Discrimination of cancerous and non-cancerous cell lines by headspace-analysis with PTR-MS

Analytical and Bioanalytical Chemistry

Volumn 397, Issue 6, 2010, Pages 2315-2324

  Brunner, C ^a,b   Szymczak, W ^b   Hollriegl V ^b   Mortl S ^b   Oelmez, H ^c   Bergner, A ^c   Huber, R M ^c   Hoeschen, C ^b   Oeh, U ^b  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c UNIVERSITY OF MUNICH   (Germany)

Author keywords

Human cells; In vitro; Proton transfer reaction mass spectrometry; Volatile organic compounds

Indexed keywords

CANCEROUS CELLS; CULTURED HUMAN CELL; EPITHELIUM CELLS; GROWTH MEDIA; GROWTH MEDIUM; HEADSPACES; HUMAN BRONCHIAL EPITHELIAL CELLS; HUMAN CELL LINES; HUMAN CELLS; IN-VITRO; LUNG CARCINOMA; MULTIVARIATE STATISTICAL ANALYSIS; PROTON TRANSFER REACTION MASS SPECTROMETRY; PROTON-TRANSFER REACTION MASS SPECTROMETRIES; RETINAL PIGMENT EPITHELIUM; VOLATILE ORGANIC;

ALDEHYDES; ANIMAL CELL CULTURE; BIOLOGICAL ORGANS; BOTTLES; CELLS; GAS CHROMATOGRAPHY; IMAGING TECHNIQUES; MASS SPECTROMETRY; MULTIVARIANT ANALYSIS; PROTON TRANSFER; VOLATILE ORGANIC COMPOUNDS;

CELL CULTURE;

ACETALDEHYDE; PROTON; TUMOR MARKER; VOLATILE ORGANIC COMPOUND;

ARTICLE; CELL LINE; CHEMISTRY; HUMAN; METABOLISM; MULTIVARIATE ANALYSIS; NEOPLASM; TUMOR CELL LINE; NEOPLASMS;

ACETALDEHYDE; CELL LINE; CELL LINE, TUMOR; HUMANS; MULTIVARIATE ANALYSIS; NEOPLASMS; PROTONS; TUMOR MARKERS, BIOLOGICAL; VOLATILE ORGANIC COMPOUNDS;

EID: 77955984590     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-010-3838-x     Document Type: Article

References (29)

1. Thekedar B (2009) Investigations on the use of breath gas analysis with proton transfer reaction mass spectrometry (PTR-MS) for a non-invasive method of early lung cancer detection. PhD Thesis. Technical University of Munich, Munich
2. A Bajtarevic C Ager M Pienz M Klieber K Schwarz M Ligor T Ligor W Filipiak H Denz M Fiegl W Hilbe W Weiss P Lukas H Jamnig M Hackl A Haidenberger B Buszewski W Miekisch J Schubert A Amann 2009 Noninvasive detection of lung cancer by analysis of exhaled breath BMC Cancer 9 348 10.1186/1471-2407-9-348
3. Alberts B (2004) Molekularbiologie der Zelle. Weinheim, VCH Verlagsgesellschaft
4. W Lindinger A Hansel A Jordan 1998 On-line monitoring of volatile organic compounds at pptv levels by means of Proton-Transfer-Reaction Mass Spectrometry (PTR-MS) Medical applications, food control and environmental research Int J Mass Spectrom Ion Process 173 191 241 10.1016/S0168-1176(97)00281-4 1:CAS:528:DyaK1cXhsFKqtLg%3D
5. W Carroll W Lenney TS Wang P Spanel A Alcock D Smith 2005 Detection of volatile compounds emitted by Pseudomonas aeruginosa using selected ion flow tube mass spectrometry Pediatr Pulmonol 39 452 456 10.1002/ppul.20170 (Pubitemid 40548288)
6. RA Allardyce AL Hill DR Murdoch 2006 The rapid evaluation of bacterial growth and antibiotic susceptibility in blood cultures by selected ion flow tube mass spectrometry Diagn Microbiol Infect Dis 55 255 261 10.1016/j.diagmicrobio. 2006.01.031 1:CAS:528:DC%2BD28XnsFynsbk%3D (Pubitemid 44128730)
7. M Bunge N Araghipour T Mikoviny J Dunkl R Schnitzhofer A Hansel F Schinner A Wisthaler R Margesin T Märk 2008 On-Line Monitoring of Microbial Volatile Metabolites by Proton Transfer Reaction-Mass Spectrometry Appl Environ Microbiol 74 2179 2186 10.1128/AEM.02069-07 1:CAS:528:DC%2BD1cXks1anu7c%3D (Pubitemid 351522073)
8. D Smith TS Wang P Spanel 2002 Kinetics and isotope patterns of ethanol and acetaldehyde emissions from yeast fermentations of glucose and glucose-6,6-d(2) using selected ion flow tube mass spectrometry: a case study Rapid Commun Mass Spectrom 16 69 76 10.1002/rcm.550 1:CAS:528: DC%2BD38XjtVKmtg%3D%3D (Pubitemid 34032282)
9. MML Steeghs B Moeskops K van Swam SM Cristescu PTJ Scheepers FJM Harren 2006 On-line monitoring of UV-induced lipid peroxidation products from human skin in vivo using proton-transfer reaction mass spectrometry Int J Mass Spectrom 253 58 64 10.1016/j.ijms.2006.02.015 1:CAS:528:DC%2BD28XltFGjsbg%3D
10. BWM Moeskops MML Steeghs S Kv SM Cristescu PTJ Scheepers FJM Harren 2006 Real-time trace gas sensing of ethylene, propanal and acetaldehyde from human skin in vivo Physiol Meas 27 1187 1196 10.1088/0967-3334/27/11/011 1:STN:280:DC%2BD28rpslGitg%3D%3D (Pubitemid 46063744)
11. D Smith TS Wang J Sule-Suso P Spanel A El Haj 2003 Quantification of acetaldehyde released by lung cancer cells in vitro using selected ion flow tube mass spectrometry Rapid Commun Mass Spectrom 17 845 850 10.1002/rcm.984 1:CAS:528:DC%2BD3sXivVensLY%3D (Pubitemid 36433170)
12. S Kato PJ Burke TH Koch VM Bierbaum 2001 Formaldehyde in human cancer cells: Detection by preconcentration-chemical ionization mass spectrometry Anal Chem 73 2992 2997 10.1021/ac001498q 1:CAS:528:DC%2BD3MXjslagtbs%3D
13. X Chen F Xu Y Wang Y Pan D Lu P Wang K Ying E Chen W Zhang 2007 A Study of the Volatile Organic Compounds Exhaled by Lung Cancer Cells In Vitro for Breath Diagnosis American Cancer Society 110 835 844 1:CAS:528: DC%2BD2sXhtVajsrfO
14. Filipiak W, Sponring A, Mikoviny T, Ager C, Schubert JK, Miekisch W, Amann A, Troppmair J (2008) Release of volatile organic compounds (VOCs) from the lung cancer cell line CALU-I in vitro. Cancer Cell International
15. G Bepler A Koehler P Kiefer K Havemann K Beisenherz G Jaques C Gropp M Haeder 1988 Characterization of the state of differentiation of six newly established human non-small-cell lung cancer cell lines Differentiation 37 158 171 10.1111/j.1432-0436.1988.tb00806.x 1:STN:280:DyaL1c3osVWiuw%3D%3D
16. W Filipiak A Sponring A Filipiak C Ager J Schubert W Miekisch A Amann J Troppmair 2010 TD-GC-MS analysis of volatile metabolites of human lung cancer and normal cells in vitro Cancer Epidemiol Biomark Prev 19 182 195 10.1158/1055-9965.EPI-09-0162 1:CAS:528:DC%2BC3cXhvFegug%3D%3D
17. A Hansel A Jordan R Holzinger P Prazeller W Vogel W Lindinger 1995 Proton transfer reaction mass spectrometry: online trace gas analysis at the ppb level Int J Mass Spectrom Ion Process 149-150 609 619 10.1016/0168-1176(95)04294-U
18. W Lindinger A Hansel A Jordan 1998 On-line monitoring of volatile organic compounds at pptv levels by means of Proton-Transfer-Reaction Mass Spectrometry (PTR-MS) Medical applications, food control and environmental research Int J Mass Spectrom Ion Process 173 191 241 10.1016/S0168-1176(97)00281-4 1:CAS:528:DyaK1cXhsFKqtLg%3D
19. A Steinbacher J Dommen C Ammann C Spirig A Neftel ASH Prevot 2004 Performance characteristics of a proton-transfer-reaction mass spectrometer (PTR-MS) derived from laboratory and field measurements Int J Mass Spectrom 239 117 128 10.1016/j.ijms.2004.07.015 1:CAS:528:DC%2BD2cXhtVKktrbI
20. Bortz J (1999) Statistik für Sozialwissenschaftler. Springer Verlag, Berlin
21. Backhaus K, Erichson B, Plinke W, Weiber R (2006) Multivariante Analysemethoden. Springer Verlag, Berlin
22. P Spanel D Smith 2008 Quantification of trace levels of the potential cancer biomarkers formaldehyde, acetaldehyde and propanol in breath by SIFT-MS Journal of Breath Research 2 1 10 10.1088/1752-7155/2/4/046003
23. K Buhr S van Ruth C Delahunty 2002 Analysis of volatile flavour compounds by Proton Transfer Reaction-Mass Spectrometry: fragmentation patterns and discrimination between isobaric and isomeric compounds Int J Mass Spectrom 221 1 7 10.1016/S1387-3806(02)00896-5 1:CAS:528:DC%2BD38XotVWmtbs%3D
24. A Sponring W Filipiak T Mikoviny C Ager JK Schubert W Miekisch A Amann J Troppmair 2009 Release of Volatile Organic Compunds from the Lung Cancer Cell Line NCI-H2087 In Vitro Anticancer Res 29 419 426 1:CAS:528:DC%2BD1MXjtFGgt70%3D
25. M Patel L Lu DS Zander L Sreerama D Coco JS Moreb 2008 ALDHI AI and ALDH3 AI expression in lung cancer: correlations with histologic type and potential precursors Lung Cancer 59 340 349 10.1016/j.lungcan.2007.08.033 (Pubitemid 351335102)
26. D Ucar CR Cogle JR Zucali B Ostmark EW Scott R Zori BA Gray JS Moreb 2009 Aldehyde dehydrogenase activity as a functional marker for lung cancer Chem Biol Interact 178 48 55 10.1016/j.cbi.2008.09.029 1:CAS:528:DC%2BD1MXhsFOju70%3D
27. F Jiang Q Qiu A Khanna NW Todd J Deepak L Xing HM Wang Z Liu Y Su SA Stass RL Katz 2009 Aldehyde dehydrogenase 1 is a tumor stem cell-associated marker in lung cancer Mol Cancer Res 7 330 338 10.1158/1541-7786.MCR-08-0393 1:CAS:528:DC%2BD1MXjtF2js70%3D
28. G Duester 2000 Families of retinoid dehydrogenases regulating vitamin A function - Production of visual pigment and retinoic acid Eur J Biochem 267 4315 4324 10.1046/j.1432-1327.2000.01497.x 1:CAS:528:DC%2BD3cXlt1Gnur8%3D (Pubitemid 30461062)
29. M Yoshimoto A Waki Y Yonekura N Sadato T Murata N Omata N Takahashi MJ Welch Y Fujibayashi 2001 Characterization of acetate metabolism in tumor cells in relation to cell proliferation: Acetate metabolism in tumor cells Nucl Med Biol 28 117 122 10.1016/S0969-8051(00)00195-5 1:CAS:528:DC%2BD3MXisVWnt70%3D (Pubitemid 32276075)