Integrated role of desferrioxamine and phenserine targeted to an iron-responsive element in the APP-mRNA 5′-untranslated region

Annals of the New York Academy of Sciences

Volumn 1035, Issue , 2004, Pages 34-48

  Venti, Amanda ^a   Giordano, Tony ^b   Eder, Paul ^a   Bush, Ashley I ^a   Lahiri, Debomoy K ^c   Greig, Nigel H ^d   Rogers, Jack T ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b LOUISIANA STATE UNIVERSITY   (United States)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Alzheimer's disease; Amyloid precursor protein (APP); Iron responsive elements

Indexed keywords

5 AMINOLEVULINATE SYNTHASE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CHELATING AGENT; CHOLINESTERASE INHIBITOR; CLIOQUINOL; COPPER; DEFEROXAMINE; DIMERCAPROL; FERRIC ION; FERRITIN; FERROPORTIN 1; LEAD; MENKES PROTEIN; MERCURY; MESSENGER RNA; METALLOPROTEIN; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; PAROXETINE; PHENSERINE; TETRATHIOMOLYBDIC ACID; TRANSFERRIN; TRANSFORMING GROWTH FACTOR BETA; ZINC;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ALZHEIMER DISEASE; CHELATION; CONFERENCE PAPER; CONTROLLED STUDY; DRUG MECHANISM; DRUG TARGETING; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBROBLAST; HUMAN; HUMAN CELL; IRON RESPONSIVE ELEMENT; LENS EPITHELIUM; NEUROBLASTOMA CELL; NONHUMAN; PROTEIN EXPRESSION; PROTEIN SECRETION; REPORTER GENE; TRANSCRIPTION REGULATION; TRANSLATION REGULATION; WESTERN BLOTTING;

EID: 14944344156     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1332.003     Document Type: Conference Paper

References (38)

1. SAMPIETRO, M. et al. 2001. The hemochromatosis gene affects the age of onset of sporadic Alzheimer's disease. Neurobiol Aging 22: 563-568.
2. LOVELL, M.A. et al. 1998. Copper, iron and zinc in Alzheimer's disease senile plaques. J. Neurol. Sci. 158: 47-52.
3. ROGERS, J.T. et al. 1999. Translation of the alzheimer amyloid precursor protein mRNA is up- regulated by interleukin-1 through 5′-untranslated region sequences. J. Biol. Chem. 274: 6421-6431.
4. RAJAGOPALAN, L.E. & J.S. MALTER. 2000. Growth factor-mediated stabilization of amyloid precursor protein mRNA is mediated by a conserved 29-nucleotide sequence in the 3′-untranslated region. J. Neurochem. 74: 52-59.
5. AMARA, F.M. et al. 1999. TGF-beta(1), regulation of alzheimer amyloid precursor protein mRNA expression in a normal human astrocyte cell line: mRNA stabilization. Brain Res. Mol. Brain Res. 71: 42-49.
6. ZAIDI, S.H. & J.S. MALTER. 1994. Amyloid precursor protein mRNA stability is controlled by a 29-base element in the 3′-untranslated region. J. Biol. Chem. 269: 24001-4013.
7. ROGERS, J.T. 1996. Ferritin translation by interleukin-1: the role of sequences upstream of the start codons of the heavy and light subunit genes. Blood 87: 2525-2537.
8. DE SAUVAGE, F., V. KRUYS, O. MARINX, et al. 1992. Alternative polyadenylation of the amyloid protein precursor mRNA. EMBO J. 11: 3099-3103.
9. MBELLA, E.G. et al. 2000. A GG nucleotide sequence of the 3′ untranslated region of amyloid precursor protein mRNA plays a key role in the regulation of translation and the binding of proteins. Mol. Cell Biol. 20: 4572-4579.
10. PINERO, D.J., J. HU & J.R. CONNOR. 2000. Alterations in the interaction between iron regulatory proteins and their iron responsive element in normal and Alzheimer's diseased brains [In Process Citation]. Cell. Mol. Biol. (Noisy-Le-Grand) 46: 761-776.
11. LA VAUTE, T. et al. 2001. Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice. Nat. Genet. 27: 209-214.
12. MELOFORS, O., B. GOOSSEN, B. JOHANSSON, et al. 1993. Translational control of 5-amino-levulinate synthase mRNA by iron-responsive elements in erythroid cells. J. Biol. Chem. 268: 5974-5978.
13. Cox, T.C. et al. 1991. Human erythroid 5-aminolevulinate synthase: promoter analysis and identification of an iron-responsive element in the mRNA. EMBO J. 10: 1891-1902.
14. COX, L.A. & G.S. ADRIAN. 1993. Post-transcriptional regulation of chimeric human transferrin genes by iron. Biochemistry 32: 4738-4745.
15. CHUNG, J., D.J. HAILE & M. WESSLING-RESNICK. 2004. Copper-induced ferroportin-1 expression in J774 macrophages is associated with increased iron efflux. Proc. Natl. Acad. Sci. USA 101: 2700-2705.
16. KNUTSON, M.D. et al. 2003. Iron loading and erythrophagocytosis increase ferroportin 1 (FPN1) expression in J774 macrophages. Blood 102: 4191-4197.
17. GUNSHIN, H. et al. 2001. Iron-dependent regulation of the divalent metal ion transporter. FEBS Lett. 509: 309-316.
18. GUNSHIN, H. et al. 1997. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 388: 482-488.
19. ROGERS, J.T. et al. 2002. An iron-responsive element type II in the 5′-untranslated region of the Alzheimer's amyloid precursor protein transcript. J. Biol. Chem. 277: 45518-45528.
20. NILSSON, L., J. ROGERS & H. POTTER. 1998. The essential role of inflammation and induced gene expression in the pathogenic pathway of Alzheimer's disease. Front. Biosci. 3: 436-446.
21. ZUKER, M. 1989. On finding all suboptimal foldings of an RNA molecule. Science 244: 48-52.
22. FENG, Y. et al. 1995. Translational suppression by trinucleotide repeat expansion at FMR1. Science 268: 731-734.
23. SVITKIN, Y.V. et al. 2001. The requirement for eukaryotic initiation factor 4A (elF4A) in translation is in direct proportion to the degree of mRNA 5′ secondary structure. RNA 7: 382-394.
24. ROGERS, J.T., P.S. EDER, X. HUANG et al. 2002. Alzheimer's disease drug discovery targeted to the APP mRNA 5′-untranslated region. J. Mol. Neurosci. 19: 77-82.
25. HAROUTUNIAN, V. et al. 1997. Pharmacological modulation of Alzheimer's beta-amyloid precursor protein levels in the CSF of rats with forebrain cholinergic system lesions. Brain Res. Mol. Brain Res. 46: 161-168.
26. PAYTON, S. et al. 2003. Drug discovery targeted to the Alzheimer's APP mRNA 5′-untranslated region: the action of paroxetine and dimercaptopropanol. J. Mol. Neurosci. 20: 267-275.
27. MORSE, L. et al. 2004. FDA pre-approved drugs targeted to the translational regulation and processing of the amyloid precursor protein. J. Mol. Neurosci. 24: 129-136.
28. CHEN, C.Y. & P. SARNOW. 1995. Initiation of protein synthesis by the eukaryotic translational apparatus on circular RNAs. Science 268: 415-417.
29. THOMSON, A.M., J.T. ROGERS & P.J. LEEDMAN. 1999. Iron-regulatory proteins, iron-responsive elements and ferritin mRNA translation. Int. J. Biochem. Cell Biol. 31: 1139-1152.
30. PORSE, B.T. et al. 1999. UV-induced modifications in the peptidyl transferase loop of 23S rRNA dependent on binding of the streptogramin B antibiotic, pristinamycin IA. RNA 5: 585-595.
31. SHAW, K.T. et al. 2001. Phenserine regulates translation of beta-amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development. Proc. Natl. Acad. Sci. USA 98: 7605-7610.
32. WASCO, W. et al. 1993. Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor. Nat. Genet. 5: 95-100.
33. VON KOCH, C.S. et al. 1997. Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice. Neurobiol. Aging 18: 661-669.
34. BELLINGHAM, S.A. et al. 2004. Copper depletion down-regulates expression of Alzheimer's disease amyloid-beta precursor protein gene. J. Biol. Chem. In press.
35. KOSIK, K. et al. 2002. Discovery of compounds that will prevent tau pathology. J. Mol. Neurosci. 19: 261-266.
36. LU, M. & K. KOSIK. 2001. Competition for microtubule-binding with dual expression of tau missense and splice isoforms. Mol. Biol. Cell. 12: 171-184.
37. SHIN, R. et al. 2003. A novel trivalent cation chelator Feralex dissociates binding of aluminum and iron associated with hyperphosphorylated tau of Alzheimer's disease. Brain Res. 961: 139-146.
38. POLIZZI, S. et al. 2002. Neurotoxic effect of aluminum among foundry workers and Alzheimer's disease. Neurotoxicology 23: 761-774.