
    • Bulgarelli, I.1    Tamiazzo, L.2    Bresciani, E.3    Rapetti, D.4    Caporali, S.5    Lattuada, D.6    Locatelli, V.7    Torsello, A.8
  • 5
    • 77549087405 scopus 로고    scopus 로고
    • Age-related loss of phospholipid asymmetry in APP(NLh)/APP(NLh)×PS-1(P264L)/PS-1(P264L) human double mutant knock-in mice: relevance to Alzheimer disease
    • Bader Lange M.L., Clair D., Markesbery W.R., Studzinki C.M., Murphey M.P., Butterfield D.A. Age-related loss of phospholipid asymmetry in APP(NLh)/APP(NLh)×PS-1(P264L)/PS-1(P264L) human double mutant knock-in mice: relevance to Alzheimer disease. Neurobiology of Disease 2010, 38:104-115.
    • (2010) Neurobiology of Disease , vol.38 , pp. 104-115
    • Bader Lange, M.L.1    Clair, D.2    Markesbery, W.R.3    Studzinki, C.M.4    Murphey, M.P.5    Butterfield, D.A.6
  • 8
    • 41549107577 scopus 로고    scopus 로고
    • The basic biology of BACE1: a key therapeutic target for Alzheimer's disease
    • Cole S.L., Vassar R. The basic biology of BACE1: a key therapeutic target for Alzheimer's disease. Current Genomics 2007, 8:509-530.
    • (2007) Current Genomics , vol.8 , pp. 509-530
    • Cole, S.L.1    Vassar, R.2
  • 10
    • 77951776829 scopus 로고    scopus 로고
    • Alzheimer's disease: strategies for disease modification
    • Citron M. Alzheimer's disease: strategies for disease modification. Nature Reviews Drug Discovery 2010, 9:387-398.
    • (2010) Nature Reviews Drug Discovery , vol.9 , pp. 387-398
    • Citron, M.1
  • 12
    • 77952094986 scopus 로고    scopus 로고
    • Beta amyloid peptide: from different aggregation forms to the activation of different biochemical pathways
    • Di Carlo M. Beta amyloid peptide: from different aggregation forms to the activation of different biochemical pathways. European Biophysical Journal 2010, 39:877-888.
    • (2010) European Biophysical Journal , vol.39 , pp. 877-888
    • Di Carlo, M.1
  • 13
    • 0037431082 scopus 로고    scopus 로고
    • Aph-1, Pen-2, and nicastrin with presenilin generate an active gamma-secretase complex
    • De Strooper B. Aph-1, Pen-2, and nicastrin with presenilin generate an active gamma-secretase complex. Neuron 2003, 38:9-12.
    • (2003) Neuron , vol.38 , pp. 9-12
    • De Strooper, B.1
  • 16
    • 0141835032 scopus 로고    scopus 로고
    • Studies on neuronal apoptosis in primary forebrain cultures: neuroprotective/anti-apoptotic action of NR2B NMDA antagonists
    • Dave J.R., Williams A.J., Moffett J.R., Koenig M.L., Tortella F.C. Studies on neuronal apoptosis in primary forebrain cultures: neuroprotective/anti-apoptotic action of NR2B NMDA antagonists. Neurotoxicity Research 2003, 5:255-264.
    • (2003) Neurotoxicity Research , vol.5 , pp. 255-264
    • Dave, J.R.1    Williams, A.J.2    Moffett, J.R.3    Koenig, M.L.4    Tortella, F.C.5
  • 17
    • 76849086405 scopus 로고    scopus 로고
    • The secretases: enzymes with therapeutic potential in Alzheimer disease
    • De Strooper B., Vassar R., Golde T. The secretases: enzymes with therapeutic potential in Alzheimer disease. Nature Reviews Neurology 2010, 6:99-107.
    • (2010) Nature Reviews Neurology , vol.6 , pp. 99-107
    • De Strooper, B.1    Vassar, R.2    Golde, T.3
  • 18
    • 66249115618 scopus 로고    scopus 로고
    • Cerebrovascular and cardiovascular pathology in Alzheimer's disease
    • de la Torre J.C. Cerebrovascular and cardiovascular pathology in Alzheimer's disease. International Review of Neurobiology 2009, 84:35-48.
    • (2009) International Review of Neurobiology , vol.84 , pp. 35-48
    • de la Torre, J.C.1
  • 22
    • 13844255273 scopus 로고    scopus 로고
    • Molecular biology and genetics of Alzheimer's disease
    • George-Hyslop P., Petit A. Molecular biology and genetics of Alzheimer's disease. Comptes Rendus Biologies 2004, 328:119-130.
    • (2004) Comptes Rendus Biologies , vol.328 , pp. 119-130
    • George-Hyslop, P.1    Petit, A.2
  • 25
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics
    • Hardy J., Selkoe D.J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 2002, 297:353-356.
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 26
    • 4644357534 scopus 로고    scopus 로고
    • Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation
    • He W., Lu Y., Qahwash I., Hu X.-Y., Chang A., Yan R. Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation. Nature Medicine 2004, 10:959-965.
    • (2004) Nature Medicine , vol.10 , pp. 959-965
    • He, W.1    Lu, Y.2    Qahwash, I.3    Hu, X.-Y.4    Chang, A.5    Yan, R.6
  • 29
    • 40349111175 scopus 로고    scopus 로고
    • Therapeutic potential of gamma-secretase inhibitors and modulators
    • Imbimbo B.P. Therapeutic potential of gamma-secretase inhibitors and modulators. Current Topics in Medicinal Chemistry 2008, 8:54-61.
    • (2008) Current Topics in Medicinal Chemistry , vol.8 , pp. 54-61
    • Imbimbo, B.P.1
  • 31
    • 33646337667 scopus 로고    scopus 로고
    • A methodology for the structural and functional analysis of signaling and regulatory networks
    • Klamt S., Saez-Rodriguez J., Lindquist J., Simeoni L., Gilles E.D. A methodology for the structural and functional analysis of signaling and regulatory networks. BMC Bioinformatics 2006, 7:56.
    • (2006) BMC Bioinformatics , vol.7 , pp. 56
    • Klamt, S.1    Saez-Rodriguez, J.2    Lindquist, J.3    Simeoni, L.4    Gilles, E.D.5
  • 32
    • 34447551397 scopus 로고    scopus 로고
    • Structural and functional analysis of cellular networks with CellNetAnalyzer
    • Klamt S., Saez-Rodriguez J., Gilles E.D. Structural and functional analysis of cellular networks with CellNetAnalyzer. BMC Systems Biology 2007, 1:2.
    • (2007) BMC Systems Biology , vol.1 , pp. 2
    • Klamt, S.1    Saez-Rodriguez, J.2    Gilles, E.D.3
  • 35
    • 70450273117 scopus 로고    scopus 로고
    • Receptor-associated protein interacts with amyloid-beta peptide and promotes its cellular uptake
    • Kanekiyo T., Bu G. Receptor-associated protein interacts with amyloid-beta peptide and promotes its cellular uptake. The Journal of Biological Chemistry 2009, 284:33352-33359.
    • (2009) The Journal of Biological Chemistry , vol.284 , pp. 33352-33359
    • Kanekiyo, T.1    Bu, G.2
  • 36
    • 0042827324 scopus 로고    scopus 로고
    • Human neprilysin is capable of degrading amyloid beta peptide not only in the monomeric form but also the pathological oligomeric form
    • Kanemitsu H., Tomiyama T., Mori H. Human neprilysin is capable of degrading amyloid beta peptide not only in the monomeric form but also the pathological oligomeric form. Neuroscience Letters 2003, 350:113-116.
    • (2003) Neuroscience Letters , vol.350 , pp. 113-116
    • Kanemitsu, H.1    Tomiyama, T.2    Mori, H.3
  • 37
    • 51549089359 scopus 로고    scopus 로고
    • C-terminal 37 residues of LRP promote the amyloidogenic processing of APP independent of FE65
    • Lakshmana M.K., Chen E., Yoon I.-S., Kang D.E. C-terminal 37 residues of LRP promote the amyloidogenic processing of APP independent of FE65. Journal of Cellular and Molecular Medicine 2008, 12:2665-2674.
    • (2008) Journal of Cellular and Molecular Medicine , vol.12 , pp. 2665-2674
    • Lakshmana, M.K.1    Chen, E.2    Yoon, I.-S.3    Kang, D.E.4
  • 38
    • 0028286128 scopus 로고
    • Glucose given after hypoxic ischemia does not affect brain injury in piglets
    • LeBlanc M.H., Huang M., Patel D., Smith E.E., Devidas M. Glucose given after hypoxic ischemia does not affect brain injury in piglets. Stroke 1994, 25:1443-1447.
    • (1994) Stroke , vol.25 , pp. 1443-1447
    • LeBlanc, M.H.1    Huang, M.2    Patel, D.3    Smith, E.E.4    Devidas, M.5
  • 39
    • 77955091162 scopus 로고    scopus 로고
    • Microglia activation and anti-inflammatory regulation in Alzheimer's disease
    • Lue L.F., Kuo Y.M., Beach T., Walker D.G. Microglia activation and anti-inflammatory regulation in Alzheimer's disease. Molecular Neurobiology 2010, 41:115-128.
    • (2010) Molecular Neurobiology , vol.41 , pp. 115-128
    • Lue, L.F.1    Kuo, Y.M.2    Beach, T.3    Walker, D.G.4
  • 42
    • 2542430828 scopus 로고    scopus 로고
    • ApoE and Abeta-42 interactions: effects of isoform and conformation on structure and function
    • Manelli A.M., Stine W.B., Van Eldik L.J., LaDu M.J. ApoE and Abeta-42 interactions: effects of isoform and conformation on structure and function. Journal of Molecular Neuroscience 2004, 23:235-246.
    • (2004) Journal of Molecular Neuroscience , vol.23 , pp. 235-246
    • Manelli, A.M.1    Stine, W.B.2    Van Eldik, L.J.3    LaDu, M.J.4
  • 43
    • 34347251931 scopus 로고    scopus 로고
    • Receptor- and non-receptor tyrosine kinases induce processing of the amyloid precurson protein: role of the low-density lipoprotein receptor-related protein
    • Minopoli G., Passaro F., Aloia L., Carolmagno F., Melillo R.M., Santoro M., Forzati F., Zambrano N., Russo T. Receptor- and non-receptor tyrosine kinases induce processing of the amyloid precurson protein: role of the low-density lipoprotein receptor-related protein. Neuro-degenerative Diseases 2007, 4:94-100.
    • (2007) Neuro-degenerative Diseases , vol.4 , pp. 94-100
    • Minopoli, G.1    Passaro, F.2    Aloia, L.3    Carolmagno, F.4    Melillo, R.M.5    Santoro, M.6    Forzati, F.7    Zambrano, N.8    Russo, T.9
  • 46
    • 0036846405 scopus 로고    scopus 로고
    • The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in APP processing
    • Pietrzik C.U., Busse T., Merriam D.E., Weggen S., Koo E.H. The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in APP processing. EMBO Journal 2002, 21:5691-5700.
    • (2002) EMBO Journal , vol.21 , pp. 5691-5700
    • Pietrzik, C.U.1    Busse, T.2    Merriam, D.E.3    Weggen, S.4    Koo, E.H.5
  • 47
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer's disease: genes, proteins, and therapy
    • Selkoe D.J. Alzheimer's disease: genes, proteins, and therapy. Physiological Reviews 2001, 81:741-766.
    • (2001) Physiological Reviews , vol.81 , pp. 741-766
    • Selkoe, D.J.1
  • 50
    • 40849139207 scopus 로고    scopus 로고
    • Retromer sorting: a pathological pathway in late-onset Alzheimer disease
    • Small S.A. Retromer sorting: a pathological pathway in late-onset Alzheimer disease. Archives of Neurology 2008, 65:323-328.
    • (2008) Archives of Neurology , vol.65 , pp. 323-328
    • Small, S.A.1
  • 55
    • 0037192120 scopus 로고    scopus 로고
    • Differential effects of proteases involved in intracellular degradation of amyloid beta-protein between detergent-soluble and -insoluble pools in CHO-695 cells
    • Sudoh S., Frosch M.P., Wolf B.A. Differential effects of proteases involved in intracellular degradation of amyloid beta-protein between detergent-soluble and -insoluble pools in CHO-695 cells. Biochemistry 2002, 41:1090-1099.
    • (2002) Biochemistry , vol.41 , pp. 1090-1099
    • Sudoh, S.1    Frosch, M.P.2    Wolf, B.A.3
  • 56
    • 0033795279 scopus 로고    scopus 로고
    • Apolipoprotein E and Alzheimer disease: an update on genetic and functional analysis
    • Saunders A.M. Apolipoprotein E and Alzheimer disease: an update on genetic and functional analysis. Journal of Neuropathology and Experimental Neurology 2000, 59:751-758.
    • (2000) Journal of Neuropathology and Experimental Neurology , vol.59 , pp. 751-758
    • Saunders, A.M.1
  • 63
    • 43649085909 scopus 로고    scopus 로고
    • Cerebral amyloid angiopathy and its relationship to Alzheimer's disease
    • Thal D.R., Griffin W.S., de Vos R.A., Ghebremedhin E. Cerebral amyloid angiopathy and its relationship to Alzheimer's disease. Acta Neuropathology 2008, 115:599-609.
    • (2008) Acta Neuropathology , vol.115 , pp. 599-609
    • Thal, D.R.1    Griffin, W.S.2    de Vos, R.A.3    Ghebremedhin, E.4
  • 64
    • 37349069999 scopus 로고    scopus 로고
    • Toll-like receptors 2 and 4 mediate Abeta(1-42) activation of the innate immune response in a human monocytic cell line
    • Udan M.L.D., Ajit D., Crouse N.R., Nichols M.R. Toll-like receptors 2 and 4 mediate Abeta(1-42) activation of the innate immune response in a human monocytic cell line. Journal of Neurochemistry 2008, 104:524-533.
    • (2008) Journal of Neurochemistry , vol.104 , pp. 524-533
    • Udan, M.L.D.1    Ajit, D.2    Crouse, N.R.3    Nichols, M.R.4
  • 65
    • 0034629292 scopus 로고    scopus 로고
    • Modulation of beta-amyloid precurson protein processing by the low density lipoprotien receptor-related protein (LRP): evidence that LRP contributes to the pathogenesis of Alzheimer's disease
    • Ulery P.G., Beers J., Mikhailenko I., Tanzi R.E., Rebeck GW, Hyman BT, Strickland DK Modulation of beta-amyloid precurson protein processing by the low density lipoprotien receptor-related protein (LRP): evidence that LRP contributes to the pathogenesis of Alzheimer's disease. Journal of Biological Chemistry 2000, 275:7410-7415.
    • (2000) Journal of Biological Chemistry , vol.275 , pp. 7410-7415
    • Ulery, P.G.1    Beers, J.2    Mikhailenko, I.3    Tanzi, R.E.4    Rebeck, G.W.5    Hyman, B.T.6    Strickland, D.K.7
  • 67
    • 70350455062 scopus 로고    scopus 로고
    • The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential
    • Vassar R., Kovacs D.M., Yan R., Wong P.C. The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential. The Journal of Neuroscience 2009, 29:12787-12794.
    • (2009) The Journal of Neuroscience , vol.29 , pp. 12787-12794
    • Vassar, R.1    Kovacs, D.M.2    Yan, R.3    Wong, P.C.4
  • 68
    • 34248190279 scopus 로고    scopus 로고
    • A beta oligomers-a decade of discovery
    • Walsh D.M., Selkoe D.J. A beta oligomers-a decade of discovery. Journal of Neurochemistry 2007, 101:1172-1184.
    • (2007) Journal of Neurochemistry , vol.101 , pp. 1172-1184
    • Walsh, D.M.1    Selkoe, D.J.2
  • 69
    • 38749095507 scopus 로고    scopus 로고
    • The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1
    • Wang W.-X., Rajeev B.W., Stromberg A.J., Ren N., Tang G., Huang Q., Rigoutsos I., Nelson P.T. The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1. Journal of Neuroscience 2008, 28:1213-1223.
    • (2008) Journal of Neuroscience , vol.28 , pp. 1213-1223
    • Wang, W.-X.1    Rajeev, B.W.2    Stromberg, A.J.3    Ren, N.4    Tang, G.5    Huang, Q.6    Rigoutsos, I.7    Nelson, P.T.8
  • 73
    • 34548496491 scopus 로고    scopus 로고
    • Low-density lipoprotein receptor-related protein promotes amyloid precursor protein trafficking to lipid rafts in the endocytic pathway
    • Yoon I.-S., Chen E., Busse T., Repetto E., Lakshmana M.K., Koo E.H., Kang D.E. Low-density lipoprotein receptor-related protein promotes amyloid precursor protein trafficking to lipid rafts in the endocytic pathway. The FASEB Journal 2007, 21:2742-2752.
    • (2007) The FASEB Journal , vol.21 , pp. 2742-2752
    • Yoon, I.-S.1    Chen, E.2    Busse, T.3    Repetto, E.4    Lakshmana, M.K.5    Koo, E.H.6    Kang, D.E.7
  • 74
    • 0032903412 scopus 로고    scopus 로고
    • Apoliprotien E promotes the binding and uptake of beta-amyloid into Chinese hamster ovary cells in an isoform-specific manner
    • Yang D.S., Small D.H., Seydel U., Smith J.D., Hallmayer J., Gandy S.E., Martins R.N. Apoliprotien E promotes the binding and uptake of beta-amyloid into Chinese hamster ovary cells in an isoform-specific manner. Neuroscience 1999, 90:1217-1226.
    • (1999) Neuroscience , vol.90 , pp. 1217-1226
    • Yang, D.S.1    Small, D.H.2    Seydel, U.3    Smith, J.D.4    Hallmayer, J.5    Gandy, S.E.6    Martins, R.N.7
  • 75
    • 34249727115 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation
    • Zhang X., Zhou K., Wang R., Cui J., Lipton S.A., Liao F.-F., Xu H., Zhang Y. Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation. Journal of Biological Chemistry 2007, 282:10873-10880.
    • (2007) Journal of Biological Chemistry , vol.282 , pp. 10873-10880
    • Zhang, X.1    Zhou, K.2    Wang, R.3    Cui, J.4    Lipton, S.A.5    Liao, F.-F.6    Xu, H.7    Zhang, Y.8


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