Characterization of novel Na +-dependent nucleobase transport systems at the blood-testis barrier

American Journal of Physiology - Endocrinology and Metabolism

Volumn 290, Issue 5, 2006, Pages

  Kato, Ryo ^a,b   Maeda, Tomoji ^a   Akaike, Toshihiro ^b   Tamai, Ikumi ^a  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

^b TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Nucleoside; Sertoli cells; Transporter

Indexed keywords

GUANOSINE; NUCLEOBASE TRANSPORTER; PURINE NUCLEOSIDE; PYRIMIDINE NUCLEOSIDE; URACIL;

ANIMAL CELL; ARTICLE; BLOOD FLOW; BLOOD TESTIS BARRIER; CELL CULTURE; CONTROLLED STUDY; DRUG INHIBITION; KINETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; RAT; SEMINIFEROUS TUBULE; SERTOLI CELL; SPERMATOCYTE;

ADENINE; ANIMALS; BIOLOGICAL TRANSPORT; BLOOD-TESTIS BARRIER; CYTOSINE; GUANINE; HYPOXANTHINE; KINETICS; MALE; MEGLUMINE; NUCLEOBASE TRANSPORT PROTEINS; NUCLEOSIDE TRANSPORT PROTEINS; PURINE NUCLEOSIDES; PYRIMIDINE NUCLEOSIDES; RATS; RATS, INBRED STRAINS; SERTOLI CELLS; SODIUM; THIOINOSINE; THYMINE; URACIL; URIDINE;

EID: 33646400259     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00160.2005     Document Type: Article

References (59)

1. Adams A and Harkness RA. Developmental changes in purine phosphoribosyltransferases in human and rat tissues. Biochem J 160: 565-576, 1976.
2. Augustine LM, Markelewicz RJ, Boekelheide K, and Cherrington N. Xenobiotic and endobiotic transporter mRNA expression in the blood-testis barrier. Drug Metab Dispos 33: 182-189, 2005.
3. Baldwin SA, Beal PR, Yao SY, King AE, Cass CE, and Young JD. The equilibrative nucleoside transporter family, SLC29. Pflügers Arch 447: 735-743, 2004.
4. Barros LF. Hypoxanthine transport in the guinea pig and human placenta is a carrier-mediated process that does not involve nucleoside transporters. Am J Obset Gynecol 171: 111-117, 1994.
5. Bart J, Groen HJ, van der Graaf WT, Hollema H, Hendrikse NH, Vaalburg W, Sleijfer DT, and de Vries EG. An oncological view on the blood-testis barrier. Lancet Oncol 3: 357-363, 2002.
6. Blackburn GM and Gait MJ. Biosynthesis of nucleotides. In: Nucleic Acids in Chemistry and Biology. London, UK: IRL, 1990, p. 137-163.
7. Blakely RD, De Felice LJ, and Hartzell HC. Molecular physiology of norepinephrine and serotonin transporters. J Exp Biol 196: 263-281, 1994.
8. Cattori V, van Montfoort JE, Stieger B, Landmann L, Meijer DK, Winterhalter KH, Meier PJ, and Hagenbuch B. Localization of organic anion transporting polypeptide 4 (Oatp4) in rat liver and comparison of its substrate specificity with Oatp1, Oatp2 and Oatp3. Pflügers Arch 443: 188-195, 2001.
9. +)-nucleoside cotransporter. J Biol Chem 270: 13596-13599, 1995.
10. Chen R and Nelson JA. Role of organic cation transporters in the renal secretion of nucleosides. Biochem Pharmacol 60: 215-219, 2000.
11. Cihlar T, Lin DC, Pritchard JB, Fuller MD, Mendel DB, and Sweet DH. The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1. Mol Pharmacol 56: 570-580, 1999.
12. de Koning H and Diallinas G. Nucleobase transporters. Mol Membr Biol 75: 75-94, 2000.
13. Deves R and Boyd CA. Transporters for cationic amino acids in animal cells: discovery, structure, and function. Physiol Rev 78: 487-545, 1998.
14. Elion B. The purine path to chemotherapy. Science 244: 41-47, 1989.
15. Ganapathy V, Smith SB, and Prasad PD. SLC19: the folate/thiamine transporter family. Pflügers Arch 447: 641-646, 2004.
16. Gati WP, Paterson AR, Tyrrell DL, Cass CE, Moravek J, and Robins MJ. Nucleobase transporter-mediated permeation of 2′,3′-dideoxyguanosine in human erythrocytes and human T-lymphoblastoid CCRFCEM cells. J Biol Chem 267: 22272-22276, 1992.
17. Gray JH, Owen RP, and Giacomini KM. The concentrative nucleoside transporter family, SLC28. Pflügers Arch 447: 728-34, 2004.
18. Griffith DA, Doherty AJ, and Jarvis SM. Nucleoside transport in cultured LLC-PK1 epithelia. Biochim Biophys Acta 1106: 303-310, 1992.
19. Griffith DA and Jarvis SM. High affinity sodium-dependent nucleobase transport in cultured renal epithelial cells (LLC-PK1). J Biol Chem 268: 20085-20090, 1993.
20. Griffith DA and Jarvis SM. Characterization of a sodium-dependent concentrative nucleobase-transport system in guinea-pig kidney cortex brush-border membrane vesicles. Biochem J 303: 901-905, 1994.
21. Griffith DA and Jarvis SM. Nucleoside and nucleobase transport systems of mammalian cells. Biochim Biophys Acta 1286: 153-181, 1996.
22. 2+. Cardiovasc Res 30: 130-137, 1995.
23. Hagenbuch B and Meier PJ. Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties. Pflügers Arch 447: 653-665, 2004.
24. Haugen TB, Hansson V, and Fritzson P. Cellular distribution, developmental changes and effects of cryptorchidism on uridine kinase in rat testis. J Reprod Fertil 83: 655-661, 1988.
25. Hogue DL and Ling V. A human nucleobase transporter-like cDNA (SLC23A1): member of a transporter family conserved from bacteria to mammals. Genomics 59: 18-23, 1999.
26. Huang QQ, Yao SY, Ritzel MW, Paterson AR, Cass CE, and Young JD. Cloning and functional expression of a complementary DNA encoding a mammalian nucleoside transport protein. J Biol Chem 269: 17757-17760, 1994.
27. Jutte NH, Jansen R, Grootegoed JA, Rommerts FF, Clausen OP, and van der Molen HJ. Regulation of survival of rat pachytene spermatocytes by lactate supply from Sertoli cells. J Reprod Fertil 65: 431-438, 1982.
28. Kato R, Maeda T, Akaike T, and Tamai I. Nucleoside transport at the blood-testis barrier studied with primary-cultured Sertoli cells. J Pharmacol Exp Ther 312: 601-608, 2005.
29. Koepsell H and Endou H. The SLC22 drug transporter family. Pflügers Arch 447: 666-676, 2004.
30. Kolb M. Novel and unusual nucleosides as drugs. Prog Drug Res 48: 195-232, 1997.
31. Lowry OH, Rosebrough NJ, Farr AL, and Randall RJ. Protein measurement with the Folin-phenol reagent. J Biol Chem 193: 265-275, 1951.
32. Lui WY, Mruk D, Lee WM, and Cheng CY. Sertoli cell tight junction dynamics: their regulation during spermatogenesis. Biol Reprod 68: 1087-1097, 2003.
33. Majumdar S, Tirucherai GS, Pal D, and Mitra AK. Functional differences in nucleoside and nucleobase transporters expressed on the rabbit corneal epithelial cell line (SIRC) and isolated rabbit cornea (Abstract). AAPS Pharm Sci 5: E15, 2003.
34. Mather JP, Attie KM, Woodruff TK, Rice GC, and Phillips DM. Activin stimulates spermatogonial proliferation in germ-Sertoli cell cocultures from immature rat testis. Endocrinology 127: 3206-3214, 1990.
35. Mori S, Ohtsuki S, Takanaga H, Kikkawa T, Kang YS, and Terasaki T. Organic anion transporter 3 is involved in the brain-to-blood efflux transport of thiopurine nucleobase analogs. J Neurochem 90: 931-941, 2004.
36. Nagao Y. Viability of meiotic prophase spermatocytes of rats is facilitated in primary culture of dispersed testicular cells on collagen gel by supplementing epinephrine or norepinephrine: evidence that meiotic prophase spermatocytes complete meiotic divisions in vitro. In Vitro Cell Dev Biol 25: 1088-1098, 1989.
37. Natsumeda Y, Prajda N, Donohue JP, Glover JL, and Weber G. Enzymic capacities of purine de novo and salvage pathways for nucleotide synthesis in normal and neoplastic tissues. Cancer Res 44: 2475-2479, 1984.
38. Noe B, Hagenbuch B, Stieger B, and Meier PJ. Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain. Proc Natl Acad Sci USA 94: 10346-10350, 1997.
39. +-nucleoside cotransporter proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib). J Biol Chem 276: 2914-2927, 2001.
40. +-nucleoside cotransporter (hCNT1). Am J Physiol Cell Physiol 272: C707-C714, 1997.
41. +/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine. Mol Membr Biol 15: 203-211, 1998.
42. Rothman RB and Baumann MH. Monoamine transporters and psycho-stimulant drugs. Eur J Pharmacol 479: 23-40, 2003.
43. Russel LD, Ettlin RA, Hikim AP, and Clegg ED. The Sertoli cell. In: Histological and Histopathological Evaluation of the Testis. Clearwater, FL: Cache River, 1990, p. 29-36.
44. Shayeghi M, Akerman R, and Jarvis SM. Nucleobase transport in opossum kidney epithelial cells and Xenopus laevis oocytes: the characterisation, structure-activity relationship of uracil analogues and oocyte expression studies of sodium-dependent and -independent hypoxanthine uptake. Biochim Biophys Acta 1416: 109-118, 1999.
45. Shiratsuchi A, Umeda M, Ohba Y, and Nakanishi Y. Recognition of phosphatidylserine on the surface of apoptotic spermatogenic cells and subsequent phagocytosis by Sertoli cells of the rat. J Biol Chem 272: 2354-2358, 1997.
46. Tamai I, Yabuuchi H, Nezu J, Sai Y, Oku A, Shimane M, and Tsuji A. Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1. FEBS Lett 419: 107-111, 1997.
47. Tamai I, Ohashi R, Nezu J, Yabuuchi H, Oku A, Shimane M, Sai Y, and Tsuji A. Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2. J Biol Chem 273: 20378-20382, 1998.
48. Tamai I, Nezu J, Uchino H, Sai Y, Oku A, Shimane M, and Tsuji A. Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun 273: 251-260, 2000.
49. + gradient-dependent transport of hypoxanthine by calf intestinal brush border membrane vesicles. J Comp Physiol [B] 173: 165-170, 2003.
50. Uldry M and Thorens B. The SLC2 family of facilitated hexose and polyol transporters. Pflügers Arch 447: 480-489, 2004.
51. Ullman B, Patrick J, and McCartan K. Expression of the high-affinity purine nucleobase transporter in mutant mouse S49 cells does not require a functional wild-type nucleoside-nucleobase transporter. Mol Cell Biol 7: 97-103, 1987.
52. Wang Y, Mackenzie B, Tsukaguchi H, Weremowicz S, Morton CC, and Hediger MA. Human vitamin C (L-ascorbic acid) transporter SVCT1. Biochem Biophys Res Commun 267: 488-494, 2000.
53. Ward JL, Sherali A, Mo ZP, and Tse CM. Kinetic and pharmacological properties of cloned human equilibrative nucleoside transporters, ENT1 and ENT2, stably expressed in nucleoside transporter-deficient PK15 cells. Ent2 exhibits a low affinity for guanosine and cytidine but a high affinity for inosine. J Biol Chem 275: 8375-8381, 2000.
54. +)-dependent nucleobase transporter with broad substrate selectivity. J Biol Chem 270: 22816-22819, 1995.
55. Weber G, Jayaram HN, Pillwein K, Natsumeda Y, Reardon MA, and Zhen YS. Salvage pathways as targets of chemotherapy. Adv Enzyme Regul 26: 335-352, 1987.
56. Wright EM and Turk E. The sodium/glucose cotransport family SLC5. Pflügers Arch 447: 510-518, 2004.
57. Yamaoka K, Tanigawara Y, Nakagawa T, and Uno T. A pharmacokinetic analysis program (MULTI) for microcomputer. J Pharmacobiodyn 4: 879-885, 1981.
58. Yao SY, Ng AM, Muzyka WR, Griffiths M, Cass CE, Baldwin SA, and Young JD. Molecular cloning and functional characterization of nitrobenzylthioinosine (NBMPR)-sensitive (es) and NBMPR-insensitive (ei) equilibrative nucleoside transporter proteins (rENT1 and rENT2) from rat tissues. J Biol Chem 272: 28423-28430, 1997.
59. Yao SY, Ng AM, Vickers MF, Sundaram M, Cass CE, Baldwin SA, and Young JD. Functional and molecular characterization of nucleobase transport by recombinant human and rat equilibrative nucleoside transporters 1 and 2. Chimeric constructs reveal a role for the ENT2 helix 5-6 region in nucleobase translocation. J Biol Chem 277: 24938 -24948, 2002.