Confirmation of association between attention deficit hyperactivity disorder and a dopamine transporter polymorphism

Molecular Psychiatry

Volumn 2, Issue 4, 1997, Pages 311-313

  Gill, M ^a   Daly, G ^b   Heron, S ^b   Hawi, Z ^a   Fitzgerald, M ^b  

^a ST JAMES S HOSPITAL   (Ireland)

^b TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Association; Attention; Child psychiatry; Dopamine; Dopamine transporter; Genetics; Hyperactivity

Indexed keywords

DOPAMINE TRANSPORTER; METHYLPHENIDATE;

ALLELE; ARTICLE; ATTENTION DEFICIT DISORDER; CHILD PSYCHIATRY; CLINICAL GENETICS; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; HAPLOTYPE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; MOTOR ACTIVITY; PRIORITY JOURNAL; VARIABLE NUMBER OF TANDEM REPEAT;

EID: 0030844034     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.mp.4000290     Document Type: Article

References (23)

1. Biederman J, Faraone S, Keenan K, Knee D, Tsuang M. Family-genetic and psychosocial risk factors in DSM-111 attention deficit disorder. J Am Acad Child Adolesc Psychiatry 1990; 29: 526-533.
2. Gillis JI, Gilger JW, Pennington BF, DeFries JC. Attention deficit disorder in reading-disabled twins: evidence for a genetic etiology. J Abnormal Child Psychology 1992; 20: 343-348.
3. Morrison JL, Stewart M. Bilateral inheritance as evidence of polygenicity in the hyperactive child syndrome. J Nerv Ment Disease 1974; 158: 226-228.
4. Alberts-Corush J, Firestone P, Goodman J. Attention and impulsivity characteristics of the biological and adoptive parents of hyperactive and normal control children. Am J Orthopsychiatry 1986; 56: 413-423.
5. Taylor E, Schachar R, Thorley G, Wieselberg HM, Everitt B, Rutter M. Which boys respond to stimulant medication? A controlled trial of methylphenidate in boys with disruptive behaviour. Psychol Med 1987; 17: 121-143.
6. Hechtman L. Genetic and neurobiological aspects of attention deficit hyperactive disorder: a review. J Psychiatry Neurosci 1994; 19: 193-201.
7. Cook EH, Stein MA, Krasowski MD, Cox NJ, Olkon DM, Kieffer JE, Leventhal BL. Association of attention-deficit disorder and the dopamine transporter gene. Am J Hum Genetics 1995; 56: 993-998.
8. Donavan DM, Vandenbergh DJ, Perry MP, Geoffrey SB, Ingersoll R, Nanthakumar E, Uhl GR. Human and mouse dopamine transporter genes: conservation of 5′-flanking sequence elements and gene structures. Mol Brain Res 1995; 30: 327-335.
9. Comings DE, Comings BG, Muhleman D, Dietz G, Shahbahrami B, Tast D, Knell E, Kocsis P, Baumgarten R, Kovacs BW. The dopamine D2 receptor locus as a modifying gene in neuropsychiatric disorders. JAMA 1991; 266: 1793-1800.
10. Comings DE, Wu S, Chiu H, Ring RH, Gade R, Ahn C, MacMurray JP, Dietz G, Muhleman D. Polygenetic inheritance of Tourette's syndrome, stuttering, attention deficit hyperactivity, conduct, and oppositional defiant disorder: the additive and subtractive effect of the three dopaminergic genes - DRD2, D beta, and DAT1. Am J Med Genet 1996; 67: 264-288.
11. LaHoste GL, Swanson JM, Wigal SB, Glabe C, Wigal T, King N, Kennedy JL. Dopamine D4 receptor gene polymorphism is associa ted with attention deficit hyperactivity disorder. Mol Psychiatry 1996; 1: 121-124.
12. Van Tol HHM, Wu CM, Guan H-C, Ohara K, Bunzow JR, Civelli O, Kennedy J, Seeman P, Niznik HB, Jovanovic V. Multiple dopamine D4 receptor variants in the human population. Nature 1992; 358: 149-152.
13. Benjamin J, Li L, Patterson C, Greenberg BD, Murphy DL, Hamer DH. Population and familial association between the D4 dopamine receptor and measures of novelty seeking. Nature Genet 1996; 12: 81-83.
14. Ebstein RP, Novick O, Umansky R, Priel B, Osher Y, Blaine D, Bennett BR, Nemanoff L, Katz M, Belmaker RH. Dopamine D4 receptor (D4DR), exon 111, polymorphism associated with the human personality trait of Novelty Seeking. Nature Genet 1996; 12: 78-80.
15. Cloninger CR, Svrakic DM, Przybeck TR. A psychobiological model of temperament and character. Arch Gen Psychiatry 1993; 50: 975-990.
16. Mannuzza S, Klein R, Bessler A, Malloy P, LaPadula M. Adult outcome of hyperactive boys: educational achievement, occupational rank, and psychiatric status. Arch Gen Psychiatry 1993; 50: 565-576.
17. Ritz MC, Kubar MJ. Psychostimulant drugs and a dopamine hypothesis regarding addiction: update on recent research. Biochem Soc Symp 1993; 59: 51-64.
18. Volkow ND, Wang GJ, Fowler JS, Gatley SJ, Ding YS, Logan J, Dewey SL, Hitzemann R, Lieberman J. Relationship between psychostimulant-induced 'high' and dopamine transporter occupancy. Proc Natl Acad Sci USA 1996; 93: 10388-10392.
19. Achenbach TM, Edelbrock CS. Manual for the Behaviour Checklist and Revised Child Behaviour Profile. Thomas A Achenbach: Burlington, VT, 1983.
20. Goyett CH, Conners CK, Ulrich RF. Normative data on revised Connors Parent and Teaching Rating Scales. J Abnormal Child Psychol 1978; 6: 221-236.
21. Ullmann RK, Sleator EK, Sprague RL. A new rating scale for diagnosis and monitoring of ADD children. Psychopharmacol Bull 1984; 20: 160-164.
22. Vandenbergh DJ, Persico AM, Hawkins AL, Griffin CA, Li X, Jabs EW, Uhl GR. Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR. Genomics 1992; 14: 1104-1106.
23. Rubenstein P, Walker M, Carpenter C, Carrier C, Krassner J, Falk C, Ginsburg F. Genetics of HLA disease associations: the use of the haplotype relative risk (HRR) and the 'haplo-delta' (Dh) estimates in juvenile diabetes from three racial groups. Hum Immunol 1981; 3: 384.