Animal models to guide clinical drug development in ADHD: Lost in translation?

British Journal of Pharmacology

Volumn 164, Issue 4, 2011, Pages 1107-1128

  Wickens, Jeffery R ^a,b   Hyland, Brian I ^b   Tripp, Gail ^a  

^a OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY GRADUATE UNIVERSITY   (Japan)

^b UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

ADHD; amphetamine; animal model; dopamine; hyperactivity; impulsivity; inattention; methylphenidate; noradrenalin

Indexed keywords

AMPHETAMINE; ATOMOXETINE; DESIPRAMINE; DEXAMPHETAMINE; DOPAMINE; DOPAMINE TRANSPORTER; DOPAMINE TRANSPORTER INHIBITOR; GUANFACINE; HALOPERIDOL; METHYLPHENIDATE; NORADRENALIN TRANSPORTER; NORADRENALIN TRANSPORTER INHIBITOR; PROTEIN INHIBITOR; PSYCHOSTIMULANT AGENT; UNCLASSIFIED DRUG;

ATTENTION DEFICIT DISORDER; ATTENTION DISTURBANCE; CLINICAL FEATURE; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DISEASE COURSE; DISEASE MODEL; DISEASE SEVERITY; DOPAMINERGIC SYSTEM; DRUG BLOOD LEVEL; DRUG DEVELOPMENT; DRUG EFFECT; DRUG MECHANISM; DRUG MEGADOSE; DRUG RESEARCH; DRUG SYNTHESIS; EVIDENCE BASED MEDICINE; GENETIC PREDISPOSITION; GENETIC SUSCEPTIBILITY; HUMAN; HYPERACTIVITY; IMPULSIVENESS; KNOCKOUT MOUSE; LOW DRUG DOSE; MENTAL TASK; MOLECULAR GENETICS; MOUSE STRAIN; NONHUMAN; NORADRENERGIC SYSTEM; PATHOPHYSIOLOGY; PHARMACODYNAMICS; PRIORITY JOURNAL; RESPONSE TIME; REVIEW; SYMPTOM; TASK PERFORMANCE; TREATMENT RESPONSE;

ANIMALS; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; DISEASE MODELS, ANIMAL; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; HUMANS; RATS; RATS, INBRED SHR; RATS, INBRED WKY; REPRODUCIBILITY OF RESULTS; TRANSLATIONAL MEDICAL RESEARCH;

EID: 80053317862     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01412.x     Document Type: Review

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