Chapter 9 Molecular mechanisms of nucleoside and nucleoside drug transport

Current Topics in Membranes

Volumn 50, Issue , 2000, Pages 329-378

  Young, James D ^a,c   Cheeseman, Christopher I ^a   Mackey, John R ^a,b   Cass, Carol E ^a   Baldwin, Stephen A ^b  

^a UNIVERSITY OF ALBERTA   (Canada)

^b CROSS CANCER INSTITUTE   (Canada)

^c UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 35448998563     PISSN: 10635823     EISSN: None     Source Type: Book Series    
DOI: 10.1016/s1063-5823(00)50011-8     Document Type: Review

References (156)

1. C.M. Anderson W. Xiong J.D. Young C.E. Cass F.E. Parkinson Demonstration of the existence of mRNAs encoding Nl/cif and N2/cit sodium/nucleoside cotransporters in rat brain Mol. Brain Res. 42 1996 358 361
2. S.A. Baldwin J.R. Mackey C.E. Cass J.D. Young Nucleoside transporters: Molecular biology and implications for therapeutic development Mol. Med. Today 5 1999 216 224
3. A.B. Barton D.B. Kaback Molecular cloning of chromosome 1 DNA from Saccharomyces cerevisiae : Analysis of the genes in FUN38-MAK16-SP07 region J. Bacteriol. 176 1994 1872 1880
4. +-dependent nucleoside transport in human myeloid leukemic cell lines and freshly isolated myeloblasts Proc. Am. Assoc. Cancer Res. 33 1992 20
5. J.A. Belt N.M. Marina D.A. Phelps C.R. Crawford Nucleoside transport in normal and neoplastic cells Adv. Enzyme Regul. 33 1993 235 252
6. S.L. Betcher J.N. Forrest Jr. R.G. Knickelbein J.W. Dobbins Sodium-adenosine cotransport in brush-border membranes from rabbit ileum Am. J. Physiol. 259 1990 G504 G510
7. R. Bissonnette The de novo and salvage pathways for the synthesis and pyrimidine residues of RNA predominate in different locations within the mouse duodenal epithelium Cell Tissue Res. 267 1992 131 137
8. J.L. Blum S.E. Jones A.U. Buzdar P.M. LoRusso I. Kuter C. Vogel B. Osterwalder H.U. Burger C.S. Brown T. Griffin Multicenter phase II study of capecitabine in paclitaxel-refractory metastatic breast cancer J. Clin. Oncol. 17 1999 485 493
9. O. Brunser J. Espinoza M. Araya S. Cruchet A. Gil Effect of dietary nucleotide supplementation on diarrheal disease in infants Acta Paediatr. 83 1994 188 191
10. D.R. Budman N.J. Meropol B. Reigner P.J. Creaven S.M. Lichtman E. Berghorn J. Behr R.J. Gordon B. Osterwalder T. Griffin Preliminary studies of a novel oral fluoropyrimidine carbamate: Capecitabine J. Clin. Oncol. 16 1998 1795 1802
11. J.K. Buolamwini Nucleoside transport inhibitors: Structure-activity relationships and potential therapeutic applications Curr. Med. Chem. 4 1997 35 66
12. J.D. Carver B. Pimentel W.L. Cox L.A. Barness Dietary nucleotide effects upon immune function in infants Pediatrics 88 1991 359 363
13. G. Casari M.A. Andrade P. Bork J. Boyle A. Daruvar C. Ouzounis R. Schneider J. Tamames A. Valencia C. Sander Challenging times for bioinformatics Nature 376 1995 647 648
14. C.E. Cass Nucleoside transport N.H. Georgopapadakou Drug Transport in Antimicrobial Therapy and Anticancer Therapy 1995 Dekker New York 403 451
15. C.E. Cass J.D. Young S.A. Baldwin Recent advances in the molecular biology of nucleoside transporters of mammalian cells Biochem. Cell Biol. 76 1999 761 770
16. C.E. Cass J.D. Young S.A. Baldwin M.A. Cabrita K.A. Graham M. Griffiths L.L. Jennings J.R. Mackey A.M.L. Ng M.W.L. Ritzel M.F. Vickers S.Y.M. Yao Nucleoside transporters of mammalian cells G. Amidon W. Sadee Membrane Transporters as Drug Targets 1999 Plenum New York 313 352
17. J. Cassidy L. Dirix D. Bissett B. Reigner T. Griffin D. Allman B. Osterwalder A.T. Van Oosterom A phase I study of capecitabine in combination with oral leucovorin in patients with intractable solid tumors Clin. Cancer Res. 4 1998 2755 2761
18. +-independent nucleoside transporters in Xenopus laevis oocytes Biochem. Pharmacol. 53 1997 1909 1918
19. +-nucleoside cotransporter J. Biol. Chem. 270 1995 13596 13599
20. B.D. Cheson Miscellaneous chemotherapeutic agents V.T. Devita 5th ed. Cancer: Principles and Practice of Oncology Vol. 1 1997 Lippincott-Raven Philadelphia 490 498
21. I.R. Coe M. Griffiths J.D. Young S.A. Baldwin C.E. Cass Assignment of the human equilibrative nucleoside transporter (hENTI) to 6p21.1-p21.2 Genomics 45 1997 459 460
22. A.R. Conant S.M. Jarvis Nucleoside influx and efflux in guinea-pig ventricular myocytes. Inhibition by analogues of lidoflazine Biochem. Pharmacol. 48 1994 873 880
23. J.E. Craig Y. Zhang M.P. Gallagher Cloning of the nupC gene of Escherichia coli encoding a nucleoside transport system, and identification of an adjacent insertion element, IS 186 Mol. Microbiol. 11 1994 1159 1168
24. C.R. Crawford C.E. Cass J.D. Young J.A. Belt Stable expression of a recombinant sodium-dependent, pyrimidine-selective nucleoside transporter (rCNTI) in a transport-deficient mouse leukemia cell line Biochem. Cell Biol. 76 1999 843 851
25. C.R. Crawford D.H. Patel C. Naeve J.A. Belt Cloning of the human equilibrative, nitrobenzyl-mercaptopurine riboside (NBMPR)-insensitive nucleoside transporter ei by functional expression in a transport-deficient cell line J. Biol. Chem. 273 1998 5288 5293
26. B. Creamer The turnover of the epithelium of the small intestine Br. Med. Bull. 23 1967 226 230
27. E. Dahlig-Harley Y. Eilam A.R.P. Paterson C.E. Cass Binding of nitrobenzyl-thioinosine to high-affinity sites on the nucleoside-transport mechanism of HeLa cells Biochem. J. 200 1981 295 305
28. J.W. Dobbins J.P. Laurenson J.N. Forrest Adenosine and adenosine analogues stimulate adenosine cyclic 3′,5′-monophosphate-dependent chloride secretion in the mammalian ileum J. Clin. Invest. 3 1984 929 935
29. B.A. Domin W.B. Mahony T.P. Zimmerman Membrane permeation mechanisms of 2′,3′-dideoxynucleosides Biochem. Pharmacol. 46 1993 725 729
30. G.L. Drusano G.J. Yuen G. Morse T.P. Cooley M. Seidlin J.S. Lambert H.A. Liebman F.T. Valentine R. Dolin Impact of bioavailability on determination of the maximal tolerated dose of 2′,3′-dideoxyinosine in phase I trials Antimicrob. Agents Chemother. 36 1992 1280 1283
31. L.P. Elwel R. Ferone A.O. Freeman J.A. Fyfe Antibacterial activity and mechanism of action of 3′-azido-3′-deoxythumidine Antimicob. Agents Chemother. 31 1987 274 280
32. X. Fang F.E. Parkinson D.A. Mowles J.D. Young C.E. Cass Functional characterization of a recombinant sodium-dependent nucleoside transporter with selectivity for pyrimidine nucleosides (cNTlrat) by transient expression in cultured mammalian cells Biochem. J. 317 1996 457 465
33. +-dependent nucleoside transport in liver: Two different isoforms from the same gene family are expressed in liver cells Biochem. J. 330 1998 997 1001
34. R.P. Ferraris S.A. Villenas J.M. Diamond Regulation of brush-border enzyme activities and enterocyte migration rates in mouse small intestine Am. J. Physiol. 262 1992 G1047 G1059
35. M. Field Ion transport in rabbit ileal mucosa. II. Effects of cyclic 3′,5′-AMP Am. J. Physiol. 221 1971 992 997
36. W.P. Gati H.K. Misra E.E. Knaus L.I. Wiebe Structural modifications at the 2′ and 3′-positions of some pyrimidine nucleosides as determinants of their interaction with the mouse erythrocyte nucleoside transporter Biochem. Pharmacol. 33 1984 3325 3331
37. F.K. Ghishan F.A. Wilson Developmental maturation of d -glucose transport by rat jejunal brush-border membrane vesicles Am. J. Physiol 248 1985 G87 G92
38. L.C. Gilstrap R.E. Bawdon S.W. Roberts S. Sobhi The transfer of the nucleoside analog ganciclovir across the perfused human placenta Am. J. Obstet. Gynecol. 170 1994 967 972
39. L.C. Gilstrap R.E. Bawdon S.W. Roberts S. Sobhi The transfer of the nucleoside analog ganciclovir across the perfused human placenta discussion Am. J. Obstet. Gynecol. 170 1994 972 973
40. D.A. Griffith S.M. Jarvis Nucleoside and nucleobase transport systems of mammalian cells Biochem. Biophys. Acta 1286 1996 153 181
41. M. Griffiths S.A. Baldwin S.Y.M. Yao E.G. Chomey D. MacGregor R.E. Isaac C.E. Cass J.D. Young Identification and molecular characterization of an unusual equilibrative nucleoside transporter from Caenorhabditis elegans which mediates uptake of the antiviral nucleoside analogs 3′-azido-3′-deoxythymidine, 2′,3′-dideoxycytidine and 2′,3′-dideoxyinosine J. Biol. Chem. 2000 (submitted)
42. M. Griffiths N. Beaumont S.Y. Yao M. Sundaram C.E. Boumah A. Davies F.Y. Kwong I. Coe C.E. Cass J.D. Young S.A. Baldwin Cloning of a human nucleoside transporter implicated in the cellular uptake of adenosine and chemotherapeutic drugs Nature Med. 3 1997 89 93
43. M. Griffiths S.Y.M. Yao F. Abidi S.E.V. Phillips C.E. Cass J.D. Young S.A. Baldwin Molecular cloning and characterization of a nitrobenzylthioinosine-insensitive ( ei ) equilibrative nucleoside transporter from human placenta Biochem. J. 328 1997 739 743
44. K.G. Griffy Pharmacokinetics of oral ganciclovir capsules in HIV-infected persons AIDS 10 Suppl. 4 1996 S3 S6
45. U. Haberkom A. Altmann I. Morr K.W. Knopf C. Germann R. Haeckel F. Oberdorfer G. van Kaick Monitoring gene therapy with herpes simplex virus thymidine kinase in hepatoma cells: Uptake of specific substrates J. Nucl. Med. 38 1997 287 294
46. U. Haberkom K. Khazaie I. Morr A. Altmann M. Muller G. van Kaick Ganciclovir uptake in human mammary carcinoma cells expressing herpes simplex virus thymidine kinase Nucl. Med. Biol. 25 1998 367 373
47. S.R. Hamilton S.Y.M. Yao J.C. Ingram M.P. Gallagher P.J.F. Henderson C.E. Cass J.D. Young S.A. Baldwin Membrane topology and subcellular distribution of the rat concentrative sodium-nucleoside co-transporter rCNT1 2000 (manuscript in preparation)
48. P.J. Hanson D.S. Parsons The utilization of glucose and the production of lactate by in vitro preparations of rat small intestine: Effect of vascular perfusion J. Physiol. 255 1976 775 795
49. Y. He I.R. Sanderson W.A. Walker Uptake, transport, and metabolism of exogenous nucleosides in intestinal epithelial cell cultures J. Nutr. 124 1994 1942 1949
50. G.I. Henderson Z.Q. Hu Y. Yang T.B. Perez B.G. Devi T.A. Frosto S. Schenker Ganciclovir transfer by human placenta and its effects on rat fetal cells Am. J. Med. Sci. 306 1993 151 156
51. A.J. Hirsh R. Tsang S. Kammila C.I. Cheeseman The effect of cholecystokinin and related peptides on jejunal transepithelial hexose transport in the Sprague-Dawley rat Am. J. Physiol. 271 1996 G755 G761
52. D.L. Hogue M.J. Ellison M.F. Vickers C.E. Cass Functional complementation of a membrane transport deficiency in Saccharomyces cerevisiae by recombinant ND4 fusion protein Biochem. Biophys. Res. Commun. 238 1997 811 816
53. D.L. Hogue M.J. Ellison J.D. Young C.E. Cass Identification of a novel membrane transporter associated with intracellular membranes by phenotypic complementation in the yeast Saccharomyces cerevisiae J. Biol. Chem. 271 1996 9801 9808
54. J. Horak Yeast nutrient transporters Biochim. Biophys. Acta 1331 1997 41 79
55. M. Hu Comparison of uptake characteristics of thymidine and zidovudine in a human intestinal epithelial model J. Pharmaceut. Sci. 82 1992 829 833
56. Q.Q. Huang S.Y.M. Yao M.W. Ritzel A.R. Paterson C.E. Cass J.D. Young Cloning and functional expression of a complementary DNA encoding a mammalian nucleoside transport protein J. Biol. Chem. 269 1994 17757 17760
57. K. Iseki M. Sugawara T. Fujiwara I. Naasani M. Kobayashi K. Miyazaki Transport mechanisms of nucleosides and the derivative, 6-mercaptopurine riboside across rat intestinal brush-border membranes Biochim. Biophys. Acta 1278 1996 105 110
58. E.S. Jakobs D.J. Van Os-Corby A.R.P. Paterson Expression of sodium-linked nucleoside transport activity in monolayer cultures of IEC-6 intestinal epithelial cells J. Biol. Chem. 265 1990 22210 22216
59. S.M. Jarvis Characterization of sodium-dependent nucleoside transport in rabbit intestinal brush-border membrane vesicles Biochim. Biophys. Acta 979 1988 132 138
60. +/nucleoside transporter in Xenopus laevis oocytes Biochem. J. 278 1991 605 607
61. S.M. Jarvis J.A. Thorn P. Glue Ribavirin uptake by human erythrocytes and the involvement of nitrobenzylthioinosine-sensitive ( es )-nucleoside transporters Br. J. Pharmacol. 123 1998 1587 1592
62. S.M. Jarvis J.D. Young Nucleoside translocation in sheep reticulocytes and fetal erythrocytes: A proposed model for the nucleoside transporter J. Physiol. 324 1982 47 66
63. S.M. Jarvis J.D. Young Nucleoside transport in rat erythrocytes: two components with differences in sensitivity to inhibition by nitrobenzylthioinosine and p-chloromercuriphenyl sulphonate J. Membr. Biol. 93 1986 1 10
64. K.M. King C.E. Cass Membrane transport of 2-chloro-2′-deoxyadenosine and 2chloro-2′-arabinofluoro-2′-deoxyadenosine is required for cytotoxicity Proc. Annu. Meet. Am. Assoc. Cancer Res. 35 1994 A3436
65. F.Y. Kwong H.E. Fincham A. Davies N. Beaumont P.J. Henderson J.D. Young S.A. Baldwin Mammalian nitrobenzylthioinosine-sensitive nucleoside transport proteins. Immunological evidence that transporters differing in size and inhibitor specificity share sequence homology J. Biol. Chem. 267 1992 21954 21960
66. F.Y. Kwong J.S. Wu M.M. Shi H.E. Fincham A. Davis P.J. Henderson S.A. Baldwin J.D. Young Enzymic cleavage as a probe of the molecular structures of mammalian equilibrative nucleoside transporters J. Biol. Chem. 268 1993 22127 22134
67. C.L. Lai R.N. Chien N.W. Leung T.T. Chang R. Guan D.I. Tai K.Y. Ng P.C. Wu J.C. Dent J. Barber S.L. Stephenson D.F. Gray A one-year trial of lamivudine for chronic hepatitis B. Asia hepatitis lamivudine study group N. Engl. J. Med. 33 1998 61 68
68. C.L. Lai C.K. Ching A.K. Tung E. Li J. Young A. Hill B.C. Wong J. Dent P.C. Wu Lamivudine is effective in suppressing hepatitis B virus DNA in Chinese hepatitis B surface antigen carriers: A placebo-controlled trial Hepatology 25 1997 241 244
69. T.T. Lang J.D. Young C.E. Cass Selective acquisition of sensitivity to cytotoxic nucleosides in a nucleoside-transport deficient T-lymphoblastoid cell line by gene transfer: Functional expression of hCNT2 Cancer Res. 2000 (submitted)
70. J.L. Leach J.H. Baxter B.E. Molitor M.B. Ramstack M.L. Masor Total potentially available nucleosides of human milk by stage of lactation Am. J. Clin. Nutr. 61 1995 1224 1230
71. +-dependent uridine transport in rat renal brush-border membrane vesicles Biochim. Biophys. Acta 942 1988 139 149
72. +-dependent uridine transport system Biochem. J. 274 1991 85 90
73. N.S. LeLeiko A.D. Bronstein B.S. Baliga H.N. Munro De novo purine nucleotide synthesis in the rat small and large intestine: Effect of dietary protein and purines J. Pediatr. Gastroenterol. Nutr. 2 1983 313 319
74. + channel determined by construction of multimeric cDNAs Neuron 9 1992 861 871
75. G. Liu E. Franssen M.I. Fitch E. Warner Patient preferences for oral versus intravenous palliative chemotherapy J. Clin. Oncol. 15 1997 110 115
76. +-nucleoside cotransporters hCNT1 and hCNT2 J. Biol. Chem. 274 1999 24475 24484
77. S.K. Loewen S.Y.M. Yao R.J. Turner J.H. Weiner P.J.F. Henderson C.E. Cass S.A. Baldwin M.P. Gallagher J.D. Young Transport of nucleosides and nucleoside drugs by a recombinant bacterial nucleoside transporter (NupC) expressed in oocytes of Xenopus laevis 8th Fisher Winternational Symposium on Cellular and Molecular Biology Banff, Alberta, Canada 1998
78. M. Mackean A. Planting C. Twelves J. Schellens D. Allman B. Osterwalder B. Reigner T. Griffin S. Kaye J. Verweij Phase I and pharmacologic study of intermittent twice-daily oral therapy with capecitabine in patients with advanced and/or metastatic cancer J. Clin. Oncol. 16 1998 2977 2985
79. J.R. Mackey S.A. Baldwin J.D. Young C.E. Cass Nucleoside transport and its significance for anticancer drug resistance Drug Resistance Updates 1 1998 310 324
80. J.R. Mackey R.S. Mani M. Selner D. Mowles J.D. Young J.A. Belt C.R. Crawford C.E. Cass Functional nucleoside transporters are required for gemcitabine and cytotoxicity in cancer cell lines Cancer Res. 58 1998 4349 4357
81. J.R. Mackey S.Y.M. Yao K.M. Smith E. Karpinski S.A. Baldwin C.E. Cass J.D. Young Gemcitabine transport mediated by recombinant plasma membrane mammalian nucleoside transporters expressed in Xenopus oocytes J. Natl. Cancer Inst. USA 91 1999 1876 1881
82. A.M. MacKinnon D.J. Deller Purine nucleoside biosynthesis in gastrointestinal mucosa Biochim. Biophys. Acta. 319 1973 1 4
83. W.B. Mahony B.A. Domin R.T. McConnell T.P. Zimmerman Acyclovir transport into human erythrocytes J. Biol. Chem. 263 1998 9285 9291
84. W.B. Mahony B.A. Domin T.P. Zimmerman Ganciclovir permeation of the human erythrocyte membrane Biochem. Pharmacol. 41 1991 263 271
85. R.S. Mani J.R. Hammond J.M.J. Marjan K.A. Graham J.D. Young S.A. Baldwin C.E. Cass Demonstration of equilibrative nucleoside transporters (hENT1, hENT2) in intracellular membranes of cultured human choriocarcinoma (BeWo) cells by functional reconstitution in proteoliposomes J. Biol. Chem. 273 1998 30818 30825
86. P. Maser C. Sutterlin A. Kralli R. Kaminsky A nucleoside transporter from Trypanosoma brucei involved in drug resistance Science 285 1999 242 244
87. E. McCloud R.K. Mathis K.E. Grant H.M. Said Intestinal uptake of uridine in suckling rats: Mechanism and ontogeny Prog. Exp. Biol. Med. 206 1994 425 430
88. R. Monno L. Marcuccio M.A. Valenza E. Leone C. Bitetto A. Larocca P. Maggi M. Quarto In vitro antimicrobial properties of azidothymidine (AZT) Acta Microbiol. Immunol. Hung. 44 1997 165 171
89. G.D. Morse M.J. Shelton A.M. O'Donnell Comparative pharmacokinetics of antiviral nucleoside analogues Clin. Pharmacokinet. 24 1993 101 123
90. E.C. Mun K.J. Tally J.B. Matthews Characterization and regulation of adenosine transport in T84 intestinal epithelial cells Am. J. Physiol. 274 1998 G261 G269
91. B. Mygind A. Munch-Peterson Transport of pyrimidine nucleosides in cells of Escherichia coli J. Biol. Chem. 254 1975 3703 3737
92. J. Neuhard P. Nygaard Pyrimidines and purines F.C. Neidhardt Escherichia coli and Salmonella typhimurium 1987 ASM International Materials Park, OH 445 473
93. T. Obata Y. Yamanaka T. Hirata Y. Uchida Role of adenosine in blood flow in rat intestine Res. Commun. Mol. Pathol. Pharmacol. 92 1996 369 372
94. +/nucleoside cotransporter from pig kidney, pkCNTI Biochim. Biophys. Acta 1415 1998 266 269
95. +/nucleoside cotransporter J. Biol. Chem. 267 1992 3557 3560
96. M. Palacin Cystinuria calls for heteromultimeric amino acid transporters Curr. Opin. Cell Biol. 10 1998 455 461
97. G.B. Park A.K. Mitra Mechanism and site dependency of intestinal mucosal transport and metabolism of thymidine analogs Pharmaceut. Res. 9 1992 326 331
98. +-dependent nucleoside purine (N1) transporter Pharmaceut. Res. 15 1998 950 952
99. S.D. Patil J.D. Unadkat Sodium-dependent nucleoside transport in the human intestinal brush-border membrane Am. J. Physiol. 272 1997 G1314 G1320
100. C.M. Perry D. Faulds Lamivudine. A review of its antiviral activity, pharmacokinetic properties, and therapeutic efficacy in the management of HIV infection Drugs 53 1997 657 680
101. K. Peter J.G. Gambertoglio Intracellular phosphorylation of zidovudine (ZDV) and other nucleoside reverse transcriptase inhibitors (RTI) used for human immunodeficiency virus (HIV) infection Pharm. Res. 15 1998 819 825
102. E.M. Peterson J. Brownell R. Vince Synthesis and biological evaluation of 5′-sulfamoylated purinyl carbocyclic nucleosides J. Med. Chem. 35 1992 3991 4000
103. G. Pialoux F. Raffi F. Brun-Vezinet V. Meiffredy P. Flandre J.A. Gastaut P. Dellamonica P. Yeni J.F. Delfraissy J.P. Aboulker A randomized trial of three maintenance regimens given after three months of induction therapy with zidovudine, lamivudine, and indinavir in previously untreated HIV-1-infected patients. Trilege (Agence Nationale de Recherches sur le SIDA 072) Study Team N. Engl. J. Med. 339 1998 1269 1276
104. P.G. Plagemann R.M. Wohlhueter C. Woffendin Nucleoside and nucleobase transport in animal cells Biochim. Biophys. Acta 947 1988 405 443
105. K.Z. Rana M.N. Dudley Clinical pharmacokinetics of stavudine Clin. Pharmacokinet. 33 1997 276 284
106. +-nucleoside cotransporter (hCNTI) Am. J. Physiol. 272 1997 C707 C714
107. +/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine Mol. Membr. Biol. 15 1998 203 211
108. M. Roden A.R. Paterson K. Turnheim Sodium-dependent nucleoside transport in rabbit intestinal epithelium Gastroenterology 100 1991 1553 1562
109. L.M. Salati C.J. Gross L.M. Henderson D.A. Saviano Absorption and metabolism of adenine, adenosine-5′-mono-phosphate, adenosine, and hypoxanthine by the vascularly perfused rat small intestine J. Nutr. 114 1984 753 760
110. M.A. Sanchez B. Ullman S.M. Landfear N.S. Carter Cloning and functional expression of a gene encoding a P1 type nucleoside transporter from Trypanosoma brucei J. Biol. Chem. 274 1999 30244 30249
111. I.R. Sanderson Y. He Nucleotide uptake and metabolism by intestinal epithelial cells J. Nutr. 124 1994 131S 137S
112. D.A. Saviano A.J. Clifford Absorption, tissue incorporation, and excretion of free purine bases in the rat Nutr. Rep. Int. 17 1978 551 556
113. D.A. Saviano A.J. Clifford Adenine, the precursor of nucleic acids in intestinal cells unable to synthesize purines de novo J. Nutr. 111 1981 1816 1822
114. int) in a human cell line (HeLa) Pharmaceut. Res. 10 1997 1316 1321
115. G.H. Schmidt M.M. Wilkinson B.A.J. Ponder Cell migration pathway in the intestinal epithelium: An in situ marker system using mouse aggregation chimeras Cell 40 1985 425 429
116. M. Schwenk E. Hegazy V.L. Del Pino Uridine uptake by isolated intestinal epithelial cells of guinea pig Biochim. Biophys. Acta 805 1984 370 374
117. C. Seeger C. Poulsen G. Dandanall Identification and characterization of genes involved in xanthosine catabolism in Escherichia coli J. Bacteriol. 177 1995 5506 5516
118. M.J. Shelton A.M. O'Donnell G.D. Morse Didanosine Ann. Pharmacother. 26 1992 660 670
119. M.J. Shelton A.M. O'Donnell G.D. Morse Zalcitabine Ann. Pharmacother. 27 1993 480 489
120. A.J. Shepard P. Barr C.S. Lewin The effect of thymidine on the antibacterial and antiviral activity of zidovudine J. Pharm. Pharmacol. 44 1992 704 706
121. P.J. Sinko P. Hu A.P. Waclawski N.R. Patel Oral absorption of anti-AIDS nucleoside analogues. 1. Intestinal transport of didanosine in rat and rabbit preparations J. Pharm. Sci. 84 1995 959 965
122. P.J. Sinko J.P. Sutyak G.D. Leesman P. Hu V.D. Makhey H. Yu C.L. Smith Oral absorption of anti-AIDS nucleoside analogues: 3. Regional absorption and in vivo permeability of 2′,3′-dideoxyinosine in an intestinal-vascular access port (IVAP) dog model Biopharm. Drug Dispos. 18 1997 697 710
123. K.M. Smith C.E. Cass E. Karpinski J.D. Young Electrophysiological studies of the human Na+-dependent nucleoside transporter hCNTI 8th Fisher Winternational Symposium on Cellular and Molecular Biology Banff, Alberta, Canada 1998
124. C. Soler A. Felipe J.F. Mata J. Casado A. Celada M. Pastor-Anglada Regulation of nucleoside transport by lipopolysaccharide, phorbol ester, and tumor necrosis factor in human B-lymphocytes J. Biol. Chem. 273 1998 26939 26945
125. R.A. Stow J.R. Bronk Nucleoside transport and metabolism in isolated rat jejunum J. Physiol. 468 1992 311 324
126. G.R. Strohmeier S.M. Reppert W.I. Lencer J.L. Madara The Alb adenosine receptor mediates cAMP response to adenosine receptor agonists in human intestinal epithelia J. Biol. Chem. 270 1995 2387 2394
127. M. Sundaram S.Y.M. Yao C.E. Cass S.A. Baldwin J.D. Young Chimaeric constructs between human and rat equilibrative nucleoside transporters (hENTI and rENT1) reveal hENTI structural domains interacting with coronary vasoactive drugs J. Biol. Chem. 273 1998 21519 21525
128. K.J. Tally B.J. Hrnjez J.A. Smith E.C. Mun J.B. Matthews Adenosine scavenging: A novel mechanism of chloride secretory control in intestinal epithelial cells Surgery 120 1996 248 254
129. M. Tanaka K. Lee O. Martinez-Augustin Y. He I.R. Sanderson A. Walker Exogenous nucleotides alter proliferation, differentiation, and apoptosis of human small intestinal epithelium J. Nutr. 126 1996 424 433
130. +-dependent uridine transport system of rabbit small intestine: Studies with mRNA-injected Xenopus laevis oocytes Biol. Pharm. Bull. 16 1993 493 496
131. C.M. Tse J.S. Wu J.D. Young Evidence for the asymmetrical binding of p-chloromercuriphenyl sulphonate to the human erythrocyte nucleoside transporter Biochim. Biophys. Acta 818 1985 316 324
132. R. Uay G. Stringel R. Thomas R. Quan Effect of dietary nucleosides on growth and maturation of the developing gut in the rat J. Paediatr. Gastroenterol. Nutr. 10 1990 497 503
133. G. Vasudevan N.S. Carter M.E. Drew S.M. Beverley M.A. Sanches A. Seyfang B. Ullman S.M. Landfear Cloning of Leishmania nucleoside transporter genes by rescue of a transport-deficient mutant Proc. Natl. Acad. Sci. 95 1998 9873 9878
134. M.F. Vickers R.S. Mani M. Sundaram D.L. Hogue J.D. Young S.A. Baldwin C.E. Cass Functional production and reconstitution of the human equilibrative nucleoside transporter (hENTI) and a glycosylation-defective derivative (hENTI/N48Q) Biochem. J. 339 1999 21 32
135. M.F. Vickers S.Y.M. Yao J.D. Young S.A. Baldwin C.E. Cass Nucleoside transporter proteins of S. cerevisiae : Demonstration of a transporter (FUI1) with high uridine selectivity in plasma membranes and a transporter (FUN26) with broad nucleoside selectivity in intracellular membranes J. Biol. Chem. 2000 (in press)
136. D. Vijayalakshimi J.A. Belt Sodium-dependent nucleoside transport in mouse intestinal epithelial cells. Two transport systems with differing substrate specificities J. Biol. Chem. 263 1988 19419 19423
137. D.D. Von Hoff M. Slavik F.M. Muggia 5-azacytidine. A new anticancer drug with effectiveness in acute myelogenous leukemia Ann. Intern. Med. 85 1976 237 245
138. A.P. Waclawski P.J. Sinko Oral absorption of anti-acquired immune deficiency syndrome nucleoside analogs. 2. Carrier-mediated intestinal transport of stavudine in rat and rabbit preparations J. Pharmaceut. Sci. 84 1995 959 965
139. +-dependent nucleoside transporters J. Biol. Chem. 272 1997 28845 28848
140. +-nucleoside transporter J. Biol. Chem. 274 1999 2298 2302
141. +-dependent nucleoside transporters Pharm. Res. 14 1997 1524 1532
142. +-dependent purine nucleoside transporter from human kidney: Cloning and functional characterization Am. J. Physiol. 273 1997 F1058 F1065
143. J.B. Williams B. Rexer S. Sirripurapu S. John R. Goldstein J.A. Phillips L.L. Haley S.N. Sait T.B. Shows C.M. Smith D.S. Gerhard The human HNP36 gene is localized to chromosome l 1q13 and produces alternative transcripts that are not mutated in multiple endocrine neoplasia, type I (MEN I) syndrome Genomics 42 1997 325 330
144. T.C. Williams A.J. Doherty D.A. Griffith S.M. Jarvis Characterization of sodium-dependent and sodium-independent nucleoside transport systems in rabbit brush-border and basolateral plasma-membrane vesicles from the renal outer cortex Biochem. J. 264 1989 223 231
145. X. Wu G. Yuan C.M. Brett A.C. Hui K.M. Giacomini Sodium-dependent nucleoside transport in choroid plexus from rabbit. Evidence for a single transporter for purine and pyrimidine nucleosides J. Biol. Chem. 267 1992 8813 8818
146. S.Y. Yao C.E. Cass J.D. Young Transport of the antiviral nucleoside analogs 3′-azido-3′-deoxythymidine and 2′,3′-dideoxycytidine by a recombinant nucleoside transporter (rCNT) expressed in Xenopus laevis oocytes Mol. Pharmacol. 50 1996 388 393
147. S.Y.M. Yao C.E. Cass J.D. Young The Xenopus oocyte expression system for the expression cloning and characterization of plasma membrane transport proteins S.A. Baldwin Membrane Transport: A Practical Approach 2000 Oxford University Press Oxford (in press)
148. S.Y.M. Yao W.R. Muzyka C.E. Cass C.I. Cheeseman J.D. Young Evidence that the transport-related proteins BAT and 4F2hc are not specific for amino acids Biochem. Cell Biol. 76 1999 859 865
149. +-dependent nucleoside transporter (hfCNT) from an ancient vertebrate, the Pacific hagfish ( Eptatretus stouti ) 8th Fisher Winternational Symposium on Cellular and Molecular Biology Banff, Alberta, Canada 1998
150. S.Y. Yao A.M. Ng W.R. Muzyka M. Griffiths C.E. Cass S.A. Baldwin J.D. Young Molecular cloning and functional characterization of nitrobenzylthioinosine (NBMPR)sensitive ( es ) and NBMPR-insensitive ( ei ) equilibrative nucleoside transporter proteins (rENTI and rENT2) from rat tissues J. Biol. Chem. 272 1997 28423 28430
151. S.Y. Yao A.M. Ng M.W. Ritzel W.P. Gati C.E. Cass J.D. Young Transport of adenosine by recombinant purine- and pyrimidine-selective sodium/nucleoside cotransporters from rat jejunum expressed in Xenopus laevis oocytes Mol. Pharmacol. 50 1996 1529 1535
152. S.Y.M. Yao M. Sundaram E.G. Chomey C.E. Cass S.A. Baldwin J.D. Young Identification of the exofacial cysteine residue (Cys140) responsible for the PCMBS inhibition of rat equilibrative nitrobenzylthioinosine-insensitive nucleoside transporter rENT2 Biochem. J. 2000 (submitted)
153. G.J. Yuen D.M. Morris P.K. Mydlow S. Haidar S.T. Hall E.K. Hussey Pharmacokinetics, absolute bioavailability, and absorption characteristics of lamivudine J. Clin. Pharmacol. 35 1995 1174 1180
154. G.J. Yuen D.M. Morris P.K. Mydlow S. Haidar S.T. Hall E.K. Hussey erratum appears in J. Clin. Pharmacol. 36 1996 373
155. 15N]alanine Eur. J. Biochem. 187 1990 437 440
156. T.P. Zimmerman W.B. Mahony K.L. Prus 3′-azido-3′-deoxythymidine. An unusual nucleoside analogue that permeates the membrane of human erythrocytes and lymphocytes by nonfacilitated diffusion J. Biol. Chem. 262 1987 5748 5754