Inhaled today, not gone tomorrow: Pharmacokinetics and environmental exposure of volatiles in exhaled breath

Journal of Breath Research

Volumn 5, Issue 3, 2011, Pages

  Beauchamp, J ^a  

^a FRAUNHOFER INSTITUTE FOR PROCESS ENGINEERING AND PACKAGING IVV   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; CARBON DIOXIDE; ISOPRENE; METHANOL; NITROGEN; ORGANIC COMPOUND; OXYGEN; PROPOFOL; VOLATILE AGENT; VOLATILE ORGANIC COMPOUND;

ALCOHOL CONSUMPTION; BREATH ANALYSIS; BREATHING; CIGARETTE SMOKING; DIET; DIETARY INTAKE; DRUG MONITORING; ENVIRONMENTAL EXPOSURE; EXPIRED AIR; GARLIC; GAS ANALYSIS; INHALATION; PHARMACOKINETICS; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; REVIEW; TOXICOKINETICS; WATER VAPOR; DANGEROUS GOODS; EXHALATION; HUMAN; INHALATIONAL DRUG ADMINISTRATION; LUNG; MASS FRAGMENTOGRAPHY; METABOLISM; METHODOLOGY; PHYSIOLOGY; VOLATILIZATION;

ADMINISTRATION, INHALATION; BREATH TESTS; ENVIRONMENTAL EXPOSURE; EXHALATION; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HAZARDOUS SUBSTANCES; HUMANS; INHALATION; LUNG; VOLATILIZATION;

EID: 80052758579     PISSN: 17527155     EISSN: 17527163     Source Type: Journal    
DOI: 10.1088/1752-7155/5/3/037103     Document Type: Review

References (117)

1. Alobaidi T A A, Hill D W and Payne J P 1976 Significance of variations in blood: breath partition coefficient of alcohol Br. Med. J. 2 1479-81
2. Amann A, Poupart G, Telser S, Ledochowski M, Schmid A and Mechtcheriakov S 2004 Applications of breath gas analysis in medicine Int. J. Mass Spectrom. 239 227-33
3. Ammann C, Brunner A, Spirig C and Neftel A 2006 Technical note: water vapour concentration and flux measurements with PTR-MS Atmos. Chem. Phys. 6 4643-51 (Pubitemid 44600397)
4. Bange H W and Williams J 2000 New directions: acetonitrile in atmospheric and biogeochemical cycles Atmos. Environ. 34 4959-60
5. Basanta M, Jarvis R M, Xu Y, Blackburn G, Tal-Singer R, Woodcock A, Singh D, Goodacre R, Paul Thomas C L and Fowler S J 2010 Non-invasive metabolomic analysis of breath using differential mobility spectrometry in patients with chronic obstructive pulmonary disease and healthy smokers Analyst 135 315-20
6. Batterman S, Zhang L, Wang S and Franzblau A 2002 Partition coefficients for the trihalomethanes among blood, urine, water, milk and air Sci. Total Environ. 284 237-47
7. Baumbach J I 2009 Ion mobility spectrometry coupled with multi-capillary columns for metabolic profiling of human breath J. Breath Res. 3 034001
8. Beauchamp J, Herbig J, Gutmann R and Hansel A 2008 On the use of Tedlar bags for breath-gas sampling and analysis J. Breath Res. 2 046001
9. Beauchamp J, Kirsch F and Buettner A 2010 Real-time breath gas analysis for pharmacokinetics: monitoring exhaled breath by on-line proton-transfer- reaction mass spectrometry after ingestion of eucalyptol-containing capsules J. Breath Res. 4 026006
10. 2, organic compounds and PM10 at a motorway location in an Austrian valley Atmos. Environ. 38 2511-22
11. Benowitz N L 1999 Biomarkers of environmental tobacco smoke exposure Environ. Health Perspect. 107 349-55 (Pubitemid 29264045)
12. Boshier P R, Cushnir J R, Priest O H, Marczin N and Hanna G B 2010 Variation in the levels of volatile trace gases within three hospital environments: implications for clinical breath testing J. Breath Res. 4 031001
13. Boucaud M, Pinguet F, Poujol S, Romieu G, Cupissol D, Astre C, Culine S and Bressolle F 2001 Salivary and plasma pharmacokinetics of topotecan in patients with metastatic epithelial ovarian cancer Eur. J. Cancer 37 2357-64 (Pubitemid 33097471)
14. Brunner C, Szymczak W, Höllriegl V, Mörtl S, Oelmez H, Bergner A, Huber R, Hoeschen C and Oeh U 2010 Discrimination of cancerous and non-cancerous cell lines by headspace-analysis with PTR-MS Anal. Bioanal. Chem. 397 2315-24
15. Bunge M, Araghipour N, Mikoviny T, Dunkl J, Schnitzhofer R, Hansel A, Schinner F, Wisthaler A, Margesin R and Mark T D 2008 On-line monitoring of microbial volatile metabolites by proton transfer reaction-mass spectrometry Appl. Environ. Microbiol. 74 2179-86 (Pubitemid 351522073)
16. Cao W and Duan Y 2006 Breath analysis: potential for clinical diagnosis and exposure assessment Clin. Chem. 52 800-11
17. Chen X, Xu F, Wang Y, Pan Y, Lu D, Wang P, Ying K, Chen E and Zhang W 2007 A study of the volatile organic compounds exhaled by lung cancer cells in vitro for breath diagnosis Cancer 110 835-44 (Pubitemid 47257662)
18. Cope K A, Watson M T, Foster W M, Sehnert S S and Risby T H 2004 Effects of ventilation on the collection of exhaled breath in humans J. Appl. Physiol. 96 1371-9 (Pubitemid 38392673)
19. Cunnington A J and Hormbrey P 2002 Breath analysis to detect recent exposure to carbon monoxide Postgrad. Med. J. 78 233-7
20. Di Francesco F, Loccioni C, Fioravanti M, Russo A, Pioggia G, Ferro M, Roehrer I, Tabucchi S and Onor M 2008 Implementation of Fowler's method for end-tidal air sampling J. Breath Res. 2 037009
21. Dillon W C, Hampl V, Shultz P J, Rubins J B and Archer S L 1996 Origins of breath nitric oxide in humans Chest 110 930-8 (Pubitemid 26347606)
22. Di Natale C, Macagnano A, Martinelli E, Paolesse R, D'Arcangelo G, Roscioni C, Finazzi-Agrò A and D'Amico A 2003 Lung cancer identification by the analysis of breath by means of an array of non-selective gas sensors Biosens. Bioelectron. 18 1209-18 (Pubitemid 36776581)
23. Ding X and Kaminsky L S 2003 Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts Annu. Rev. Phamacol. Toxicol. 43 149-73
24. Dubois A B, Douglas J S, Stitt J T and Mohsenin V 1998 Production and absorption of nitric oxide gas in the nose J. Appl. Physiol. 84 1217-24
25. Erhart S et al 2009 3-Heptanone as a potential new marker for valproic acid therapy J. Breath Res. 3 016004
26. Eriksen S P and Kulkarni A B 1963 Methanol in normal human breath Science 141 639-40
27. Falk A, Gullstrand E, Löf A andWigaeus-Hjelm E 1990a Liquid/air partition coefficients of four terpenes Br. J. Ind. Med. 47 62-4
28. Falk A A, Hagberg M T, Löf A E, Wigaeus-Hjelm E M and Zhiping W 1990b Uptake, distribution and elimination of α-pinene in man after exposure by inhalation Scand. J. Work Environ. Health 16 372-8 (Pubitemid 20319965)
29. Falk-Filipsson A, Löf A, Hagberg M, Hjelm E W and Wang Z P 1993 d-Limonene exposure to humans by inhalation: uptake, distribution, elimination, and effects on the pulmonary function J. Toxicol. Env. Health 38 77-88 (Pubitemid 23045953)
30. Fens N, Zwinderman A H, Van Der Schee M P, de Nijs S B, Dijkers E, Roldaan A C, Cheung D, Bel E H and Sterk P J 2009 Exhaled breath profiling enables discrimination of chronic obstructive pulmonary disease and asthma Am. J. Respir. Crit. Care Med. 180 1076-82
31. Fenske J D and Paulson S E 1999 Human breath emissions of VOCs J. Air Waste Manage. Assoc. 49 594-8
32. Friedman M I, Preti G, Deems R O, Friedman L S, Munoz S J and Maddrey W C 1994 Limonene in expired lung air of patients with liver disease Digest. Dis. Sci. 39 1672-6 (Pubitemid 24263142)
33. Galassetti P R, Novak B, Nemet D, Rose-Gottron C, Cooper D M, Meinardi S, Newcomb R, Zaldivar F and Blake D R 2005 Breath ethanol and acetone as indicators of serum glucose levels: an initial report Diabetes Technol. Ther. 7 115-23 (Pubitemid 40354581)
34. Gonzales M, Pepin J, Frost E, Carrier J, Sirard S, Fortier L-C and Valiquette L 2010 Faecal pharmacokinetics of orally administered vancomycin in patients with suspected Clostridium difficile infection BMC Infect. Dis. 10 363
35. Gordon S M, Wallace L A, Brinkman M C, Callahan P J and Kenny D V 2002 Volatile organic compounds as breath biomarkers for active and passive smoking Environ. Health Perspect. 110 689-98
36. Hansanugrum A and Barringer S A 2010 Effect of milk on the deodorization of malodorous breath after garlic ingestion J. Food Sci. 75 C549-58
37. Harrison G R, Critchley A D J, Mayhew C A and Thompson J M 2003 Real-time breath monitoring of propofol and its volatile metabolites during surgery using a novel mass spectrometric technique: a feasibility study Br. J. Anaesth. 91 797-9 (Pubitemid 37508819)
38. Herbig J, Muller M, Schallhart S, Titzmann T, Graus M and Hansel A 2009 On-line breath analysis with PTR-TOF J. Breath Res. 3 027004
39. Herbig J, Titzmann T, Beauchamp J, Kohl I and Hansel A 2008 Buffered end-tidal (BET) sampling - a novel method for real-time breath-gas analysis J. Breath Res. 2 037008
40. Holzinger R, Jordan A, Hansel A and Lindinger W 2001 Automobile emissions of acetonitrile: assessment of its contribution to the global source J. Atmos. Chem. 38 187-93 (Pubitemid 32194463)
41. Hunnisett A, Howard J and Davies S 1990 Gut fermentation (or auto-brewery) syndrome. A new clinical test with initial observations and discussion of clinical and biological implications J. Nutr. Med. 1 33-8
42. Jäger W, Nasel B, Nasel C, Binder R, Stimpfl T, Vycudilik W and Buchbauer G 1996 Pharmacokinetic studies of the fragrance compound 1,8-cineol in humans during inhalation Chem. Senses 21 477-80 (Pubitemid 26275853)
43. Janovsky U, Scholl-Bürgli S, Karall D, Beauchamp J, Hansel A, Poupart G, Schmid A and Amann A 2005 Breath gas analysis in patients suffering from propionic acidaemia Breath Analysis for Clinical Diagnosis and Therapeutic Monitoring ed A Amann and D Smith (Singapore: World Scientific) pp 401-7
44. Jones A W 1978 Variability of the blood:breath alcohol ratio in vivo J Stud. Alcohol 39 1931-9
45. Jones A W 1987 Elimination half-life of methanol during hangover Pharmacol. Toxicol. 60 217-20 (Pubitemid 17053597)
46. Jones A W and Andersson L 2003 Comparison of ethanol concentrations in venous blood and end-expired breath during a controlled drinking study Forensic Sci. Int. 132 18-25
47. Jones A W, Sato A and Forsander O A 1985 Liquid/air partition coefficients of acetaldehyde: values and limitations in estimating blood concentrations from analysis of breath Alcohol. Clin. Exp. Res. 9 461-4 (Pubitemid 16245579)
48. Karl T, Jordan A, Hansel A, Holzinger R and Lindinger W 1998 Benzene and acetontrile in smokers and nonsmokers Ber. Nat.-Med. Verein Innsbruck 85 7-15
49. Karl T, Prazeller P, Mayr D, Jordan A, Rieder J, Fall R and Lindinger W 2001 Human breath isoprene and its relation to blood cholesterol levels: new measurements and modeling J. Appl. Physiol. 91 762-70 (Pubitemid 32681109)
50. King J, Koc H, Unterkofler K, Mochalski P, Kupferthaler A, Teschl G, Teschl S, Hinterhuber H and Amann A 2010 Physiological modeling of isoprene dynamics in exhaled breath J. Theor. Biol. 267 626-37
51. King J, Kupferthaler A, Unterkofler K, Koc H, Teschl S, Teschl G, Miekisch W, Schubert J, Hinterhuber H and Amann A 2009 Isoprene and acetone concentration profiles during exercise on an ergometer J. Breath Res. 3 027006
52. King J, Unterkofler K, Teschl G, Teschl S, Koc H, Hinterhuber H and Amann A 2011 A mathematical model for breath gas analysis of volatile organic compounds with special emphasis on acetone Math. Biol. at press (doi:10.1007/s00285-010-0398-9)
53. Koc H, King J, Teschl G, Unterkofler K, Teschl S, Mochalski P, Hinterhuber H and Amann A 2011 The role of mathematical modeling in VOC analysis using isoprene as a prototypic example J. Breath Res. 5 037102
54. Kushch I et al 2008 Compounds enhanced in a mass spectrometric profile of smokers' exhaled breath versus non-smokers as determined in a pilot study using PTR-MS J. Breath Res. 2 026002
55. Kwak J and Preti G 2011 Volatile disease biomarkers in breath: a critique Curr. Pharm. Biotechnol. at press
56. Larsson B T 1965 Gas chromatography of organic volatiles in human breath and saliva Acta Chem. Scand. 19 159-64
57. Law M R and Hackshaw A K 1996 Environmental tobacco smoke Br. Med. Bull. 52 22-34
58. Lindberg L, Brauer S, Wollmer P, Goldberg L, Jones A W and Olsson S G 2007 Breath alcohol concentration determined with a new analyzer using free exhalation predicts almost precisely the arterial blood alcohol concentration Forensic Sci. Int. 168 200-7 (Pubitemid 46629121)
59. Lindinger W, Hansel A and Jordan A 1998 On-line monitoring of volatile organic compounds at pptv levels by means of proton-transfer-reaction mass spectrometry (PTR-MS) medical applications, food control and environmental research Int. J. Mass Spectrom. Ion Process. 173 191-241
60. Lindinger W, Taucher J, Jordan A, Hansel A and Vogel W 1997 Endogenous production of methanol after the consumption of fruit Alcohol. Clin. Exp. Res. 21 939-43 (Pubitemid 27355696)
61. Luceri F, Pieraccini G, Moneti G and Dolara P 1993 Primary aromatic amines from side-stream cigarette smoke are common contaminants of indoor air Toxicol. Ind. Health 9 405-13 (Pubitemid 23191584)
62. Mackay D A M, Lang D A and Berdick M 1959 The objective measurement of odor - III. Breath odor and deodorization Proc. Sci. Sect. Toilet Goods Assoc. 32 45-51
63. Mayer F and Breuer K 2006 Material odor-odoractive compounds identified in different materials - the surprising similarities with certain foods, possible sources and hypotheses on their formation Indoor Air 16 373-82 (Pubitemid 44327689)
64. Mayer F, Breuer K and Sedlbauer K 2009 Material and Indoor Odors and Odorants Organic Indoor Air Pollutants ed T Salthammer and E Uhde (Weinheim: Wiley) pp 165-87
65. Metsälä M, Schmidt F M, Skyttä M, Vaittinen O and Halonen L 2010 Acetylene in breath: background levels and real-time elimination kinetics after smoking J. Breath Res. 4 046003
66. Miekisch W, Kischkel S, Sawacki A, Liebau T, Mieth M and Schubert J K 2008 Impact of sampling procedures on the results of breath analysis J. Breath Res. 2 026007
67. Miekisch W, Schubert J K and Noeldge-Schomburg G F E 2004 Diagnostic potential of breath analysis - focus on volatile organic compounds Clin. Chim. Acta 347 25-39 (Pubitemid 39099603)
68. NTP 2005 Report on Carcinogens Eleventh Edition US Department of Health and Human Services, Public Health Service, National Toxicology Program, section III-258
69. O'Hara M E, Clutton-Brock T H, Green S and Mayhew C A 2009a Endogenous volatile organic compounds in breath and blood of healthy volunteers: examining breath analysis as a surrogate for blood measurements J. Breath Res. 3 027005
70. O'Hara M E, Clutton-Brock T H, Green S, O'Hehir S and Mayhew C A 2009b Mass spectrometric investigations to obtain the first direct comparisons of endogenous breath and blood volatile organic compound concentrations in healthy volunteers Int. J. Mass Spectrom. 281 92-6
71. O'Hara M E, O'Hehir S, Green S and Mayhew C A 2008 Development of a protocol to measure volatile organic compounds in human breath: a comparison of rebreathing and on-line single exhalations using proton transfer reaction mass spectrometry Physiol. Meas. 29 309-30 (Pubitemid 351423042)
72. Opdam J J G and Smolders J F J 1986 Alveolar sampling and fast kinetics of tetrachloroethene in man: I. Alveolar sampling Br. J. Ind. Med. 43 814-24 (Pubitemid 17203092)
73. Pailer M, Hübsch W J and Kuhn H 1966 Über das vorkommen aromatischer amine im zigarettenrauch Monatsh. Chem. 97 1448-51
74. Pauling L, Robinson A B, Teranishi R and Cary P 1971 Quantitative analysis of urine vapor and breath by gas-liquid partition chromatography Proc. Natl Acad. Sci. USA 68 2374-6
75. Phillips M, Cataneo R N, Condos R, Ring Erickson G A, Greenberg J, La Bombardi V, Munawar M I and Tietje O 2007 Volatile biomarkers of pulmonary tuberculosis in the breath Tuberculosis 87 44-52 (Pubitemid 44960164)
76. Phillips M, Cataneo R N, Saunders C, Hope P, Schmitt P and Wai J 2010 Volatile biomarkers in the breath of women with breast cancer J. Breath Res. 4 026003
77. Phillips M et al 2004 Heart allograft rejection: detection with breath alkanes in low levels (the HARDBALL study) J. Heart Lung Transplant 23 701-8 (Pubitemid 38721439)
78. Phillips M et al 2008 Detection of lung cancer using weighted digital analysis of breath biomarkers Clin. Chim. Acta 393 76-84
79. Phillips M, Herrera J, Krishnan S, Zain M, Greenberg J and Cataneo R N 1999 Variation in volatile organic compounds in the breath of normal humans J. Chromatogr. B 729 75-88 (Pubitemid 29264111)
80. Pierce C H, Dills R L, Silvey G W and Kalman D A 1996 Partition coefficients between human blood or adipose tissue and air for aromatic solvents Scand. J. Work Environ. Health 22 112-8 (Pubitemid 26151162)
81. Pleil J D 2008 Role of exhaled breath biomarkers in environmental health science J. Toxicol. Environ. Health B 11 613-29
82. Pleil J D, Kim D, Prah J D, Ashley D L and Rappaport S M 2005 The unique value of breath biomarkers for estimating pharmacokinetic rate constants and body burden from environmental exposures Breath Analysis for Clinical Diagnosis and Therapeutic Monitoring ed A Amann and D Smith (Singapore: World Scientific) pp 347-59
83. Pleil J D and Lindstrom A B 1995 Measurement of volatile organic compounds in exhaled breath as collected in evacuated electropolished canisters J. Chromatogr. B 665 271-9
84. Pleil J D and Lindstrom A B 1997 Exhaled human breath measurement method for assessing exposure to halogenated volatile organic compounds Clin. Chem. 43 723-30
85. Polzin G M, Kosa-Maines R E, Ashley D L and Watson C H 2007 Analysis of volatile organic compounds in mainstream cigarette smoke Environ. Sci. Technol. 41 1297-302
86. Preti G, Labows J N, Kostelc J G, Aldinger S and Daniele R 1988 Analysis of lung air from patients with bronchongenic carcinoma and controls using gas chromatography-mass spectrometry J. Chromatogr. B 432 1-11
87. Prévôt A S H, Dommen J and Bäumle M 2000 Influence of road traffic on volatile organic compound concentrations in and above a deep Alpine valley Atmos. Environ. 34 4719-26 (Pubitemid 30628305)
88. Ramchandani V A, Bosron W F and Li T K 2001 Research advances in ethanol metabolism Pathol. Biol. 49 676-82 (Pubitemid 33091859)
89. Rieder J, Lirk P, Ebenbichler C, Gruber G, Prazeller P, Lindinger W and Amann A 2001 Analysis of volatile organic compounds: possible applications in metabolic disorders and cancer screening Wien. Klin. Wochenschr. 113 181-5 (Pubitemid 32244768)
90. Risby T H 2008 Critical issues for breath analysis J. Breath Res. 2 030302
91. Sato A and Nakajima T 1979 Partition coefficients of some aromatic hydrocarbons and ketones in water, blood and oil Br. J. Ind. Med. 36 231-4
92. Schubert J K, Miekisch W, Birken T, Geiger K and Noldge-Schomburg G F 2005 Impact of inspired substance concentrations on the results of breath analysis in mechanically ventilated patients Biomarkers 10 138-52 (Pubitemid 40916672)
93. 2-controlled sampling of alveolar gas in mechanically ventilated patients J. Appl. Physiol. 90 486-92
94. Schwarz K, Filipiak W and Amann A 2009a Determining concentration patterns of volatile compounds in exhaled breath by PTR-MS J. Breath Res. 2 027002
95. Schwarz K et al 2009b Breath acetone - aspects of normal physiology related to age and gender as determined in a PTR-MS study J. Breath Res. 2 027003
96. Smith D and Spanel P 1996 The novel selected-ion flow tube approach to trace gas analysis of air and breath Rapid Commun. Mass Spectrom. 10 1183-98
97. Smith D, Wang T and Spanel P 2002 On-line, simultaneous quantification of ethanol, some metabolites and water vapour in breath following the ingestion of alcohol Physiol. Meas. 23 477
98. Stedman R L 1968 Chemical composition of tobacco and tobacco smoke Chem. Rev. 68 153-207
99. Steeghs M M L, Cristescu S M, Munnik P, Zanen P and Harren F J M 2007 An off-line breath sampling and analysis method suitable for large screening studies Physiol. Meas. 28 503-14
100. Stewart R D, Hake C L and Wu A 1976 Use of breath analysis to monitor methylene chloride exposure Scand. J. Work Environ. Health 2 57-70
101. Suddendorf R F 1989 Research on alcohol metabolism among Asians and its implications for understanding causes of alcoholism Public Health Rep. 104 615-20 (Pubitemid 20029109)
102. Takita A, Masui K and Kazama T 2007 On-line monitoring of end-tidal propofol concentration in anesthetized patients Anesthesiology 106 659-64 (Pubitemid 46555608)
103. Taucher J, Hansel A, Jordan A and Lindinger W 1996 Analysis of compounds in human breath after ingestion of garlic using proton-transfer-reaction mass spectrometry J. Agric. Food Chem. 44 3778-82 (Pubitemid 126453367)
104. Teranishi R, Mon T R, Robinson A B, Cary P and Pauling L 1972 Gas chromatography of volatiles from breath and urine Anal. Chem. 44 18-20
105. Thekedar B, Oeh U, Szymczak W, Hoeschen C and Paretzke H G 2011 Influences of mixed expiratory sampling parameters on exhaled volatile organic compound concentrations J. Breath Res. 5 016001
106. Turner C, Španěl P and Smith D 2006 A longitudinal study of ethanol and acetaldehyde in the exhaled breath of healthy volunteers using selected-ion flow-tube mass spectrometry Rapid Commun. Mass Spectrom. 20 61-8 (Pubitemid 41815180)
107. Van Der Graaff M, Vermeulen N P E, Heij P, Boeijinga J K and Breimer D D 1986 Pharmacokinetics of orally administered hexobarbital in plasma and saliva of healthy subjects Biopharm. Drug Dispos. 7 265-72 (Pubitemid 16079716)
108. von Basum G, Dahnke H, Halmer D, Hering P and Mürtz M 2003 Online recording of ethane traces in human breath via infrared laser spectroscopy J. Appl. Physiol. 95 2583-90 (Pubitemid 37445006)
109. Wainman T, Zhang J, Weschler C J and Lioy J 2000 Ozone and limonene in indoor air: a source of submicron particle exposure Environ. Health Perspect. 108 1139-45 (Pubitemid 32049098)
110. Wallace L, Buckley T, Pellizzari E and Gordon S 1996 Breath measurements as volatile organic compound biomarkers Environ. Health Perspect. 104 861-9 (Pubitemid 26402323)
111. Wallace L A and Pellizzari E D 1995 Recent advances in measuring exhaled breath and estimating exposure and body burden for volatile organic compounds (VOCs) Environ. Health Perspect. 103 95-8
112. Wang T, Pysanenko A, Dryahina K, Spanel P and Smith D 2008 Analysis of breath, exhaled via the mouth and nose, and the air in the oral cavity J. Breath Res. 3 037013
113. Wehinger A, Schmid A, Mechtcheriakov S, Ledochowski M, Grabmer C, Gastl G A and Amann A 2007 Lung cancer detection by proton transfer reaction mass-spectrometric analysis of human breath gas Int. J. Mass Spectrom. 265 49-59
114. Weschler C J 2009 Changes in indoor pollutants since the 1950s Atmos. Environ. 43 153-69
115. Wilson P F, Freeman C G, McEwan M J, Milligan D B, Allardyce R A and Shaw G M 2001 Alcohol in breath and blood: a selected ion flow tube mass spectrometric study Rapid Commun. Mass Spectrom. 15 413-7
116. Xiao Y, Jacob D J and Turquety S 2007 Atmospheric acetylene and its relationship with CO as an indicator of air mass age J. Geophys. Res. 112 D12305
117. Yeung C Y, Wong F H W, Tam A Y C, Ma Y P, Kwan H C and Fung K W 1991 Automatic end-expiratory air sampling device for breath hydrogen test in infants Lancet 337 90-3