Colon cancer-derived factors activate NF-κB in myeloid cells via TLR2 to link inflammation and tumorigenesis

Molecular Medicine Reports

Volumn 4, Issue 6, 2011, Pages 1083-1088

  Maeda, Shin ^a   Hikiba, Yohko ^b   Sakamoto, Kei ^b   Nakagawa, Hayato ^c   Hirata, Yoshihiro ^c   Hayakawa, Yoku ^c   Akanuma, Masao ^b  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

^b INSTITUTE FOR ADULT DISEASES   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

Colon cancer; Inflammation; NF B

Indexed keywords

CYTOKINE; I KAPPA B; I KAPPA B KINASE BETA; I KAPPA B KINASE GAMMA; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; CANCER CELL; CANCER CELL CULTURE; COLITIS; COLON CARCINOGENESIS; COLORECTAL CARCINOMA; CULTURE MEDIUM; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MACROPHAGE; MACROPHAGE ACTIVATION; MACROPHAGE MIGRATION; MOUSE; NONHUMAN; SUPERNATANT; TUMOR CELL; TUMOR GROWTH;

ANIMALS; CELLS, CULTURED; COLONIC NEOPLASMS; CULTURE MEDIA; HUMANS; I-KAPPA B KINASE; INFLAMMATION; INTERLEUKIN-6; MACROPHAGES; MICE; NF-KAPPA B; TOLL-LIKE RECEPTOR 2;

EID: 80053122580     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2011.545     Document Type: Article

References (27)

1. Jemal A, Siegel R, Ward E, et al: Cancer statistics. CA Cancer J Clin 56: 106-130, 2006.
2. Kinzler KW and Vogelstein B: Lessons from hereditary colorectal cancer. Cell 87: 159-170, 1996. (Pubitemid 26358996)
3. Luo JL, Kamata H and Karin M: IKK/NF-kappaB signaling: balancing life and death - a new approach to cancer therapy. J Clin Invest 115: 2625-2632, 2005. (Pubitemid 41434385)
4. Karin M, Cao Y, Greten FR and Li ZW: NF-kappaB in cancer: from innocent bystander to major culprit. Nat Rev Cancer 2: 301-310, 2002. (Pubitemid 37328783)
5. Ghosh S and Karin M: Missing pieces in the NF-kappaB puzzle. Cell 109 (Suppl): S81-S96, 2002.
6. Sakamoto K, Maeda S, Hikiba Y, et al: Constitutive NF-kappaB activation in colorectal carcinoma plays a key role in angiogenesis, promoting tumor growth. Clin Cancer Res 15: 2248-2258, 2009.
7. Bargou RC, Emmerich F, Krappmann D, et al: Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells. J Clin Invest 100: 2961-2969, 1997. (Pubitemid 28022832)
8. Nakshatri H, Bhat-Nakshatri P, Martin DA, Goulet RJ Jr and Sledge GW Jr: Constitutive activation of NF-kappaB during progression of breast cancer to hormone-independent growth. Mol Cell Biol 17: 3629-3639, 1997. (Pubitemid 27281838)
9. Wang W, Abbruzzese JL, Evans DB, Larry L, Cleary KR and Chiao PJ: The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells. Clin Cancer Res 5: 119-127, 1999. (Pubitemid 29045184)
10. Dhawan P and Richmond A: A novel NF-kappa B-inducing kinase-MAPK signaling pathway up-regulates NF-kappa B activity in melanoma cells. J Biol Chem 277: 7920-7928, 2002. (Pubitemid 34968242)
11. Lind DS, Hochwald SN, Malaty J, et al: Nuclear factor-kappa B is up-regulated in colorectal cancer. Surgery 130: 363-369, 2001. (Pubitemid 32721692)
12. Lindholm PF, Bub J, Kaul S, Shidham VB and Kajdacsy-BallaA: The role of constitutive NF-kappaB activity in PC-3 human prostate cancer cell invasive behavior. Clin Exp Metastasis 18: 471-479, 2000. (Pubitemid 32844248)
13. Takada Y, Kobayashi Y and Aggarwal BB: Evodiamine abolishes constitutive and inducible NF-kappaB activation by inhibiting IkappaBalpha kinase activation, thereby suppressing NF-kappaB-regulated antiapoptotic and metastatic gene expression, up-regulating apoptosis, and inhibiting invasion. J Biol Chem 280: 17203-17212, 2005. (Pubitemid 41389187)
14. Maeda S, Hsu LC, Liu H, et al: Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing. Science307: 734-738, 2005. (Pubitemid 40194645)
15. Maeda S, Hikiba Y, Sakamoto K, et al: Ikappa B kinasebeta/nuclear factor-kappaB activation controls the development of liver metastasis by way of interleukin-6 expression. Hepatology50: 1851-1860, 2009.
16. Lewis CE and Pollard JW: Distinct role of macrophages in different tumor microenvironments. Cancer Res 66: 605-612, 2006. (Pubitemid 43165918)
17. Takeuchi O and Akira S: Toll-like receptors; their physiological role and signal transduction system. Int Immunopharmacol 1: 625-635, 2001. (Pubitemid 32206524)
18. Guha M and Mackman N: LPS induction of gene expression in human monocytes. Cell Signal 13: 85-94, 2001. (Pubitemid 32222977)
19. Aggarwal BB, Shishodia S, Sandur SK, Pandey MK and SethiG: Inflammation and cancer: how hot is the link? Biochem Pharmacol 72: 1605-1621, 2006. (Pubitemid 44666739)
20. Devalaraja MN, Wang DZ, Ballard DW and Richmond A: Elevated constitutive IkappaB kinase activity and IkappaB-alpha phosphorylation in Hs294T melanoma cells lead to increased basal MGSA/GRO-alpha transcription. Cancer Res 59: 1372-1377, 1999. (Pubitemid 29136272)
21. Andoh A, Takaya H, Saotome T, et al: Cytokine regulation of chemokine (IL-8, MCP-1, and RANTES) gene expression in human pancreatic periacinar myofibroblasts. Gastroenterology119: 211-219, 2000. (Pubitemid 30452595)
22. Mosser DM and Edwards JP: Exploring the full spectrum of macrophage activation. Nat Rev Immunol 8: 958-969, 2008.
23. Annunziata CM, Davis RE, Demchenko Y, et al: Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma. Cancer Cell 12: 115-130, 2007. (Pubitemid 47199123)
24. Kim S, Takahashi H, Lin WW, et al: Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis. Nature 457: 102-106, 2009.
25. Hagemann T, Lawrence T, McNeish I, et al: 'Re-educating' tumor-associated macrophages by targeting NF-kappaB. J Exp Med 205: 1261-1268, 2008. (Pubitemid 351831483)
26. Lin EY, Li JF, Gnatovskiy L, et al: Macrophages regulate the angiogenic switch in a mouse model of breast cancer. Cancer Res66: 11238-11246, 2006. (Pubitemid 46009952)
27. Naugler WE, Sakurai T, Kim S, et al: Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 317: 121-124, 2007. (Pubitemid 47056470)