Role of exhaled breath biomarkers in environmental health science

Journal of Toxicology and Environmental Health - Part B: Critical Reviews

Volumn 11, Issue 8, 2008, Pages 613-629

  Pleil, Joachim D ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; DNA; PROTEIN;

ADIPOSE TISSUE; AIR QUALITY; BLOOD; BREATH ANALYSIS; ENVIRONMENTAL HEALTH; ENVIRONMENTAL PROTECTION; ENVIRONMENTAL STRESS; EXHALATION; HUMAN; LAVAGE; QUALITY CONTROL; REVIEW; URINE;

BIOLOGICAL MARKERS; BREATH TESTS; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL HEALTH; EXHALATION; HUMANS;

EID: 52949136674     PISSN: 10937404     EISSN: 15216950     Source Type: Journal    
DOI: 10.1080/10937400701724329     Document Type: Review

References (179)

1. Aggazzotti, G., Fantuzzi, G., Righi, E., Tartoni, P. L., Cassinadri, T., and Predieri, G. 1993. Chloroform in alveolar air of individuals attending indoor swimming pools. Arch. Environ. Health 48:250-254.
2. Aggazzotti, G., Fantuzzi, G., Righi, E., and Predieri, G. 1998. Blood and breath analyses as biological indicators of exposure to trihalomehanes in indoor swimming pools. Sci. Total Environ. 217:155-163.
3. Albertini, R., Bird, M., Doerrer, N., Needham, L., Robison, S., Sheldon, L., and Zenick, H. 2006. The use of biomonitoring data in exposure and human health risk assessments. Environ. Health Perspect. 114:1755-1762.
4. Amann, A., and Smith, D, eds. 2005. Breath gas analysis for medical diagnostics. Singapore: World Scientific Publishers.
5. American Cancer Society. 2007. American Cancer Society. http://www.cancer.org/, accessed May 15, 2007.
6. American Heart Association. 2007. American Heart Association. http://www.americanheart.org/, accessed May 15, 2007.
7. Andreoli, R., Manini, P., Corradi, M., Mutti, A., and Niessen, A. 2003. Determination of patterns of biologically relevant aldehydes in exhaled breath condensate of healthy subjects by liquid chromatography/atmospheric chemical ionization tandem mass spectrometry, Rapid Commun. Mass Spectrom. 17:637-645.
8. ATS. 2005. ATS workshop proceedings: Exhaled nitric oxide and nitric oxide metabolism in exhaled breath condensate. Proc. Am. Thoracic Soc. 3:131-145.
9. ATS/ERS. 2005. Recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005. Am. J. Respir. Crit. Care Med. 171:912-930.
10. Ball, R., and Schwartz, S. L. 2002. Kinetic and dynamic models of diving gases in decompression sickness prevention. Clin. Pharmacokinet. 41:389-402.
11. Barreto, M., Villa, M. P., Corradi, M., Barberi, S., Monaco, G., Martella, S., Bohmerova, Z., Sabatino, G., and Ronchetti, R. 2006. Noninvasive assessment of airway inflammation in ship engine workers. Int J. Immunopathol. Pharmacol. 19:601-608.
12. Barregard, L., Sallsten, G., Gustafson, P., Andersson, L., Johansson, L., Basu, S., and Stigendal, L. 2006. Experimental exposure to wood-smoke particles in healthy humans: Effects on markers of inflammation, coagulation, and lipid peroxidation. Inhal. Toxicol. 18:845-853.
13. Bates, M. N., Buckland, S. J., Garrett, N., Caudill, N., and Ellis, H, 2005. Methodological aspects of a national population based study of persistent organochlorine compounds in serum. Chemosphere 58:943-951.
14. Baumbach, J., and Eiceman, G, 1999. Ion mobility spectrometry: Arriving on-site and moving beyond a low profile. Appl. Spectros. 53:338-354.
15. Beaver, W. L., Lamarra, N., and Wasserman, K, 1981. Breath-by-breath measurement of true alveolar gas exchange, J. Appl. Physiol. 51:1662-1675.
16. Benoit, F. M., Davidson, W. R., Lovett, A. M., Nacson, S., and Ngo, A. 1985. Breath analysis by APCI/MS - Human exposure to volatile organic solvents. Int. Arch. Occup. Environ. Health 55:113-120.
17. Bernard, A., Carbonelle, S., Nickmilder, M., and de Burbure, C. 2005. Non-invasive biomarkers of pulmonary damage and inflammation: Application to children exposed to ozone and trichloramine. Toxicol. Appl. Pharmacol. 206:185-190.
18. Birnbaum, L. S., and Cohen-Hubal, E. A. 2006. Polybrominated diphenyl ethers: A case study for using biomonitoring data to address risk assessment questions. Environ. Health Perspect. 114:1770-1775.
19. Boffetta, P., and Nyberg, F. 2003. Contribution of environmental factors to cancer. Br. Med. Bull. 68:71-94.
20. Borrill, Z. L., Smith, J. A., Naylor, J., Woodstock, A. A., and Singh, D. 2006. The effect of gas standardisation on exhaled breath condensate pH. Eur. Respir. J. 28:251-256.
21. Boyce, P. D., Kim, J. Y., Weissman, D. N., Hunt, J., and Christiani, D. C. 2006. pH increase observed in exhaled breath condensate from welding fume exposure. J. Occup. Environ. Med. 48:353-356.
22. Boycott, A. E., Damant, G. C. C., and Haldane, J. S. 1908. The prevention of compressed-air illness. J. Hyg. Cambridge Press 8: 342-443.
23. Brugnone, F., Perbellini, L., Faccini, G. B., Pasini, F., Maranelli, G., Romeo, L., Gobbi, M., and Zedde, A. 1989. Breath and blood levels of benzene, toluene, cumene and styrene in non-occupational exposure, Int. Arch. Occup. Environ Health. 61:303-311.
24. Brusasco, V., Crapo, R., and Viegi, G., eds. 2005. Series of four: ATS/ERS Task Force: Standardisation of Lung Function Testing. Eur. Respir. J. 26:153-161,
25. 26:319-338,
26. 26:511-522,
27. 26:720-735.
28. Buckley, T. J., Prah, J. D., Ashley, D. A., Zweidinger, R. A., and Wallace, L. A. 1997. Body burden measurements and models to assess inhalation exposure to methyl tertiary butyl ether (MTBE) J. Air Waste Manage Assoc. 47:739-752.
29. Buszewski, B., Kesy, M., Ligor, T., and Amann, A. 2007. Human exhaled air analytics: Biomarkers of diseases. Biomed. Chromatogr. 21:553-566.
30. Cao, W., and Duan, Y. 2006. Breath analysis: Potential for clinical diagnosis and exposure assessment. Clin. Chem. 52:800-811.
31. Chatkin, J., Fritscher, L., de Abreau, C., Cavalet-Blanc, D., Chatkin, G., Wagner, M., and Fritscher, C. 2007. Exhaled carbon monoxide as a marker for evaluating smoking abstinence in a Brazilian population sample. Prim. Care Respir. J. 16:36-40.
32. Chinery, R. L., and Gleason, A. K. 1993. A compartmental model for the prediction of breath concentration and absorbed dose of chloroform after exposure while showering, Risk Anal. 13:51-62.
33. Chiu, W. A., Micallef, S., Monster, A. C., and Bois, F. Y. 2007. Toxicokinetics of inhaled trichloroethylene and tetrachloroethylene in humans at 1 ppm: Empirical results and comparisons with previous studies. Toxicol. Sci. 95:23-36.
34. Cooper, G. S., Germolec, D., Heindel, J., and Selgrade, M. 1999. Linking environmental agents and autoimmune diseases Environ. Health Perspect. 107(suppl. 5):659-660.
35. Cope, K. A., Watson, M. T., Foster, W. M., Sehnert, S. S., and Risby, T. H. 2004. Effects of ventilation on the collection of exhaled breath in humans. J. Appl. Physiol. 96:1371-1379.
36. Coppede, F., Mancuso, M., Siciliano, G., Migliori, L., and Murri, L. 2006. Genes and the environment in neurodegenration. Biosci. Rep. 26:341-367.
37. Corradi, M., Alinovi, R., Goldoni, M., Vettori, M., Folesani, G., Mozzoni, P., Cavazzini, S., Bergamaschi, E., Rossi, L., and Mutti, A. 2002. Biomarkers of oxidative stress alter controlled human exposure to ozone. Toxicol Lett. 134:219-225.
38. Corradi, M., Rubinstein, I., Andreoli, R., Manini, P., Caglieri, A., Poli, D., Alinovi, R., and Mutti, A. 2003. Aldehydes in exhaled breath condensate of patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 167:1380-1386.
39. Corradi, M., and Mutti, A. 2005. Exhaled breath analysis: From occupational to respiratory medicine. Acta Biomed. 76(suppl. 2):20-29.
40. Deng, C., Zhang, X., and Li, N. 2004. Investigation of volatile biomarkers in lung cancer blood using solid-phase microextraction and capillary gas chromatography. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 808:269-277.
41. deKok, T. M., Driece, H. A., Hogervorst, J. G., and Briede, J. J. 2006. Toxicological assessment of ambient and traffic related particulate matter: A review of recent studies. Mutat. Res. 613:103-122.
42. Detels, R., McEwen, J., Beaglehole, R., and Tanaka, H., eds. 2002. Oxford textbook of public health. New York: Oxford University Press.
43. Diaz-Sanchez, D., Rumold, R., and Gong, H. 2006. Challenge with environmental tobacco smoke exacerbates allergic airway disease in human beings. J. Allergy Clin. Immunol. 118:441-446.
44. Dick, R. B., Krieg, E. F., Setzer, J., and Taylor, B. 1992. Neurobehavioral effects from acute exposures to methyl isobutyl ketone and methyl ethyl ketone. Fundam. Appl. Toxicol. 19:453-473.
45. Dwyer, T. M. 2004. Sampling airway surface liquid: Non-volatiles in the exhaled breath condensate. Lung 182:241-250.
46. Effros, R. M. 2003. Saving the breath condensate approach. Am. J. Respir. Crit. Care Med. 168:1129-1130.
47. Effros, R. M., Dunning, M. B., Biller, J., and Shaker, R. 2004. The promise and perils of exhaled breath condensates. Am. J. Physiol. Lung Cell. Mol. Physiol. 287:L1073-L1080.
48. Effros, R. M., Peterson, B., Casaburi, R., Su, J., Dunning, M., Torday, J., Biller, J., and Shaker, R. 2005. Epithelial lining fluid solute concentrations in chronic obstructive lung disease patients and normal subjects. J. Appl. Physiol. 99:1286-1292.
49. Egeghy, P. P., Nylander-French, L., Gwin, K. K., HertzPicciotto, I., and Rappaport, S. M. 2002. Self-collected breath sampling for monitoring low level benzene exposures among automobile mechanics. Ann. Occup. Hyg. 46:489-500.
50. Egeghy, P. P., Hauf-Cabalo, L., Gibson, R., and Rappaport, S. M, 2003. Benzene and naphthalene in air and breath as indicators of exposure to jet fuel. Occup. Environ. Med. 60:969-976.
51. Epstein, S. K., Ciubotaru, R. L., Zilberberg, M. D., Kaplan, L. M., Jacoby, C., Freeman, R., and Kaplan, M. M, 1998. Analysis of impaired exercise capacity in patients with cirrhosis. Dig. Dis Sci. 43:1701-1707.
52. Farmer, P. B., Sepai, O., Lawerence, R., Autrup, H., and Sabro-Nielsen, P. 1996. Biomonitoring human exposure to environmental carcinogenic chemicals. Mutagenesis 11:363-381.
53. Fiserova-Bergarova, V., and Holaday, D. A. 1979. Uptake and clearance of inhalation anaesthetics in man. Drug Metab. Rev. 9:43-60.
54. Fisher, J. W., Mahle, D., and Abbas, R. 1998. A human physiologically based pharmacokinetic model for trichloroethylene and its metabolites trichloroacetic acid and free trichloroethanol. Toxicol, Appl. Pharmacol 152:339-359.
55. Food and Drug Administration. 2007. U.S. Food and Drug Administration. http://www.fda.gov/cdrh/MDA/DOCS/H030004.html, accessed May 15, 2007.
56. Foster, W. M., Jiang, L., Stetkiewicz, P. T., and Risby, T. H. 1996. Breath isoprene: Temporal changes in respiratory output after exposure to ozone. J. Appl. Physiol. 80:706-710.
57. Furtaw, E. J. 2001. An overview of human exposure modeling activities at the U.S. EPA's National Exposure Research Laboratory. Toxicol. Ind. Health 17:302-314.
58. German, J. B., Hammock, B. D., and Watkins, S. M. 2005. Metabolomics: Building on a century of biochemistry to guide human health. Metabolomics 1:3-9.
59. Gessner, C., Scheibe, R., Wotzel, M., Hammerschmidt, S., Kuhn, H., Englemann, L., Hoheisel, G., Gillissen, A., and Sack, U. 2005. Exhaled breath condensate cytokine patterns in chronic obstructive pulmonary disease. Respir. Med. 99:1229-1240.
60. Giunta, F., Lagomarsini, G., Fausto, C., Quartarone, M. C., Brandi, L. S., Corini, M., Ferrari, A., and Pasini, L. 1995. Gas monitoring and uptake. Appl. Cardiopulmon. Pathophysiol. 5(suppl. 2):31-39.
61. Gordon, S. M., Szidon, J. P., Krotoszinski, B. K., Gibbons, R. D., and O'Neill, H. J. 1985. Volatile organic compounds in exhaled air from patients with lung cancer. Clin. Chem. 31:1278-1282.
62. Gordon, S. M., Wallace, L. A., Pellizzari, E. D., and O'Neill, H. J. 1988. Human breath measurements in a clean-air chamber to determine half-lives for volatile organic compounds. Atmos. Environ. 22:2165-2170.
63. Gordon, S. M., Callahan, P. J., Kenny, D. V., and Pleil, J. D, 1996. Direct sampling and analysis of volatile organic compounds in air by membrane introduction and glow discharge ion trap mass spectrometry with filtered noise fields. Rapid Commun. Mass Spectrom. 10:1038-1046.
64. Gordon, S. M., Wallace, L. A., Callahan, P. J., Kenny, D. V., and Brinkman, M. C. 1998. Effect of water temperature on dermal exposure to chloroform. Environ Health Perspect. 106:337-345.
65. Grandjean, P., and Landrigan, P. J, 2006. Developmental neurotoxicity of industrial chemicals. Lancet 368:2167-2178.
66. Griffin, J. L. 2003. Metabonomics: NMR spectroscopy and pattern recognition analysis of body fluids and tissues for characterization of xenobiotic toxicity and disease diagnosis. Curr. Opin. Chem. Biol. 7:648-654.
67. Hansen, H., DeRosa, C. T., Pohl, H., Fay, M., and Mumtaz, M. M. 1998. Public health challenges posed by chemical mixtures. Environ Health Perspect. 106(suppl. 6):1271-1280.
68. Hoglund, C. O., Axen, J., Kemi, C., Jernelov, S., Grunewald, J., Muller-Suur, C., Smith, Y., Gronneberg, R., Eklund, A., Stierna, P., and Lekander, M. 2006. Changes in immune regulation in response to examination stress in atopic and healthy individuals. Clin. Exp. Allergy 36:982-992.
69. Horvath, I., Hunt, J., and Barnes, P. J. 2005. ATS/ERS Task Force, exhaled breath condensate: Methodological recommendations and unresolved questions. Eur. Respir. J. 26:523-548.
70. Hwang, E. S., and Kim, G. H. 2007. Biomarkers for oxidative stress status of DNA, lipids, and proteins in vitro and in vivo cancer research. Toxicology 229:1-10.
71. Jo, W. K., Weisel, C. P., and Lioy, P. J. 1990. Chloroform exposure and the health risk associated with multiple uses of chlorinated tap water. Risk Anal. 10:581-585.
72. Johanson, G., Nihlen, A., and Lof, A. 1995. Toxicokinetics and acute effects of MTBE and ETBE in male volunteers. Toxicol. Lett. 82-83:713-718.
73. Kern, J. K., and Jones, A. M. 2006. Evidence of toxicity, oxidative stress, and neuronal insult in autism. J. Toxicol. Environ. Health B 9:485-499.
74. Kharitonov, S. A., and Barnes, P. J. 2002. Biomarkers of some pulmonary diseases in exhaled breath. Biomarkers 7:1-32.
75. Kharitonov, S. A. 2004. Exhaled markers of pulmonary lung diseases: ready for routine monitoring? Swiss Med. Weekly 34:175-192.
76. Kim, D., Andersen, M. E., Pleil, J. D., Nylander-French, L. A., and Prah, J. D. 2007. Refined PBPK model of aggregate exposure to methyl tertiary-butyl ether. Toxicol. Lett. 169:222-235.
77. Koek, M. M., Muilwijk, B., van der Werf, M. J., and Hankemeier, T. 2006. Microbial metabolomincs with gas chromatography/mass spectrometry. Anal Chem. 78:1272-1281.
78. Kostrzewski, P., Wiaderna-Brycht, A., and Czerski, B, 1997. Biological monitoring of experimental human exposure to trimethylbenzene. Sci. Total Environ. 199:73-81.
79. Krotoszynski, B., Gabriel, G., and O'Neil, H. 1977. Characterization of human expired air: a promising investigative and diagnostic technique. J, Chromatogr, Sci. 15:239-244.
80. Lauwerys, R. R., Bernard, A., Roels, H., and Buchet, J. P. 1995. Health risk assessment of long-term exposure to non-genotoxic chemicals: Application of biological indices. Toxicol. Lett. 77:39-44.
81. Lewtas, J., Walsh, D., Williams, R., and Dobias, L. 1997. Air pollution exposure-DNA adduct dosimetry in humans and rodents: Evidence for non-linearity at high doses. Mutat. Res. 378:51-63.
82. Lin, Y. S., Kupper, L. L., and Rappaport, S. M. 2005. Air samples versus biomarkers for epidemiology. Occup. Environ. Med. 62:750-760.
83. Lindinger, W., Hansel, A., and Jordan, A. 1998. Proton transfer reaction mass spectrometry (PTR-MS): On-line monitoring of volatile organic compounds at pptv levels. Chem. Soc. Rev. 27:347-354.
84. Lindstrom, A. B., Pleil, J. D., and Berkoff, D. C. 1997. Alveolar breath sampling and analysis to assess trihalomethane exposures during competitive swimming training. Environ. Health Perspect. 105:636-642.
85. Lippman, M., Cohen, B. S., and Schlesinger, R. B. 2003. Environmental health science. New York: Oxford University Press.
86. Liu, J., and Thomas, P. S. 2005. Exhaled breath condensate as a method of sampling airway nitric oxide and other markers of inflammation. Med. Sci. Monit. 11:M53-M63.
87. MacIntyre, N. 1996. New modes of mechanical ventilation. Clin. Chest Med. 17:411-421.
88. Marczin, N., Kharitonov, S. A., and Yacoub, M. H. 2003. Disease markers in exhaled breath. New York: Marcel Dekker.
89. Martin, L. 1997. Effects of increased dissolved nitrogen from scuba diving: Decompression sickness. In Scuba diving explained, Section G. Flagstaff, AZ: Best Publishing.
90. Mattson, M. P. 2006. Deciphering developmental CNS disorders. NeuroMol. Med. 8:433-434.
91. Mayes, M. D. 1999. Epidemiological studies of environmental agents and systemic autoimmune diseases. Environ. Health Perspect. 107(Suppl. 5):743-748.
92. McCafferty, J. B., Bradshaw, T. A., Tate, S., Greening, A. P., and Innes, J. A. 2004. Effects of breathing pattern and inspired air conditions on breath condensate volume, pH, nitrite and protein concentrations. Thorax 59:694-698.
93. McKone, T. E. 1993. Linking a PBPK model for chloroform with measured breath concentrations in showers: imPlications for dermal exposure models. J. Expos. Anal. Environ. Epidemiol. 3:339-365.
94. Mendelsohn, M. L., Peeters, J. P., and Normandy, M. J., eds. 1995. Biomarkers and occupational health: Progress and perspectives. Washington, DC: Joseph Henry Press.
95. Miekisch, W., Schubert, J. K., and Noeldge-Schomberg, G. F. E. 2004. Diagnostic potential of breath analysis-Focus on volatile organic compounds. Clin. Chim. Acta 347:25-39.
96. Mitchell, L. E. 2005. Epidemiology of neural tube defects. Am. J. Med. Genet. C Semin. Med. Genet. 135C:88-94.
97. Montuschi, P., and Barnes, P. J. 2002. Analysis of exhaled breath condensate for monitoring airway inflammation. Trends Pharmacol. Sci. 23:232-237.
98. Montuschi, P. 2005. New perspectives in monitoring lung inflammation: Analysis of exhaled breath condensate. London: CRC Press.
99. Morgan, G. E., Mikhail, M. S., and Murray, M. J. 2002. The practice of anesthesiology. In Clinical anesthesiology, 3rd ed., chapter 1. New York: McGraw-Hill.
100. Morello-Frosch, R. A., Woodruff, T. J., Axelrad, D. A., and Caldwell, J. C. 2000. Air toxics and health risks in California: The public health implications of outdoor concentrations. Risk Anal. 20:273-291.
101. Mussali-Galante, P., Avila-Costa, M. R., Pinon-Zarate, G., Martinez-Levy, G., Rodríguez-Lara, V., Rojas-Lemus, M., Avila-Cascado, M. C., and Fortoul, T. I. 2005. DNA damage as an early biomarker of effect in human health. Toxicol. Ind. Health 21:155-166.
102. Mutti, A., and Corradi, M. 2006. Recent developments in human biomonitoring: Non-invasive assessment of target tissue dose and effects of pneumotoxic metals. Med. Lav. 97:199-206.
103. National Research Council. 2006. Human biomonitoring for environmental chemicals. Washington, DC: National Academies Press.
104. Nihlen, A., Lof, A., and Johanson, G. 1998. Experimental exposure to methyl tertiary butyl ether. 1. Toxicokinetics in humans. Toxicol. Appl Pharmacol. 148:274-280.
105. Olden, K., and White, S. L. 2005. Health related disparities: influence of environmental factors. Med. Clin. North Am. 89:721-738.
106. Ott, M. G. 2005. Exposure assessment as a component of observational health studies and environmental risk assessment. Scand. J. Work Environ. Health. 31(suppl. 1):110-114.
107. Passam, F., Hoing, S., Prinianakis, G., Siafakas, N., Milic-Emili, J., and Georgopaulos, D. 2003. Effect of different levels of pressure support and proportional assist ventilation on breathing pattern, work of breathing and gas exchange in mechanically ventilated hypercapnic COPD patients with acute respiratory failure. Respiration 70:355-361.
108. Pauling, L., Robinson, A. B., Teranishi, R., and Cary, P. 1971. Quantitative analyses of urine vapor and breath by gas-liquid partition chromatography. Proc. Natl. Acad. Sci. USA 68:2374-2376.
109. Pearce, M. S., and Hayes, L. 2005. Self reported smoking status and exhaled carbon monoxide: Results from two population-based epidemiologic studies in the North of England. Chest 128:1233-1238.
110. Pellizzari, E. D., Wallace, L. A., and Gordon, S. M. 1992. Elimination kinetics of volatile organics in humans using breath measurements. J. Expos. Anal. Environ. Epidemiol. 2:341-355.
111. Perera, F. P., and Weinstein, I. B. 2000. Molecular epidemiology: Recent advances and future directions. Carcinogenesis 21:517-524.
112. Phillips, M., and Greenberg, J. 1992. Ion trap detection of volatile organic compounds in alveolar breath. Clin. Chem. 38:60-66.
113. Phillips, M., Greenberg, J., and Awad, J. 1994. Metabolic and environmental origins of organic compounds in breath. J. Clin. Pathol. 47:1052-1053.
114. Phillips, M., Boehmer, J. P., Cataneo, R. N., Cheema, T., Eisen, H. J., Fallon, J. T., Fisher, P. E., Gass, A., Greenberg, J., Kobashigawa, J., Mancini, D., Rayburn, B., and Zucker, M. J. 2004. Prediction of heart transplant rejection with a breath test for markers of oxidative stress. Am. J. Cardiol. 94:1593-1594.
115. Pierce, J. D., and Gerald, K. 1994. Differences in end-tidal carbon dioxide and breathing patterns in ventilator-dependent patients using pressure support ventilation. Am. J. Crit. Care 3:276-281.
116. Pleil, J. D., and Lindstrom, A. B. 1995a. Collection of a single alveolar exhaled breath for volatile organic compounds analysis. Am. J. Ind. Med. 28:109-121.
117. Pleil, J. D., and Lindstrom, A. B. 1995b. Measurement of volatile organic compounds in exhaled breath as collected in evacuated electropolished canisters. J. Chromatogr. B. 665:271-279.
118. Pleil, J. D., and Lindstrom, A. B. 1997. Exhaled human breath measurement for assessing exposure to halogenated volatile organic compounds. Clin. Chem. 43:723-730.
119. Pleil, J. D., and Lindstrom, A. B. 1998. Sample timing and mathematical considerations for modeling breath elimination of volatile organic compounds. Risk Anal. 18:585-602.
120. Pleil, J. D., Fisher, J. W., and Lindstrom, A. B. 1998. Trichloroethene levels in human blood and exhaled breath from controlled inhalation exposure. Environ. Health Perspect. 106:573-580.
121. Pleil, J. D., Smith, L. B., and Zelnick, S. D. 2000. Personal exposure to JP-8 jet fuel vapors and exhaust at air force bases. Environ. Health Perspect. 108:183-192.
122. Pleil, J. D., Kim, D., Prah, J. D., Ashley, D. L., and Rappaport, S. M. 2005. The unique value of breath biomarkers for estimating pharmacokinetic rate constants and body burden from environmental exposures. In Breath gas analysis for medical diagnostics, eds. A. Amann and D. Smith, pp. 347-361. Singapore: World Scientific.
123. Pleil, J. D., Kim, D., Prah, J. D., and Rappaport, S. M. 2007a. Exposure reconstruction for reducing uncertainty in risk assessment: Example using MTBE biomarkers and a simple pharmacokinetic model. Biomarkers 12:331-348.
124. Pleil, J. D., Hubbard, H. F., Sobus, J. R., and Madden, M. C. 2007b. Measurement of endogenous volatile polar metabolites in exhaled breath condensate (EBC) to gauge biological response to environmental stressors. J. Breath Res. doi:10.1088/1752-7155/2/2/026001.
125. Prah, J. D., Ashley, D. A., Blount, B. G., Case, M. W., Leavens, T. L., Pleil, J. D., and Cardinali, F. L. 2004. Dermal, oral, and inhalation pharmacokinetics of methyl tertiary butyl ether (MTBE) in human volunteers. Toxicol. Sci. 77:195-205.
126. Ramachandran, G, 2005. Occupational exposure assessment for air contaminants. New York: CRC Press.
127. Rappaport, S. M., and Kupper, L. L. 2004. Variability of environmental exposures to volatile organic compounds. J. Expos. Anal. Environ. Epidemiol. 14:92-107.
128. Raymer, J. H., Pellizzarri, E. D., Thomas, K. W., and Cooper, S. D. 1991. Elimination of volatile organic compounds in breath after exposure to occupational and environmental microenvironments. J. Expos. Anal. Environ. Epidemiol. 1:439-451.
129. Risby, T. H. 2003. Further discussion on breath condensate analysis. Am. J. Respir. Crit. Care Med. 167:1301-1302.
130. Risby, T. H. 2005. Current status of clinical breath analysis. In Breath gas analysis for medical diagnostics, eds. A. Amann and D. Smith, pp. 251-267. Singapore: World Scientific.
131. Risby, T. H., and Solga, S. F. 2006. Current status of clinical breath analysis. Appl. Phys. B 85:421-426.
132. Ritter, L., Goushleff, N. C., Arbuckle, T., Cole, D., and Raizenne, M. 2006. Addressing the linkages between exposure to pesticides and human health effects-Research trends and priorities for research. J. Toxicol. Environ. Health B 9:441-456.
133. Robroeks, C. M., Jobsis, Q., Damoiseaux, J. G., Heijmans, P. H., Rosias, P. P., Hendriks, H. J., and Dompeling, E, 2006. Cytokines in exhaled breath condensate of children with asthma and cystic fibrosis. Ann. Allergy Asthma Immunol. 96:349-355.
134. Roecker, K., Prettin, S., and Sorichter, S, 2005. Gas exchange measurements with high temporal resolution: the breath-by-breath approach. Int. J. Sports Med. 26(suppl. 1):S11-S18.
135. Rosenbaum, R. K., Margni, M., and Jolliet, O. 2007. A flexible matrix algebra framework for the multimedia multipathway modeling of emission to impacts. Environ. Int. 33:624-634.
136. Sandhu, R. S., Petroni, D. H., and George, W. J. 2005. Ambient particulate matter, C-reactive protein, and coronary heart disease. Inhal. Toxicol. 17:409-413.
137. Scherer, G. 2005. Biomonitoring of inhaled complex mixtures-Ambient air, diesel exhaust and cigarette smoke. Exp. Toxico.l Pathol. 57(suppl. 1):75-110.
138. Schiffman, S. S., Studwell, C. E., Landerman, L. R., Berman, K., and Sundy, J. S. 2005. Symptomatic effects of exposure to diluted air sampled from a swine confinement atmosphere on healthy human subjects. Environ. Health Perspect. 113:567-576.
139. Schneider, M. J. 2006. Introduction to public health, 2nd ed. Sudbury, MA: Jones and Bartlett.
140. Schreiber, J. S., Hudnell, H. K., Geller, A. M., House, D. E., Aldous, K. M., Force, M. S., Langguth, K., Prohonic, E. J., and Parker, J. C. 2002. Apartment residents' and day care workers' exposures to tetrachloroethylene and deficits in visual contrast sensitivity. Environ. Health Perspect. 112:655-664.
141. Schubert, J. K., Miekisch, W., Geiger, K., and Noldge-Schomburg, G. F. E. 2004. Breath analysis in critically ill patients: Potential and limitations. Expert Rev. Mol. Diagn. 4:619-629.
142. Schubert, J. K., Miekisch, W., Birken, T., Geiger, K., and Noldge-Schomburg, G. F. 2005. Impact of inspired substance concentrations on the results of breath analysis in mechanically ventilated patients. Biomarkers 10:138-152.
143. Scotter, J., Chambers, S. T., and Syhre, M, 2005. Direct detection of Aspergillus fumigatus from breath samples (Abstract 278). Infectious Diseases Society of America 43rd Annual Meeting, October 6-9. San Francisco.
144. Sehnert, S. S., Jiang, L., Burdick, J. F., and Risby, T. H. 2002. Breath biomarkers for detection of human liver disease. Biomarkers 7:174-187.
145. Senthilmohan, S. T., Milligan, D. B., McEwan, M. J., Freeman, C. G., and Wilson, P. F. 2000. Quantitative analysis of trace gases of breath during exercise using the new SIFT-MS technique. Redox Rep. 5:151-153.
146. Serdar, B., Egeghy, P. P., Waidyanatha, S., Gibson, R., and Rappaport, S. M. 2003. Urinary biomarkers of exposure to jet fuel (JP-8). Environ Health Perspect. 111:1760-1764.
147. Serkova, N. J., and Niemann, C. U. 2006. Pattern recognition and biomarker validation using quantitative 1H-NMR-based metabolomics. Expert Rev. Mol. Diagn. 6:717-731.
148. Sikand, R. S., Magnussen, H., Scheid, P., and Piiper, J, 1976. Convective and diffusive gas mixing in the lungs: Experiments and model analysis. J. Appl. Physiol. 40:362-371.
149. Sim, E., Stanley, L. A., Risch, A., and Thygesen, P. 1995. Xenogenetics in multifactoral disease susceptibility. Trends Genet. 11:509-512.
150. Simmons, J. E., Evans, M. V., and Boyes, W. K. 2005. Moving from external exposure to internal dose: Duration extrapolation based on physiologically based pharmacokinetic derived estimates of internal dose. J. Toxicol. Environ. Health A 68:927-950.
151. Smeets, M. A. M., Maute, C., and Dalton, P. H. 2001. Acute sensory irritation from exposure to isopropanol (2-propanol) at TLV in workers and controls: Objective versus subjective effects. Ann. Occup. Hyg. 46:359-373.
152. Smith, D., and Spanel, P. 2005. Selected ion flow tube mass spectrometry (SIFT-MS) for on-line trace gas analysis. Mass Spectrom. Rev. 24:661-700.
153. Spanel, P., and Smith, D, 2001. On-line measurement of the absolute humidity of air, breath, and liquid headspace samples by selected ion flow tube mass spectrometry. Rapid Commun. Mass Spectrom. 15:563-569.
154. Suk, W. A., and Collman, G. W. 1998. Genes and the environment: Their impact on children's health. Environ. Health Perspect. 106(suppl. 3):817-820.
155. Tu, R. H., Mitchell, C. S., Kay, G. G., and Risby, T. H. 2004. Human exposure to the jet fuel JP-8. Aviat. Space Environ. Med. 75:49-59.
156. Turner, C., Spanel, P., and Smith, D. 2006a. Longitudinal study of ammonia, acetone, and propanol in the exhaled breath of 30 subjects using selected ion flow tube mass spectrometry, SIFT-MS. Physiol. Meas. 27:321-327.
157. Turner, C., Spanel, P., and Smith, D. 2006b. Longitudinal study of ethanol and acetaldehyde in the exhaled breath of healthy volunteers using selected ion flow tube mass spectrometry. Rapid Commun, Mass Spectrom 20:61-68.
158. U.S. Environmental Protection Agency. 2007a. United States Environmental Protection Agency. http://www.epa.gov/nerlpage/who.html, accessed May 15, 2007.
159. U.S. Environmental Protection Agency. 2007b. United States Environmental Protection Agency. http://www.epa.gov/nheerl/humanhealth/HHRS_final_web.pdf, accessed May 15, 2007.
160. U.S. Environmental Protection Agency. 2007c. United States Environmental Protection Agency. http://www.epa.gov/ord/npd/hhrp, accessed May 15, 2007.
161. U.S. Environmental Protection Agency. 2007d. National Exposure Research Laboratory (NERL). http://www.epa.gov/nerl, accessed May 15, 2007.
162. U.S. Environmental Protection Agency. 2007e. National Health and Environmental Effects Laboratory (NHEERL). http://www.epa.gov/nheerl, accessed May 15, 2007.
163. U.S. Environmental Protection Agency. 2007f. United States Environmental Protection Agency. http://www.epa.gov, accessed May 15, 2007.
164. Viant, M. R., Rosenblum, E. S., and Tieerdema, R. S. 2003. NMR-based metabolomics: A powerful approach for characterizing the effects of environmental stressors on organism health. Environ. Sci. Technol. 37:4982-4989.
165. Vineis, P., Hoek, G., Kryzanowski, M., Vigna-Taglianti, F., Veglia, F., Airoldi, L., Autrup, H., Dunning, A., Garte, S., Hainaut, P., Malaveille, C., Matullo, G., Overvad, K., Raaschou-Nielsen, O., Clavel-Chapelon, F., Linseisen, J., Boeing, H., Tirchopoulou, A., Palli, D., Peluso, M., Krogh, V., Tumino, R., Panico, S., Bueno-De-Mesquita, H. B., Peeters, P. H., Lund, E. E., Gonzalez, C. A., Martinez, C., Dorronsoro, M., Barricarte, A., Cirera, L., Quiros, J. R., Berglund, G., Forsberg, B., Day, N. E., Key, T. J., Saracci, R., Kaaks, R., and Riboli, E., 2006. Air pollution and risk of lung cancer in a prospective study in Europe. Int. J. Cancer. 119:169-174.
166. Von Basum, G., Dahnke, H., Halmer, D., Hering, P., and Murtz, M., 2003. Online recording of ethane traces in human breath via infrared laser spectroscopy. J. Appl. Physiol. 95:2583-2590.
167. Wallace, L. A. 1991. Personal exposure to 25 volatile organic compounds; EPA's 1987 TEAM Study in Los Angeles, California. Toxicol. Ind. Health 7:203-208.
168. Wallace, L. A., and Pellizzari, E. D. 1995. Recent advances in measuring exhaled breath and estimating exposure and body burden for volatile organic compounds. Environ. Health Perspect. 103(suppl. 3):95-98.
169. Wallace, L. A., Pellizzarri, E. D., Hartwell, T. D., Perritt, R., and Ziegenfus, R. 1987a. Exposures to benzene and other volatile compounds from active and passive smoking. Arch. Environ. Health 42:272-279.
170. Wallace, L. A., Pellizzarri, E. D., Hartwell, T. D., Sparacino, C., Whitmore, R., Sheldon, L., Zelon, H., and Perritt, R. 1987b. The TEAM (Total Exposure Assessment Methodology) Study; Personal exposures to toxic substances in air, drinking water, and breath 400 residents of New Jersey, North Carolina, and North Dakota. Environ. Res. 43:290-307.
171. Wallace, L. A., Pellizzari, E. D., and Gordon, S. M. 1993. A linear model relating breath concentrations to environmental exposures: Application to a chamber study of four volunteers exposed to volatile organic chemicals. J. Expos. Anal. Environ. Epidemiol. 3:75-102.
172. Weisel, C. P., and Jo, W. K. 1996. Ingestion, inhalation, and dermal exposure to chloroform and trichloroethene from tap water. Environ. Health Perspect. 104:48-51.
173. Wick, G., and Grubeck-Loebenstein, B. 1997. The aging immune system: Primary and secondary alterations of immune reactivity in the elderly. Exp. Gerontol. 32:401-413.
174. Wilson, S. H., and Suk, W. A., eds. 2002. Biomarkers of environmentally associated diseases: Technologies, concepts, and perspectives. Boca Raton, FL: CRC Press LLC.
175. Wogan, G., Hecht, S., Felton, J., Conney, A., and Loeb, L. 2004. Environmental and chemical carcinogenesis. Semin. Cancer Biol. 14:473-486.
176. Wysocki, G., McCurdy, M., So, S., Weidman, D., Roller, C., Curl, R., and Tittel, F, 2004. Pulsed quantum cascade laser based sensor for trace-gas detection of carbonyl sulfide. Appl. Opt. 43:6040-6046.
177. Yu, R., and Weisel, C. P. 1996. Measurement of benzene in human breath associated with an environmental exposure. J. Expos. Anal. Environ. Epidemiol. 6:261-267.
178. Zartarian, V., Bahadori, T., and McKone, T, 2005. Adoption of an official ISEA Glossary. J. Expos. Anal. Environ. Epidemiol. 15:1-5.
179. Zhang, J. J., and Lioy, P. J. 2002. Human exposure assessment in air