Nucleobase transport by human equilibrative nucleoside transporter 1 (hENT1)

Journal of Biological Chemistry

Volumn 286, Issue 37, 2011, Pages 32552-32562

  Yao, Sylvia Y M ^a   Ng, Amy M L ^a   Cass, Carol E ^a,b   Baldwin, Stephen A ^c   Young, James D ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b CROSS CANCER INSTITUTE   (Canada)

^c UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

5-FLUOROURACIL; 6-MERCAPTOPURINE; AMINO ACID SEQUENCE; BINDING POCKETS; CYSTEINE RESIDUES; EXPRESSION VECTORS; HETEROLOGOUS EXPRESSION; NANOMOLAR CONCENTRATION; NUCLEOBASES; NUCLEOSIDE TRANSPORTERS; ORTHOLOGS; PYRIMIDINE BASIS; PYRIMIDINE NUCLEOSIDES; RIBONUCLEOSIDES; SITE DIRECTED MUTAGENESIS; TRANSMEMBRANE HELICES; TRANSPORT ACTIVITY; TRANSPORT EFFICIENCY; TRANSPORTER PROTEINS; VICKERS; WILD TYPES; XENOPUS OOCYTE;

AMINO ACIDS; AROMATIC COMPOUNDS; ENZYME INHIBITION; MAMMALS;

BIOMOLECULES;

ADENINE; CYSTEINE; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1; FLUOROURACIL; GUANINE; HYPOXANTHINE; MERCAPTOPURINE; NITROBENZYLTHIOINOSINE; NUCLEIC ACID BASE; NUCLEOBASE TRANSPORTER; SERINE; THYMINE; URACIL; URIDINE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ENGINEERING; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; OOCYTE; PLASMID; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN TRANSPORT; SITE DIRECTED MUTAGENESIS; XENOPUS;

AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; BIOLOGICAL TRANSPORT, ACTIVE; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1; EQUILIBRATIVE-NUCLEOSIDE TRANSPORTER 2; HUMANS; MUTAGENESIS, SITE-DIRECTED; MUTATION, MISSENSE; NUCLEOSIDES; OOCYTES; RATS; RECOMBINANT PROTEINS; XENOPUS LAEVIS;

MAMMALIA; RATTUS;

EID: 80052783528     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.236117     Document Type: Article

References (57)

1. Zhang, J., Visser, F., King, K. M., Baldwin, S. A., Young, J. D., and Cass, C. E. (2007) Metastasis Rev. 26, 85-110
2. King, A. E., Ackley, M. A., Cass, C. E., Young, J. D., and Baldwin, S. A. (2006) Trends Pharmacol. Sci. 27, 416-425
3. Cabrita, M. A., Baldwin, S. A., Young, J. D., and Cass, C. E. (2002) Biochem. Cell. Biol. 80, 623-638
4. Young, J. D., Cheeseman, C. I., Mackey, J. R., Cass, C. E., and Baldwin, S. A. (2000) in Current Topics in Membranes (Barrett, K. E., and Donowitz, M., eds.) pp. 329-378, Academic Press, San Diego, CA
5. Griffith, D. A., and Jarvis, S. M. (1996) Biochim. Biophys. Acta 1286, 153-181
6. de Koning, H., and Diallinas, G. (2000) Mol. Membr. Biol. 17, 75-94
7. Gray, J. H., Owen, R. P., and Giacomini, K. M. (2004) Pflugers Arch. 447, 728-734
8. Baldwin, S. A., Beal, P. R., Yao, S. Y., King, A. E., Cass, C. E., and Young, J. D. (2004) Pflugers Arch. 447, 735-743
9. Young, J. D., Yao, S. Y., Sun, L., Cass, C. E., and Baldwin, S. A. (2008) Xenobiotica. 38, 995-1021
10. Parkinson, F. E., Damaraju, V. L., Graham, K., Yao, S. Y., Baldwin, S. A., Cass, C. E., and Young, J. D. (2011) Curr. Top. Med. Chem. 11, 948-972
11. Griffiths, M., Beaumont, N., Yao, S. Y., Sundaram, M., Boumah, C. E., Davies, A., Kwong, F. Y., Coe, I., Cass, C. E., Young, J. D., and Baldwin, S. A. (1997) Nat. Med. 3, 89-93
12. Griffiths, M., Yao, S. Y., Abidi, F., Phillips, S. E., Cass, C. E., Young, J. D., and Baldwin, S. A. (1997) Biochem. J. 328, 739-743
13. Yao, S. Y., Ng, A. M., Muzyka, W. R., Griffiths, M., Cass, C. E., Baldwin, S. A., and Young, J. D. (1997) J. Biol. Chem. 272, 28423-28430
14. Baldwin, S. A., Yao, S. Y., Hyde, R. J., Ng, A. M., Foppolo, S., Barnes, K., Ritzel, M. W.,Cass, C. E., and Young, J. D. (2005) J. Biol. Chem. 280, 15880-15887
15. Govindarajan, R., Leung, G. P., Zhou, M., Tse, C. M., Wang, J., and Unadkat, J. D. (2009) Am. J. Physiol. Gastrointest. Liver Physiol. 296, G910-G922
16. Engel, K., Zhou, M., and Wang, J. (2004) J. Biol. Chem. 279, 50042-50049
17. Barnes, K., Dobrzynski, H., Foppolo, S., Beal, P. R., Ismat, F., Scullion, E. R., Sun, L., Tellez, J., Ritzel, M. W., Claycomb, W. C., Cass, C. E., Young, J. D., Billeter-Clark, R., Boyett, M. R., and Baldwin, S. A. (2006) Circ. Res. 99, 510-519
18. Yao, S. Y., Ng, A. M., Vickers, M. F., Sundaram, M., Cass, C. E., Baldwin, S. A., and Young, J. D. (2002) J. Biol. Chem. 277, 24938-24948
19. Landfear, S. M., Ullman, B., Carter, N. S., and Sanchez, M. A. (2004) Eukaryot. Cell 3, 245-254
20. Parker, M. D., Hyde, R. J., Yao, S. Y., McRobert, L., Cass, C. E., Young, J. D., McConkey, G. A., and Baldwin, S. A. (2000) Biochem. J. 349, 67-75
21. Sundaram, M., Yao, S. Y., Ingram, J. C., Berry, Z. A., Abidi, F., Cass, C. E., Baldwin, S. A., and Young, J. D. (2001) J. Biol. Chem. 276, 45270-45275
22. Aronow, B., and Ullman, B. (1986) J. Biol. Chem. 261, 2014-2019
23. Liman, E. R., Tytgat, J., and Hess, P. (1992) Neuron 9, 861-871
24. Yao, S. Y., Cass, C. E., and Young, J. D. (2000) in Membrane Transport: A Practical Approach (Baldwin, S. A., ed.) pp. 47-78, Oxford University Press, New York
25. Baldwin, S. A., McConkey, G. A., Cass, C. E., and Young, J. D. (2007) Curr. Pharm. Des. 13, 569-580
26. Liu, K. H., and Tsay, Y. F. (2003) EMBO J. 22, 1005-1013
27. Plagemann, P. G., Wohlhueter, R. M., and Woffendin, C. (1988) Biochim. Biophys. Acta 947, 405-443
28. Gati, W. P., Paterson, A. R., Tyrrell, D. L., Cass, C. E., Moravek, J., and Robins, M. J. (1992) J. Biol. Chem. 267, 22272-22276
29. Griffith, D. A., Doherty, A. J., and Jarvis, S. M. (1992) Biochim. Biophys. Acta 1106, 303-310
30. Ullman, B., Patrick, J., and McCartan, K. (1987) Mol. Cell. Biol. 7, 97-103
31. Hoque, K. M., Chen, L., Leung, G. P., and Tse, C. M. (2008) Am. J. Physiol. Regul. Integr. Comp. Physiol. 294, R1988-R1995
32. Griffith, D. A., and Jarvis, S. M. (1993) J. Biol. Chem. 268, 20085-20090
33. Griffith, D. A., and Jarvis, S. M. (1994) Biochem. J. 303, 901-905
34. Barros, L. F. (1994) Am. J. Obstet. Gynecol. 171, 111-117
35. Washington, C. B., and Giacomini, K. M. (1995) J. Biol. Chem. 270, 22816-22819
36. Shayeghi, M., Akerman, R., and Jarvis, S. M. (1999) Biochim. Biophys. Acta 1416, 109-118
37. Kato, R., Maeda, T., Akaike, T., and Tamai, I. (2006) Am. J. Physiol. Endocrinol. Metab. 290, E968-E975
38. Kato, R., Maeda, T., Akaike, T., and Tamai, I. (2009) Biol. Pharm. Bull. 32, 450-455
39. Pantazopoulou, A., and Diallinas, G. (2007) FEMS Microbiol. Rev. 31, 657-675
40. Yamamoto, S., Inoue, K., Murata, T., Kamigaso, S., Yasujima, T., Maeda, J. Y., Yoshida, Y., Ohta, K. Y., and Yuasa, H. (2010) J. Biol. Chem. 285, 6522-6531
41. Caulfield, M. J., Munroe, P. B., O'Neill, D., Witkowska, K., Charchar, F. J., Doblado, M., Evans, S., Eyheramendy, S., Onipinla, A., Howard, P., Shaw-Hawkins, S., Dobson, R. J., Wallace, C., Newhouse, S. J., Brown, M., Connell, J. M., Dominiczak, A., Farrall, M., Lathrop, GM., Samani, N. J., Kumari, M., Marmot, M., Brunner, E., Chambers, J., Elliott, P., Kooner, J., Laan, M., Org, E., Veldre, G., Viigimaa, M., Cappuccio, F. P., Ji, C., Iacone, R., Strazzullo, P., Moley, K. H., and Cheeseman, C. (2008) PLoS Med. 5, e197
42. Smith, K. M., Ng, A. M., Yao, S. Y., Labedz, K. A., Knaus, E. E., Wiebe, L. I., Cass, C. E., Baldwin, S. A., Chen, X. Z.,Karpinski, E., and Young, J. D. (2004) J. Physiol. 558, 807-823
43. Ritzel, M. W., Yao, S. Y., Ng, A. M., Mackey, J. R., Cass, C. E., and Young, J. D. (1998) Mol. Membr. Biol. 15, 203-211
44. Ritzel, M. W., Ng, A. M., Yao, S. Y., Graham, K., Loewen, S. K., Smith, K. M., Ritzel, R. G., Mowles, D. A., Carpenter, P., Chen, X. Z., Karpinski, E., Hyde, R. J., Baldwin, S. A., Cass, C. E., and Young, J. D. (2001) J. Biol. Chem. 276, 2914-2927
45. Newstead, S., Drew, D., Cameron, A. D., Postis, V. L., Xia, X., Fowler, P. W., Ingram, J. C., Carpenter, E. P., Sansom, M. S., McPherson, M. J., Baldwin, S. A., and Iwata, S. (2011) EMBO J. 30, 417-426
46. Belt, J. A., and Noel, L. D. (1985) Biochem. J. 232, 681-688
47. Crawford, C. R., Patel, D. H., Naeve, C., and Belt, J. A. (1998) J. Biol. Chem. 273, 5288-5293
48. Ward, J. L., Sherali, A., Mo, Z. P., and Tse, C. M. (2000) J. Biol. Chem. 275, 8375-8381
49. Stein, W. D. (1986) in Transport and Diffusion across Cell Membrane, pp. 231-337, Academic Press, Orlando, FL
50. Nagai, K., Nagasawa, K., Kihara, Y., Okuda, H., and Fujimoto, S. (2007) Int. J. Pharm. 333, 56-61
51. Yao, S. Y., Sundaram, M., Chomey, E. G., Cass, C. E., Baldwin, S. A., and Young, J. D. (2001) Biochem. J. 353, 387-393
52. Young, J. D., Yao, S. Y., Cass, C. E., and Baldwin, S. A. (2003) Equilibrative Nucleoside Transport Proteins: Red Cell Transport in Health and Disease, pp. 321-337, Springer, Berlin
53. Abramson, J., Smirnova, I., Kasho, V., Verner, G., Kaback, H. R., and Iwata, S. (2003) Science 301, 610-615
54. Huang, Y., Lemieux, M. J., Song, J., Auer, M., and Wang, D. N. (2003) Science 301, 616-620
55. Arastu-Kapur, S., Arendt, C. S., Purnat, T., Carter, N. S., and Ullman, B. (2005) J. Biol. Chem. 280, 2213-2219
56. Papageorgiou, I., De Koning, H. P., Soteriadou, K., and Diallinas, G. (2008) Int. J. Parasitol. 38, 641-653
57. Valdés, R., Arastu-Kapur, S., Landfear, S. M., and Shinde, U. (2009) J. Biol. Chem. 284, 19067-19076