Telomeres in trisomy 21 amniocytes

Cytogenetic and Genome Research

Volumn 135, Issue 1, 2011, Pages 12-18

  Sukenik Halevy, R ^a,b   Biron Shental, T ^a,c   Sharony, R ^a,c   Fejgin, M D ^a,c   Amiel, A ^a,d  

^a MEIR MEDICAL CENTER   (Israel)

^b HAEMEK MEDICAL CENTER   (Israel)

^c TEL AVIV UNIVERSITY   (Israel)

^d BAR ILAN UNIVERSITY   (Israel)

Author keywords

Amniocytes; Down syndrome; FISH; Telomeres; TERC; Trisomy 21

Indexed keywords

RNA;

AMNION CELL; ARTICLE; CHROMOSOME ANALYSIS; CLINICAL FEATURE; CONTROLLED STUDY; DOWN SYNDROME; FLUORESCENCE IN SITU HYBRIDIZATION; GENE; GENE AMPLIFICATION; GENE DOSAGE; HTERC GENE; HUMAN; HUMAN CELL; PREGNANCY; PRIORITY JOURNAL; TELOMERE; TRISOMY 21;

AMNIOCENTESIS; AMNIOTIC FLUID; CASE-CONTROL STUDIES; CELL CULTURE TECHNIQUES; CYTOGENETICS; DEMENTIA; DOWN SYNDROME; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENE DOSAGE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LEUKEMIA; PREGNANCY; PRENATAL DIAGNOSIS; RISK FACTORS; RNA; SOFTWARE; TELOMERASE; TELOMERE;

EID: 80052706858     PISSN: 14248581     EISSN: 14219794     Source Type: Journal    
DOI: 10.1159/000329714     Document Type: Article

References (68)

1. Allsopp RC, Harley CB: Evidence of a critical telomere length in senescent human fibroblasts. Exp Cell Res 219: 130-136 (1995).
2. Allsopp RC, Vaziri H, Patterson C, Goldstein S, Younglai EV, et al: Telomere length predicts replicative capacity of human fibroblasts. Proc Natl Acad Sci USA 89: 10114-10118 (1992).
3. Altug-Teber O, Bonin M, Walter M, Mau-Holzmann UA, Dufke A, et al: Specific transcriptional changes in human fetuses with autosomal trisomies. Cytogenet Genome Res 119: 171-184 (2007). (Pubitemid 351235048)
4. Amiel A, Korenstein A, Gaber E, Avivi L: Asynchronous replication of alleles in genomes carrying an extra autosome. Eur J Hum Genet 7: 223-230 (1999). (Pubitemid 29150234)
5. Amiel A, Leopold L, Gronich N, Yukla M, Fejgin MD, Lishner M: The influence of different chromosomal aberrations on molecular cytogenetic parameters in chronic lymphocytic leukemia patients. Cancer Genet Cytogenet 167: 145-149 (2006). (Pubitemid 43776947)
6. Bercovich D, Ganmore I, Scott LM, Wainreb G, Birger Y, et al: Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome. Lancet 372: 1484-1492 (2008).
7. Birchler JA, Newton KJ: Modulation of protein levels in chromosomal dosage series of maize: The biochemical basis of aneuploid syndromes. Genetics 99: 247-266 (1981).
8. Biron-Shental T, Sukenik Halevy R, Goldberg- Bittman L, Kidrond D, Fejgin MD, et al: Telomeres are shorter in placental trophoblasts of pregnancies complicated with intrauterine growth restriction (IUGR). Early Hum Dev 86: 451-456 (2010a).
9. Biron-Shental T, Sukenik-Halevy R, Sharon Y, Goldberg-Bittman L, Kidron D, et al: Short telomeres may play a role in placental dysfunction in preeclampsia and intrauterine growth restriction. Am J Obstet Gynecol 202: 381.e1-e7 (2010b).
10. Blasco MA, Gasser SM, Lingar J: Telomeres and telomerase. Genes Dev 13: 2353-2359 (1999). (Pubitemid 29453605)
11. Bodnar AG, Ouellette M, Frolkis M, Holt SE, Chiu CP, et al: Extension of life-span by introduction of telomerase into normal human cells. Science 279: 349-352 (1998). (Pubitemid 28063364)
12. Bryce LA, Morrison N, Hoare SF, Muir S, Keith WN: Mapping of the gene for the human telomerase reverse transcriptase, hTERT, to chromosome 5p15.33 by fluorescence in situ hybridization. Neoplasia 2: 197-201 (2000). (Pubitemid 30346075)
13. Cao Y, Bryan TM, Reddel RR: Increased copy number of the RERT and TERC telomerase subunit genes in cancer cells. Cancer Sci 99: 1092-1099 (2008). (Pubitemid 351676619)
14. Chou CY, Liu LY, Chen CY, Tsai CH, Hwa HL, et al: Gene expression variation increase in trisomy 21 tissues. Mamm Genome 19: 398-405 (2008).
15. Chuang TC, Moshir S, Garini Y, Chuang AY, Young IT, et al: The three-dimensional organization of telomeres in the nucleus of mammalian cells. BMC Biol 2: 1-8 (2004).
16. Cohen SB, Graham ME, Lovrecz GO, Bache N, Robinson PJ, et al: Protein composition of catalytically active human telomerase from immortal cells. Science 315: 1850-1853 (2007). (Pubitemid 46580145)
17. Colgin LM, Reddel RR: Telomere maintenance mechanisms and cellular immortalization. Curr Opin Genet Dev 9: 97-103 (1999). (Pubitemid 29080393)
18. Conti A, Fabbrini F, D'Agostino P, Negri R, Greco D, et al: Altered expression of mitochondrial and extracellular matrix genes in the heart of human fetuses with chromosome 21 trisomy. BMC Genomics 8: 268 (2007).
19. Counter CM, Avilion AA, LeFeuvre CE, Stewart NG, Greider CW, et al: Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J 11: 1921-1929 (1992).
20. de Pauw ES, Verwoerd NP, Duinkerken N, Willemze R, Raap AK, et al: Assessment of telomere length in hematopoietic interphase cells using in situ hybridization and digital fluorescence microscopy. Cytometry 32: 163-169 (1998). (Pubitemid 28285992)
21. Dixon N, Kishnani PS, Zimmerman S: Clinical manifestations of hematologic and oncologic disorders in patients with Down syndrome. Am J Med Genet C Semin Med Genet 142C:149-157 (2006). (Pubitemid 44298197)
22. Epel ES, Blackburn EH, Lin J, Dhabhar FS, Adler NE, et al: Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci USA 101: 17312-17315 (2004). (Pubitemid 39627816)
23. Epstein CJ, Korenberg JR, Annerén G, Antonarakis SE, Aymé S, et al: Protocols to establish genotype-phenotype correlations in Down syndrome. Am J Hum Genet 49: 207-235 (1991). (Pubitemid 21891669)
24. Feng J, Funk WD, Wang SS, Weinrich SL, Avilion AA, et al: The RNA component of human telomerase. Science 269: 1236-1241 (1995).
25. Gilley D, Herbert BS, Huda N, Tanaka H, Reed T: Factors impacting human telomere homeostasis and age-related disease. Mech Ageing Dev 129: 27-34 (2008). (Pubitemid 351199864)
26. Greider CW: Mammalian telomere dynamics: Healing, fragmentation shortening and stabilization. Curr Opin Genet Dev 4: 203-211 (1994). (Pubitemid 24114851)
27. Greider CW, Blackburn EH: Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 43: 405-413 (1985). (Pubitemid 16213265)
28. Hadi E, Sharony R, Goldberg-Bittman L, Biron- Shental T, Fejgin M, et al: Telomere aggregates in trisomy 21 amniocytes. Cancer Genet Cytogenet 195: 23-26 (2009).
29. Harley CB, Futcher AB, Greider CW: Telomeres shorten during ageing of human fibroblasts. Nature 345: 458-460 (1990).
30. Holmes DK, Bates N, Murray M, Ladusans EJ, Morabito A, et al: Hematopoietic progenitor cell deficiency in fetuses and children affected by Down's syndrome. Exp Hematol 34: 1611-1615 (2006). (Pubitemid 44839014)
31. Holt SE, Brown EJ, Zipursky A: Telomerase and the benign and malignant megakaryoblastic leukemias of Down syndrome. J Pediatr Hematol Oncol 24: 14-17 (2002). (Pubitemid 34094322)
32. Horan MP: Application of serial analysis of gene expression to the study of human genetic disease. Hum Genet 126: 605-614 (2009).
33. Jenkins EC, Velinov MT, Ye L, Gu H, Li S, et al: Telomere shortening in T lymphocytes of older individuals with Down syndrome and dementia. Neurobiol Aging 27: 941-945 (2006).
34. Jenkins EC, Ye L, Gu H, Ni SA, Duncan CJ, et al: Increased 'absence' of telomeress may indicate Alzheimer's disease/dementia status in older individuals with Down syndrome. Neurosci Lett 440: 340-343 (2008).
35. Jenkins EC, Ye L, Gu H, Ni SA, Velinov M, et al: Shorter telomeres may indicate dementia status in older individuals with Down syndrome. Neurobiol Aging 31: 765-771 (2010).
36. Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, et al: Specific association of human telomerase activity with immortal cells and cancer. Science 266: 2011-2015 (1994).
37. Kitay-Cohen Y, Goldberg-Bittman L, Hadary R, Fejgin MD, Amiel A: Telomere length in hepatitis C. Cancer Genet Cytogenet 187: 34-38 (2008).
38. Lockrow J, Prakasam A, Huang P, Bimonte-Nelson H, Sambamurti K, et al: Cholinergic degeneration and memory loss delayed by vitamin E in a Down syndrome mouse model. Exp Neurol 216: 278-289 (2009).
39. Lockstone HE, Harris LW, Swatton JE, Wayland MT, Holland AJ, et al: Gene expression profiling in the adult Down syndrome brain. Genomics 90: 647-660 (2007). (Pubitemid 350166832)
40. Lubec G, Engidawork E: The brain in Down syndrome (TRISOMY 21). J Neurol 249: 1347-1356 (2002).
41. Mason PJ, Wilson DB, Bessler M: Dyskeratosis congenita - a disease of dysfunctional telomere maintenance. Curr Mol Med 5: 159-170 (2005). (Pubitemid 40601643)
42. McClintock B: The stability of broken ends of chromosomes in Zea mays Genetics 26: 234-282 (1941).
43. Mitchell JR, Wood E, Collins K: A telomerase component is defective in the human disease dyskeratosis congenita. Nature 402: 551-555 (1999).
44. Muller HJ: The remaking of chromosomes. Collecting Net 13: 181-198 (1938).
45. Nakamura TM, Morin GB, Chapman KB, Weinrich SL, Andrews WH, et al: Telomerase catalytic subunit homologes from fission yeast and human. Science 277: 955-959 (1997). (Pubitemid 27366681)
46. O'Sullivan JN, Finley JC, Risques RA, Shen WT, Gollahon KA, et al: Telomere length assessment in tissue sections by quantitative FISH: Image analysis algorithms. Cytometry A 58: 120-131 (2004). (Pubitemid 38509173)
47. Panossian LA, Porter VR, Valenzuela HF, Zhu X, Reback E, et al: Telomere shortening in T cells correlates with Alzheimer's disease status. Neurobiol Aging 24: 77-84 (2003). (Pubitemid 35454145)
48. Patja K, Pukkala E, Sund R, Iivanainen M, Kaski M: Cancer incidence of persons with Down syndrome in Finland: A population-based study. Int J Cancer 118: 1769-1772 (2006). (Pubitemid 43376441)
49. Patterson D: Molecular genetic analysis of Down syndrome. Hum Genet 126: 195-214 (2009).
50. Plentz RR, Caselitz M, Bleck JS, Gebel M, Flemming P, et al: Hepatocellular telomere shortening correlates with chromosomal instability and the development of human hepatoma. Hepatology 40: 80-86 (2004). (Pubitemid 38868926)
51. Prandini P, Deutsch S, Lyle R, Gagnebin M, Delucinge Vivier C, et al: Natural gene-expression variation in Down syndrome modulates the outcome of gene-dosage imbalance. Am J Hum Genet 81: 252-263 (2007). (Pubitemid 47236074)
52. Raynaud CM, Hernandez J, Llorca FP, Nuciforo P, Mathieu MC, et al: DNA damage repair and telomere length in normal breast, preneoplastic lesions, and invasive cancer. Am J Clin Oncol 33: 341-345 (2010).
53. Rhee DB, Wang Y, Mizesko M, Zhou F, Haneline L, Liu Y: FANCC suppresses short telomereinitiated telomere sister chromatid exchange. Hum Mol Genet 19: 879-887 (2010).
54. Rooney PH, Murray GI, Stevenson DA, Haites NE, Cassidy J, McLeod HL: Comparative genomic hybridization and chromosomal instability in solid tumours. Br J Cancer 80: 862-873 (1999). (Pubitemid 29209852)
55. Salpea KD, Nicaud V, Tiret L, Talmud PJ, Humphries SE; EARS II group: The association of telomere length with paternal history of premature myocardial infarction in the European Atherosclerosis Research Study II. J Mol Med 86: 815-824 (2008).
56. Samani NJ, Boultby R, Butler R, Thompson JR, Goodall AH: Telomere shortening in atherosclerosis. Lancet 358: 472-473 (2001). (Pubitemid 32769858)
57. Shapiro BL: Down syndrome - a disruption of homeostasis. Am J Med Genet 14: 241-269 (1983). (Pubitemid 13193913)
58. Slijepcevic P: Telomere length measurement by Q-FISH. Methods Cell Sci 23: 17-22 (2001). (Pubitemid 34116331)
59. Soder AI, Hoare SF, Muir S, Going JJ, Parkinson EK, et al: Amplification, increased dosage and in situ expression of the telomerase RNA gene in human cancer. Oncogene 14: 1013-1021 (1997). (Pubitemid 27129245)
60. Sommer CA, Pavarino-Bertelli EC, Goloni-Bertollo EM, Henrique-Silva F: Identification of dysregulated genes in lymphocytes from children with Down syndrome. Genome 51: 19-29 (2008). (Pubitemid 351287666)
61. Sugita M, Tanaka N, Davidson S, Sekiya S, Varella- Garcia M, et al: Molecular definition of a small amplification domain within 3q26 in tumors of cervix, ovary, and lung. Cancer Genet Cytogenet 117: 9-18 (2000). (Pubitemid 30099648)
62. Tunstall-Pedoe O, Roy A, Karadimitris A, de la Fuente J, Fisk NM, et al: Abnormalities in the myeloid progenitor compartment in Down syndrome fetal liver precede acquisition of GATA1 mutations. Blood 112: 4507-4511 (2008).
63. Valdes AM, Richards JB, Gardner JP, Swaminathan R, Kimura M, et al: Telomere length in leukocytes correlates with bone mineral density and is shorter in women with osteoporosis. Osteoporos Int 18: 1203-1210 (2007). (Pubitemid 47300273)
64. Vaziri H, Schächter F, Uchida I, Wei L, Zhu X, et al: Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes. Am J Hum Genet 52: 661-667 (1993). (Pubitemid 23310132)
65. Vermolen BJ, Garini Y, Young IT, Dirks RW, Raz V: Segmentation and analysis of the threedimensional redistribution of nuclear components in human mesenchymal stem cell. Cytometry A 73: 816-824 (2008).
66. von Zglinicki T, Saretzki G, Döcke W, Lotze C: Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: A model for senescence? Exp Cell Res 220: 186-193 (1995).
67. Zipursky A, Peeters M, Poon A: Megakaryoblastic leukemia and Down's syndrome. Pediatr Hematol Oncol 4: 211-230 (1987).
68. Zipursky A, Brown E, Christensen H, Sutherland R, Doyle J: Leukemia and/or myeloproliferative syndrome in neonates with Down syndrome. Semin Perinatol 21: 97-101 (1997). (Pubitemid 27247332)