Breath ethanol and acetone as indicators of serum glucose levels: An initial report

Diabetes Technology and Therapeutics

Volumn 7, Issue 1, 2005, Pages 115-123

  Galassetti, Pietro R ^a,b   Novak, Brian ^a   Nemet, Dan ^a   Rose Gottron, Christie ^a   Cooper, Dan M ^a   Meinardi, Simone ^a   Newcomb, Robert ^a   Zaldivar, Frank ^a   Blake, Donald R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETONE; ALCOHOL; FATTY ACID; GLUCOSE; INSULIN;

ADULT; AMBIENT AIR; ARTICLE; BREATH ANALYSIS; CHROMATOGRAPHY; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; FERMENTATION; GAS ANALYSIS; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLUCOSE TOLERANCE TEST; HUMAN; HUMAN EXPERIMENT; INSULIN BLOOD LEVEL; INTESTINE FLORA; MALE; MASS SPECTROMETRY; NORMAL HUMAN; OXIDATION; PRIORITY JOURNAL; YEAST;

ACETONE; ADULT; BIOLOGICAL MARKERS; BLOOD GLUCOSE; BREATH TESTS; ETHANOL; FEMALE; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN; MALE; REFERENCE VALUES; REGRESSION ANALYSIS;

EID: 14844352153     PISSN: 15209156     EISSN: None     Source Type: Journal    
DOI: 10.1089/dia.2005.7.115     Document Type: Article

References (33)

1. Pauling L, Robison AB, Teranishi R, Cary P: Quantitative anlysis of urine vapor and breath by gas-liquid partition chromatography. Proc Natl Acad Sci USA 1971;68:2374-2376.
2. Arterbery VE, Pryor WA, Jiang L, Sehnert SS, Foster WM, Abrams RA, Williams JR, Wharam MD Jr, Risby TH: Breath ethane generation during clinical total body irradiation as a marker of oxygen-free-radical-mediated lipid peroxidation: a case study. Free Radic Biol Med 1994;17:569-576.
3. Kneepkens CM, Ferreira C, Lepage G, Roy CC: The hydrocarbon breath test in the study of lipid peroxidation: principles and practice. Clin Invest Med 1992;15:163-186.
4. Lemoyne M, Van Gossum A, Kurian R, Ostro M, Axler J, Jeejeebhoy KN: Breath pentane analysis as an index of lipid peroxidation: a functional test of vitamin E status. Am J Clin Nutr 1987;46:267-272.
5. Sobotka PA, Brottman MD, Weitz Z, Birnbaum AJ, Skosey JL, Zarling EJ: Elevated breath pentane in heart failure reduced by free radical scavenger. Free Radic Biol Med 1993;14:643-647.
6. Weitz ZW, Birnbaum AJ, Sobotka PA, Zarling EJ, Skosey JL: High breath pentane concentrations during acute myocardial infarction. Lancet 1991;337: 933-935.
7. Olopade CO, Zakkar M, Swedler WI, Rubinstein I: Exhaled pentane levels in acute asthma. Chest 1997; 111:862-865.
8. Paredi P, Kharitonov SA, Leak D, Shah PL, Cramer D, Hodson ME, Barnes PJ: Exhaled ethane is elevated in cystic fibrosis and correlates with carbon monoxide levels and airway obstruction. Am J Respir Crit Care Med 2000;161:1247-1251.
9. Tassopoulos CN, Barnett D, Fraser TR: Breath-acetone and blood-sugar measurements in diabetes. Lancet 1969;1:1282-1286.
10. Viken RJ, Rose RJ, Morzorati SL, Christian JC, Li TK: Subjective intoxication in response to alcohol challenge: heritability and covariation with personality, breath alcohol level, and drinking history. Alcohol Clin Exp Res 2003;27:795-803.
11. Blake DR, Hurst DF, Smith TW Jr, Whipple WJ, Chen TY, Blake NJ, Rowland FS: Summertime measurements of selected nonmethane hydrocarbons in the Arctic and Subartic during the 1988 Arctic Boundary Layer Experiment (ABLE-3A). J Geophys Res 1992;97:16559-16588.
12. Colman JJ, Swanson AL, Meinardi S, Sive BC, Blake DR, Rowland FS: Description of the analysis of a wide range of volatile organic compounds in whole air samples collected during PEM-tropics A and B. Anal Chem 2001;73:3723-3731.
13. Ladkin RG, Davis JNP: Rupture of the stomach in an African child. BMJ 1948;i:644.
14. Musa-Veloso K, Rarama E, Comeau F, Curtis R, Cunnane S: Epilepsy and the ketogenic diet: assessment of ketosis in children using breath acetone. Pediatr Res 2002;52:443-448.
15. Musa-Veloso K, Likhodii SS, Cunnane SC: Breath acetone is a reliable indicator of ketosis in adults consuming ketogenic meals. Am J Clin Nutr 2002; 76:65-70.
16. Owen OE, Caprio S, Reichard GA Jr, Mozzoli MA, Boden G, Owen RS: Ketosis of starvation: a revisit and new perspectives. Clin Endocrinol Metab 1983;12:359-379.
17. American Diabetes Association: Clinical practice recommendations. Diabetes Care 2002;25(Suppl 1): S1-S147.
18. Dahshan A, Donovan K: Auto-brewery syndrome in a child with short gut syndrome: case report and review of the literature. J Pediatr Gastroenterol Nutr 2001;33:214-215.
19. Cope K, Risby T, Diehl AM: Increased gastrointestinal ethanol production in obese mice: implications for fatty liver disease pathogenesis. Gastroenterology 2000;119:1340-1347.
20. Nair S, Cope K, Risby TH, Diehl AM, Terence RH: Obesity and female gender increase breath ethanol concentration: potential implications for the pathogenesis of nonalcoholic steatohepatitis. Am J Gastroenterol 2001;96:1200-1204.
21. Kaji H, Asanuma Y, Yahara O, Shibue H, Hisamura M, Saito N, Kawakami Y, Murao M: Intragastrointestinal alcohol fermentation syndrome: report of two cases and review of the literature. J Forensic Sci Soc 1984;24:461-471.
22. Baraona E, Julkunen R, Tannenbaum L, Lieber CS: Role of intestinal bacterial overgrowth in ethanol production and metabolism in rats. Gastroenterology 1986;90:103-110.
23. Bivin WS, Heinen BN: Production of ethanol from infant food formulas by common yeasts. J Appl Bacteriol 1985;58:355-357.
24. Kaji H, Asanuma Y, Ide H, Saito N, Hisamura M, Murao M, Yoshida T, Takahashi K: The auto-brewery syndrome - the repeated attacks of alcoholic intoxication due to the overgrowth of Candida (albicans) in the gastrointestinal tract. Mater Med Pol 1976;8:429-435.
25. Jones AW: Histamine-2-receptor antagonists and serum ethanol levels. Ann Intern Med 1993;119:952-953.
26. Jones AW, Andersson L: Comparison of ethanol concentrations in venous blood and end-expired breath during a controlled drinking study. Forensic Sci Int 2003;132:18-25.
27. Logan BK, Jones AW: Endogenous ethanol 'auto-brewery syndrome' as a drunk-driving defense challenge. Med Sci Law 2000;40:206-215.
28. Cope KA, Watson MT, Foster M, Sehnert SS, Risby TH: Effects of ventilation on the collection of exhaled breath in humans. J Appl Physiol 2004;96:1371-1379.
29. Koorevaar G, Van Stekelenburg GJ: Mammalian acetoacetate decarboxylase activity. Its distribution in subfractions of human albumin and occurrence in various tissues of the rat. Clin Chim Acta 1976;71:173-183.
30. Freund G, Weinsier RL: Standardized ketosis in man following medium chain triglyceride ingestion. Metabolism 1966;15:980-991.
31. Winter WE: Type 2 diabetes mellitus: the challenge of a metabolic epidemic. J Clin Ligand Assay 1998;21:293-308.
32. Cruz ML, Weigensberg J, Huang TTK, Ball G, Shaibi GQ, Goran MI: The metabolic syndrome in overweight Hispanic youth and the role of insulin sensitivity. J Clin Endocrinol Metab 2004;89:108-113.
33. Steinberg J: Diagnosis of the metabolic syndrome in children. Curr Opin Lipidol 2003;14:555-559.