메뉴 건너뛰기




Volumn 9, Issue 1, 2009, Pages 24-30

SSRIs act as selective brain steroidogenic stimulants (SBSSs) at low doses that are inactive on 5-HT reuptake

Author keywords

[No Author keywords available]

Indexed keywords

17BETA (N,N DIISOPROPYLCARBAMOYL) ANDROST 3,5DIENE 3 CARBOXYLIC ACID; 3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; BENZODIAZEPINE; CARBOXYLIC ACID DERIVATIVE; FLUOXETINE; FLUVOXAMINE; NEUROSTEROID; NORFLUOXETINE; PAROXETINE; SEROTONIN; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; SKF 105111; UNCLASSIFIED DRUG;

EID: 59349112888     PISSN: 14714892     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coph.2008.12.006     Document Type: Review
Times cited : (131)

References (46)
  • 2
    • 31444441701 scopus 로고    scopus 로고
    • New approaches to antidepressant drug discovery: beyond monoamines
    • Berton O., and Nestler I.J. New approaches to antidepressant drug discovery: beyond monoamines. Nat Rev Neurosci 7 (2006) 137-151
    • (2006) Nat Rev Neurosci , vol.7 , pp. 137-151
    • Berton, O.1    Nestler, I.J.2
  • 3
    • 1642487147 scopus 로고    scopus 로고
    • Psychobiological mechanisms of resilience and vulnerability: implications for successful adaptation to extreme stress
    • Charney D.S. Psychobiological mechanisms of resilience and vulnerability: implications for successful adaptation to extreme stress. Am J Psychiatry 161 (2004) 195-216
    • (2004) Am J Psychiatry , vol.161 , pp. 195-216
    • Charney, D.S.1
  • 4
    • 1242263295 scopus 로고    scopus 로고
    • From monoamines to genomic targets: a paradigm shift for drug discovery in depression
    • Wong M.L., and Licinio J. From monoamines to genomic targets: a paradigm shift for drug discovery in depression. Nat Rev Drug Discov 3 (2004) 136-151
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 136-151
    • Wong, M.L.1    Licinio, J.2
  • 5
    • 3042631898 scopus 로고    scopus 로고
    • Antidepressants and brain monoaminergic systems: a dimensional approach to understanding their behavioural effects in depression and anxiety disorders
    • Morilak D., and Frazer A. Antidepressants and brain monoaminergic systems: a dimensional approach to understanding their behavioural effects in depression and anxiety disorders. . Int J Neuropsychopharmacol 7 (2004) 193-218
    • (2004) . Int J Neuropsychopharmacol , vol.7 , pp. 193-218
    • Morilak, D.1    Frazer, A.2
  • 7
    • 0029884812 scopus 로고    scopus 로고
    • Benzodiazepines on trial: a research strategy for their rehabilitation
    • Costa E., and Guidotti A. Benzodiazepines on trial: a research strategy for their rehabilitation. TIPS 17 (1996) 192-200
    • (1996) TIPS , vol.17 , pp. 192-200
    • Costa, E.1    Guidotti, A.2
  • 8
    • 21744447595 scopus 로고    scopus 로고
    • A receptor
    • A receptor subtypes, mediate 'fast' synaptic inhibition in the mammalian brain, and consequently have anxiolytic, analgesic, anticonvulsant, sedative, hypnotic, and anesthetic properties.
    • A receptor subtypes, mediate 'fast' synaptic inhibition in the mammalian brain, and consequently have anxiolytic, analgesic, anticonvulsant, sedative, hypnotic, and anesthetic properties.
    • (2005) Nat Rev Neurosci , vol.6 , pp. 565-575
    • Bellelli, D.1    Lambert, J.J.2
  • 13
    • 47749083851 scopus 로고    scopus 로고
    • GABA(A)R plasticity during pregnancy: relevance to postpartum depression
    • Maguire J., and Mody I. GABA(A)R plasticity during pregnancy: relevance to postpartum depression. Neuron 59 (2008) 207-213
    • (2008) Neuron , vol.59 , pp. 207-213
    • Maguire, J.1    Mody, I.2
  • 14
    • 0029067030 scopus 로고
    • Gas chromatographic-mass fragmentographic quantitation of 3 alpha-hydroxy-5 alpha-pregnan-20-one (allopregnanolone) and its precursors in blood and brain of adrenalectomized and castrated rats
    • Measured subpicomolar concentrations of allopregnanolone in brain by gas chromatography-mass spectrometry and suggested that the brain is a steroidogenic organ that produces allopregnanolone in physiologically relevant concentrations.
    • Cheney D.L., Uzunov D., Costa E., and Guidotti A. Gas chromatographic-mass fragmentographic quantitation of 3 alpha-hydroxy-5 alpha-pregnan-20-one (allopregnanolone) and its precursors in blood and brain of adrenalectomized and castrated rats. J Neurosci 15 (1995) 4641-4650. Measured subpicomolar concentrations of allopregnanolone in brain by gas chromatography-mass spectrometry and suggested that the brain is a steroidogenic organ that produces allopregnanolone in physiologically relevant concentrations.
    • (1995) J Neurosci , vol.15 , pp. 4641-4650
    • Cheney, D.L.1    Uzunov, D.2    Costa, E.3    Guidotti, A.4
  • 15
    • 0002349845 scopus 로고
    • Steroid hormones in the brain: several mechanisms
    • Fuxe K., Gustafson J.A., and Wettenberg L. (Eds), Pergamon, Elmsford, NY. Reported for the first time that the biosynthesis of neurosteroids in the rat brain is independent of the supply by peripheral endocrine glands. Several biological functions have been proposed for neurosteroids.
    • Baulieu E.E. Steroid hormones in the brain: several mechanisms. In: Fuxe K., Gustafson J.A., and Wettenberg L. (Eds). Steroid Hormone Regulation of the Brain (1981), Pergamon, Elmsford, NY 3-14. Reported for the first time that the biosynthesis of neurosteroids in the rat brain is independent of the supply by peripheral endocrine glands. Several biological functions have been proposed for neurosteroids.
    • (1981) Steroid Hormone Regulation of the Brain , pp. 3-14
    • Baulieu, E.E.1
  • 19
    • 0029970863 scopus 로고    scopus 로고
    • Fluoxetine-elicited changes in brain neurosteroid content measured by negative ion mass fragmentography
    • Fluoxetine dose-dependently increased the content of allopregnanolone in several brain regions of the rat suggesting that a fluoxetine stimulation of brain allopregnanolone biosynthesis might be operative in the anxiolytic and antidysphoric actions of this drug.
    • Uzunov D.P., Cooper T.B., Costa E., and Guidotti A. Fluoxetine-elicited changes in brain neurosteroid content measured by negative ion mass fragmentography. Proc Natl Acad Sci U S A 93 (1996) 12599-12604. Fluoxetine dose-dependently increased the content of allopregnanolone in several brain regions of the rat suggesting that a fluoxetine stimulation of brain allopregnanolone biosynthesis might be operative in the anxiolytic and antidysphoric actions of this drug.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 12599-12604
    • Uzunov, D.P.1    Cooper, T.B.2    Costa, E.3    Guidotti, A.4
  • 20
    • 0032212066 scopus 로고    scopus 로고
    • Can the antidysphoric and anxiolytic profiles of selective serotonin reuptake inhibitors be related to their ability to increase brain 3 alpha, 5 alpha-tetrahydroprogesterone (allopregnanolone) availability?
    • Guidotti A., and Costa E. Can the antidysphoric and anxiolytic profiles of selective serotonin reuptake inhibitors be related to their ability to increase brain 3 alpha, 5 alpha-tetrahydroprogesterone (allopregnanolone) availability?. Biol Psychiatry 44 (1998) 865-873
    • (1998) Biol Psychiatry , vol.44 , pp. 865-873
    • Guidotti, A.1    Costa, E.2
  • 22
    • 33748901641 scopus 로고    scopus 로고
    • Decreased cerebrospinal fluid allopregnanolone levels in women with posttraumatic stress disorder
    • This study suggests that a dysfunction of GABAergic neurotransmission in PTSD may be induced by lower brain allopregnanolone levels.
    • Rasmusson A.M., Pinna G., Paliwal P., Weisman D., Gottschalk C., Charney D., Krystal J., and Guidotti A. Decreased cerebrospinal fluid allopregnanolone levels in women with posttraumatic stress disorder. Biol Psychiatry 60 (2006) 704-713. This study suggests that a dysfunction of GABAergic neurotransmission in PTSD may be induced by lower brain allopregnanolone levels.
    • (2006) Biol Psychiatry , vol.60 , pp. 704-713
    • Rasmusson, A.M.1    Pinna, G.2    Paliwal, P.3    Weisman, D.4    Gottschalk, C.5    Charney, D.6    Krystal, J.7    Guidotti, A.8
  • 23
    • 0033198566 scopus 로고    scopus 로고
    • Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives
    • Rupprecht R., and Holsboer F. Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives. Trend Neurosci 9 (1999) 410-416
    • (1999) Trend Neurosci , vol.9 , pp. 410-416
    • Rupprecht, R.1    Holsboer, F.2
  • 26
    • 44449155724 scopus 로고    scopus 로고
    • Decreased corticolimbic allopregnanolone expression during social isolation enhances contextual fear: a model relevant for posttraumatic stress disorder
    • Protracted social isolation of mice combined with contextual fear conditioning exposure may be a suitable model to study the neurochemical correlates of emotion and anxiety spectrum disorders relating to PTSD. Selective activation of neurosteroidogenesis may be a useful intervention in PTSD therapy.
    • Pibiri F., Nelson M., Guidotti A., Costa E., and Pinna G. Decreased corticolimbic allopregnanolone expression during social isolation enhances contextual fear: a model relevant for posttraumatic stress disorder. Proc Natl Acad Sci U S A 105 (2008) 5567-5572. Protracted social isolation of mice combined with contextual fear conditioning exposure may be a suitable model to study the neurochemical correlates of emotion and anxiety spectrum disorders relating to PTSD. Selective activation of neurosteroidogenesis may be a useful intervention in PTSD therapy.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 5567-5572
    • Pibiri, F.1    Nelson, M.2    Guidotti, A.3    Costa, E.4    Pinna, G.5
  • 27
    • 33744504184 scopus 로고    scopus 로고
    • Fluoxetine and norfluoxetine stereospecifically and selectively increase brain neurosteroid content at doses inactive on 5-HT reuptake
    • This review provides evidence on new mechanisms of pharmacological action of SSRI and concludes that the term 'SSRI' may be misleading in defining the pharmacological profile of fluoxetine and its congeners. The term 'selective brain steroidogenic stimulants' (SBSSs) is proposed.
    • Pinna G., Costa E., and Guidotti A. Fluoxetine and norfluoxetine stereospecifically and selectively increase brain neurosteroid content at doses inactive on 5-HT reuptake. Psychopharmacology 186 (2006) 362-372. This review provides evidence on new mechanisms of pharmacological action of SSRI and concludes that the term 'SSRI' may be misleading in defining the pharmacological profile of fluoxetine and its congeners. The term 'selective brain steroidogenic stimulants' (SBSSs) is proposed.
    • (2006) Psychopharmacology , vol.186 , pp. 362-372
    • Pinna, G.1    Costa, E.2    Guidotti, A.3
  • 28
    • 0037452699 scopus 로고    scopus 로고
    • In socially isolated mice, the reversal of brain allopregnanolone down-regulation mediates the anti-aggressive action of fluoxetine
    • In socially isolated mice, fluoxetine and norfluoxetine stereospecifically reverse brain allopregnanolone downregulation and reduce aggression. The effects of fluoxetine and norfluoxetine on 5-HT reuptake occur for doses that are 50-fold higher and are not stereospecific.
    • Pinna G., Dong E., Matsumoto K., Costa E., and Guidotti A. In socially isolated mice, the reversal of brain allopregnanolone down-regulation mediates the anti-aggressive action of fluoxetine. Proc Natl Acad Sci U S A 100 (2003) 2035-2040. In socially isolated mice, fluoxetine and norfluoxetine stereospecifically reverse brain allopregnanolone downregulation and reduce aggression. The effects of fluoxetine and norfluoxetine on 5-HT reuptake occur for doses that are 50-fold higher and are not stereospecific.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 2035-2040
    • Pinna, G.1    Dong, E.2    Matsumoto, K.3    Costa, E.4    Guidotti, A.5
  • 29
    • 36749048035 scopus 로고    scopus 로고
    • Downregulation of neurosteroid biosynthesis in cortico-limbic circuits mediates social isolation induced behavior in mice
    • The expression of 5a-RI mRNA is specifically downregulated in glutamatergic pyramidal neurons that converge on the amygdala from cortical and hippocampal regions and may account for the appearance of behavioral disorders such as anxiety, aggression, and cognitive dysfunction.
    • Agís-Balboa R.-C., Pinna G., Pibiri F., Kadriu B., Costa E., and Guidotti A. Downregulation of neurosteroid biosynthesis in cortico-limbic circuits mediates social isolation induced behavior in mice. Proc Natl Acad Sci U S A 104 (2007) 18736-18741. The expression of 5a-RI mRNA is specifically downregulated in glutamatergic pyramidal neurons that converge on the amygdala from cortical and hippocampal regions and may account for the appearance of behavioral disorders such as anxiety, aggression, and cognitive dysfunction.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 18736-18741
    • Agís-Balboa, R.-C.1    Pinna, G.2    Pibiri, F.3    Kadriu, B.4    Costa, E.5    Guidotti, A.6
  • 30
    • 0035663937 scopus 로고    scopus 로고
    • The socially-isolated mouse: a model to study the putative role of allopregnanolone and 5alpha-dihydroprogesterone in psychiatric disorders
    • Guidotti A., Dong E., Matsumoto K., Pinna G., Rasmusson A.M., and Costa E. The socially-isolated mouse: a model to study the putative role of allopregnanolone and 5alpha-dihydroprogesterone in psychiatric disorders. Brain Res Rev 37 (2001) 110-115
    • (2001) Brain Res Rev , vol.37 , pp. 110-115
    • Guidotti, A.1    Dong, E.2    Matsumoto, K.3    Pinna, G.4    Rasmusson, A.M.5    Costa, E.6
  • 31
    • 0033914535 scopus 로고    scopus 로고
    • Social isolation-induced decreases in both the abundance of neuroactive steroids and GABAA receptor function in rat brain
    • Serra M., Pisu M.G., Littera M., Papi G., Sanna E., Tuveri F., Usala L., Purdy R.H., and Biggio G.J. Social isolation-induced decreases in both the abundance of neuroactive steroids and GABAA receptor function in rat brain. J Neurochem 75 (2000) 732-740
    • (2000) J Neurochem , vol.75 , pp. 732-740
    • Serra, M.1    Pisu, M.G.2    Littera, M.3    Papi, G.4    Sanna, E.5    Tuveri, F.6    Usala, L.7    Purdy, R.H.8    Biggio, G.J.9
  • 32
    • 51749097102 scopus 로고    scopus 로고
    • Neurosteroid biosynthesis regulates sexually dimorphic fear and aggressive behavior in mice
    • Pinna G., Pibiri F., Agis-Balboa R., Nelson M., Guidotti A., and Costa E. Neurosteroid biosynthesis regulates sexually dimorphic fear and aggressive behavior in mice. Neurochem Res 33 (2008) 1990-2007
    • (2008) Neurochem Res , vol.33 , pp. 1990-2007
    • Pinna, G.1    Pibiri, F.2    Agis-Balboa, R.3    Nelson, M.4    Guidotti, A.5    Costa, E.6
  • 33
    • 0033954998 scopus 로고    scopus 로고
    • A receptor agonist muscimol
    • Demonstrated for the first time that endogenous allopregnanolone physiologically upregulates GABAergic tone and by such a mechanism plays a permissive/facilitatory role on the muscimol-induced loss of the righting reflex.
    • A receptor agonist muscimol. Neuropharmacology 39 (2000) 440-448. Demonstrated for the first time that endogenous allopregnanolone physiologically upregulates GABAergic tone and by such a mechanism plays a permissive/facilitatory role on the muscimol-induced loss of the righting reflex.
    • (2000) Neuropharmacology , vol.39 , pp. 440-448
    • Pinna, G.1    Uzunova, V.2    Matsumoto, K.3    Puia, G.4    Mienville, J.-M.5    Costa, E.6    Guidotti, A.7
  • 34
    • 34250890703 scopus 로고    scopus 로고
    • Neural mechanisms of aggression
    • Nelson R.J., and Trainor B.C. Neural mechanisms of aggression. Nat Rev Neurosci 8 (2007) 536-546
    • (2007) Nat Rev Neurosci , vol.8 , pp. 536-546
    • Nelson, R.J.1    Trainor, B.C.2
  • 35
  • 36
    • 33747051450 scopus 로고    scopus 로고
    • Neurocircuitry models of posttraumatic stress disorder and extinction: human neuroimaging research-past, present, and future
    • Rauch S.L., Shin L.M., and Phelps EA. Neurocircuitry models of posttraumatic stress disorder and extinction: human neuroimaging research-past, present, and future. Biol Psychiatry 60 (2006) 376-382
    • (2006) Biol Psychiatry , vol.60 , pp. 376-382
    • Rauch, S.L.1    Shin, L.M.2    Phelps EA3
  • 37
    • 0034076609 scopus 로고    scopus 로고
    • Emotion circuits in the brain
    • LeDoux J.E. Emotion circuits in the brain. Annu Rev Neurosci 23 (2000) 155-158
    • (2000) Annu Rev Neurosci , vol.23 , pp. 155-158
    • LeDoux, J.E.1
  • 38
    • 34548790136 scopus 로고    scopus 로고
    • The role of the medial prefrontal cortex-amygdala circuit in stress effects on the extinction of fear
    • Akirav I., and Maroun M. The role of the medial prefrontal cortex-amygdala circuit in stress effects on the extinction of fear. Neural Plast (2007) 30873
    • (2007) Neural Plast , pp. 30873
    • Akirav, I.1    Maroun, M.2
  • 40
    • 0026503504 scopus 로고
    • Analysis of the enantiomers of fluoxetine and norfluoxetine in plasma and tissue using chiral derivatization and normal-phase liquid chromatography
    • Potts B.D., and Parli J. Analysis of the enantiomers of fluoxetine and norfluoxetine in plasma and tissue using chiral derivatization and normal-phase liquid chromatography. J Liquid Chromatogr 15 (1992) 665-681
    • (1992) J Liquid Chromatogr , vol.15 , pp. 665-681
    • Potts, B.D.1    Parli, J.2
  • 41
    • 1942501614 scopus 로고    scopus 로고
    • Fluoxetine and norfluoxetine stereospecifically facilitate pentobarbital sedation by increasing neurosteroids
    • Normalization of pentobarbital-induced sedation elicited by the S-isomers of fluoxetine and norfluoxetine is related to the reversal of the downregulation of brain Allo content and is independent of SSRI activity.
    • Pinna G., Costa E., and Guidotti A. Fluoxetine and norfluoxetine stereospecifically facilitate pentobarbital sedation by increasing neurosteroids. Proc Natl Acad Sci U S A 101 (2004) 6222-6225. Normalization of pentobarbital-induced sedation elicited by the S-isomers of fluoxetine and norfluoxetine is related to the reversal of the downregulation of brain Allo content and is independent of SSRI activity.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 6222-6225
    • Pinna, G.1    Costa, E.2    Guidotti, A.3
  • 42
    • 1642564005 scopus 로고    scopus 로고
    • Chronic antidepressants reverse cerebrocortical allopregnanolone decline in the olfactory-bulbectomized rat
    • Uzunova V., Wrynn A.S., Kinnunen A., Ceci M., Kohler C., and Uzunov D.P. Chronic antidepressants reverse cerebrocortical allopregnanolone decline in the olfactory-bulbectomized rat. Eur J Pharmacol 486 (2004) 31-34
    • (2004) Eur J Pharmacol , vol.486 , pp. 31-34
    • Uzunova, V.1    Wrynn, A.S.2    Kinnunen, A.3    Ceci, M.4    Kohler, C.5    Uzunov, D.P.6
  • 43
    • 33744503400 scopus 로고    scopus 로고
    • Relevance of endogenous 3alpha-reduced neurosteroids to depression and antidepressant action
    • Uzunova V., Sampson L., and Uzunov D.P. Relevance of endogenous 3alpha-reduced neurosteroids to depression and antidepressant action. Psychopharmacology 186 (2006) 351-361
    • (2006) Psychopharmacology , vol.186 , pp. 351-361
    • Uzunova, V.1    Sampson, L.2    Uzunov, D.P.3
  • 44
    • 0033539661 scopus 로고    scopus 로고
    • Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes
    • Griffin L.D., and Mellon S.H. Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes. Proc Natl Acad Sci U S A 96 (1999) 13512-13517
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 13512-13517
    • Griffin, L.D.1    Mellon, S.H.2
  • 45
    • 48349096449 scopus 로고    scopus 로고
    • Behavioural neuroscience: the circuit of fear
    • Sah P., and Westbrook R.F. Behavioural neuroscience: the circuit of fear. Nature 454 (2008) 589-590
    • (2008) Nature , vol.454 , pp. 589-590
    • Sah, P.1    Westbrook, R.F.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.