Non-invasive metabolomic analysis of breath using differential mobility spectrometry in patients with chronic obstructive pulmonary disease and healthy smokers

Analyst

Volumn 135, Issue 2, 2010, Pages 315-320

  Basanta, Maria ^a   Jarvis, Roger M ^a   Xu, Yun ^a   Blackburn, Gavin ^b   Tal Singer, Ruth ^c   Woodcock, Ashley ^a   Singh, Dave ^a   Goodacre, Royston ^a   Paul Thomas, C L ^b   Fowler, Stephen J ^a,d  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b LOUGHBOROUGH UNIVERSITY   (United Kingdom)

^c GLAXOSMITHKLINE   (United States)

^d LANCASHIRE TEACHING HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 76749130199     PISSN: 00032654     EISSN: 13645528     Source Type: Journal    
DOI: 10.1039/b916374c     Document Type: Article

References (22)

1. M. Corradi I. Rubinstein R. Andreoli P. Manini A. Caglieri D. Poli R. Alinovi A. Mutti Aldehydes in exhaled breath condensate of patients with chronic obstructive pulmonary disease Am. J. Respir. Crit. Care Med. 2003 167 1380 1386
2. M. Phillips R. N. Cataneo J. Greenberg R. Gunawardena A. Naidu F. Rahbari-Oskoui Effect of age on the breath methylated alkane contour, a display of apparent new markers of oxidative stress J. Lab. Clin. Med. 2000 136 243 249
3. R. Goodacre Metabolomics of a superorganism J. Nutr. 2007 137 259S 266S
4. D. Smith P. Spanel The challenge of breath analysis for clinical diagnosis and therapeutic monitoring Analyst 2007 132 390 396
5. A. Wehinger A. Schmid S. Mechtcheriakov M. Ledochowski C. Grabmer G. A. Gastl A. Amann Lung cancer detection by proton transfer reaction mass-spectrometric analysis of human breath gas Int. J. Mass Spectrom. 2007 256 49 59
6. S. Dragonieri R. Schot B. J. Mertens S. Le Cessie S. A. Gauw A. Spanevello O. Resta N. P. Willard T. J. Vink K. F. Rabe E. H. Bel P. J. Sterk An electronic nose in the discrimination of patients with asthma and controls J. Allergy Clin. Immunol. 2007 120 856 862
7. P. J. Mazzone J. Hammel R. Dweik J. Na C. Czich D. Laskowski T. Mekhail Diagnosis of lung cancer by the analysis of exhaled breath with a colorimetric sensor array Thorax 2007 62 565 568
8. D. S. Levin R. A. Miller E. G. Nazarov P. Vouros Rapid separation and quantitative analysis of peptides using a new nanoelectrospray-differential mobility spectrometer-mass spectrometer system Anal. Chem. 2006 78 5443 5452
9. H. Borsdof G. A. Eiceman Ion mobility spectrometry: principles and applications Appl. Spectrosc. Rev. 2006 41 323 375
10. R. A. Miller E. G. Nazarov G. A. Eiceman A. T. King A MEMS radio-frequency ion mobility spectrometer for chemical vapour detection Sens. Actuators, A 2001 91 301 312
11. M. Basanta T. Koimtzis D. Singh I. Wilson C. L. P. Thomas An adaptive breath sampler for use with human subjects with an impaired respiratory function Analyst 2007 132 153 163
12. American Thoracic Society Standardization of spirometry, 1994 update Am. J. Respir. Crit. Care Med. 1995 152 1107 1136
13. M. Basanta D. Singh S. Fowler I. Wilson R. Dennis C. L. P. Thomas Increasing analytical space in gas chromatography-differential mobility spectrometry with dispersion field amplitude programming J. Chromatogr., A 2007 1173 129 138
14. P. H. C. Eilers Parametric time warping Anal. Chem. 2004 76 404 411
15. N. P. V. Nielsen J. M. Carstensen J. Smedsgaard Aligning of single and multiple wavelength chromatographic profiles for chemometric data analysis using correlation optimised warping J. Chromatogr., A 1998 805 17 35
16. T. Skov F. van den Berg G. Tomasi R. Bro Automated alignment of chromatographic data J. Chemom. 2006 20 484 497
17. Y. Xu F. Gong S. J. Dixon R. G. Brereton H. A. Soini M. V. Novotny E. Oberzaucher K. Grammer D. J. Penn Application of dissimilarity indices, principal co-ordinates analysis and rank tests to peak tables in metabolomics of the gas chromatography mass spectrometry of human sweat Anal. Chem. 2007 79 5633 5641
18. C. E. Metz Basic principles of ROC analysis Semin. Nucl. Med. 1978 8 283 298
19. H. Martens and T. Næs, Multivariate Calibration, John Wiley, Chichester, 1989
20. R. K. H. Galvao M. C. U. Araujo M. D. N. Martins G. E. Jose M. J. C. Pontes E. C. Silva T. C. B. Saldanha An application of subagging for the improvement of prediction accuracy of multivariate calibration models Chemom. Intell. Lab. Syst. 2006 81 60 67
21. D. Poli P. Carbognani M. Corradi M. Goldoni O. Acampa B. Balbi L. Bianchi M. Rusca A. Mutti Exhaled volatile organic compounds in patients with non-small cell lung cancer: cross-sectional and nested short-term follow-up study Respir. Res. 2005 6 71 80
22. D. I. Broadhurst D. B. Kell Statistical strategies for avoiding false discoveries in metabolomics and related experiments Metabolomics 2006 2 171 196