Design, synthesis and SAR study of hydroxychalcone inhibitors of human β-secretase (BACE1)

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 26, Issue 5, 2011, Pages 643-648

  Ma, Lei ^a,b   Yang, Zhengyi ^a   Li, Chenjing ^a   Zhu, Zhiyuan ^a   Shen, Xu ^a   Hu, Lihong ^a,b  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Alzheimer's disease; BACE1; Chalcone; Glycyrrhiza uralensis; SAR

Indexed keywords

BETA SECRETASE 2; CHALCONE; GLYCYRRHIZA URALENSIS EXTRACT; HYDROXYL GROUP; ISOLIQUIRITIGENIN;

ARTICLE; DRUG DESIGN; DRUG SYNTHESIS; GLYCYRRHIZA URALENSIS; IC 50; INHIBITION KINETICS; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

AMYLOID PRECURSOR PROTEIN SECRETASES; CHALCONES; DRUG DESIGN; ENZYME ACTIVATION; ENZYME INHIBITORS; GLYCYRRHIZA URALENSIS; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

GLYCYRRHIZA URALENSIS;

EID: 80052850006     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.3109/14756366.2010.543420     Document Type: Article

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