메뉴 건너뛰기




Volumn 296, Issue 4, 2009, Pages

Facilitated mitochondrial import of antiviral and anticancer nucleoside drugs by human equilibrative nucleoside transporter-3

Author keywords

Anti human immunodeficiency virus drugs; Lysosomes; Mitochondrial transport

Indexed keywords

EQUILIBRATIVE NUCLEOSIDE TRANSPORTER; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 3; FIALURIDINE; GEMCITABINE; RIBAVIRIN; SMALL INTERFERING RNA; STAVUDINE; UNCLASSIFIED DRUG; YELLOW FLUORESCENT PROTEIN; ANTIBODY; ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; BACTERIAL PROTEIN; EPITOPE; NUCLEOSIDE TRANSPORTER; PHOTOPROTEIN; SLC29A3 PROTEIN, HUMAN; YELLOW FLUORESCENT PROTEIN, BACTERIA;

EID: 66149097607     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.90672.2008     Document Type: Article
Times cited : (124)

References (39)
  • 1
    • 0014409018 scopus 로고
    • Determination of intramitochondrial pH and intramitochondrial-extramitochondrial pH gradient of isolated heart mitochondria by the use of 5,5-dimethyl-2,4-oxazolidinedione
    • Addanki S, Cahill D, Sotos JF. Determination of intramitochondrial pH and intramitochondrial-extramitochondrial pH gradient of isolated heart mitochondria by the use of 5,5-dimethyl-2,4-oxazolidinedione. J Biol Chem 243: 2337-2348, 1968.
    • (1968) J Biol Chem , vol.243 , pp. 2337-2348
    • Addanki, S.1    Cahill, D.2    Sotos, J.F.3
  • 2
    • 0014428867 scopus 로고
    • Reliability of the quantitation of intra-mitochondrial pH and pH gradient of heart mitochondria
    • Addanki S, Cahill D, Sotos JF. Reliability of the quantitation of intra-mitochondrial pH and pH gradient of heart mitochondria. Anal Biochem 25: 17-29, 1968.
    • (1968) Anal Biochem , vol.25 , pp. 17-29
    • Addanki, S.1    Cahill, D.2    Sotos, J.F.3
  • 3
    • 0029162556 scopus 로고
    • Mammalian deoxyribonucleoside kinases
    • Arner ES, Eriksson S. Mammalian deoxyribonucleoside kinases. Pharmacol Ther 67: 155-186, 1995.
    • (1995) Pharmacol Ther , vol.67 , pp. 155-186
    • Arner, E.S.1    Eriksson, S.2
  • 5
    • 18144403118 scopus 로고    scopus 로고
    • Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes
    • Baldwin SA, Yao SY, Hyde RJ, Ng AM, Foppolo S, Barnes K, Ritzel MW, Cass CE, Young JD. Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes. J Biol Chem 280: 15880-15887, 2005.
    • (2005) J Biol Chem , vol.280 , pp. 15880-15887
    • Baldwin, S.A.1    Yao, S.Y.2    Hyde, R.J.3    Ng, A.M.4    Foppolo, S.5    Barnes, K.6    Ritzel, M.W.7    Cass, C.E.8    Young, J.D.9
  • 7
    • 0034699898 scopus 로고    scopus 로고
    • Adverse effects of antiretroviral therapy
    • Carr A, Cooper DA. Adverse effects of antiretroviral therapy. Lancet 356: 1423-1430, 2000.
    • (2000) Lancet , vol.356 , pp. 1423-1430
    • Carr, A.1    Cooper, D.A.2
  • 8
    • 1342308339 scopus 로고    scopus 로고
    • Molecular requirements of the human nucleoside transporters hCNT1, hCNT2, and hENT1
    • Chang C, Swaan PW, Ngo LY, Lum PY, Patil SD, Unadkat JD. Molecular requirements of the human nucleoside transporters hCNT1, hCNT2, and hENT1. Mol Pharmacol 65: 558-570, 2004.
    • (2004) Mol Pharmacol , vol.65 , pp. 558-570
    • Chang, C.1    Swaan, P.W.2    Ngo, L.Y.3    Lum, P.Y.4    Patil, S.D.5    Unadkat, J.D.6
  • 9
    • 34047235999 scopus 로고    scopus 로고
    • Transplacentally exposed human and monkey newborn infants show similar evidence of nucleoside reverse transcriptase inhibitor-induced mitochondrial toxicity
    • Divi RL, Leonard SL, Kuo MM, Nagashima K, Thamire C, St Claire MC, Wade NA, Walker VE, Poirier MC. Transplacentally exposed human and monkey newborn infants show similar evidence of nucleoside reverse transcriptase inhibitor-induced mitochondrial toxicity. Environ Mol Mutagen 48: 201-209, 2007.
    • (2007) Environ Mol Mutagen , vol.48 , pp. 201-209
    • Divi, R.L.1    Leonard, S.L.2    Kuo, M.M.3    Nagashima, K.4    Thamire, C.5    St Claire, M.C.6    Wade, N.A.7    Walker, V.E.8    Poirier, M.C.9
  • 10
    • 0344667703 scopus 로고    scopus 로고
    • Nucleoside reverse transcriptase inhibitor usage and the incidence of peripheral neuropathy in HIV/AIDS patients
    • Dragovic G, Jevtovic D. Nucleoside reverse transcriptase inhibitor usage and the incidence of peripheral neuropathy in HIV/AIDS patients. Antivir Chem Chemother 14: 281-284, 2003.
    • (2003) Antivir Chem Chemother , vol.14 , pp. 281-284
    • Dragovic, G.1    Jevtovic, D.2
  • 11
    • 9644268195 scopus 로고    scopus 로고
    • Identification and characterization of a novel monoamine transporter in the human brain
    • Engel K, Zhou M, Wang J. Identification and characterization of a novel monoamine transporter in the human brain. J Biol Chem 279: 50042-50049, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 50042-50049
    • Engel, K.1    Zhou, M.2    Wang, J.3
  • 14
    • 0037174138 scopus 로고    scopus 로고
    • Cardiolipin: A proton trap for oxidative phosphorylation
    • Hainers TH, Dencher NA. Cardiolipin: a proton trap for oxidative phosphorylation. FEBS Lett 528: 35-39, 2002.
    • (2002) FEBS Lett , vol.528 , pp. 35-39
    • Hainers, T.H.1    Dencher, N.A.2
  • 15
  • 16
    • 0034995844 scopus 로고    scopus 로고
    • The ENT family of eukaryote nucleoside and nucleobase transporters: Recent advances in the investigation of structure/function relationships and the identification of novel isoforms
    • Hyde RJ, Cass CE, Young JD, Baldwin SA. The ENT family of eukaryote nucleoside and nucleobase transporters: recent advances in the investigation of structure/function relationships and the identification of novel isoforms. Mol Membr Biol 18: 53-63, 2001.
    • (2001) Mol Membr Biol , vol.18 , pp. 53-63
    • Hyde, R.J.1    Cass, C.E.2    Young, J.D.3    Baldwin, S.A.4
  • 17
    • 33747888517 scopus 로고    scopus 로고
    • Equilibration of adenylates in the mitochondrial intermembrane space maintains respiration and regulates cytosolic metabolism
    • Igamberdiev AU, Kleczkowski LA. Equilibration of adenylates in the mitochondrial intermembrane space maintains respiration and regulates cytosolic metabolism. J Exp Bot 57: 2133-2141, 2006.
    • (2006) J Exp Bot , vol.57 , pp. 2133-2141
    • Igamberdiev, A.U.1    Kleczkowski, L.A.2
  • 19
    • 58149308564 scopus 로고    scopus 로고
    • Membrane deformation under local pH gradient: Mimicking mitochondrial cristae dynamics
    • Khalifat N, Puff N, Bonneau S, Fournier J, Angelova MI. Membrane deformation under local pH gradient: mimicking mitochondrial cristae dynamics. Biophys J 95: 4924-4933, 2008.
    • (2008) Biophys J , vol.95 , pp. 4924-4933
    • Khalifat, N.1    Puff, N.2    Bonneau, S.3    Fournier, J.4    Angelova, M.I.5
  • 20
    • 34047239196 scopus 로고    scopus 로고
    • A brief overview of mechanisms of mitochondrial toxicity from NRTIs
    • Kohler JJ, Lewis W. A brief overview of mechanisms of mitochondrial toxicity from NRTIs. Environ Mol Mutagen 48: 166-172, 2007.
    • (2007) Environ Mol Mutagen , vol.48 , pp. 166-172
    • Kohler, J.J.1    Lewis, W.2
  • 21
    • 1042301403 scopus 로고    scopus 로고
    • Mitochondrial expression of the human equilibrative nucleoside transporter 1 (hENT1) results in enhanced mitochondrial toxicity of antiviral drugs
    • Lai Y, Tse CM, Unadkat JD. Mitochondrial expression of the human equilibrative nucleoside transporter 1 (hENT1) results in enhanced mitochondrial toxicity of antiviral drugs. J Biol Chem 279: 4490-4497, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 4490-4497
    • Lai, Y.1    Tse, C.M.2    Unadkat, J.D.3
  • 22
    • 33745198904 scopus 로고    scopus 로고
    • Identification of the mitochondrial targeting signal of the human equilibrative nucleoside transporter 1 (hENT1): Implications for interspecies differences in mitochondrial toxicity of fialuridine
    • Lee EW, Lai Y, Zhang H, Unadkat JD. Identification of the mitochondrial targeting signal of the human equilibrative nucleoside transporter 1 (hENT1): implications for interspecies differences in mitochondrial toxicity of fialuridine. J Biol Chem 281: 16700-16706, 2006.
    • (2006) J Biol Chem , vol.281 , pp. 16700-16706
    • Lee, E.W.1    Lai, Y.2    Zhang, H.3    Unadkat, J.D.4
  • 23
    • 0028990381 scopus 로고
    • Mitochondrial toxicity of antiviral drugs
    • Lewis W, Dalakas MC. Mitochondrial toxicity of antiviral drugs. Nat Med 1: 417-422, 1995.
    • (1995) Nat Med , vol.1 , pp. 417-422
    • Lewis, W.1    Dalakas, M.C.2
  • 24
    • 24044471039 scopus 로고    scopus 로고
    • Nucleoside reverse transcriptase inhibitors, mitochondrial DNA and AIDS therapy
    • Lewis W. Nucleoside reverse transcriptase inhibitors, mitochondrial DNA and AIDS therapy. Antivir Ther 10, Suppl 2: M13-M27, 2005.
    • (2005) Antivir Ther , vol.10 , Issue.SUPPL. 2
    • Lewis, W.1
  • 25
    • 0034017591 scopus 로고    scopus 로고
    • Human intestinal es nucleoside transporter: Molecular characterization and nucleoside inhibitory profiles
    • Lum PY, Ngo LY, Bakken AH, Unadkat JD. Human intestinal es nucleoside transporter: molecular characterization and nucleoside inhibitory profiles. Cancer Chemother Pharmacol 45: 273-278, 2000.
    • (2000) Cancer Chemother Pharmacol , vol.45 , pp. 273-278
    • Lum, P.Y.1    Ngo, L.Y.2    Bakken, A.H.3    Unadkat, J.D.4
  • 28
    • 67649996802 scopus 로고    scopus 로고
    • Moore AL, Rich PR. Organization of the respiratory chain and oxidative phosphorylation. In: Encyclopedia of Plant Physiology, 18. Higher Plant Cell Respiration, edited by Douce R, Day DA. Berlin: Springer, 1985, p. 134-172.
    • Moore AL, Rich PR. Organization of the respiratory chain and oxidative phosphorylation. In: Encyclopedia of Plant Physiology, Vol. 18. Higher Plant Cell Respiration, edited by Douce R, Day DA. Berlin: Springer, 1985, p. 134-172.
  • 29
    • 2442697922 scopus 로고    scopus 로고
    • Targeting and assembly of rat mitochondrial translocase of outer membrane 22 (TOM22) into the TOM complex
    • Nakamura Y, Suzuki H, Sakaguchi M, Mihara K. Targeting and assembly of rat mitochondrial translocase of outer membrane 22 (TOM22) into the TOM complex. J Biol Chem 279: 21223-21232, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 21223-21232
    • Nakamura, Y.1    Suzuki, H.2    Sakaguchi, M.3    Mihara, K.4
  • 30
    • 0033544888 scopus 로고    scopus 로고
    • Localization of endogenous Grb10 to the mitochondria and its interaction with the mitochondrial-associated Raf-1 pool
    • Nantel A, Huber M, Thomas DY. Localization of endogenous Grb10 to the mitochondria and its interaction with the mitochondrial-associated Raf-1 pool. J Biol Chem 274: 35719-35724, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 35719-35724
    • Nantel, A.1    Huber, M.2    Thomas, D.Y.3
  • 31
    • 0035815726 scopus 로고    scopus 로고
    • Identification and characterization of a mitochondrial targeting signal in rat cytochrome P450 2E1 (CYP2E1)
    • Neve EP, Ingelman-Sundberg M. Identification and characterization of a mitochondrial targeting signal in rat cytochrome P450 2E1 (CYP2E1). J Biol Chem 276: 11317-11322, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 11317-11322
    • Neve, E.P.1    Ingelman-Sundberg, M.2
  • 32
    • 0035344460 scopus 로고    scopus 로고
    • Versatility of the mitochondrial protein import machinery
    • Pfanner N, Geissler A. Versatility of the mitochondrial protein import machinery. Nat Rev Mol Cell Biol 2: 339-349, 2001.
    • (2001) Nat Rev Mol Cell Biol , vol.2 , pp. 339-349
    • Pfanner, N.1    Geissler, A.2
  • 33
    • 0024598293 scopus 로고
    • Detection and characterization of a nucleoside transport system in human fibroblast lysosomes
    • Pisoni RL, Thoene JG. Detection and characterization of a nucleoside transport system in human fibroblast lysosomes. J Biol Chem 264: 4850-4856, 1989.
    • (1989) J Biol Chem , vol.264 , pp. 4850-4856
    • Pisoni, R.L.1    Thoene, J.G.2
  • 34
    • 34247562746 scopus 로고    scopus 로고
    • How can organellar protein N-terminal sequences be dual targeting signals? In silico analysis and mutagenesis approach
    • Pujol C, Marechal-Drouard L, Duchene AM. How can organellar protein N-terminal sequences be dual targeting signals? In silico analysis and mutagenesis approach. J Mol Biol 369: 356-367, 2007.
    • (2007) J Mol Biol , vol.369 , pp. 356-367
    • Pujol, C.1    Marechal-Drouard, L.2    Duchene, A.M.3
  • 35
    • 0037174926 scopus 로고    scopus 로고
    • Bimodal targeting of microsomal CYP2E1 to mitochondria through activation of an N-terminal chimeric signal by cAMP-mediated phosphorylation
    • Robin MA, Anandatheerthavarada HK, Biswas G, Sepuri NB, Gordon DM, Pain D, Avadhani NG. Bimodal targeting of microsomal CYP2E1 to mitochondria through activation of an N-terminal chimeric signal by cAMP-mediated phosphorylation. J Biol Chem 277: 40583-40593, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 40583-40593
    • Robin, M.A.1    Anandatheerthavarada, H.K.2    Biswas, G.3    Sepuri, N.B.4    Gordon, D.M.5    Pain, D.6    Avadhani, N.G.7
  • 36
    • 0032922413 scopus 로고    scopus 로고
    • Nucleobase transport inopossum kidney epithelial cells and Xenopus laevis oocytes: The characterisation, structure-activity relationship of uracil analogues and oocyte expression studies of sodium-dependent and -independent hypoxanthine uptake
    • Shayeghi M, Akerman R, Jarvis SM. Nucleobase transport inopossum kidney epithelial cells and Xenopus laevis oocytes: the characterisation, structure-activity relationship of uracil analogues and oocyte expression studies of sodium-dependent and -independent hypoxanthine uptake. Biochim Biophys Acta 1416: 109-118, 1999.
    • (1999) Biochim Biophys Acta , vol.1416 , pp. 109-118
    • Shayeghi, M.1    Akerman, R.2    Jarvis, S.M.3
  • 39
    • 0034918036 scopus 로고    scopus 로고
    • Transport of antiviral 3′-deoxy-nucleoside drugs by recombinant human and rat equilibrative, nitrobenzylthioinosine (NBMPR)-insensitive (ENT2) nucleoside transporter proteins produced in Xenopus oocytes
    • Yao SY, Ng AM, Sundaram M, Cass CE, Baldwin SA, Young JD. Transport of antiviral 3′-deoxy-nucleoside drugs by recombinant human and rat equilibrative, nitrobenzylthioinosine (NBMPR)-insensitive (ENT2) nucleoside transporter proteins produced in Xenopus oocytes. Mol Membr Biol 18: 161-167, 2001.
    • (2001) Mol Membr Biol , vol.18 , pp. 161-167
    • Yao, S.Y.1    Ng, A.M.2    Sundaram, M.3    Cass, C.E.4    Baldwin, S.A.5    Young, J.D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.