Kinetic and mutational analysis of the Trypanosoma brucei NBT1 nucleobase transporter expressed in Saccharomyces cerevisiae reveals structural similarities between ENT and MFS transporters

International Journal for Parasitology

Volumn 38, Issue 6, 2008, Pages 641-653

  Papageorgiou, I ^a,c   De Koning, H P ^b   Soteriadou, K ^c   Diallinas, G ^a  

^a UNIVERSITY OF ATHENS   (Greece)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c HELLENIC PASTEUR INSTITUTE   (Greece)

Author keywords

Antiparasitic drugs; Homology threading; Purine; Specificity; Structure function relationships

Indexed keywords

GUANOSINE; NUCLEOBASE TRANSPORTER; NUCLEOBASE TRANSPORTER 1; PURINE; UNCLASSIFIED DRUG;

DRUG; GENE EXPRESSION; KINETICS; MEMBRANE; MODELING; MUTATION; PROTOZOAN; YEAST;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; HYDROPHOBICITY; KINETICS; MUTATIONAL ANALYSIS; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; TRYPANOSOMA BRUCEI;

ANIMALS; BIOLOGICAL TRANSPORT; GENE EXPRESSION; KINETICS; LEISHMANIA MAJOR; NUCLEOBASE TRANSPORT PROTEINS; PROTOZOAN PROTEINS; SACCHAROMYCES CEREVISIAE; TRYPANOSOMA BRUCEI BRUCEI;

LEISHMANIA MAJOR; PROTOZOA; SACCHAROMYCES CEREVISIAE; TRYPANOSOMA BRUCEI; TRYPANOSOMA BRUCEI BRUCEI;

EID: 41549100692     PISSN: 00207519     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpara.2007.10.005     Document Type: Article

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