Immune activation in the intestinal mucosa before the onset of colitis in Gαi2-deficient mice

Scandinavian Journal of Immunology

Volumn 52, Issue 1, 2000, Pages 80-90

  Ohman ^a   Franzen ^b   Rudolph, ^c   Harriman, ^d   Hornquist, Hultgren ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b ÖREBRO MEDICAL CENTRE HOSPITAL   (Sweden)

^c UNIVERSITY OF ZURICH   (Switzerland)

^d CENTOCOR INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CD19 ANTIGEN; CD4 ANTIGEN; CD45RB ANTIGEN; GAMMA INTERFERON; GUANINE NUCLEOTIDE BINDING PROTEIN; HERMES ANTIGEN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; INTEGRIN RECEPTOR; INTERLEUKIN 1BETA; L SELECTIN; PROTEIN SUBUNIT; T LYMPHOCYTE ANTIGEN; TROPOMYOSIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HISTOPATHOLOGY; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOGLOBULIN PRODUCTION; IMMUNOLOGICAL MEMORY; IMMUNOPATHOGENESIS; IMMUNOSTIMULATION; INTESTINE FLORA; INTESTINE MUCOSA; LYMPHOCYTE SUBPOPULATION; MALE; MOUSE; MUCOSAL IMMUNITY; NEUTROPHILIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; ULCERATIVE COLITIS; WEIGHT REDUCTION;

ANIMALS; ANTIBODIES, BACTERIAL; AUTOANTIBODIES; COLITIS; CYTOKINES; FEMALE; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; INTESTINAL MUCOSA; MALE; MICE; NEUTROPHILS; TROPOMYOSIN; WEIGHT LOSS;

EID: 0005220480     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.2000.00759.x     Document Type: Article

References (47)

1. 1 Hamilton SR, Morson BC. Ulcerative colitis pathology. In: Haubrich WS, Schaffner F, Berk JE, eds, Gastroenterology, 5th edn. Philadelphia: WB Saunders, 1995;1326-37.
2. 2 Whelan G. Overwiev of etiology, pathogenesis and epidemiology of inflammatory bowel disease. In: Haubrich WS, Schaffner F, Berk JE, eds, Gastroenterology, 5th edn. Philadelphia: WB Saunders, 1995;1318-25.
3. 3 Elson CO, Sartor RB, Tennyson GS et al. Experimental models of inflammatory bowel disease. Gastroenterology 1995;10:1344-67.
4. 4 Reinecker HC, Steffen M, Witthoeft T et al. Enhanced secretion of tumor necrosis factor-alpha, IL-6 and IL-1β by isolated lamina propria mononuclear cells from patients with ulcerative colitis and Crohn's disease. Clin Exp Immunol 1993;94:174-81.
5. 5 Derkx B, Taminiau J, Radema S et al. Tumor-necrosis-factor antibody treatment in Crohn's disease. Lancet 1993;342:173-4.
6. 6 Shanahan F, Targan SR. Mechanisms of tissue injury in inflammatory bowel disease. In: MacDermott RP, Stenson WF, eds, Current Topics in Gastroenterology. Inflammatory Bowel Disease. New York: Elsevier, 1992;77-94.
7. 7 Satsangi J, Parkes M, Louis E et al. Two stage genome-wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12. Nat Genet 1996;14:199-202.
8. 8 Rudolph U, Finegold MJ, Rich SS et al. Ulcerative colitis and adenocarcinoma of the colon in Gαi2-deficient mice. Nat Genet 1995;10:143-51.
9. 9 Daub H, Weiss FU, Wallasch C et al. Role of transactivation of the EGF receptor in signaling by G-protein-couples receptors. Nature 1996;379:557-60.
10. 10 Saklatvala J, Rawlinson L, Marshall CJ et al. Interleukin 1 and tumor necrosis factor activate the mitogen-activated protein (MAP) kinase kinase in cultured cells. FEBS Lett 1993;334:189-92.
11. a C-terminal antibodies. Proc Natl Acad Sci 1989;86:7809-13.
12. i2 inhibit cyclic AMP accumulation. Nature 1991;351:63-5.
13. 13 Winitz S, Russell M, Qiant NX et al. Involvement of Ras and Raf in the Gi-coupled acetylcholine muscarinic receptor activation of mitogen-activated protein (MAP) kinase kinase and MAP kinase. J Biol Chem 1993;268:19196-9.
14. 14 Chaffin KE, Perlmutter RM. A pertussis toxin-sensitive process controls thymocyte emigration. Eur J Immunol 1991;21:2565-73.
15. 15 Arai H, Tsou CL, Charo IF. Chemotaxis in a lymphocyte cell line transfected with C-C chemokine receptor 2B: evidence that directed migration is mediated by betagamma dimers released by activation of Galphai-coupled receptors. Proc Natl Acad Sci 1997;94:14495-9.
16. + lamina propria cell lines: phenotypic and functional characterization. Immunology 1992;75:66-73.
17. 17 Kopf M, Brombacher F, Köhler G et al. IL-4 deficient Balb/C mice resist infection with Leishmania major. J Exp Med 1996;184: 1127-36.
18. + T cells and proinflammatory Th1-type cytokines. J Immunol 1997;158: 1068-77.
19. 19 Elson CO, Eadling W, Lefkowitz J. A lavage technique allowing repeated measurement of IgA antibody in mouse intestinal secretions. J Immunol Methods 1984;67:101-8.
20. 20 Kenneth RH. A new dimension in biological analyses. In: Kenneth RH, McKearn TJ, Bechtol KB, eds, Hybridomas. New York: Plenum Press, 1981;376-7.
21. 21 McCarthy DA, Ramptom DS, Liu YC. Peripheral blood neutrophils in inflammatory bowel disease. Morphological evidence of in vivo activation in active disease. Clin Exp Immunol 1991;86:489-93.
22. 22 Das K, Dasgupta A, Mandal A et al. Autoimmunity to cytoskeletal protein Tropomyosin. J Immunol 1993;150:2487-93.
23. 23 Kirsner JB, Shorter RG. Recent developments in 'nonspecific' inflammatory bowel disease (first of two parts). N Engl J Med 1982;306:775-85.
24. 24 Kirsner JB, Shorter RG. Recent developments in 'nonspecific' inflammatory bowel disease (second of two parts). N Engl J Med 1982;306:837-48.
25. 25 Buller HA. Problems in diagnosis of IBD in children. Neth J Med 1997;50:8-11.
26. 26 Tancrède C. Role of human microflora in health and disease. Eur J Microbiol Infect Dis 1992;11:1012-15.
27. 27 Beagley KW, Fujihashi K, Lagoo AS et al. Differences in intraepithelial lymphocyte T cell subsets isolated from murine small versus large intestine. J Immunol 1995;154:5611-19.
28. 28 Camerini V, Panwala C, Kronenberg M. Regional specialization of the mucosal immune system. J Immunol 1993;151:1765-76.
29. 29 Boll G, Reimann J. Lamina propria T cell subsets in the small and large intestine of euthymic and athymic mice. Scand J Immunol 1995;42:191-201.
30. 30 Helgeland L, Vaage JT, Rolstad B et al. Regional phenothypic specialization of intraepithelial lymphocytes in the rat intestine does not depend on microbial colonization. Scand J Immunol 1997;46:349-57.
31. 31 Berlin C, Berg EL, Briskin MJ et al. α4β7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. Cell 1993;74:185-95.
32. 32 Cepek KL, Shaw SK, Parker CM et al. Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the αEβ7 integrin. Nature 1994;372:190-3.
33. M290β7 (αEβ7). Eur J Immunol 1995;25:852-6.
34. 34 Salmi M, Andrew DP, Butcher EC et al. Dual binding capacity of mucosal immunoblasts to mucosal and synovial endothelium in humans: dissection of the molecular mechanisms. J Exp Med 1995;181:137-49.
35. 35 Burgio VL, Fais S, Boirivant M et al. Peripheral monocyte and naïve T cell recruitment and activation in Crohn's disease. Gastroenterology 1995;109:1029-37.
36. + T cells. J Immunol 1997;158:2099-106.
37. 37 McDonald SAC, Palmen MJHJ, van Rees EP et al. Characterization of the mucosal cell-mediated immune response in IL-2 knock-out mice before and after onset of colitis. Immunology 1997;91:73-80.
38. 38 Sadlack B, Merz H, Schorle H et al. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 1993;75:253-61.
39. 39 Kuhn R, Lohler J, Rennick D et al. Interleukin-10 deficient mice develop chronic enterocolitis. Cell 1993;75:263-74.
40. high T cells to SCID recipients. J Immunol 1997;158: 3464-73.
41. 41 Taurog JD, Richardson JA, Croft JA et al. The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats. J Exp Med 1994;180:2359-64.
42. 42 Strober W, Ehrhardt RO. Chronic intestinal inflammation, an unexpected outcome in cytokine or T cell receptor mutant mice. Cell 1993;75:203-5.
43. 43 Sartor RB. The influence of normal microbial flora on the development of chronic mucosal inflammation. Res Immunol 1997;148: 567-76.
44. 44 Duchmann R, Neurath MF, Meyer zum Buschenfelde KH. Responses to self and non-self intestinal microflora in health and inflammatory bowel disease. Res Immunol 1997;148:589-94.
45. 45 Duchmann R, Kaiser I, Hermann E et al. Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD). Clin Exp Immunol 1995;102:448-55.
46. 46 Hibi TB, Ohara M, Toda K et al. In vitro anticolon antibody production by mucosal or peripheral blood lymphocytes from patients with ulcerative colitis. Gut 1990;31:1371-6.
47. 47 Hamilton MI, Bradley NJ, Srai S et al. Autoimmunity in ulcerative colitis: tropomyosin is not the major antigen determinant of the Das monoclonal antibody. Clin Exp Immunol 1995;99:404-11.