Neurobiology of Attention Deficit Hyperactivity Disorder

Child and Adolescent Psychiatric Clinics of North America

Volumn 17, Issue 2, 2008, Pages 285-307

  Kieling, Christian ^a   Goncalves, Renata R F ^a   Tannock, Rosemary ^b   Castellanos, Francisco X ^c,d  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c NEW YORK UNIVERSITY CHILD STUDY CENTER   (United States)

^d NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATTENTION DEFICIT DISORDER; BASAL GANGLION; BEHAVIOR; BRAIN SIZE; CEREBELLUM; CULTURAL FACTOR; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL FACTOR; ETHNICITY; FRONTAL CORTEX; GENE INTERACTION; HEREDITY; HUMAN; NEUROBIOLOGY; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; RISK FACTOR;

ADOLESCENT; ADULT; ANIMALS; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; BASAL GANGLIA; BRAIN; CEREBELLUM; CHILD; GENE EXPRESSION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; PREFRONTAL CORTEX; RISK FACTORS; SOCIAL ENVIRONMENT;

EID: 39149096278     PISSN: 10564993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chc.2007.11.012     Document Type: Review

References (158)

1. Kupfer D.J., First M.B., and Regier D.A. A research agenda for DSM-V. 1st edition (2002), American Psychiatric Association, Washington, DC
2. Caspi A., Moffitt T.E., Newman D.L., et al. Behavioral observations at age 3 years predict adult psychiatric disorders. Longitudinal evidence from a birth cohort. Arch Gen Psychiatry 53 11 (1996) 1033-1039
3. Lynam D.R., Caspi A., Moffitt T.E., et al. Longitudinal evidence that psychopathy scores in early adolescence predict adult psychopathy. J Abnorm Psychol 116 1 (2007) 155-165
4. Porges S.W. Asserting the role of biobehavioral sciences in translational research: the behavioral neurobiology revolution. Dev Psychopathol 18 3 (2006) 923-933
5. Goldman L.S., Genel M., Bezman R.J., et al. Diagnosis and treatment of attention-deficit/hyperactivity disorder in children and adolescents. Council on Scientific Affairs, American Medical Association. JAMA 279 14 (1998) 1100-1107
6. Sonuga-Barke E.J., and Sergeant J. The neuroscience of ADHD: multidisciplinary perspectives on a complex developmental disorder. Dev Sci 8 2 (2005) 103-104
7. Coghill D., Nigg J., Rothenberger A., et al. Whither causal models in the neuroscience of ADHD?. Dev Sci 8 2 (2005) 105-114
8. Volkmar F. Toward understanding the basis of ADHD. Am J Psychiatry 162 6 (2005) 1043-1044
9. Spencer T.J., Biederman J., Wilens T.E., et al. Overview and neurobiology of attention-deficit/hyperactivity disorder. J Clin Psychiatry 63 Suppl 12 (2002) 3-9
10. Biederman J., Faraone S.V., Keenan K., et al. Family-genetic and psychosocial risk factors in DSM-III attention deficit disorder. J Am Acad Child Adolesc Psychiatry 29 4 (1990) 526-533
11. Banerjee T.D., Middleton F., and Faraone S.V. Environmental risk factors for attention-deficit hyperactivity disorder. Acta Paediatr 96 9 (2007) 1269-1274
12. Linnet K.M., Dalsgaard S., Obel C., et al. Maternal lifestyle factors in pregnancy risk of attention deficit hyperactivity disorder and associated behaviors: review of the current evidence. Am J Psychiatry 160 6 (2003) 1028-1040
13. Braun J.M., Kahn R.S., Froehlich T., et al. Exposures to environmental toxicants and attention deficit hyperactivity disorder in US children. Environ Health Perspect 114 12 (2006) 1904-1909
14. Dopfner M., Rothenberger A., and Sonuga-Barke E. Areas for future investment in the field of ADHD: preschoolers and clinical networks. Eur Child Adolesc Psychiatry 13 Suppl 1 (2004) I130-I135
15. Kapoor A., Petropoulos S., and Matthews S.G. Fetal programming of hypothalamic-pituitary-adrenal (HPA) axis function and behavior by synthetic glucocorticoids. Brain Res Rev (2007), in press
16. Thapar A., Holmes J., Poulton K., et al. Genetic basis of attention deficit and hyperactivity. Br J Psychiatry 174 (1999) 105-111
17. Smalley S.L. Genetic influences in childhood-onset psychiatric disorders: autism and attention-deficit/hyperactivity disorder. Am J Hum Genet 60 6 (1997) 1276-1282
18. Centers for Disease Control and Prevention (CDC). Cigarette smoking among adults-United States, 2006. MMWR Morb Mortal Wkly Rep 56 44 (2007) 1157-1161
19. Bardy A.H., Seppala T., Lillsunde P., et al. Objectively measured tobacco exposure during pregnancy: neonatal effects and relation to maternal smoking. Br J Obstet Gynaecol 100 8 (1993) 721-726
20. Kuczkowski K.M. The effects of drug abuse on pregnancy. Curr Opin Obstet Gynecol 19 (2007) 578-585
21. Leung G.M., Ho L.M., and Lam T.H. The economic burden of environmental tobacco smoke in the first year of life. Arch Dis Child 88 (2003) 767-771
22. Milberger S., Biederman J., Faraone S.V., et al. Is maternal smoking during pregnancy a risk factor for attention deficit hyperactivity disorder in children?. Am J Psychiatry 153 9 (1996) 1138-1142
23. Milberger S., Biederman J., Faraone S.V., et al. Further evidence of an association between maternal smoking during pregnancy and attention-deficit hyperactivity disorder: findings from a high-risk sample of siblings. J Clin Child Psychol 27 3 (1998) 352-358
24. Thapar A., Fowler T., Rice F., et al. Maternal smoking during pregnancy and attention-deficit hyperactivity disorder symptoms in offspring. Am J Psychiatry 160 11 (2003) 1985-1989
25. Kotimaa A.J., Moilanen I., Taanila A., et al. Maternal smoking and hyperactivity in 8-year-old children. J Am Acad Child Adolesc Psychiatry 42 7 (2003) 826-833
26. Rodriguez A., and Bohlin G. Are maternal smoking and stress during pregnancy related to ADHD symptoms in children?. J Child Psychol Psychiatry 46 3 (2005) 246-254
27. Schmitz M., Denardin D., Laufer Silva T., et al. Smoking during pregnancy and attention-deficit/hyperactivity disorder, predominantly inattentive type: a case-control study. J Am Acad Child Adolesc Psychiatry 45 11 (2006) 1338-1345
28. Ernst M., Heishman S.J., Spurgeon L., et al. Smoking history and nicotine effects on cognitive performance. Neuropsychopharmacology 25 (2001) 313-319
29. Batstra L., Hadders-ALgra M., and Neeleman J. Effect of antenatal exposure to maternal smoking on behavioural problems and academic achievement in childhood: prospective evidence from a Dutch birth cohort. Early Hum Dev 75 1-2 (2003) 21-33
30. Langley K., Rice F., van den Bree M.B., et al. Maternal smoking during pregnancy as an environmental risk factor for attention-deficit hyperactivity disorder behaviour. A review. Minerva Pediatr 57 6 (2005) 359-371
31. Mick E., Biederman J., Faraone S.V., et al. Case-control study of attention-deficit hyperactivity disorder and maternal smoking, alcohol use, and drug use during pregnancy. J Am Acad Child Adolesc Psychiatry 41 4 (2002) 378-385
32. Weissman M.M., Warner V., Wickramaratne P.J., et al. Maternal smoking during pregnancy and psychopathology in offspring followed to adulthood. J Am Acad Child Adolesc Psychiatry 38 (1999) 892-899
33. Goodwin R.D., Keyes K., and Simuro N. Mental disorders and nicotine dependence among pregnant women in the United States. Obstet Gynecol 109 4 (2007) 875-883
34. Williams J.H., and Ross L. Consequences of prenatal toxin exposure for mental health in children and adolescents: a systematic review. Eur Child Adolesc Psychiatry 16 (2007) 243-253
35. Slotkin T.A., MacKillop E.A., Rudder C.L., et al. Permanent, sex-selective effects of prenatal or adolescent nicotine exposure, separately or sequentially, in rat brain regions: indices of cholinergic and serotonergic synaptic function, cell signaling, and neural cell number and size at 6 months of age. Neuropsychopharmacology 32 (2007) 1082-1097
36. Liang K., Poytress B.S., Chen Y., et al. Neonatal nicotine exposure impairs nicotinic enhancement of central auditory processing and auditory learning in adult rats. Eur J Neurosci 24 3 (2006) 857-866
37. Roy T.S., Seidler F.J., and Slotkin T.A. Prenatal nicotine exposure evokes alterations of cell structure in hippocampus and somatosensory cortex. J Pharmacol Exp Ther 300 (2002) 124-133
38. Slawecki C.J., Thomas J.D., Riley E.P., et al. Neonatal nicotine exposure alters hippocampal EEG and event-related potentials (ERPs) in rats. Pharmacol Biochem Behav 65 (2000) 711-718
39. Slawecki C.J., Thorsell A., and Ehlers C.L. Long-term neurobehavioral effects of alcohol or nicotine exposure in adolescent animal models. Ann N Y Acad Sci 1021 (2004) 448-452
40. Vaglenova J., Birru S., Pandiella N.M., et al. An assessment of the long-term developmental and behavioral teratogenicity of prenatal nicotine exposure. Behav Brain Res 150 1-2 (2004) 159-170
41. Fried P.A., Watkinson B., and Siegel L.S. Reading and language in 9- to 12-year olds prenatally exposed to cigarettes and marijuana. Neurotoxicol Teratol 19 3 (1997) 171-183
42. Fried P.A., Watkinson B., and Gray R. Differential effects on cognitive functioning in 13- to 16-year-olds prenatally exposed to cigarettes and marihuana. Neurotoxicol Teratol 25 4 (2003) 427-436
43. Jacobsen L.K., Slotkin T.A., Mencl W.E., et al. Gender-specific effects of prenatal and adolescent exposure to tobacco smoke on auditory and visual attention. Neuropsychopharmacology 32 12 (2007) 2453-2464
44. Collins B.N., Wileyto E.P., Murphy M.F., et al. Adolescent environmental tobacco smoke exposure predicts academic achievement test failure. J Adolesc Health 41 4 (2007) 363-370
45. Yolton K., Dietrich K., Auinger P., et al. Exposure to environmental tobacco smoke and cognitive abilities among US children and adolescents. Environ Health Perspect 113 1 (2005) 98-103
46. Currie J., and Stabile M. Child mental health and human capital accumulation: the case of ADHD. J Health Econ 25 6 (2006) 1094-1118
47. Frazier T.W., Youngstrom E.A., Glutting J.J., et al. ADHD and achievement: meta-analysis of the child, adolescent, and adult literatures and a concomitant study with college students. J Learn Disabil 40 1 (2007) 49-65
48. Kharrazi M., DeLorenze G.N., Kaufman F.L., et al. Environmental tobacco smoke and pregnancy outcome. Epidemiology 15 6 (2004) 660-670
49. Delpisheh A., Kelly Y., Rizwan S., et al. Population attributable risk for adverse pregnancy outcomes related to smoking in adolescents and adults. Public Health 121 11 (2007) 861-868
50. Ward C., Lewis S., and Coleman T. Prevalence of maternal smoking and environmental tobacco smoke exposure during pregnancy and impact on birth weight: retrospective study using Millennium Cohort. BMC Public Health 7 (2007) 81
51. Mikkola K., Ritari N., Tommiska V., et al. Neurodevelopmental outcome at 5 years of age of a national cohort of extremely low birth weight infants who were born in 1996-1997. Pediatrics 116 6 (2005) 1391-1400
52. Indredavik M.S., Vik T., Heyerdahl S., et al. Psychiatric symptoms in low birth weight adolescents, assessed by screening questionnaires. Eur Child Adolesc Psychiatry 14 4 (2005) 226-236
53. Botting N., Powls A., Cooke R.W., et al. Attention-deficit hyperactivity disorders and other psychiatric outcomes in very low birth weight children at 12 years. J Child Psychol Psychiatry 38 8 (1997) 931-941
54. Szatmari P., Saigal S., Rosenbaum P., et al. Psychiatric disorders at five years among children with birth weights less than 1000 g: a regional perspective. Dev Med Child Neurol 32 11 (1990) 954-962
55. Lahti J., Raikkonen K., Kajantie E., et al. Small body size at birth and behavioural symptoms of ADHD in children aged five to six years. J Child Psychol Psychiatry 47 11 (2006) 1167-1174
56. Bhutta A.T., Cleves M.A., Casey P.H., et al. Cognitive and behavioral outcomes of school-aged children who were born preterm: a meta-analysis. JAMA 288 6 (2002) 728-737
57. Emgard M., Paradisi M., Pirondi S., et al. Prenatal glucocorticoid exposure affects learning and vulnerability of cholinergic neurons. Neurobiol Aging 28 1 (2007) 112-121
58. Seckl J.R., and Holmes M.C. Mechanisms of disease: glucocorticoids, their placental metabolism, and fetal programming of adult pathophysiology. Nat Clin Pract Endocrinol Metab 3 6 (2007) 479-488
59. Knopik V.S., Sparrow E.P., Madden P.A., et al. Contributions of parental alcoholism, prenatal substance exposure, and genetic transmission to child ADHD risk: a female twin study. Psychol Med 35 5 (2005) 625-635
60. Sapolsky R.M. Gene therapy for psychiatric disorders. Am J Psychiatry 160 2 (2003) 208-220
61. Biederman J., Faraone S.V., and Monuteaux M.C. Differential effect of environmental adversity by gender: Rutter's index of adversity in a group of boys and girls with and without ADHD. Am J Psychiatry 159 9 (2002) 1556-1562
62. Knopik V.S., Heath A.C., Jacob T., et al. Maternal alcohol use disorder and offspring ADHD: disentangling genetic and environmental effects using a children-of-twins design. Psychol Med 36 10 (2006) 1461-1471
63. Caspi A., McClay J., Moffitt T.E., et al. Role of genotype in the cycle of violence in maltreated children. Science 297 5582 (2002) 851-854
64. Slotkin T.A., Pinkerton K.E., Auman J.T., et al. Perinatal exposure to environmental tobacco smoke up-regulates nicotinic cholinergic receptors in monkey brain. Brain Res Dev Brain Res 133 2 (2002) 175-179
65. Kahn R.S., Khoury J., Nichols W.C., et al. Role of dopamine transporter genotype and maternal prenatal smoking in childhood hyperactive-impulsive, inattentive, and oppositional behaviors. J Pediatr 143 1 (2003) 104-110
66. Brookes K.J., Mill J., Guindalini C., et al. A common haplotype of the dopamine transporter gene associated with attention-deficit/hyperactivity disorder and interacting with maternal use of alcohol during pregnancy. Arch Gen Psychiatry 63 1 (2006) 74-81
67. Neuman R.J., Lobos E., Reich W., et al. Prenatal smoking exposure and dopaminergic genotypes interact to cause a severe ADHD subtype. Biol Psychiatry 61 12 (2007) 1320-1328
68. Todd R.D., and Neuman R.J. Gene-environment interactions in the development of combined type ADHD: evidence for a synapse-based model. Am J Med Genet B Neuropsychiatr Genet 144B 8 (2007) 971-975
69. Laucht M., Skowronek M.H., Becker K., et al. Interacting effects of the dopamine transporter gene and psychosocial adversity on attention-deficit/hyperactivity disorder symptoms among 15-year-olds from a high-risk community sample. Arch Gen Psychiatry 64 5 (2007) 585-590
70. Mill J., Caspi A., Williams B.S., et al. Prediction of heterogeneity in intelligence and adult prognosis by genetic polymorphisms in the dopamine system among children with attention-deficit/hyperactivity disorder: evidence from 2 birth cohorts. Arch Gen Psychiatry 63 4 (2006) 462-469
71. Castellanos F.X., and Tannock R. Neuroscience of attention-deficit/hyperactivity disorder: the search for endophenotypes. Nat Rev Neurosci 3 8 (2002) 617-628
72. Langley K., Marshall L., van den Bree M., et al. Association of the dopamine D4 receptor gene 7-repeat allele with neuropsychological test performance of children with ADHD. Am J Psychiatry 161 1 (2004) 133-138
73. Kieling C., Roman T., Doyle A.E., et al. Association between DRD4 gene and performance of children with ADHD in a test of sustained attention. Biol Psychiatry 60 10 (2006) 1163-1165
74. Swanson J., Oosterlaan J., Murias M., et al. Attention-deficit/hyperactivity disorder children with a 7-repeat allele of the dopamine receptor D4 gene have extreme behavior but normal performance on critical neuropsychological tests of attention. Proc Natl Acad Sci U S A 97 9 (2000) 4754-4759
75. Manor I., Tyano S., Eisenberg J., et al. The short DRD4 repeats confer risk to attention-deficit hyperactivity disorder in a family-based design and impair performance on a continuous performance test (TOVA). Mol Psychiatry 7 7 (2002) 790-794
76. Bellgrove M.A., Hawi Z., Lowe N., et al. DRD4 gene variants and sustained attention in attention-deficit hyperactivity disorder (ADHD): effects of associated alleles at the VNTR and -521 SNP. Am J Med Genet B Neuropsychiatr Genet 136 1 (2005) 81-86
77. Swanson J.M., Kinsbourne M., Nigg J., et al. Etiologic subtypes of attention-deficit/hyperactivity disorder: brain imaging, molecular genetic and environmental factors, and the dopamine hypothesis. Neuropsychol Rev 17 1 (2007) 39-59
78. Levitt P. Developmental neurobiology and clinical disorders: lost in translation?. Neuron 46 3 (2005) 407-412
79. Krain A.L., and Castellanos F.X. Brain development and ADHD. Clin Psychol Rev 26 4 (2006) 433-444
80. Hynd G.W., Semrud-Clikeman M., Lorys A.R., et al. Brain morphology in developmental dyslexia and attention-deficit disorder/hyperactivity. Arch Neurol 47 8 (1990) 919-926
81. Hynd G.W., Semrud-Clikeman M., Lorys A.R., et al. Corpus callosum morphology in attention-deficit hyperactivity disorder: morphometric analysis of MRI. J Learn Disabil 24 3 (1991) 141-146
82. Hynd G.W., Hern K.L., Novey E.S., et al. Attention-deficit hyperactivity disorder and asymmetry of the caudate nucleus. J Child Neurol 8 4 (1993) 339-347
83. Castellanos F.X., Lee P.P., Sharp W., et al. Developmental trajectories of brain volume abnormalities in children and adolescents with attention-deficit/hyperactivity disorder. JAMA 288 14 (2002) 1740-1748
84. Durston S., Hulshoff Pol H.E., Schnack H.G., et al. Magnetic resonance imaging of boys with attention-deficit/hyperactivity disorder and their unaffected siblings. J Am Acad Child Adolesc Psychiatry 43 3 (2004) 332-340
85. Mostofsky S.H., Cooper K.L., Kates W.R., et al. Smaller prefrontal and premotor volumes in boys with attention-deficit/hyperactivity disorder. Biol Psychiatry 52 8 (2002) 785-794
86. Swanson J.M., Hinshaw S.P., Arnold L.E., et al. Clinical and cognitive definitions of attention deficits in children with attention-deficit/hyperactivity disorder. In: Posner M.I. (Ed). Cognitive neuroscience of attention (2004), Guilford, New York 430-445
87. Valera E.M., Faraone S.V., Murray K.E., et al. Meta-analysis of structural imaging findings in attention-deficit/hyperactivity disorder. Biol Psychiatry 61 12 (2007) 1361-1369
88. Castellanos F.X., Giedd J.N., Marsh W.L., et al. Quantitative brain magnetic resonance imaging in attention-deficit hyperactivity disorder. Arch Gen Psychiatry 53 7 (1996) 607-616
89. Castellanos F.X., Giedd J.N., Berquin P.C., et al. Quantitative brain magnetic resonance imaging in girls with attention-deficit/hyperactivity disorder. Arch Gen Psychiatry 58 3 (2001) 289-295
90. Durston S. A review of the biological bases of ADHD: what have we learned from imaging studies?. Ment Retard Dev Disabil Res Rev 9 3 (2003) 184-195
91. Castellanos FX, Margulies DS, Clare Kelly AM, et al. Cingulate precuneus interactions: a new locus of dysfunction in adult attention-deficit/hyperactivity disorder. Biological Psychiatry, in press.
92. Halperin J.M., and Schulz K.P. Revisiting the role of the prefrontal cortex in the pathophysiology of attention-deficit/hyperactivity disorder. Psychol Bull 132 4 (2006) 560-581
93. Filipek P.A., Semrud-Clikeman M., Steingard R.J., et al. Volumetric MRI analysis comparing subjects having attention-deficit hyperactivity disorder with normal controls. Neurology 48 3 (1997) 589-601
94. Kates W.R., Frederikse M., Mostofsky S.H., et al. MRI parcellation of the frontal lobe in boys with attention-deficit hyperactivity disorder or Tourette syndrome. Psychiatry Res 116 1-2 (2002) 63-81
95. Hill D.E., Yeo R.A., Campbell R.A., et al. Magnetic resonance imaging correlates of attention-deficit/hyperactivity disorder in children. Neuropsychology 17 3 (2003) 496-506
96. Casey B.J., Castellanos F.X., Giedd J.N., et al. Implication of right frontostriatal circuitry in response inhibition and attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 36 3 (1997) 374-383
97. Semrud-Clikeman M., Steingard R.J., Filipek P., et al. Using MRI to examine brain-behavior relationships in males with attention-deficit disorder with hyperactivity. J Am Acad Child Adolesc Psychiatry 39 4 (2000) 477-484
98. Willcutt E.G., Doyle A.E., Nigg J.T., et al. Validity of the executive function theory of attention-deficit/hyperactivity disorder: a meta-analytic review. Biol Psychiatry 57 11 (2005) 1336-1346
99. Tannock R., Martinussen R., and Frijters J. Naming speed performance and stimulant effects indicate effortful, semantic processing deficits in attention-deficit/hyperactivity disorder. J Abnorm Child Psychol 28 3 (2000) 237-252
100. Tannock R., Banaschewski T., and Gold D. Color naming deficits and attention-deficit/hyperactivity disorder: a retinal dopaminergic hypothesis. Behav Brain Funct 2 (2006) 4
101. Rubia K., Overmeyer S., Taylor E., et al. Hypofrontality in attention-deficit hyperactivity disorder during higher-order motor control: a study with functional MRI. Am J Psychiatry 156 6 (1999) 891-896
102. Rubia K., Smith A.B., Brammer M.J., et al. Abnormal brain activation during inhibition and error detection in medication-naive adolescents with ADHD. Am J Psychiatry 162 6 (2005) 1067-1075
103. Dickstein S.G., Bannon K., Xavier Castellanos F., et al. The neural correlates of attention-deficit hyperactivity disorder: an ALE meta-analysis. J Child Psychol Psychiatry 47 10 (2006) 1051-1062
104. Sowell E.R., Thompson P.M., Welcome S.E., et al. Cortical abnormalities in children and adolescents with attention-deficit hyperactivity disorder. Lancet 362 9397 (2003) 1699-1707
105. Shaw P., Lerch J., Greenstein D., et al. Longitudinal mapping of cortical thickness and clinical outcome in children and adolescents with attention-deficit/hyperactivity disorder. Arch Gen Psychiatry 63 5 (2006) 540-549
106. Shaw P., Gornick M., Lerch J., et al. Polymorphism of the dopamina D4 receptor, clinical outcome, and cortical structure in attention-deficit/hyperactivity disorder. Arch Gen Psychiatry 64 8 (2007) 921-931
107. Shaw P., Eckstrand K., Sharp W., et al. Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation. PNAS 104 49 (2007) 19649-19654
108. Graybiel A.M., Aosaki T., Flaherty A.W., et al. The basal ganglia and adaptive motor control. Science 265 5180 (1994) 1826-1831
109. Lou H.C., Henriksen L., and Bruhn P. Focal cerebral hypoperfusion in children with dysphasia and/or attention-deficit disorder. Arch Neurol 41 8 (1984) 825-829
110. Lou H.C., Henriksen L., Bruhn P., et al. Striatal dysfunction in attention-deficit and hyperkinetic disorder. Arch Neurol 46 1 (1989) 48-52
111. Castellanos F.X., Giedd J.N., Eckburg P., et al. Quantitative morphology of the caudate nucleus in attention-deficit/hyperactivity disorder. Am J Psychiatry 151 12 (1994) 1791-1796
112. Mataro M., Garcia-Sanchez C., Junque C., et al. Magnetic resonance imaging measurement of the caudate nucleus in adolescents with attention-deficit/hyperactivity disorder and its relationship with neuropsychological and behavioral measures. Arch Neurol 54 8 (1997) 963-968
113. Giedd J.N., Castellanos F.X., Casey B.J., et al. Quantitative morphology of the corpus callosum in attention-deficit/hyperactivity disorder. Am J Psychiatry 151 5 (1994) 665-669
114. Pineda D.A., Restrepo M.A., Sarmiento R.J., et al. Statistical analyses of structural magnetic resonance imaging of the head of the caudate nucleus in Colombian children with attention-deficit/hyperactivity disorder. J Child Neurol 17 2 (2002) 97-105
115. Castellanos F.X., Sharp W.S., Gottesman R.F., et al. Anatomic brain abnormalities in monozygotic twins discordant for attention-deficit/hyperactivity disorder. Am J Psychiatry 160 9 (2003) 1693-1696
116. Allen G., Buxton R.B., Wong E.C., et al. Attentional activation of the cerebellum independent of motor involvement. Science 275 5308 (1997) 1940-1943
117. Mackie S., Shaw P., Lenroot R., et al. Cerebellar development and clinical outcome in attention- deficit/hyperactivity disorder. Am J Psychiatry 164 4 (2007) 647-655
118. Willoughby M.T. Developmental course of ADHD symptomatology during the transition from childhood to adolescence: a review with recommendations. J Child Psychol Psychiatry 44 1 (2003) 88-106
119. Wilens T.E., Biederman J., and Spencer T.J. Attention-deficit/hyperactivity disorder across the lifespan. Annu Rev Med 53 (2002) 113-131
120. Auerbach J.G., Atzaba-Poria N., Berger A., et al. Emerging developmental pathways to ADHD: possible path markers in early infancy. Neural Plast 11 1-2 (2004) 29-43
121. Auerbach J.G., Landau R., Berger A., et al. Neonatal behavior of infants at familial risk for ADHD. Infant Behav Dev 28 (2005) 220-224
122. Berger A, Neuman K, Sagi-Shmueli A, et al. Vigilance in 1-year-old infants at familial risk for attention-deficit/hyperactivity disorder, submitted for publication.
123. Blackman J.A. Attention-deficit/hyperactivity disorder in preschoolers. Does it exist, and should we treat it?. Pediatr Clin North Am 46 5 (1999) 1011-1025
124. Lavigne J.V., Gibbons R.D., Christoffel K.K., et al. Prevalence rates and correlates of psychiatric disorders among preschool children. J Am Acad Child Adolesc Psychiatry 35 2 (1996) 204-214
125. Lahey B.B., Pelham W.E., Stein M.A., et al. Validity of DSM-IV attention-deficit/hyperactivity disorder for younger children. J Am Acad Child Adolesc Psychiatry 37 7 (1998) 695-702
126. Lahey B.B., Pelham W.E., Loney J., et al. Three-year predictive validity of DSM-IV attention-deficit/ hyperactivity disorder in children diagnosed at 4-6 years of age. Am J Psychiatry 161 11 (2004) 2014-2020
127. Barkley R.A., and Biederman J. Toward a broader definition of the age-of-onset criterion for attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 36 9 (1997) 1204-1210
128. Applegate B., Lahey B.B., Hart E.L., et al. Validity of the age-of-onset criterion for ADHD: a report from the DSM-IV field trials. J Am Acad Child Adolesc Psychiatry 36 9 (1997) 1211-1221
129. Rohde L.A., Biederman J., Zimmermann H., et al. Exploring ADHD age-of-onset criterion in Brazilian adolescents. Eur Child Adolesc Psychiatry 9 3 (2000) 212-218
130. Faraone S.V., Biederman J., Spencer T., et al. Diagnosing adult attention-deficit/hyperactivity disorder: are late-onset and subthreshold diagnoses valid?. Am J Psychiatry 163 10 (2006) 1720-1729 quiz 1859
131. Faraone S.V., Biederman J., Doyle A., et al. Neuropsychological studies of late-onset and subthreshold diagnoses of adult attention-deficit/hyperactivity disorder. Biol Psychiatry 60 10 (2006) 1081-1087
132. Reinhardt M.C., Benetti L., Victor M.M., et al. Is age-at-onset criterion relevant for the response to methylphenidate in attention-deficit/hyperactivity disorder?. J Clin Psychiatry 68 7 (2007) 1109-1116
133. Rucklidge J., and Tannock R. Apparent adolescent onset of ADHD-beware!. J Am Acad Child Adolesc Psychiatry 39 9 (2000) 1075-1076
134. August G.J., Stewart M.A., and Holmes C.S. A four-year follow-up of hyperactive boys with and without conduct disorder. Br J Psychiatry 143 (1983) 192-198
135. Biederman J., Faraone S.V., Milberger S., et al. Is childhood oppositional-defiant disorder a precursor to adolescent conduct disorder? Findings from a four-year follow-up study of children with ADHD. J Am Acad Child Adolesc Psychiatry 35 9 (1996) 1193-1204
136. Cantwell D.P., and Baker L. Stability and natural history of DSM-III childhood diagnoses. J Am Acad Child Adolesc Psychiatry 28 5 (1989) 691-700
137. Hart E.L., Lahey B.B., Loeber R., et al. Developmental change in attention-deficit/hyperactivity disorder in boys: a four-year longitudinal study. J Abnorm Child Psychol 23 6 (1995) 729-749
138. Spencer T.J., Biederman J., and Mick E. Attention-deficit/hyperactivity disorder: diagnosis, lifespan, comorbidities, and neurobiology. J Pediatr Psychol 32 6 (2007) 631-642
139. Hill J.C., and Schoener E.P. Age-dependent decline of attention-deficit/hyperactivity disorder. Am J Psychiatry 153 9 (1996) 1143-1146
140. Biederman J., Mick E., and Faraone S.V. Age-dependent decline of symptoms of attention-deficit/ hyperactivity disorder: impact of remission definition and symptom type. Am J Psychiatry 157 5 (2000) 816-818
141. Barkley R.A., Fischer M., Smallish L., et al. The persistence of attention-deficit/hyperactivity disorder into young adulthood as a function of reporting source and definition of disorder. J Abnorm Psychol 111 2 (2002) 279-289
142. Faraone S.V., Biederman J., and Mick E. The age-dependent decline of attention-deficit/hyperactivity disorder: a meta-analysis of follow-up studies. Psychol Med 36 2 (2006) 159-165
143. Spira E.G., and Fischel J.E. The impact of preschool inattention, hyperactivity, and impulsivity on social and academic development: a review. J Child Psychol Psychiatry 46 7 (2005) 755-773
144. Nolan E.E., Gadow K.D., and Sprafkin J. Teacher reports of DSM-IV ADHD, ODD, and CD symptoms in schoolchildren. J Am Acad Child Adolesc Psychiatry 40 2 (2001) 241-249
145. Lahey B.B., Pelham W.E., Loney J., et al. Instability of the DSM-IV subtypes of ADHD from preschool through elementary school. Arch Gen Psychiatry 62 8 (2005) 896-902
146. Biederman J., Mick E., and Faraone S.V. Normalized functioning in youths with persistent attention-deficit/hyperactivity disorder. J Pediatr 133 4 (1998) 544-551
147. Mannuzza S., Klein R.G., Bessler A., et al. Educational and occupational outcome of hyperactive boys grown up. J Am Acad Child Adolesc Psychiatry 36 9 (1997) 1222-1227
148. Biederman J., Newcorn J., and Sprich S. Comorbidity of attention-deficit/hyperactivity disorder with conduct, depressive, anxiety, and other disorders. Am J Psychiatry 148 5 (1991) 564-577
149. Kadesjo C., Hagglof B., Kadesjo B., et al. Attention-deficit/hyperactivity disorder with and without oppositional-defiant disorder in 3- to 7-year-old children. Dev Med Child Neurol 45 10 (2003) 693-699
150. Mannuzza S., Klein R.G., Bessler A., et al. Adult psychiatric status of hyperactive boys grown up. Am J Psychiatry 155 4 (1998) 493-498
151. Mannuzza S., Klein R.G., Bonagura N., et al. Hyperactive boys almost grown up. V. Replication of psychiatric status. Arch Gen Psychiatry 48 1 (1991) 77-83
152. Biederman J., Wilens T.E., Mick E., et al. Does attention-deficit/hyperactivity disorder impact the developmental course of drug and alcohol abuse and dependence?. Biol Psychiatry 44 4 (1998) 269-273
153. Milberger S., Biederman J., Faraone S.V., et al. ADHD is associated with early initiation of cigarette smoking in children and adolescents. J Am Acad Child Adolesc Psychiatry 36 1 (1997) 37-44
154. Wilens T.E., Biederman J., and Mick E. Does ADHD affect the course of substance abuse? Findings from a sample of adults with and without ADHD. Am J Addict 7 2 (1998) 156-163
155. Goldston D.B., Walsh A., Mayfield Arnold E., et al. Reading problems, psychiatric disorders, and functional impairment from mid- to late adolescence. J Am Acad Child Adolesc Psychiatry 46 1 (2007) 25-32
156. Bonafina M.A., Newcorn J.H., McKay K.E., et al. ADHD and reading disabilities: a cluster analytic approach for distinguishing subgroups. J Learn Disabil 33 3 (2000) 297-307
157. Dykman R.A., and Ackerman P.T. Attention-deficit disorder and specific reading disability: separate but often overlapping disorders. J Learn Disabil 24 2 (1991) 96-103
158. Insel T.R., and Quirion R. Psychiatry as a clinical neuroscience discipline. JAMA 294 17 (2005) 2221-2224